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Ditemukan 20 dokumen yang sesuai dengan query
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Supenya Chittapun
"ABSTRACT
To overcome the disadvantages of open pond and cement tube as an outdoor algal cultured system, a simple inclined algal culture system was developed. the system composed of an 18.9 L polyethylene terephthalate (PET)bottle placed on a degree adjustable stand using an air pump to generate water mixing and circulation. The system was tested by culturing 45 mL Oscillatoria sp. in 13 L Blue-Green-11 (BG-11)medium supplemented with 3 g L-1 NaNO3 in plastic bottle, which was placed on different angles of inclination, viz. 45°, 60° and 90°. The system was operated outdoor under natural daylight and temperature. After 11 days, 11.5 L culture medium was poured out and 11.5 L fresh medium was refilled. Algal cell was precipitated to measure algal yield. Then, cell harvesting was done every 7 days for 6 batches. This system could culture algae continuously for 5 batches. The highest productivity was 32.23 gram wet (gw) ×m-2×d-1, which was recorded from a second and fifth round of 45° angular system and also from third round of 60° angular system. The result showed that this simple inclined algal culture system can be done continuously for one and a half month with high productivity by 45° inclination, which was proved as a good mixing and circulation. Showing advantages over open-pond, this system was moveable and could reduce possibility of contamination."
Pathum Thani: Thammasat University, 2017
607 STA 22:3 (2017)
Artikel Jurnal  Universitas Indonesia Library
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Rike Khoirunnisa
"[ABSTRAK
Kekerasan dalam rumah tangga (KDRT) dapat terjadi sepanjang kehidupan seorang wanita, termasuk ketika wanita sedang hamil, dimana kehamilan dianggap sebagai saat dimana wanita harus dilindungi. Karya ilmiah ini bertujuan untuk memaparkan analisis praktik klinik keperawatan kesehatan masyarakat perkotaan: Asuhan keperawatan pada ibu hamil yang dengan kekerasan dalam rumah tangga dalam periode perinatal. pengkajian pada kasus ibu hamil dengan KDRT, ditemukan masalah keperawatan yaitu kecemasan, ketidakefektifan koping keluarga, resiko tinggi cedera pada janin dan resiko tinggi kekerasan berulang. Intervensi keperawatan yang diberikan untuk masalah kecemasan yaitu menjelaskan kondisi kesehatan janin dalam kandungan, tehnik relaksasi napas dalam, serta pendampingan untuk mengatasi masalah ketidakefektifan koping keluarga dan resiko kekerasan berulang. Hasil praktik ini menyarankan pada petugas kesehatan untuk memberikan asuhan keperawatan pada ibu dengan KDRT tidak hanya berpusat pada masalah fisik, tetapi juga penting memberikan dukungan psikologis bagi korban; ABSTRACT Domestic violence can occur throughout a woman's life, including when a woman is pregnant. The period of pregnancy is regarded as a time when women should be protected. This scientific paperaimed to describe the analysis of clinical practice of urban community health nursing: Nursing care for pregnant women with domestic violence in the perinatal period. In the assessment on pregnant women with domestic violence, it was found that the nursing problems included anxiety, ineffective family coping, high risk of injury to the fetus and the high risk of recurring violence. Nursing interventions given for anxiety problems was explaining the health condition of the fetus in the womb, breathing in relaxation techniques, as well as assistance to overcome the problem of ineffectiveness family coping and the risk of recurring violence. This practice results suggest that health care workers need to provide nursing care in women with domestic violence not only to focus on physical issues, but it is also important to give psychological support to the mothers;Domestic violence can occur throughout a woman's life, including when a woman is pregnant. The period of pregnancy is regarded as a time when women should be protected. This scientific paperaimed to describe the analysis of clinical practice of urban community health nursing: Nursing care for pregnant women with domestic violence in the perinatal period. In the assessment on pregnant women with domestic violence, it was found that the nursing problems included anxiety, ineffective family coping, high risk of injury to the fetus and the high risk of recurring violence. Nursing interventions given for anxiety problems was explaining the health condition of the fetus in the womb, breathing in relaxation techniques, as well as assistance to overcome the problem of ineffectiveness family coping and the risk of recurring violence. This practice results suggest that health care workers need to provide nursing care