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"Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan konsumsi pangan probiotik pada mahasiswi Program Studi Gizi Fakultas Kesehatan Masyarakat Universitas Indonesia tahun 2011. Penelitian ini adalah penelitian kuantitatif dengan menggunakan desain studi cross sectional dan pengambilan sampel dilakukan dengan cara sampel jenuh pada mahasiswi Program Studi Gizi seluruh angkatan. Hasil penelitian menunjukkan konsumsi terakhir pangan probiotik pada > 4 minggu lalu sebesar 37,4%, disusul oleh responden yang mengonsumsi pangan probiotik pada < 2 minggu lalu yakni 34,6%, konsumsi 2-4 minggu lalu sebesar 27,9%. Pihak yang menganjurkan konsumsi adalah inisiatif sendiri yakni 86,3%, sebagian besar mengaku merasakan manfaat dari konsumsi probiotik yakni 56,9%, tidak melihat saran/petunjuk pemakaian produk yakni sebesar 72,1%, dan responden mengkonsumsi dua merek produk pangan probiotik sebesar 50,3%. Rata-rata skor pengetahuan responden mengenai probiotik adalah 38,84 poin dari skor maksimal 80 poin. Sebanyak 44,7% memiliki uang saku Rp.0-Rp 500.000, memiliki skor aktivitas fisik 0,7184, tidak memiliki riwayat konstipasi dalam satu bulan terakhir sebesar 83,1%, dan memiliki rata-rata frekuensi keterpaparan media promosi mengenai probiotik sebanyak 29,15 kali dalam satu bulan. Hubungan yang bermakna hanya ditemui pada variabel aktivitas fisik (p=0,016), sedangkan variabel lainnya tidak memiliki hubungan yang signifikan yakni hubungan konsumsi pangan probiotik sebagai variabel dependent dengan pengetahuan (p=0,173), besar uang saku (p=0,695), riwayat konstipasi dalam satu bulan terakhir (p=0,915), dan media promosi probiotik (p=0,833) sebagai variabel independen. Dibutuhkan penelitian lanjutan pada kelompok usia yang berbeda dengan penambahan variabel penelitian seperti kebiasaan makan.

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This study aims to determine the factors associated with the consumption of probiotic foods in female students of Nutrition Program of Public Health Faculty at the University of Indonesia in 2011. This study is a quantitative study using cross-sectional study design and sampling is done by saturated sampling of students at Nutrition Program Study throughout the year.

The result showed final consumption of probiotic foods in > 4 weeks ago are 37,4%, followed by respondents who consumed probiotic foods at < 2 weeks ago are 34,6%, consumption of 2-4 weeks ago are 27,9%. Students that promote the consumption their own initiative are 86,3%, most claim to feel the benefits of probiotic foods consumption are 56,9%, did not see a suggestion/user of products are 72,1%, and the respondents consume two brands of probiotic food products are 50,3%. An average score of knowledge about probiotics is 38,84 points from 80 maximum points. A total of 44,7% had an allowance (per month) of Rp.0-Rp.500.000, an average score of physical activity are is 0,7184, no history of constipation in the past month are 83,1%, and has an average 29,15 time in a month of exposure to media promotion of probiotics.

A significant association was only found on the variable of physical activity (p=0,016), whereas other variables had no significant relationship which is the relationship of food consumption of probiotic foods as a dependent variable with knowledge, (p=0,173), large pocket money (p=0,695), history of constipation in the past month (p=0,915), and media promotion (p=0,833) as independent variables. Further research is needed in different age groups with the addition of the study variables such as eating habit. "

