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"[ABSTRAKPenelitian ini bertujuan untuk mengetahui hubungan asupan vitamin A dan kadar retinol dengan status anemia pada dua kelompok ibu hamil trimester tiga, yaitu kelompok anemia dan non anemia. Penelitian ini merupakan penelitian potong lintang yang dilaksanakan di sepuluh puskesmas kecamatan Jakarta Timur dan merupakan bagian dari penelitian besar Departemen Gizi Fakultas Kedokteran Universitas Indonesia yang berjudul “Peran Gizi, Faktor Maternal dan Pelayanan Kesehatan pada Ibu Hamil Trimester Ketiga terhadap Komposisi Mikrobiota Ibu dan Berat Lahir Bayi: Studi Kohort di Jakarta”. Pengambilan data dilakukan pada bulan April hingga Mei 2015. Sebanyak 113 subjek ibu hamil trimester tiga dengan usia kehamilan diatas 32 minggu ikut dalam penelitansetelah memenuhi kriteria penelitian dan dibagi dalam dua kelompok berdasarkan kadar hemoglobin yaitu anemia (Hb<11g/dL) dan non anemia (Hb≥11g/dL). Setelah itu dilakukan pengukuran antropometri, wawancara asupan, pemeriksaan hemoglobin, dan serum retinol. Data yang dikumpulkan meliputi karakteristik demografi, antropometri, asupan makanan (makronutrien dan mikronutrien), kadar hemoglobin, dankadar serum retinol. Rentang usia subjek dalam penelitian ini adalah 19-44 tahun. Sebagian besar subjek (59,6%) memiliki tingkat pendidikan menengah (lulus SMP atau SMA). Rerata usia kehamilan pada subjek penelitian ini adalah 34,32 ± 1,86 minggu pada kelompok anemia dan 35,18±1,73 minggu pada kelompok non anemia.Rerata asupan protein pada kedua kelompok ibu masih berada di bawah AKG yaitu <77g/hari. Rerata asupan lemak pada kelompok anemia lebih tinggi daripada kelompok non anemia (p=0,04). Asupan Fe kedua kelompok sudah sesuai dengan AKG yaitu 40mg/hari (p=0,82). Asupan folat pada kelompok anemia lebih rendahdan kurang dari AKG dibandingkan kelompok non anemia (p=0,16).Asupan vitamin B12, hampir tidak ada perbedaan rerata antara dua kelompok dan sudah sesuai dengan AKG. Median asupan vitamin A pada kelompok non anemia lebih tinggi dari kelompok anemia (p=0,52). Rerata kadar retinol pada kelompok anemia adalah 1,40±0,50 dan pada kelompok non anemia adalah 1,45±0,44. (p=0,55).Tidak didapatkan hasil yang bermakna setelah dilakukan analisis multivariat sebagai kontrol perancu.

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ABSTRACTThe aim of the study was to determine the relationship between vitamin A and retinol levels with anemia status in two groups of three trimester pregnant women, namely the anemic and non anemic. This was a cross-sectional study conducted in ten sub-district Government Health Centre in East Jakarta and which part of a large research department of Nutrition Faculty of Medicine, University of Indonesia, entitled "The Role of Nutrition, Maternal Factors and Maternal Health Services with the Composition of the Microbiota in Third Trimester Maternal and Infant Birth Weight : The study cohort in Jakarta". Data was collected from April untill May 2015. A total of 113 third trimester pregnant women with gestational age above 32 weeks (35.0 ± 1.8) were participated in research after met the study criterions. They were divided into two groups based on the levels of hemoglobin which were anemic (Hb<11g /dL) and non anemic(Hb≥ 11g / dL), and continue with anthropometric examination, interview and Hb measurement. The data collected included demographic characteristics, anthropometry, food intake (macronutrients and micronutrients), hemoglobin, and serum retinol. The age range of the subjects in this study was 19-44 years old. Most subjects (59.6%) had secondary education (graduated from high school or high school). The mean gestational age of the subjects was 34.32 ± 1.86 weeks in anemic group and 35.18 ± 1.73 weeks in non anemic. Mean of protein intake in both groups are still under RDA which < 77g/day. The mean of fat intake in anemic group was higher than non-anemic group (p=0.04). Iron intake in both groups are in accordance with the RDA which 40mg/day (p=0.82). Folate intake was lower in anemia group than non-anemic group (p=0.16). There was no difference between vitamin B12 intake in both group andwere in accordance with RDA. The median of vitamin A intake in non-anemic group was higher than non-anemic group (p = 0.52). The mean retinol serum levels in anemic group was 1.40 ± 0.50 and non-anemic group was 1.45 ± 0.44. (P = 0.55). No significant results obtained from multivariate analysis in order to control the confounders., The aim of the study was to determine the relationship between vitamin A and retinol levels with anemia status in two groups of three trimester pregnant women, namely the anemic and non anemic. This was a cross-sectional study conducted in ten sub-district Government Health Centre in East Jakarta and which part of a large research department of Nutrition Faculty of Medicine, University of Indonesia, entitled "The Role of Nutrition, Maternal Factors and Maternal Health Services with the Composition of the Microbiota in Third Trimester Maternal and Infant Birth Weight : The study cohort in Jakarta". Data was collected from April untill May 2015. A total of 113 third trimester pregnant women with gestational age above 32 weeks (35.0 ± 1.8) were participated in research after met the study criterions. They were divided into two groups based on the levels of hemoglobin which were anemic (Hb<11g /dL) and non anemic(Hb≥ 11g / dL), and continue with anthropometric examination, interview and Hb measurement. The data collected included demographic characteristics, anthropometry, food intake (macronutrients and micronutrients), hemoglobin, and serum retinol. The age range of the subjects in this study was 19-44 years old. Most subjects (59.6%) had secondary education (graduated from high school or high school). The mean gestational age of the subjects was 34.32 ± 1.86 weeks in anemic group and 35.18 ± 1.73 weeks in non anemic. Mean of protein intake in both groups are still under RDA which < 77g/day. The mean of fat intake in anemic group was higher than non-anemic group (p=0.04). Iron intake in both groups are in accordance with the RDA which 40mg/day (p=0.82). Folate intake was lower in anemia group than non-anemic group (p=0.16). There was no difference between vitamin B12 intake in both group andwere in accordance with RDA. The median of vitamin A intake in non-anemic group was higher than non-anemic group (p = 0.52). The mean retinol serum levels in anemic group was 1.40 ± 0.50 and non-anemic group was 1.45 ± 0.44. (P = 0.55). No significant results obtained from multivariate analysis in order to control the confounders.]"