in women with domestic violence not only to focus on physical issues, but it is also important to give psychological support to the mothers;Domestic violence can occur throughout a woman's life, including when a woman is pregnant. The period of pregnancy is regarded as a time when women should be protected. This scientific paperaimed to describe the analysis of clinical practice of urban community health nursing: Nursing care for pregnant women with domestic violence in the perinatal period. In the assessment on pregnant women with domestic violence, it was found that the nursing problems included anxiety, ineffective family coping, high risk of injury to the fetus and the high risk of recurring violence. Nursing interventions given for anxiety problems was explaining the health condition of the fetus in the womb, breathing in relaxation techniques, as well as assistance to overcome the problem of ineffectiveness family coping and the risk of recurring violence. This practice results suggest that health care workers need to provide nursing care in women with domestic violence not only to focus on physical issues, but it is also important to give psychological support to the mothers, Domestic violence can occur throughout a woman's life, including when a woman is pregnant. The period of pregnancy is regarded as a time when women should be protected. This scientific paperaimed to describe the analysis of clinical practice of urban community health nursing: Nursing care for pregnant women with domestic violence in the perinatal period. In the assessment on pregnant women with domestic violence, it was found that the nursing problems included anxiety, ineffective family coping, high risk of injury to the fetus and the high risk of recurring violence. Nursing interventions given for anxiety problems was explaining the health condition of the fetus in the womb, breathing in relaxation techniques, as well as assistance to overcome the problem of ineffectiveness family coping and the risk of recurring violence. This practice results suggest that health care workers need to provide nursing care in women with domestic violence not only to focus on physical issues, but it is also important to give psychological support to the mothers]"
Fakultas Ilmu Keperawatan Universitas Indonesia, 2015
PR-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Engla Merizka
"ABSTRAK
Latar belakang. Pasien yang mendapatkan trasfusi darah berulang berisiko
mempunyai aloantibodi terhadap antigen yang ada pada permukaan sel darah
merah. Aloantibodi tersebut dapat menyebabkan terjadinya reaksi transfusi berupa hemolisis sel darah merah pada transfusi darah berikutnya. Untuk mencegah terjadinya hemolisis sel darah merah maka pasien talasemia sebaiknya mendapatkan darah yang sesuai dengan antigen sel darah merah yang dimilikinya. Namun hal ini belum dimungkinkan karena keterbatasan pemeriksaan rutin pretransfusi yang dilakukan untuk setiap pasien talasemia yang mendapatkan transfusi darah berulang.
Metode penelitian. Delapan puluh delapan sampel pasien talasemia yang
mendapat transfusi darah berulang dilakukan skrining antibodi sel darah merah
dengan metode Indirect Coomb's Test (ICT) dan dilanjutkan dengan identifikasi
antibodi. Sampel yang terdeteksi mempunyai antibodi dikonfirmasi dengan
pemeriksaan fenotyping dan genotyping untuk melihat jenis antigen yang ada di permukaan sel merah.
Hasil. Dari hasil skrining antibodi terdeteksi adanya aloantibodi pada tujuh dari
88 sampel. Dari delapan sampel yang diidentifikasi terdapat tiga sampel
mempunyai anti E (47%), empat (57 %) sampel tidak dapat disimpulkan jenis
antibodi apa yang terdapat dalam sampel.
Simpulan. Pasien talasemia yang memiliki aloantibodi pada sampel darahnya
memiliki genotype RHCE*Ce dan sesuai dengan hasil fenotyping. Dapat
disimpulkan bahwa antibodi pada pasien merupakan aloantibodi. Pada penelitian ini didapatkan persentase aloantibodi pada pasien talasemia sebanyak tujuh (8%) dari total 88 sampel (100 %). Dengan dilakukannya skrining antibodi diharapkan dapat mengurangi risiko terbentuknya aloantibodi dengan memberikan darah donor yang sesuai dengan antibodi yang dimiliki pasien sehingga tidak terjadi hemolisis.

ABSTRACT
Background. Patients who receive repeated blood trasfusi alloantibody risk
having the antigen on the surface of red blood cells. Alloantibody can cause
transfusion reactions in the form of a red blood cell hemolysis on next blood
transfusions. To prevent the occurrence of the red blood cell hemolysis in
thalassemia patients should receive blood that best match the red blood cell
antigen has. But this was not possible due to the limitations of routine pretransfusion examination performed for every patient with thalassemia who receive repeated blood transfusions.