"ABSTRAKPenelitian pemanfaatan enzim urikase dari Lactobacillus plantarum Mar 8 dan KMar C2 sebagai probiotik dalam cokelat untuk mendegradasi asam urat. Tujuan penelitian mengetahui cara pembuatan mikrokapsul, menguji viabilitas L. plantarum dalam mikrokapsul dan cokelat, serta menganalisis penurunan kadar asam urat sebelum, selama dan sesudah mengkonsumsi cokelat probiotik. Bakteri L. plantarum disalut menggunakan susu skim 10% dan lemak cokelat 3% dibuat menjadi mikrokapsul dengan metode spray drying. Viabilitas L. plantarum diukur pada kondisi sebelum enkapsulasi, setelah enkapsulasi, setelah penyimpanan dan cokelat itu sendiri. Cokelat probiotik digunakan untuk terapi responden dengan kadar asam urat 4,0-10,0 mg/dL untuk perempuan dan 5,0-10,0 mg/dL untuk laki-laki. Hasil penelitian menunjukkan pembuatan mikrokapsul berhasil dengan jumlah rendenem 45,21% dan penurunan viabilitas 1 log dari 1,04 x 10 cfu/g menjadi 1,925 x 10 cfu/g. Hasil viabilitas mikrokapsul dalam cokelat 1,7 x 10 cfu/g sehingga konsentrasi probiotik 3,4 x 10 cfu/g, memenuhi syarat sebagai probiotik. Aktivitas enzim urikase pada L. plantarum campuran Mar8+KMar C2 sebesar 0,567 U/mL. Asam urat pada responden intervensi mengalami penurunan setelah mengkonsumsi cokelat probiotik sebanyak 74% total responden. Kadar asam urat mengalami penurunan secara signifikan pada responden intervensi dan konsumsi makanan dengan purin tidak memengaruhi proses penurunan kadar asam urat selama responden mengkonsumsi cokelat probiotik

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ABSTRACTThe research using uricase enzymes from Lactobacillus plantarum Mar 8 and KMar C2 as probiotics in chocolate to degrade uric acid. The research purpose study of maked microcapsules, viability of L. plantarum in microcapsules and chocolate, analyze the decreased in uric acid levels before, during and after consuming probiotic chocolate. L. plantarum bacteria was coated using 10% skim milk and 3% chocolate fat made into microcapsules with spray drying method. The assay used in viability research in conditions before encapsulation, after encapsulation, after storage and in chocolate. Probiotic chocolate is used for respondent decreased with uric acid levels 4.0 - 10.0 mg / dL for women and 5.0 - 10.0 mg / dL for men. The result making a microcapsule was successful, proved performed with the acquisition of 45.21% rendenam and viability decreased by 1 log from 1.04 x 10 cfu g to 1.925 x 10 cfu/g. The result in chocolate is 1.7 x 10 cfu/g and concentration for probiotic is 3.4 x 107 cfu/g, so that chocolate can be used as a probiotic. The uricase enzyme activity in L. plantarum mixed Mar 8 + KMar C2 was 0.567 U/mL. Uric acid in respondents increased 74% of the total intervention respondents. Uric acid levels increased a significant decreased in the intervention respondents and consumption of food with purines did not affect the process of decreasing uric acid levels during the respondents consuming chocolate probiotics"

"AbstrakKegiatan pengabdian kepada masyarakat ini dilakukan di Kelurahan Malumbi. Kabupaten Sumba Timur, Nusa Tengara Timur. Sasaran kegiatan adalah kelompok Tani Tunas Baru dan kelompok Tani Malumbi. Tujuan pengabdian ini untuk memberikan ilmu dan informasi tentang teknik budidaya ikan yang baik dan benar serta aplikasi probiotik EM 4 dalam pakan pada kedua kelompok tani tersebut. Kegiatan ini berupa workshop dan pedampingan praktik. Pengabdian yang dilakukan memberikan ilmu dan wawasan yang baru pada kedua kelompok tani tersebut. Kegiatan budidaya tersebut meliputi tahap persiapan kolam pemeliharaan, teknik pemupukan, teknik penebaran benih dalam wadah baru, teknik pemberian pakan yang baik dan benar, serta sistem pergantian air. Selain itu, pendampingan terkait dengan aplikasi probiotikjuga dilakukan. Hasil pendampingan menunjukkan bahwa pemberian probiotik EM-4 memberikan hasil yang baik terhadap laju pertumbuhan dan kelulusan hidup ikan, masing-masing sebesar 18% dan 80% jika dibandingkan dengan kontrol. Diharapkan petani ikan pada kelompok Tunas Baru dan Tani Malumbi dapat menerapkan ilmu yang telah diterapkan selama satu bulan pendampingan. "

"Berbagai kesulitan yang dihadapi peternak dalam budidaya ayam pedaging (broiler) umumnya berupa serangan dan fluktuasi harga ternak dari hasil usahanya yang sering sekali tidak memadai...."

