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Abstrak :
Though kidney transplantation is considered a routine procedure, there are still significant challenges in post-transplant management. Core Concepts in Renal Transplantation is a clinically focused authoritative guide to the management of kidney transplantation. This comprehensive, state-of-the-art reference summarizes the recent changes in the field of transplantation, offering the complete range of up-to-date information on all the various aspects of basic immunobiology and the medical care of the transplant recipient.

Abstrak :
Administration of a renal dose of dopamine in acute renal failure still attracts a lot of controversy, store there has not been a study that found a significant protective effect on the kidneys. Nevertheless, according to its ability to increase renal blood flow in laboratory animals and normal subjects, several parties still maintain its use, even though the required dose is very much individualized. The side effect of dopamine, such as tachycardia, arrhythmia, miocardiac ischemia, and intestinal ischemia due to precapilary vasoconstriction causing bacterial translo-caiionfrom the intestinal lumen to the systemic bloodstream, even though relatively rare, should receive adequate attention.

Abstrak :
Penggunaan jamu pelangsing “SF” yang merupakan kombinasi dari Phaseolus vulgaris, Guazuma ulmifolia, Garcinia cambogia, dan Green tea secara berulang dan dalam jangka waktu yang panjang menyebabkan perlu dilakukan pengujian terhadap tingkat keamanannya. Oleh karena itu penelitian ini dirancang untuk mengetahui pengaruh pemberian jamu pelangsing terhadap fungsi ginjal selama 90 hari. Jamu diberikan secara oral kepada 80 ekor tikus putih galur Sprangue-Dawley yang terdiri dari 40 ekor tikus jantan dan 40 ekor tikus betina. Hewan uji dibagi secara acak kedalam empat kelompok, yaitu satu kelompok normal yang diberi CMC 0,5% dan tiga kelompok perlakuan yang masing-masing diberi jamu dosis 1,35 g/kg bb, 2,70 g/kg bb, dan 5,40 g/kg bb tikus. Pada hari ke-91 dilakukan pengambilan darah untuk pengukuran kadar urea dan kreatinin plasma secara kolorimetri. Hasil ANAVA satu arah (α = 0,05) menunjukan tidak ada perbedaan bermakna dari kadar urea dan kreatinin plasma antara kelompok kontrol dan kelompok perlakuan. Oleh karena itu dapat disimpulkan bahwa penggunaan jamu pelangsing selama 90 hari tidak mempengaruhi fungsi ginjal.

Abstrak :
Banyak orang berusaha untuk menurunkan maupun menjaga agar berat badan ideal. Tujuan penelitian ini untuk mengetahui pengaruh pemberian jamu pelangsing "SF" pada tikus putih selama 90 hari terhadap organ ginjal ditinjau dari kadar urea dan histologis ginjal. Hewan coba yang digunakan tikus putih jantan dan betina galur Sprague-Dawley berumur 3-4 bulan dengan berat badan 200-300 g. Pada hari ke-91 tikus diambil darahnya melalui mata dan dibedah untuk diambil ginjalnya. Selanjutnya dilakukan pengukuran kadar urea plasma dengan metode kolorimetri serta histologis ginjal. Kadar rata-rata urea plasma kelompok perlakuan berkisar 31-37 mg/dl dan kelompok kontrol 34-37 mg/dl. Diameter rata-rata glomerulus ginjal kelompok perlakuan berkisar 0,88-0,96 μm dan kelompok kontrol 0,93 μm. Jarak ruang rata-rata antara glomerulus dengan kapsula Bowman berkisar 0,09-0,11 μm dan kelompok kontrol 0,1 μm. Hasil uji Oneway ANOVA pada
=0,05 terhadap kadar urea plasma, diameter glomerulus ginjal dan jarak ruang antara glomerulus dengan kapsula Bowman tidak menunjukkan perbedaan bermakna baik antar kelompok perlakuan maupun dengan kelompok kontrol. Penggunaan sediaan jamu pelangsing "SF" selama 90 hari tidak mempengaruhi fungsi organ ginjal tikus putih.

Abstrak :
This book provides a comprehensive look at renal cell carcinoma, exploring its biology as well as current and future molecular targets for renal cancer carcinoma.