Research methods. Eighty-eight samples thalassemia patients receiving repeated blood transfusions carried red cell antibody screening method Indirect Coomb's Test (ICT) and continued with the identification of antibodies. Samples were detected with antibodies was confirmed by examination fenotyping and genotyping to see what kind of a cell surface antigen that is red.
Results. From the results of antibody screening detected seven out of 88 samples contained alloantibody. Of the eight samples has identified three samples contained anti-E (47%), four (57%) samples can not be inferred what kind of antibodies contained in the sample.
Conclusions. Patients with thalassemia who have alloantibody on blood samples have genotype RHCE * Ce and in accordance with the results of fenotyping. It can be concluded that the antibodies in patients is alloantibody. In this study, the percentage of patients with thalassemia alloantibody seven (8%) of the total 88 samples (100%). The effect of antibody screening is expected to reduce the risk of developing alloantibody by providing appropriate donor blood with antibodies that owned the patient so there is no hemolysis."
2016
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Demy Faheem Dasril
"Pendahuluan: Cedera ACL merupakan penyakit dengan impact besar pada pasien usia produktif. Pada penelitian ini, fokus utama adalah pilihan graft. Autograft quadriceps merupakan pilihan yang rasional untuk masyarakat Asia dimana diameter serta panjang tendon hamstring lebih kecil. Kami bermaksud melakukan perbandingan luaran klinis antara autograft quadriceps dan hamstring pada kasus rekonstruksi ACL per artroskopik.
Metode: Desain penelitian adalah kohort prospektif. Tiga puluh pasien diikutsertakan dalam studi ini yang dibagi menjadi dua grup (quadriceps dan hamstring). Pengambilan data berlangsung selama 1 tahun (Februari 2016-2017) di RSPAD Gatot Subroto dan RS Cipto Mangunkusumo, Jakarta. Instrumen yang digunakan adalah rolimeter dan 3 buah kuesioner (IKDC, Tegner-Lysholm, dan KOOS). Evaluasi dilakukan secara repeated time measurements.
Hasil: Rerata rolimeter kelompok quadriceps 3,12 ± 0,94 dan kelompok hamstring 3,87 ± 0,61 (p=0,015). Parameter side to side difference didapatkan lebih baik pada kelompok quadriceps (0,34 ± 0,70) dibandingkan hamstring (0,84 ± 0,60) dengan p=0,04. Pada skor IKDC, didapatkan data 1 bulan (p=0,002; rentang 95%IK [8,81-31,79]) dan 3 bulan (p=0,004; 95%IK [4,85-20,39]) paska operasi yang baik. Skoring Tegner-Lysholm bermakna pada kedua data (numerik dan kategorik). Pada data numerik (1 bulan paska operasi), didapatkan nilai p=0,004 yang sinkron dengan data kategorik (p=0,050). Untuk skoring KOOS, didapatkan hasil bermakna pada 3 dan 6 bulan paska operasi pada sub-item nyeri (p=0,034) serta symptoms (p=0,001).
Diskusi: Luaran klinis pada kelompok quadriceps lebih baik dibandingkan hamstring, baik secara parameter obyektif maupun subyektif.

Introduction: ACL rupture has a high impact in productive-age population. In this research, the main focus is the graft choice. Quadriceps is a rational choice for Asian population in which the diameter and length of the hamstring tendon is small. In this research, we evaluate the clinical outcome between quadriceps and hamstring autografts in arthroscopic-assisted ACL reconstruction.
Methods: Research design was prospective cohort. Total sample was 30 patients divided into 2 groups (quadriceps and hamstring). Sampling was taken between February 2016-2017 (1 year) in Army Hospital Gatot Subroto and Cipto Mangunkusumo Hospital, Jakarta. Instruments used in this study are the rolimeter and questionnaires (IKDC, Tegner-Lysholm, dan KOOS). Data assessment was carried out in repeated time measurements.