"[ABSTRAKLatar Belakang : Pada penderita Systemic Lupus Erythematosus (SLE) terdapat defek pada sel T regulator baik dalam hal jumlah maupun fungsi sel T regulator. Pemberian probiotik dalam hal ini pemberian Lactabacillus reuteri diharapkan mampu menstimulasi timbulnya respon imun yang bersifat imunoregulator dengan cara meningkatkan jumlah sel T regulator dan menurunkan produksi IL6. Tujuan : Mengetahui pengaruh pemberian probiotik terhadap toleransi sistem imun penderita SLE melalui perubahan kadar T regulator (CD4+CD25+Foxp3+) dan IL 6. Metode :30 subjek pasien SLE dengan manifestasi ringan yang datang ke poliklinik Alergi Imunologi RSCM, diberikan probiotik Lactobacillus reuteri (15 orang) dan placebo (15 orang) selama 8 minggu. CD4+CD25+FoxP3+ dan IL 6 diperiksa sebelum dan sesudah perlakuan menggunakan flowcytometri dan pemeriksaan ELISA. Hasil : Pemberian Lactobacillus reuteri selama 8 minggu meningkatkan kadarCD4+CD25+FoxP3+secara bermakna (1,38+ 8,36% VS 3,71+3,17% ; P=0,007 ; CI =-3,91 ? -0,74) . Terdapat penurunan kadar IL 6 setelah perlakuan, baik pada kelompok yang diberikan Lactobacillus reuteri (4,76+5,75 pg/ml VS 3,7 +3,36 pg/ml ; P=0,25 ; CI -0,83- 2,9) maupun pada kelompok placebo ( 2,6+2,02 pg/ml VS 2,07+2,39 ; P= 0,35 ; CI = -0,57 ? 1,52). Namun begitu, pada akhir penelitian perubahan tersebut tidak menimbulkan perbedaan bermakna kadar CD4+CD25+FoxP3+dan IL 6antara kedua kelompok. Kesimpulan :Terjadi peningkatan bermakna kadar CD4+CD25+FoxP3+ pada kelompok yang diberikan probiotik Lactobacillus reuteri selama 8 minggu.

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ABSTRACTBackgroud : In patients with Systemic Lupus Erythematosus (SLE) there areabnormality on T lymphocytes, including the existence of a defect in the regulatory Tcells both in terms of number and function. Giving probiotic, in this caseLactabacillus reuteri administration, is expected to stimulate the immune response tobe more tolerance by increasing the number of regulatory T cells and decreasing theIL6 production.Aim : To know the effect of probiotic (Lactobacillus reuteri ) on the immune systemof patients with SLE through changes in the levels of regulatory T cells (CD4+CD25+Foxp3+) and IL 6Method :Thirty ofSLE patients with mild manifestations, who came to Allergy andImmunology Clinic of Cipto Mangunkusumo Hospital, were given the probioticLactobacillus reuteri (15 people) and placebo (15 people) for 8 weeks. CD4+ CD25 +FoxP3+ and IL 6 were examined before and after exposure using flowcytometri andELISA. We then analyzed the levels of CD4 + CD25 + FoxP3 + and IL6 before andafter exposure.Result : Administration of Lactobacillus reuteri for 8 weeks brought statisticallysignificant improvement on CD4+ CD25 + FoxP3 +level (1,38+ 8.36% + 3.17% vs.3.71; P = 0.007; CI = -3.91 - -0.74). There were decreased level of IL 6 inLactobacillus reuteri group (4.76 + 5.75 pg / ml VS3,71 + 3.36 pg / ml; P = 0.25; CI -0,83- 2, 9) and the placebo group (2.6 + 2.02 pg / ml vs. 2.07 + 2.39; P = 0.35; CI = -0.57 - 1.5). However,at the end of study, those changes didn?t make statisticallysignificant difference of CD4+CD25+FoxP3+ and IL 6 level between two group.Conclusion : A significant increase of the levels of CD4 + CD25 + FoxP3 + were foundafter 8 weeks Lactobacillus reuteri administration, Backgroud : In patients with Systemic Lupus Erythematosus (SLE) there areabnormality on T lymphocytes, including the existence of a defect in the regulatory Tcells both in terms of number and function. Giving probiotic, in this caseLactabacillus reuteri administration, is expected to stimulate the immune response tobe more tolerance by increasing the number of regulatory T cells and decreasing theIL6 production.Aim : To know the effect of probiotic (Lactobacillus reuteri ) on the immune systemof patients with SLE through changes in the levels of regulatory T cells (CD4+CD25+Foxp3+) and IL 6Method :Thirty ofSLE patients with mild manifestations, who came to Allergy andImmunology Clinic of Cipto Mangunkusumo Hospital, were given the probioticLactobacillus reuteri (15 people) and placebo (15 people) for 8 weeks. CD4+ CD25 +FoxP3+ and IL 6 were examined before and after exposure using flowcytometri andELISA. We then analyzed the levels of CD4 + CD25 + FoxP3 + and IL6 before andafter exposure.Result : Administration of Lactobacillus reuteri for 8 weeks brought statisticallysignificant improvement on CD4+ CD25 + FoxP3 +level (1,38+ 8.36% + 3.17% vs.3.71; P = 0.007; CI = -3.91 - -0.74). There were decreased level of IL 6 inLactobacillus reuteri group (4.76 + 5.75 pg / ml VS3,71 + 3.36 pg / ml; P = 0.25; CI -0,83- 2, 9) and the placebo group (2.6 + 2.02 pg / ml vs. 2.07 + 2.39; P = 0.35; CI = -0.57 - 1.5). However,at the end of study, those changes didn’t make statisticallysignificant difference of CD4+CD25+FoxP3+ and IL 6 level between two group.Conclusion : A significant increase of the levels of CD4 + CD25 + FoxP3 + were foundafter 8 weeks Lactobacillus reuteri administration]"

