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Abstrak :
Summary: "Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues, and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental, and molecular biology; chemical and material sciences (i.e., nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. The goal of this book is to draw attention to the critical role that the pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. This is the first state-of-the-art book in this rapidly evolving field of research"

Abstrak :
Lintas Rel Terpadu Jabodebek (LRT Jabodebek) telah menjadi moda transportasi alternatif yang signifikan bagi warga Jakarta, menjangkau rute sepanjang 42km dengan lintas pelayanan: Cibubur-Cawang, Cawang – Dukuh Atas dan Jatimulya – Cawang, melibatkan total 18 stasiun. Menggunakan listrik sebagai sumber energi kereta, LRT Jabodebek mengkonversi catu daya supply 20kV dari PLN menjadi arus searah 750 volt. Dengan headway hanya 3 menit dan jumlah stasiun yang banyak, LRT Jabodebek menunjukan potensi besar untuk regenerative braking. Regenerative braking merupakan fenomena dimana energi kinetic kereta dikonversi menjadi energi listrik selama pengereman, memungkinkan kereta menghasilkan energi listrik setiap kali melakukan pengereman. Penelitian ini menggunakan perangkat lunak Etap 18.0.C – Etrax analisis untuk mensimulasikan regenerative braking di LRT Jabodebek, bertujuan untuk mengetahui nilai konsumsi energi selama operasi normal dan saat recovery energy regenerative braking dengan pola operasi beban penuh (peak load) dan diluar beban penuh (Peak off Load). Hasil dari simulasi menunjukan penggunaan recovery energy regenerative braking dapat menurunkan konsumsi energi hingga 14,22% saat beban penuh (peak load) dan 14,13% saat diluar beban penuh (Peak off Load). Penurunan konsumsi energi berpotensi mengurangi biaya energi listrik pada operasi LRT Jabodebek. ......The Jabodebek Integrated Rail Transit (LRT Jabodebek) has become a significant alternative mode of transportation for Jakarta residents, covering a route of 42 km with service lines: Cibubur-Cawang, Cawang-Dukuh Atas, and Jatimulya-Cawang, involving a total of 18 stations. Utilizing electricity as the train's energy source, LRT Jabodebek converts the 20kV power supply from the national electricity company (PLN) into a 750-volt direct current to supply the train. With a headway of only 3 minutes and a substantial number of stations, LRT Jabodebek demonstrates significant potential for regenerative braking. Regenerative braking is a phenomenon where the kinetic energy of the train is converted into electrical energy during braking, allowing the train to generate electrical energy each time it brakes. This study employs the Etap 18.0.C – Etrax Analsys software to simulate regenerative braking in LRT Jabodebek, aiming to determine the energy consumption values during normal operations and during the recovery of regenerative braking energy with peak load and off-peak load operating patterns. The simulation results indicate that the use of recovery energy from regenerative braking can reduce energy consumption by up to 14.22% during peak load and 14.13% during off-peak load. The reduction in energy consumption has the potential to decrease the electricity costs in the operation of LRT Jabodebek.

Abstrak :
Proposal Desain Urban ini muncul dari ide regenerasi - gagasan bahwa lanskap yang rusak dapat diperbaiki dan direvitalisasi. Saya percaya bahwa regenerasi ini dimulai dengan menghubungkan manusia dengan alam - mengubah pola pikir mereka dari kepemilikan lanskap menjadi bagian dari ekosistem. Orang-orang Aborigin di Australia hidup dengan gagasan ini sebagai inti dari budaya mereka - Gammage, dalam bukunya "The Biggest Estate on Earth" mengeksplorasi cara orang-orang ini tidak percaya bahwa mereka memiliki kekuasaan atas tanah; bahwa tanah itu memiliki kekuatan spiritual yang kuat yang harus dipupuk dan dipelihara. Dari ide-ide ini, desain telah dibentuk menjadi jenis baru pinggiran kota yang menantang gagasan blok tanah milik pribadi ke lanskap komunal, dibentuk oleh tipologi halaman berkelanjutan di sekitar lahan yang basah, yang dikembangkan untuk meminimalkan dampak manusia terhadap lingkungan dengan tujuan menumbuhkan 'Pikiran yang Timbul' dalam suatu komunitas. Selanjutnya, dibingkai dengan halaman berkelanjutan arsitektur sebagai alat untuk menghubungkan ruang hidup dan alam sehingga memungkinkan regenerasi lanskap. Dengan demikian, arsitektur yang ditunjuk adalah untuk merevitalisasi dan membawa kenikmatan bagi orang-orang untuk merasakan alam dalam bentuk yang paling murni. ......This Urban Design proposal was sprung from the idea of regeneration - the notion that a damaged landscape can be repaired and revitalized. I believe that this regeneration starts with connecting people to nature - changing their mindset from ownership of a landscape to be a part of the ecosystem. The Aboriginal people of Australia lived with this idea at the core of their culture - Gammage, in his book “The Biggest Estate on Earth” explores the way that these people did not believe they had power over the land; that the land has a powerful spiritual force that must be nurtured and maintained. From these ideas, the design has been shaped into a new kind of suburb that challenges the idea of privately owned blocks of land to a communal landscape, shaped by a sustainable courtyard typology around a wetland, developed to minimize the human impact on the environment with the purpose of growing an ‘Emergent Mind’ within a community. Furthermore, framed with architectural sustainable courtyard as a tool to connect the living space and the nature so that it enables landscape regeneration. Accordingly, the designated architecture is to revitalize and to bring enjoyment for people to feel nature in its most pristine form.