Abstrak :
The aim of this study was to investigate the effect of ant (hypertensive agents with different degrees of renal excretion lisinopril (L) eliminated in the kidney and fosinopril (F), only 50% of which is eliminated through the kidney on renal function in hypertension patients with mild to moderate renal failure. Materials and methods: Patients were divided into two groups. The first group was given F 10 mg/day and the second group was given L 10 mg/day. Groups were divided randomly, and drugs were given for 6 weeks each night at 8.00p.m. The hypertension status of each subject was determined from systolic blood pressureJ140 mmHg or diastolic blood pressure -f 90 mg/dl. Subjects were both male and female, with an age range of 18- 65 years old. Results: The results from the creatinine examination of the 10 mgF group was (3.06 ±0.97) mg/dl after drug use, which showed no decrease in renal function. The difference was insignificant (p=0.17). The 10 mgL group the creatinine level was (3.22 ±0.17), where as in the 10 mg L group the creatinine level was (3.22 ± 0.75) mg/dl before the use of the drug and (4.11 ± 2.14) mg/dl after the use of the drug respectively. There was no worsening of the renal function, which did not differ significantly (p=0.11). There was a significant difference (p < 0.05) in the creatinine level of the 10 mg F and 10 mg L groups. The serum creatinine level before and after treatment did show any significant changes at. 6 week. However, the serum creatinine profile over 6 week was more significant in the F group than in the L groups.

Abstrak :
Latar Belakang: Periostin memainkan peran sebagai mediator proses inflamasi termasuk inflamasi dan fibrosis ginjal. Namun, data signifikansi periostin pada acute kidney injury terbatas. Kami meneliti korelasi kadar periostin urin dengan fungsi ginjal pada pasien keganasan yang mendapat terapi cisplatin dosis tinggi. Metode: Penelitian kohort prospektif ini dilakukan di n ruang rawat HOM lantai 8 gedung A, di RSCM dari November 2019 hingga jumlah sampel minimal terpenuhi dengan cara consecutive sampling. Data dianalisis menggunakan SPSS versi 23.0 sesuai tujuan penelitian. Hasil: Dari 37 responden diketahui 70,3% laki-laki, 29,7% berusia 41-50 tahun, 59,5% menderita KNF, serta 64,9% memiliki Skor Karnofsky 80. Kadar ureum dan kreatinin darah responden meningkat dari pra kemoterapi hingga 1 minggu paska kemoterapi I. Begitu juga dengan nilai eGFR yang makin menurun. Perubahan kadar periostin menurun selama kemoterapi I dan II, naik kembali 1 minggu paska kemoterapi III dengan nilai p>0,05. Pada uji korelasi kadar periostin urin dengan variabel fungsi ginjal lainnya tidak didapatkan domain yang signifikan bermakna (p>0,05) dengan nilai koefisien korelasi lemah (r = 0,017-0,254) dan beberapa domain memiliki arah korelasi negatif. Simpulan: Tidak didapatkan korelasi bermakna kadar periostin urin dengan kadar ureum darah, kreatinin darah serta laju filtrasi glomerulus pasien keganasan dengan terapi cisplatin dosis tinggi. ......Background: Periostin plays role as mediator of inflammatory processes including inflammation and kidney fibrosis. However, data on the significance of periostin in acute kidney injury are limited. We investigated the correlation of urine periostin levels with kidney function in malignant patients receiving high-dose cisplatin therapy. Methods: This prospective cohort study was conducted in the 8th floor HOM care room in building A, in the RSCM from November 2019 until the minimum sample size was fulfilled by consecutive sampling. Data were analyzed using SPSS version 23.0 according to the purpose of study. Results: Of the 37 respondents known to be 70.3% male, 29.7% aged 41-50 years, 59.5% suffer from NPC, and 64.9% have Karnofsky score of 80. Urea levels and blood creatinine of respondents increased from pre-chemotherapy to 1 week after chemotherapy I. Likewise, the eGFR value decreases. Changes in periostin levels decreased during chemotherapy I and II, rising again 1 week after chemotherapy III with a p value> 0.05. In the correlation test of urinary periostin levels with other kidney function variables, no significant domain was found (p> 0.05) with a weak correlation coefficient (r = 0.017-0.254) and some domains had a negative correlation direction. Conclusion: No significant correlation was found in urine periostin levels with blood urea levels, blood creatinine and glomerular filtration rates of malignant patients with high-dose cisplatin therapy.