"[ABSTRAKPenyakit jantung kongenital merupakan anomali kongenital yang paling sering terjadi dengan insiden 8-10 kasus dari 1000 kelahiran. Anak dengan penyakit jantung kongenital membutuhkan pengobatan dalam jangka waktu yang lama. Beberapa obat yang dikonsumsi oleh anak dengan penyakit jantung kongenital dapat menyebabkan terjadinya karies. Disebutkan bahwa anak dengan penyakit jantulng kongenital memiliki insiden karies yang lebih tinggi dibandingkan dengan anak normal. Tingkat keparahan resiko terjadinya karies dapat diperiksa melalui penghitungan nilai pH plak. Probiotik sering digunakan untuk pencegahan karies pada anak. Manfaat penggunaan probiotik dapat mengurangi resiko terjadinya karies. Penelitian ini dilakukan dengan cara mengambil sampel plak pada subjek sebelum berkumur minuman probiotik, kemudian subjek berkumur dengan minuman probiotik, dan 30 menit setelah berkumur minuman probiotik Hasil yang didapatkan dari 15 orang anak, probiotik dapat meningkatkan nilai pH plak (p=0,001) sebelum berkumur dan sesaat setelah berkumur, dan dapat bertahan 30 menit setelah berkumur minuman probiotik (p=0,430).

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ABSTRACTCongenital Heart Disease is the most common congenital anomaly occurred with an incidence of 8-10 cases out of 1000 births. Children with congenital heart disease are need treatment in the long term. Some drugs consumed by children with congenital heart disease may cause caries. As mentioned that children with congenital heart disease has a higher incidence of caries compared to normal children. The risk level of caries can be checked by calculating the plaque pH values. Probiotics are often used for prevention of caries in children. Benefits of using probiotics can reduce the risk of caries. This research is use samples of plaque on the subject before rinsing probiotic drink, then the subject gargling with probiotic drinks, and 30 minutes after rinsing probiotic drinks Results obtained from 15 children, probiotics can enhance the plaque pH values (p = 0.001) before rinsing and shortly after the rinse, and can last 30 minutes after rinsing probiotic drink (p = 0.430).;Congenital Heart Disease is the most common congenital anomaly occurred with an incidence of 8-10 cases out of 1000 births. Children with congenital heart disease are need treatment in the long term. Some drugs consumed by children with congenital heart disease may cause caries. As mentioned that children with congenital heart disease has a higher incidence of caries compared to normal children. The risk level of caries can be checked by calculating the plaque pH values. Probiotics are often used for prevention of caries in children. Benefits of using probiotics can reduce the risk of caries. This research is use samples of plaque on the subject before rinsing probiotic drink, then the subject gargling with probiotic drinks, and 30 minutes after rinsing probiotic drinks Results obtained from 15 children, probiotics can enhance the plaque pH values (p = 0.001) before rinsing and shortly after the rinse, and can last 30 minutes after rinsing probiotic drink (p = 0.430)., Congenital Heart Disease is the most common congenital anomaly occurred with an incidence of 8-10 cases out of 1000 births. Children with congenital heart disease are need treatment in the long term. Some drugs consumed by children with congenital heart disease may cause caries. As mentioned that children with congenital heart disease has a higher incidence of caries compared to normal children. The risk level of caries can be checked by calculating the plaque pH values. Probiotics are often used for prevention of caries in children. Benefits of using probiotics can reduce the risk of caries. This research is use samples of plaque on the subject before rinsing probiotic drink, then the subject gargling with probiotic drinks, and 30 minutes after rinsing probiotic drinks Results obtained from 15 children, probiotics can enhance the plaque pH values (p = 0.001) before rinsing and shortly after the rinse, and can last 30 minutes after rinsing probiotic drink (p = 0.430).]"

