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Abstrak :
The research to accelerate furosemide, dissolution rate has been done through physical property modification by solid dispersion forming polyvinylpyrolidone (PVP) carrier with solvent method.Pure furosemide prosses property of being practically insoluble in water and has low biovailability .In current research,six weight ratio of furosemide to PVP being used are 1:1;1:3;1:5;1:9 and 1:15.Physical mixtures are made in equivalent weight ratio. The dissolution rate was examined by paddle method in phosphat buffer pH5,8.Solid dispersion caracterised with in vitro dissolution study,X -ray diffraction,infra red spectrophometer and differential scanning calometric.The result shows that solid dispersion of furosemide with PVP carrier is lugher compare to physical mixture dissolution rate and pure furosemide.The ratio furosemide to PVP who has the lughest dissolution rate is 1:15.The analyzing shows the existing of altering crystaline to amorphous state.

Abstrak :
ABSTRAK
Pemberian tablet gliklazida pada dosis tunggal secara oral memiliki bioavailabilitas yang rendah karena sifatnya yang praktis tidak larut dalam air, sehingga menyebabkan laju disolusi yang rendah dan menurunkan daya absorbsi pada saluran gastrointestinal. Tujuan penelitian ini adalah untuk mengetahui pengaruh dari penambahan superdisintegran kalium polakrilin dan pembawa polivinilpirolidon (PVP) terhadap kelarutan gliklazida dan laju disolusi tablet gliklazida dalam sistem dispersi padat. Dispersi padat dibuat dengan metode pelarutan dengan jumlah perbandingan berat yaitu gliklazida : polivinilpirolidon : kalium polakrilin = 1 : 1 : 0,1. Kemudian dikarakterisasi menggunakan alat X-Ray Difractometer (XRD) dan Differential Scanning Calorimetry (DSC). Uji disolusi dilakukan dalam medium larutan dapar posfat pH 7.4 menggunakan alat uji disolusi tipe 2 ( tipe dayung ). Hasil penelitian menunjukkan adanya peningkatan kelarutan gliklazida pada dispersi padat gliklazida-polivinilpirolidonkalium polakrilin sebesar 1,23 kali dibandingkan dengan kelarutan gliklazida murni. Laju disolusi gliklazida pada tablet yang mengandung dispersi padat gliklazida-polivinilpirolidon meningkat 1,47 kali dibandingkan dengan laju disolusi gliklazida pada tablet yang mengandung campuran fisik gliklazidapolivinilpirolidon- kalium polakrilin.

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ABSTRACT
Bioavailabilty of a gliclazide administered peroral shows a low value because that practically insoluble in water which leads to poor dissolution rate and subsequent decrease of its gastrointestinal absorbtion. The purpose of this research is to investigate the effect of adding superdisintegran polacrilin potassium and polyvinylpyrolidone (PVP) vehicle on the gliclazide solubility and dissolution rate of gliclazide tablet in solid dispersion system. Solid dispersion prepared by solvent method with a total weight ratio used is gliclazide : polyvinylpyrolidone : polacrilin potassium = 1 : 1 : 0,1. Then characterized using X-Ray Difractometer (XRD) and Differential Scanning Calorimetry (DSC). The dissolution test was carried out in the medium of pH 7.4 phosphate buffer solution using a type 2 dissolution tester (paddle type). The results showed an increase in the gliclazide solubility of solid dipersion gliclazidepolyvinylpyrolidone- polacrilin potassium of 1,23 times compared with pure gliclazide solubility. Gliclazide dissolution rate of tablets containing solid dispersion gliclazide-polyvinylpyrolidone increased 1,47 times compared with gliclazide dissolution rate of tablets containing physical mixture gliclazidepolyvinylpyrolidone- polacrilin potassium.