Abstrak :
ABSTRACT
Advances in tissue engineering techniques have made it possible to use human cells as biological material. This has enabled pharmacological studies to be conducted to investigate drug effects and toxicity, to clarify the mechanisms underlying diseases, and to elucidate how they compensate for impaired organ function. Many researchers have tried to construct artificial organs using these techniques, but none has succeeded in growing a whole organ. Unlike other digestive organs with complicated functions, such as the processing and absorption of nutrients, the esophagus has the relatively simple function of transporting content, which can be replicated easily by a substitute. In regenerative medicine, various combinations of materials have been applied, including scaffolding, cell sources, and bioreactors. Exciting results of tissue engineering techniques for the esophagus have been reported. In animal models, replacing full-thickness and full-circumferential defects remains challenging because of stenosis and leakage after implantation. Although many reports have manipulated various scaffolds, most have emphasized the importance of both epithelial and mesenchymal cells for the prevention of stenosis. However, the results of repair of partial full-thickness defects and mucosal defects have been promising. Two successful approaches for the replacement of mucosal defects in a clinical setting have been reported, although in contrast to the many animal models, there are few pilot studies in humans. We review the recent results and evaluate the future of regenerative medicine for the esophagus.

Abstrak :
[ABSTRAK
Global komuter di Australia sedang dalam masa puncaknya, iklim kering lokal mendorong arsitek untuk melahirkan inovasi baru yang dapat mengatasi isu tersebut. Pengertian dari hidup secara pusar regeneratif memberikan sebuah solusi untuk mengurangi kebutuhan pegawai untuk pulang-pergi dengan menyediakan akomodasi dan sebuah pusat responsif lingkungan di tempat mereka bekerja. Menyadarkan pentingnya suatu desain arsitektur yang dapat mempengaruhi dan mengoptimalkan kinerja manusia dengan mengatur variabel Pencahayaan, Akustik, dan kenyamanan Termal.

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ABSTRACT
Australia global commuters are at an all time high. The local arid climate calls for architects to bring forth new sustainable innovation to counter this issue. A living concept of a Regenerative Hub suggests a solution to lessen the need for employees commuting by providing on-site accommodation and a responsive center for the environment. Sustainable housing that caters to on site occupants, realizes the importance of design to optimize human performance through architecture by altering the variables of Lighting, Acoustics and Thermal Comfort., Australia global commuters are at an all time high. The local arid climate calls for architects to bring forth new sustainable innovation to counter this issue. A living concept of a Regenerative Hub suggests a solution to lessen the need for employees commuting by providing on-site accommodation and a responsive center for the environment. Sustainable housing that caters to on site occupants, realizes the importance of design to optimize human performance through architecture by altering the variables of Lighting, Acoustics and Thermal Comfort.]

Abstrak :
ABSTRACT
The idea of living in suburbs, surrounding the central business district, is highly desirable in Australia as people long for connection with nature, even when it means they have to travel further for work. In a contemporary city like Perth, explosive population increases the demand to expand the living area and forces the design of the suburbs to adapt to it. As a result, suburbs are losing their initial intention which, if continues without any changes, will alienate people further from their natural environment. This writing is aimed to re-imagine a 12-hectare site in Lefroy Road, Beaconsfield, in three different stages: masterplan, cluster, and studio design; to reconnect people back to their natural environment. By reflecting back to the aboriginal land management in Australia, the site is designed using a regenerative approach, both in agriculture and architecture, to restore the functioning landscape of a suburb. The design proposal will collectively reintroduce native plants and native animals back to the site. This will help in restoring the site to become a functioning landscape in which all elements of nature will perform a mutualistic function that will benefit the people, aligning with the principles of aboriginal land management that had been successful a long time ago in Australia.