Results: Mean difference of quadriceps (3,12 ± 0,94) and hamstring (3,87 ± 0,61) is statistically different (p=0,015). Side to side difference shows better result in quadriceps (0,34 ± 0,70) compared to hamstring (0,84 ± 0,60) with p=0,04. IKDC scores in 1 month (p=0,002; CI95% [8,81-31,79]) and 3 months (p=0,004; CI95% [4,85-20,39]) post operative is better in quadriceps group. In Tegner-Lysholm assessment (1 month post operative), the numbers were consistent between numeric data (p=0,004) and categoric data (p=0,050) in quadriceps group. There was an improvement during 3 and 6 months post operative KOOS sub-item scales; pain (p=0,034) and symptoms (p=0,001).
Discussion: The functional outcome of quadriceps group was better than hamstring group, based on objective and subjective parameters."
Depok: Fakultas Kedokteran Universitas Indonesia, 2017
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Mohammad Yusup
"Berlapis-lapisnya lembaga audit sektor publik (pemerintah) di Indonesia telah menimbulkan aroma tersendiri. Setiap tataran pemerintahan memiliki lembaga audit. Di luar lembaga kepresidenan terdapat satu badan pemeriksa keuangan yaitu Badan Pemeriksa Keuangan Republik Indonesia (BPK-RI). Lembaga audit tersebut merupakan lembaga audit ekstern. Di lingkungan eksekutif (Presiden RI) terdapat beberapa lembaga audit intern pemerintah. Lembaga audit tersebut terdiri atas Badan Pengawasan Keuangan dan Pembangunan (BPKP) untuk tingkat nasional; Inspektorat Jenderal Departemen untuk tingkat departemen; Inspektorat Utama/Inspektorat Lembaga Pemerintah Non Departemen untuk Lembaga Pemerintah Non Departemen; Badan Pengawas Provinsi untuk tingkat provinsi; Badan Pengawas Kabupaten untuk tingkat kabupaten; dan Badan Pengawas Kota untuk tingkat kota. Maraknya lembaga-lembaga audit di atas telah memunculkan dugaan terjadinya penugasan yang datang silih berganti kepada entitas pemerintahan yang diaudit khususnya entitas pemerintah daerah. Dengan lain perkataan, permasalahan yang dominan dan potensial terjadi adalah audit berulang-ulang atas Anggaran Pendapatan dan Belanja Daerah (APBD).
Dugaan terjadinya audit berulang-ulang terus bergulir dari masa ke masa termasuk pasca dilaksanakan kebijakan desentralisasi fiskal (tahun 2001). Padahal pada tahun 2001 telah diterbitkan serangkaian peraturan perundang-undangan berkaitan dengan mandat atau kewenangan lembaga audit sektor publik. Solusi terhadap permasalahan dimaksud memerlukan identifikasi terhadap penyebab utama dan akibat dari, audit berulang-ulang atas pelaksanaan peraturan perundang-undangan tersebut. Best Practice system pengawasan keuangan negara di negara lain merupakan salah satu bahan pertimbangan solusinya. Dengan demikian polemik terjadinya audit berulang-ulang atas penggunaan dana anggaran satuan keria perangkat daerah dari suatu pemerintahan daerah seharusnya tidak perlu berkelanjutan. Hal ini dapat terjadi, apabila semua pihak yang berkompeten melihat permasalahan audit atas APED secara jernih, obyektif dan tidak resisten.