"Latar belakang dan tujuan: Tuberkulosis (TB) sampai saat ini merupakan tantangan dan ancaman besar bagi kesehatan masyarakat di dunia. Insidens TB paru di kota Bekasi tahun 2014 adalah 1359/2.510.951 penduduk dan 3099 total kasus selama tahun 2014. Defisiensi mikronutrien seperti retinol dapat terjadi akibat hilangnya nafsu makan, gangguan absorbsi usus halus yang menyebabkan keadaan imununosupresi sehingga meningkatkan risiko infeksi TB. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar retinol serum dengan derajat bacterial TB paru kasus baru di tingkat pelayanan primer.Metode: Penelitian mempergunakan desain potong lintang dengan 135 sampel yang diambil dengan cara cluster consecutive sampling di puskesmas wilayah kota Bekasi pada penderita TB paru kasus baru yang belum mendapatkan terapi obat anti tuberkulosis (OAT). Hasil: Karakteristik subjek TB paru kasus baru di puskesmas menurut usia dengan nilai tengah 35,5 tahun (IQR 18-65), laki-laki 62,3%, perokok 44,9%, IMT gizi kurang 56,5%, hipoalbumin 17,4%, kadar retinol serum defisien 40,6%. Lesi kavitas 30,4?% dan derajat bacterial load mayoritas scanty dan +1 dengan persentase berturut-turut 10,1% dan 39,1%. Terdapat perbedaan bermakna kadar albumin, IMT, lesi kavitas dengan bacterial load dengan nilai p=0,003, p=0,014, p=0,011 namun tidak terdapat hubungan bermakna antara kadar retinol serum dengan bacterial load.

Kesimpulan: Kadar retinol serum tidak berhubungan dengan derajat bacterial load pasien TB paru kasus baru di wilayah kerja kota Bekasi serta terdapat hubungan bermakna antara IMT, kadar albumin dan lesi radiologis dengan bacterial load.

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Background: Tuberculosis (TB) remains a threat for community health across the globe including Indonesia. The incidence of pulmonary TB in Bekasi, Indonesia in 2014 is 1,395/2,510,951 people and there were 3.099 cases in 2014. Micronutrient deficiency such as retinol can be caused by loss of appetite and disorder in intestinal absorption which could lead to immunosuppressive condition that increased the risk of TB. This study aims to find the correlation between serum retinol level and semi-quantitative bacterial load in new case of pulmonary TB at a community health center.

Methods: This cross-sectional study involved 135 subjects collected through cluster consecutive sampling in a primary health care in Bekasi, Indonesia. The study included new pulmonary TB cases which had no history of taking any anti-TB drugs.

Results: The median age of the subjects was 35.5 years old (IQR 18-65) and most of subjects were males (62.3%), smokers (44.9%), had low body mass index (BMI) (56.5%), had hypoalbuminemia (17.4%), serum retinol deficient (40.6%), presented with cavity lesion (30.4%) and presented with scanty and +1 semi-quantitative bacterial load (10.1% and 39.1%, respectively). There was no significant correlation between serum retinol level and semi-quantitative bacterial load. However, there were significant correlations between serum albumin level, BMI and presence of cavity lesion and semi-quantitative bacterial load (p=0.003, p=0.014, and p=0.011, respectively).

Conclusion: There was no correlation between serum retinol level and semi-quantitative bacterial load in new cases of pulmonary TB patients. There were significant correlations between serum albumin level, BMI and presence of cavity lesion and semi-quantitative bacterial load."