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ABSTRAK
Gagasan untuk tinggal di daerah tepi kota, di sekitar kawasan pusat bisnis, lebih dipilih di Australia karena orang merindukan koneksi dengan alam, bahkan walaupun itu berarti mereka harus melakukan perjalanan lebih jauh untuk bekerja. Di kota kontemporer seperti Perth, populasi yang berkembang pesat meningkatkan permintaan untuk memperluas area tempat tinggal dan memaksa desain daerah tepi kota beradaptasi dengan hal tersebut. Akibatnya, tujuan awal daerah tepi kota mulai memudar. Jika hal tersebut berlanjut tanpa ada perubahan, manusia akan menjadi lebih teralienasi dengan lingkungan alam mereka. Karya tulis ini bertujuan untuk membayangkan kembali sebuah lahan seluas 12 hektar di Lefroy Road, Beaconsfield, dalam tiga tahap yang berbeda: masterplan, klaster, dan desain studio untuk menghubungkan manusia kembali dengan lingkungan alam mereka. Dengan merefleksikan kembali pada pengelolaan lahan penduduk asli Australia, lahan tersebut dirancang menggunakan pendekatan regeneratif, baik di bidang pertanian maupun arsitektur, untuk memulihkan fungsi lanskap di daerah tepi kota. Proposal desain akan secara kolektif memperkenalkan kembali tanaman asli dan hewan asli ke lahan tersebut. Hal Ini kemudian akan membantu memulihkan situs menjadi lanskap yang berfungsi di mana semua elemen alam akan memiliki fungsi timbal balik yang akan bermanfaat bagi manusia, selaras dengan prinsip-prinsip pengelolaan lahan yang telah terlebih dahuli sukses dilakukan oleh penduduk asli Australia.

Abstrak :
Latar Belakang: Fokus disinfeksi saluran akar telah berubah dari disinfeksi agresif menjadi seleksi protektif dalam prosedur regeneratif endodontik. Larutan irigasi sintetik yang digunakan hingga saat ini toksik terhadap sel punca pulpa, salah satunya yang memiliki kemampuan proliferasi dan transdiferensiasi tinggi adalah hDPSCs. Oleh sebab itu, penelitian terkait disinfeksi berbahan alami yang mampu mempertahankan viabilitas sel punca terus berkembang pesat. Salah satu larutan irigasi alami yang bersifat antimikrobial dan agen kelator adalah larutan cuka apel. Untuk menjadikannya obat herbal terstandar hingga fitofarmaka, perlu diidentifikasi kelompok senyawa kimia dan uji viabilitas hDPSCs. Tujuan: Menganalisis pengaruh larutan cuka apel berbagai konsentrasi terhadap viabilitas hDPSCs Metode: hDPSCs ditambahkan DMEM+FBS10% (kontrol negatif), EDTA 17% (kontrol positif), larutan cuka apel dengan konsentrasi 2,5%, 5%, dan 10% dengan enam kali pengulangan. Selanjutnya, persentase viabilitas hDPSCs didapat dari MTT assays melalui microplate reader dalam nilai absorbansi. Data kemudian diolah statistik melalui uji parametrik One-way ANOVA. Hasil: Nilai rerata viabilitas sel hDPSC pada semua kelompok perlakuan bernilai diatas 70% sehingga tidak toksik menurut standar ISO dengan rerata viabilitas tertinggi pada kelompok 2,5% dan terendah pada kelompok EDTA 17% diikuti kelompok 10%. Kesimpulan: Larutan cuka apel dapat diidentifikasi kelompok senyawa kimia dan nilai viabilitas sel paling tinggi pada konsentrasi 2,5%. ......Background: Focus on root canals disinfection have shift from aggressive to protective selection in regenerative endodontic procedures. Synthetic root canals irrigation that had been used until now are toxic toward pulp stem cells, one of them, hDPSCs which have higher proliferation and transdifferentiation ability. Therefore, research on natural disinfection which maintain stem cell viability keep developing rapidly. One of the natural disinfection that has antimicrobial effect and chelating agent is apple cider vinegar. To standardized it as modern medicine, need to identify group of chemical compounds and analyzing the viability percentage of hDPSCs. Objective: Analyze the impact of apple cider vinegar solution in various concentrations on viability of hDPSCs. Methods: hDPSCs were given DMEM+FBS10% (negative control), 17% EDTA (positive control), apple cider vinegar solution in 2.5%, 5% and 10% concentrations with six repetitions. Percentage viability of hDPSCs were analyze from MTT assays with microplate reader in absorbance value. Then, data were proccessed statictically with parametric One-way ANOVA. Results: The average viability of hDPSCs were above 70% which considered non-toxic according to ISO, with the highest cells viability in 2.5% and the lowest cells viability in 17% EDTA followed by 10% groups. Conclusion: Apple cider vinegar solution’s chemical compounds can be identified with the highest cells viability were at 2.5%.