"
Jakarta: Program Pascasarjana Universitas Indonesia, 2006
T17183
UI - Tesis Membership  Universitas Indonesia Library
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"Thalassemia b mayor adalah penyakit yang disebabkan oleh kelainan sintesis rantai polipeptida b yang diturunkan secara otosom resesif. Pengobatan thalassemia b mayor pada umumnya berupa pemberian transfusi berulang, yang mengakibatkan penumpukan besi dan berakhir dengan hemokromatosis. Penumpukan besi dapat terjadi pada organ tubuh antara lain ginjal. Tujuan penelitian ini untuk mengetahui adanya gangguan fungsi ginjal pada penderita thalassemia b mayor berumur 15-28 tahun yang telah mendapatkan 6 unit packed red cells. Pada penelitian ini telah diperiksa kadar besi serum (SI) dan daya ikat besi total (TIBC) serta kadar mikroalbumin dan b2-mikroglobulin (b2-m) dalam urin. Hasil yang didapat 94,7% penderita menunjukkan peningkatan saturasi transferin dan 40% diantaranya disertai hemokromatosis; 73,4% disertai mikroalbuminuria, 1,3% dengan albuminuria dan 21,3% dengan peningkatan b2-m urin. Jumlah kasus dengan kelainan ginjal dijumpai pada 78,6%. (Med J Indones 2003; 12: 215-223)

b-thalassemia major is a disease caused by b polypeptide chain synthesis disorder which is inherited in an autosomal recessive manner from both parents and which is marked by little or no b-globin chain synthesis. Treatment for b-thalassemia major patients is by giving repeated blood transfusions, which causes iron accumulation, leading to hemochromatosis. Iron accumulation can occur in various body organ, including the kidneys. The aim of this study was to investigate the existence of renal impairment in b-thalassemia major patients. The subjects of this study were b-thalassemia major patients aged 15 - 28 years old who had received 6 units of packed red cells or more within 6 months. In this study, urine and serum samples of the subjects were taken and examined. Assay of serum iron was performed with Hitachi 737. Results were that 94.7% patients showed an increase in transferrin saturation and 40% of them had hemochromatosis; 73.4% had microalbuminuria; 1.3% had albuminuria and 21.3% had increased urinary b2-microglobulin (b2-m). A total of 78.6% of patients showed renal impairment. Conclusion of this study suggested that glomerular dysfunction happens in an earlier stage of the disease process. The high incidence of microalbuminuria is also attributed to defective ability of the proximal tubular cells to reabsorb protein besides dysfunction of the glomeruli. (Med J Indones 2003; 12: 215-223)"
Medical Journal of Indonesia, 12 (4) October December 2003: 215-223, 2003
MJIN-12-4-OctDec2003-215
Artikel Jurnal  Universitas Indonesia Library
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Alfian
"Super Duplex Stainless Steel (SDSS) adalah material yang dibentuk oleh kombinasi unik fasa ferit (alfa) dan austenit (gamma) yang idealnya memiliki jumlah fraksi volum yang sama besar yang menawarkan kombinasi yang menarik dari sifat mekanik dan ketahanan korosi. Pengelasan TIG atau GTAW adalah jenis pengelasan yang paling umum digunakan dalam material DSS dan SDSS di berbagai industri. Pemanasan cepat dan siklus pendinginan yang terjadi dalam proses pengelasan dapat mengganggu keseimbangan fasa alfa / gamma.
Banyak penelitian telah dilakukan terkait dengan perubahan struktur mikro akibat adanya proses pengelasan dalam material SDSS yang berdampak pada sifat mekanik dan ketahanan korosi. Namun, studi dan referensi terkait dampak pengelasan berulang pada material SDSS masih sangat jarang. Padahal dalam praktiknya, karena sulitnya mendapatkan kualitas hasil lasan yang baik pada material SDSS, perbaikan pengelasan sering dilakukan.
Dalam penelitian ini, spesimen dievaluasi untuk mensimulasikan siklus pengelasan berulang yang terdiri dari lasan asli (OW), Perbaikan- 1 (R1), Perbaikan- 2 (R2) dan Perbaikan- 3 (R3). Perubahan struktur mikro diamati melalui mikroskop elektron optik, fasa intermetalik diperiksa dengan SEM- EDS. Sementara itu, ketahanan korosi sumuran diselidiki dengan menggunakan uji korosi gravimetri, uji polarisasi potensio- dinamik dan uji potensio- statik suhu sumuran kritis (CPT).
Hasil penelitian menunjukkan bahwa endapan nitrida, karbida dan oksida mulai muncul di area terpapar panas (HAZ) pada spesimen R- 2 dan R-m3. Berdasarkan uji korosi gravimetri, uji polarisasi potensio- dinamik dan uji potensio- statik CPT menunjukkan bahwa ketahanan korosi sumuran menurun dengan meningkatnya jumlah pengulangan atau proses perbaikan pengelasan. Penurunan ketahanan korosi secara signifikan mulai terjadi pada spesimen R- 2.

Super Duplex Stainless Steel (SDSS) is a material that is formed by a unique combination of ferrite and austenite microstructure that ideally has the same large volume fraction that offers an interesting combination of mechanical properties and corrosion resistance. TIG Welding or GTAW is the most common type of welding used in DSS and SDSS materials in various industries. Rapid heating and cooling cycles in the welding process can interfere with the alfa / gamma phase balance.