"ABSTRAKPeradangan kronik saluran cerna seperti Inflammatory Bowel Disease (IBD) berisiko menjadi karsinoma kolorektal, disebabkan oleh ketidakseimbangan mikrobiota komensal dan patogen. Dadih sebagai probiotik dapat mempertahankan keseimbangan mikrobiota usus sehingga mengurangi risiko radang usus. Untuk melihat keefektifan probiotik susu kerbau hasil fermentasi lokal berasal dari Sumatera Barat yang mengandung Bakteri Asam Laktat, dilakukan penelitian menggunakan hewan coba. Desain penelitian eksperimental menggunakan 4 kelompok mencit Balb/c terdiri dari 6 ekor per kelompok yakni, kelompok normal diberi aquades 8 minggu, kelompok (+) dadih diberi dadih 8 minggu (112 mg/20g/BB), kelompok (+) DSS mencit diberi DSS konsentrasi 3% sebanyak 3 siklus 6 minggu, serta kelompok uji diberi dadih 8 minggu dan DSS sebanyak 3 siklus. Mencit kemudian di-euthanasia dan diambil darah intrakardiak. Kadar sitokin TNF-alpha, IL-1β dan IL-10 diperiksa menggunakan Luminex dari serum. Dadih yang digunakan mengandung bakteri Lactococcus lactis subsp. lactis sebanyak 3x107 CFU/gram. Ada beda signifikan kadar TNF-alpha (p=0,033) dan IL-1β (p=0,007) antar kelompok namun tidak terdapat perbedaan signifikan IL-10 antar kelompok (p=0,091). Serta, ada beda signifikan kadar sitokin TNF-alpha mencit diberi dadih dan DSS dengan median kadar sitokin 26,641 (16,027-35,206) lebih rendah dibandingkan mencit yang hanya diberi DSS 41,220 (36,226-101,920) namun, median kadar sitokin IL-10 lebih tinggi sebesar 109,951 (92,621-130,436) dibandingkan mencit DSS sebesar 85,164 (57,292-111,548) serta tidak terdapat perbedaan signifikan untuk IL-1β. Dadih sebagai probiotik dapat meningkatkan kadar sitokin anti-inflamasi dan menurunkan sitokin pro-inflamasi dalam keadaan radang. Sehingga dapat disimpulkan bahwa dadih dapat digunakan untuk mencegah terjadinya peradangan usus.