Abstrak :
ABSTRAK
Latar belakang: Terapi regeneratif periodontal GTR memiliki keterbatasan pada defek tulang alveolar satu dinding. Rekayasa jaringan menggunakan teknologi periodontal ligament cell sheet pada chitosan dengan kombinasi molekul adhesif Arginylglycyaspartic Acid RGD diharapkan dapat meningkatkan kadar periostin sebagai indikator regenerasi tulang. Tujuan: Mengevaluasi peningkatan kadar periostin pascaaplikasi RGD pada chitosan-periodontal ligament cell sheet PDLCS . Metode: Aplikasi chitosan-PDLCS dengan penambahan RGD n=3 dan tanpa RGD n=3 pada defek tulang satu dinding yang dibuat pada insisif lateral M. nemestrina. Sampel CKG dikumpulkan setiap minggu selama empat minggu dan disimpan dalam suhu -80 C. Analisis kadar protein menggunakan perangkat ELISA Human POSTN Elabscience. Hasil: Terdapat peningkatan kadar periostin pascaaplikasi RGD pada PDLCS dibandingkan kelompok non-RGD pada minggu pertama dan kedua, dan penurunan kadar periostin pada minggu ketiga dan keempat dengan perbedaan bermakna pada minggu kedua dan keempat p.

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ABSTRACT
Background Periodontal regenerative therapy has limitations on one wall alveolar bone defect. Tissue engineering using periodontal ligament cell sheet on chitosan addition of adhesive molecule Arginylglycyaspartic Acid RGD is expected to increase periostin levels as an indicator of bone regeneration. Objective To see levels of periostin post application of RGD on chitosan periodontal ligament cell sheet PDLCS . Method Application of chitosan PDLCS with addition of RGD n 3 and without RGD n 3 on one wall bone defect made on the lateral incisor of M. nemestrina. The CKG sample was collected weekly for four weeks and stored at 80 C. Analysis of protein content using ELISA Human POSTN Elabscience. Results Periostin level was increased in RGD PDLCS compared to non RGD groups in the first and second weeks, and decreased periostin levels in the third and fourth weeks with significant differences in second and fourth weeks p

Abstrak :
Hybrid electric vehicle banyak dikembangkan di negara maju karena memiliki keunggulan yakni dapat menghemat pemakaian bahan bakar hingga dua kali lipat. Kendaraan hibrida adalah kendaraan yang memiliki dua atau lebih sistem propulsi, umumnya adalah penggerak berbahan bakar minyak bumi/sel bahan bakar dan sistem pengerak elektrik. Dalam riset ini telah dilakukan perancangan dan pengujian prototipe kontrol traksi kendaraan hibrida berpenggerak kombinasi serial-paralel mesin bensin berdaya 6,54 kW dan motor listrik 0,5kW. Pengunaan transmisi CVT (continous variable transmission) dan penggerak bertenaga listrik brushless terintegrasi sebagai motor dan generator serta melekat pada masingmasing roda belakang memperhalus perpindahan daya ketika beroperasi. Sistem pengisian baterai kendaraan ini berasal dari tiga buah sumber pengisian dengan dua buah jalur tegangan yakni altenator berkapasitas pengisian 12 V / 7 Ah, sistem power take off berupa alternator tambahan yang digerakkan motor bakar untuk mengatasi kekurangan pengisian empat buah baterai disusun seri dengan kapasitas 48 V/ 32 Ah dan sistem regenerative berasal dari kedua motor listrik pada saat kendaran bekerja menggunakan motor bakar maupun pada saat pengereman. Pengujian regenerative dari motor listrik menghasilkan daya sebesar 199,44 W pada putaran 737 RPM dan pada pengujian jalan mode hibrida dapat menghemat pemakaian bahan bakar hingga 80%. ......Hybrid electric vehicle developed in many developed countries because it has the advantage that can save fuel consumption more than doubled. Hybrid electric vehicles have two or more propulsion systems, generally is driven by internal combustion engine / fuel cell and electric motor. In this research design and testing of a prototype hybrid electric vehicle traction control having a serialparallel configuration by combining of gasoline engine power 6,54 kW and 0,5 kW electric motor. The use of transmission CVT (continuous variable transmission) and electric-powered drive brushless motor and generator are integrated as well as attached to each rear wheel is refined the displacement power when operating. Vehicle battery charging system is derived from three sources of charge with two lines namely voltage altenator with charging capacity of 12 V / 7 Ah, the power take-off in the form of additional motor driven alternator to overcome the deficiency charging of four batteries in series connection with a capacity of 48 V / 32 Ah and regenerative system comes from two electric motors at work using a motor vehicle fuel or when braking. Tests of the regenerative electric motor to produce power equal to 199,44 W at 737 rpm and for test drive result on Hybrid mode has reduced consumtion of fuel up to 80%.