Many studies have been carried out related to changes in microstructure due to the welding process in SDSS materials which have an impact on mechanical properties and corrosion resistance. However, the studies and references in repeated welding cycles of SDSS materials are infrequently. In fact, because of the difficulty in obtaining quality welds of SDSS material, repaired welding is often carried out.
In this study, the specimens were evaluated to simulate repeated welding cycles consist of the original weld (OW), Repair- 1 (R1), Repair- 2 (R2) and Repair- 3 (R3). The microstructural evolutions were observed through optical electron microscope, intermetallic phases were examined by SEM EDS. Meanwhile, pitting corrosion resistance were investigated by means of gravimetric corrosion test, electrochemical potentio- dynamic polarization and potentio- static critical pitting temperature (CPT).
The result show that the nitride, carbides and oxide precipitates starts appear in R- 2 and R- 3 welding cycles heat- affected zone. Based on gravimetric corrosion test, potentiodynamic polarization test and CPT test show that the pitting corrosion resistance decreased significantly in repair 2 and repair 3 specimens. The more repetitions in the welding process will reduce pitting corrosion resistance. The significant reduction of corrosion resistance started in R-2 specimens.
"
Depok: Fakultas Teknik Universitas Indonesia, 2019
T52609
UI - Tesis Membership  Universitas Indonesia Library
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Eko Cahyono
"Penelitian efek perlakuan panas pada ketahanan korosi pitting dan struktur mikro pada lasan berulang material super duplex stainless steel UNS S32760 dievaluasi melalui uji korosi pitting, karakterisasi struktur mikro, dan analisis SEM-EDS. Spesimen yang digunakan dalam penelitian ini adalah lasan asli (OW) dan spesimen pengelasan berulang yang diberikan perlakukuan panas, yaitu lasan yang diulang sekali (HR1), lasan yang diulang dua kali (HR2), dan lasan yang diulang tiga kali (HR3).
Hasil penelitian menunjukkan bahwa OW menunjukan ketidakseimbangan fraksi ferit-austenit yang signifikan yang mengurangi ketahanan korosi pitting. Perlakuan panas pada temperatur 1100 ºC secara bertahap dapat mengembalikan keseimbangan fraksi ferit-austenit dan melarutkan fasa intermetalik sehingga meningkatkan sifat ketahanan korosi pitting pada spesimen lasan berulang, HR1, HR2, dan HR3.

The effect of heat treatment on the pitting corrosion resistance and microstructure of UNS S32760 super duplex stainless steel`s repeated welds was investigated through a pitting corrosion test and microstructure characterization. The specimens include an original weld (OW) and three heat-treated specimens, namely a once-repeated weld (HR1), a twice-repeated weld (HR2), and a three-time-repeated weld (HR3).
The results show that the OW represents a significant imbalance of ferrite-austenite fractions reducing the pitting corrosion resistance. Conversely, 1100 ºC heat treatment on HR1, HR2, and HR3 gradually returns the equilibrium of ferrite-austenite fractions and dissolve intermetallic phase which improves the pitting corrosion resistance.
"
Depok: Fakultas Teknik Universitas Indonesia, 2019
T53184
UI - Tesis Membership  Universitas Indonesia Library
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Nadia Larasinta Heriatmo
"Latar Belakang: Phaleria macrocarpa (PM) mengandung mangiferin yang memiliki kemampuan sebagai kelator besi dengan membentuk kompleks. Kompleks dapat menekan akumulasi besi pada pasien talasemia yang rutin transfusi. Kondisi besi berlebih dapat mempengaruhi terjadinya cedera organ ginjal. Penelitian bertujuan untuk mengetahui efektivitas ekstrak etanol buah PM sebagai agen kelator besi diamati pada organ ginjal tikus model besi berlebih.