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ABSTRACTChronic inflammation in the gastrointestinal tract, such as Inflammatory Bowel Disease (IBD), is a risk factor for colorectal cancer (CRC) causes the imbalance between commensal and pathogen microbiota in the intestine. Dadih could improve the balance between commensal and pathogen bacteria, and also between pro-inflammatory and anti-inflammatory responses. Aim of this research is to see the effectiveness of probiotic made from locally fermented buffalo milk originating from West Sumatra using animal model. This in vivo experimental research used 4 groups of Balb/c mice consisted of 6 mice per group there are normal group mice indued by aquades for 8 weeks, DSS(+) group mice induced by dadih for 8 weeks with doses 112mg/20g/BB, DSS(+) group mice induced DSS with concentration 3% as much as 3 cycle for 6 weeks and the last treatment group mice induced dadih for 8 weeks and DSS dor 6 weeks. The further more, mice doing euthanasia and taking blood to get the serum. Serum will be using for cytokine investigation consist of TNF-alpha, IL-1β and IL-10 with Luminex. The results showed dadih contained Lactococcus lactis ssp. lactis with 3x107 CFU/gram. The significant differences in TNF-alpha and IL-1β level with p = 0,033 and 0.007 respectively. However, there was no significant difference in IL-10 (p = 0.091). A further test was conducted to see the differences between groups the results showed that there were significant differences in TNF-alpha mice induced dadih+DSS group has median cytokine lower than DSS group equal to 26,641 (16,027-35,206) than 41,220 (36,226-101,920) but IL-10 cytokine dadih+DSS group has higher median cytokine 109,951 (92,621-130,436) than DSS group has 85,164 (57,292-111,548), but was no significant different at IL-1β cytokine. This research showed that dadih could enhance anti-inflammatory cytokines and suppress pro-inflammatory cytokines. Therefore, as locally made probiotic, dadih could be used to prevent intestinal inflammation."

"Latar belakang: merupakan salah satu tindakan pembedahan yang mempengaruhi motilitas gastrointestinal. Penelitian Cihoric et al menunjukkan sebanyak 12,5% pasien pasca laparotomi mengalami komplikasi disfungsi gastrointestinal. Disfungsi pada motilitas gastrointestinal merupakan komplikasi yang sering terjadi pada prosedur pembedahan abdomen. Dari 100 pasien operasi laparotomi digestif, ditemukan sebanyak 40% pasien di ICU mengalami peningkatan gastric residual volume pada pasien pasca operatif laparotomi digestif. Pemberian suplementasi dengan Lactobaciillus acidophilus diketahui dapat meningkatkan motilitas gaster.Tujuan: Penelitian ini bertujuan untuk mengetahui efek hubungan antara pemberian probiotik Lactobacillus acidophillus dengan GRV.Metode: Desain penelitian yang digunakan adalah eksperimental atau uji klinis acak tersamar ganda. Sebanyak 55 subjek yang mengikuti randomisasi, 54 subjek yang akan menjalani operasi laparotomi gastrointestinal dimasukkan ke dalam penelitian, 1 subjek drop out karena sepsis. Subjek penelitian diberikan kapsul probiotik Lactobacillus acidophilus 109 (kelompok probiotik) atau diberikan kapsul laktosa (kelompok plasebo) selama 3 hari sebelum operasi. Kadar GRV diukur 2 hari sesudah prosedur.Hasil: Dari 54 subjek dengan 27 subjek tiap kelompok mengikuti penelitian hingga selesai. Pada hari pertama (24 jam), GRV 24 jam dengan pemberian probiotik dan kelompok kontrol menunjukkan hasil yang tidak signifikan (p value 0,669). Pada hari ke 2 (48 jam), GRV 48 jam dengan pemberian probiotik dan kelompok kontrol menunjukkan hasil yang tidak signifikan (p value 1,000). Hasil yang tidak signifikan pada GRV 24 jam dan 48 jam dapat dipengaruhi faktor perancu yaitu geriatri, riwayat kelainan saraf, obesitas, riwayat penggunaan vasopressor, riwayat konsumsi opioid, hiperkapnia dan hiperglikemia selama di ICU.Simpulan: Pemberian probiotik Lactobacillus acidophilus dengan GRV tidak mempunyai efek hubungan dibandingkan dengan placebo.

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Background: Laparotomy is a surgical procedure that affects gastrointestinal motility. Research by Cihoric et al showed that 12.5% ​​of post-laparotomy patients experienced complications of gastrointestinal dysfunction. Dysfunction in gastrointestinal motility is a frequent complication of abdominal surgical procedures. Out of 100 patients with digestive laparotomy surgery, it was found that as many as 40% of patients in the ICU experienced an increase in gastric residual volume in postoperative digestive laparotomy patients. Supplementation with Lactobaciillus acidophilus is known to increase gastric motility.

Aim: This study aims to determine the effect of the relationship between administration of Lactobacillus acidophillus probiotics and GRV.

Methods: The study design used was an experimental or double-blind randomized clinical trial. A total of 55 subjects who followed the randomization, 54 subjects who would undergo gastrointestinal laparotomy were included in the study, 1 subject dropped out due to sepsis. Research subjects were given probiotic capsules Lactobacillus acidophilus 109 (probiotic group) or given lactose capsules (placebo group) for 3 days before surgery. GRV levels were measured 2 days after the procedure.