Metode: 30 tikus Sprague-Dawley dibagi acak 6 kelompok: normal (N), besi berlebih (KN), besi berlebih diobati Deferiprone dosis 462,5 mg/kgBB (D), besi berlebih diobati mangiferin dosis 50mg /kgBB (M), besi berlebih diobati ekstrak PM dosis 100mg/kgBB (PM100), besi berlebih diobati ekstrak PM dosis 200mg/kgBB (PM200). Injeksi besi diberikan 2kali/minggu selama 3 minggu dilanjutkan 8 minggu bersama pengobatan. Kadar besi ginjal diukur menggunakan AAS. Kadar urea dan kreatinin plasma serta TNF-α ginjal diukur menggunakan kit.
Hasil: Mangiferin dari ekstrak terdeteksi pada ginjal tikus model besi berlebih diukur dengan HPLC. Mangiferin dan PM tidak dapat menurunkan kadar besi di organ ginjal dan kadar ureum plasma signifikan. Pengaruh mangiferin dan PM pada kadar kreatinin plasma tidak linier. Mangiferin dan PM dapat menurunkan kadar TNF-α ginjal signifikan dengan KN dan D.
Kesimpulan: Mangiferin dan PM memiliki potensi kelator besi dan menurunkan respon inflamasi pada kondisi besi berlebih.

Background: Mangiferin, active compound in Phaleria macrocarpa (PM), has been shown as an iron chelating agent by forming complexes. The complex can reduce iron accumulation in thalassemia patients receive transfusions. Renal organ failure can be impacted by the high iron. This study aims to determine the effectiveness of ethanolic extract of PM fruit as iron chelating agent observed in the kidney of iron overload rat.
Methods: 30 Sprague-Dawley divided randomly six groups: normal (N), iron-overload (KN), iron-overload treated Deferiprone dosage 462,5 mg/kgBW (D), iron-overload treated mangiferin dosage 50mg/kgBW (M), iron-overload treated PM extract dosage 100mg/kgBW (PM100) and iron-overload treated with PM extract dosage 200mg/kgBW (PM200). Iron injection was administered twice/week for 3 weeks, continued 8 weeks with treatment. Kidney iron levels of rats measured using AAS. Plasma urea and creatinine levels as well as renal TNF-α measured using kit.
Results: Mangiferin from extract was detected in the kidney of rat iron overload models which measured using HPLC. Mangiferin and PM cannot significantly reduce plasma urea and kidney iron levels. Effect of mangiferin and PM on plasma creatinine levels not linearly. Mangiferin and PM can reduce renal TNF-α levels significantly.
Conclusion: Mangiferin and PM have ability as iron chelator and reduce inflammatory response caused iron overload.
"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Putu Adriel Widyadana
"Penelitian ini bertujuan untuk mencari pengaruh jangka panjang pembangunan Jalan Raya Pos terhadap distribusi spasial wilayah di Pulau Jawa. Penelitian ini menggunakan metode Repeated Cross Section untuk mengolah data Potensi Desa pada tahun 2014, 2018 dan 2021 serta jarak desa dari Jalan Raya Pos untuk mencari dampak pembangunan Jalan Raya Pos terhadap lokasi bank, sekolah dan fasilitas kesehatan per 1000 rumah tangga di Pulau Jawa. Ditemukan bahwa dalam jangka panjang, Jalan Raya Pos akan meningkatkan jumlah bank per 1000 rumah tangga pada kota-kota utama dan wilayah yang berada dalam radius 5 Kilometer dari Jalan Raya Pos, sedangkan jumlah sekolah dan fasilitas per 1000 rumah tangga akan meningkat di wilayah dengan radius yang lebih jauh. Hal ini menunjukkan adanya dampak aglomerasi aktivitas ekonomi dan suburbanisasi akibat Jalan Raya Pos.

This study aims to find the long-term effect of the construction of the Great Post Road on the spatial distribution of regions in Java Island. This study uses the Repeated Cross Section method to process data on Village Potential Data (Potensi Desa) in 2014, 2018 and 2021 as well as the distance of villages from The Great Post Road to find the impact of Jalan Raya Pos development on the location of banks, schools and health facilities per 1000 households on Java Island. It was found that in the long run, The Great Post Road will increase the number of banks per 1000 households in the main cities and areas within a 5 Kilometer radius of the Great Post Road, while the number of schools and facilities per 1000 households will increase in areas with a longer radius. This suggests an agglomeration of economic activity and suburbanization effect of The Great Post Road."
Depok: Fakultas Ekonomi dan Bisnis Universitas Indonesia, 2024
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