Results: Of the 54 subjects with 27 subjects in each group, they followed the research to completion. On the first day (24 hours), the 24-hour GRV with the administration of probiotics and the control group showed insignificant results (p value 0.669). On day 2 (48 hours), GRV 48 hours with probiotic administration and the control group showed insignificant results (p value 1,000). Results that were not significant at GRV 24 hours and 48 hours could be influenced by confounding factors, geriatrics, history of neurological disorders, obesity, history of vasopressor use, history of consumption of opioids, hypercapnia and hyperglycemia while in the ICU.

Conclusion: Administration of Lactobacillus Acidophilus probiotics with GRV had no association effect compared to placebo."

"Latar Belakang: Mukositis merupakan salah satu efek samping yang timbul akibat kemoterapi. Mukositis menyebabkan timbulnya rasa sakit, ketidaknyamanan, kesulitan berbicara, menelan, makan, minum, kekurangan nutrisi, kelemahan sistemik hingga infeksi. Probiotik mengandung mikroorganisme nonpatogen yang memberikan manfaat bagi kesehatan dan membantu dalam pencegahan inflamasi pada rongga mulut. Beberapa studi telah melaporkan manfaat probiotik bagi kesehatan oral. Tujuan: Menganalisis efek probiotik Lactobacillus casei terhadap keadaan klinis mukosa oral pada anak dengan Leukemia Limfositik Akut yang menjalani kemoterapi sebelum berkumur probiotik L.casei, setelah berkumur L.casei selama 7 hari dan 14 hari. Metode Penelitian: Penelitian dilakukan di RS Kanker Dharmais dan RS Kramat 128. Sebelas pasien yang memenuhi kriteria. Tiga hari setelah pemberian kemoterapi, peneliti memeriksa keadaan klinis rongga mulut menggunakan Oral Assessment Guide (OAG). Pasien kemudian mulai berkumur probiotik L.casei dua kali sehari selama 7 hari dan 14 hari. Skor OAG diperiksa kembali setelah berkumur probiotik L.casei selama 7 hari dan 14 hari. Hasil: Terdapat penurunan skor OAG yang bermakna antara sebelum berkumur dengan setelah berkumur probiotik L.casei selama 7 hari dan 14 hari. Kesimpulan: Probiotik L.casei memberikan efek pada anak dengan leukemia limfositik akut yang menjalani kemoterapi dan dapat menjadi terapi alternatif terhadap mukositis oral.

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Mucositis is one of the side effects induced by chemotherapy. It results in pain, discomfort, difficulties in talking, swallowing, eating, drinking, poor nutrition, systemic weakness and life-threatening infections. Probiotics contain nonpathogenic live microorganisms that give benefit to our health and help in preventing inflammation in the oral cavity. Several studies have reported the use of probiotics for oral health purposes. Objective: To analyze the effect of probiotic Lactobacillus casei to clinical appearance of oral mucosa in children with Acute Lymphocytic Leukemia that underwent the chemotherapy process before gargling, 7 days after gargling, and 14 days after gargling with probiotic. Methods: The study was held in National Cancer Hospital “Dharmais” and Kramat 128 Hospital. Eleven patients were meet the criteria. Three days after the chemotherapy started, the researcher checked the patient’s oral mucosa condition using Oral Assessment Guide (OAG). Then the patient started to gargle the probiotic twice a day for 7 days and the researcher rechecked the score of oral mucositis after 7 days and 14 days. Results: There was a significance decreasing OAG score between before gargling with 7 days and 14 days after gargling L.casei probiotics. Conclusion: L.casei probiotics gave effects in children with acute lymphocytic leukemia during chemotherapy and could be an alternative therapy for oral mucositis."

"Perolehan produk pangan probiotik sebagai flavor gurih (savory) memungkinkan konsumsi probiotik secara inovatif. Seasoning berprebiotik adalah pekatan/konsentrat hasil pemurnian biomassa probiotik yang mengandung Bakteri Asam Laktat (BAL) dari campuran lactobacillus bulgaricus dan streptococcus thermophilus dan metabolitnya dengan subtrat berupa kacang merah terfermentasi oleh kapang rhizopus-PL19 sebagai kaldu nabati...."