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"Latar belakang: Necrotizing enterocolitis / enterokolitis nekrotikan (NEC/EKN) adalah masalah serius yang sering terjadi pada neonatus, dengan tingkat insiden dan mortalitas yang tinggi, terutama pada bayi berat lahir yang rendah. Beberapa faktor telah diidentifikasi sebagai berpotensi meningkatkan risiko dan derajat keparahan EKN. Meskipun penelitian sebelumnya telah dilakukan di berbagai negara, belum ada penelitian serupa EKN dilakukan di Indonesia untuk memahami faktor-faktor yang berhubungan dengan EKN.Metode: Penelitian ini memiliki desain penelitian kohort retrospektif dan dilakukan di Unit Penelitian Kesehatan Neonatologi FKUI-RSCM dengan pengambilan sampel pada periode tahun 2016-2021 dan penulisan hasil penelitian pada Mei 2022-Desember 2023. Populasi target melibatkan neonatus dengan EKN, dengan populasi terjangkau merupakan pasien neonatus dengan derajat EKN I dan II yang diambil pada periode penelitian. Pasien dengan kelainan kongenital saluran cerna atau menjalani operasi lainnya selain tata laksana EKN dieksklusi dari penelitian. Variabel yang dinilai dalam penelitian ini adalah usia kehamilan, jenis kelamin, jenis kelahiran, skor APGAR, berat lahir rendah, sindrom gawat napas, sepsis, kadar C- reactive protein (CRP), pemberian antibiotik, jenis antibiotik, dan penggunaan ventilator.Hasil: Hasil penelitian menunjukkan bahwa tidak ada hubungan yang signifikan antara faktor-faktor seperti usia kehamilan, jenis kelahiran, skor APGAR, berat lahir rendah, sindrom gawat napas, sepsis, kadar CRP, pemberian antibiotik, jenis antibiotik, penggunaan ventilator, dan jenis kelamin dengan insiden peningkatan derajat keparahan EKN (p > 0,05) maupun waktu peningkatan derajat keparahan EKN (p > 0,05).Kesimpulan: Berdasarkan penelitian ini, dapat disimpulkan bahwa dalam populasi pasien neonatus dengan EKN derajat I dan II di RSCM, faktor-faktor internal dan eksternal yang diteliti tidak berhubungan secara signifikan dengan insiden maupun waktu peningkatan derajat keparahan EKN.

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Background: Necrotizing enterocolitis (NEC) is a serious problem that often occurs in neonates, with a high incidence and mortality rate, especially in neonates with very low birth weight. Several factors have been identified as potentially increasing the risk and severity of NEC. Although previous research has been conducted in various countries, there has been no similar study conducted in Indonesia to understand the factors associated with NEC.

Methods: This study has a retrospective cohort study design and was conducted in the Neonatology Research Center Unit, RSCM-FKUI with subject recruitment during the period of 2016 to 2021 and research report written during the period of May 2022 to December 2023. The target population included neonates with NEC, with the accessible population consisting of neonates with NEC I and II. Patients with congenital gastrointestinal tract disorders or those undergoing surgeries other than NEC management were excluded from the study. Variables assessed in this study included gestational age, sex, type of birth, APGAR score, very low birth weight, respiratory distress syndrome, sepsis, C-reactive protein (CRP) levels, antibiotic use, type of antibiotics, and ventilator use.

Results: The study results showed no significant relationship between factors such as gestational age, type of birth, APGAR score, very low birth weight, respiratory distress syndrome, sepsis, CRP levels, antibiotic use, type of antibiotics, ventilator use, and gender with the incidence of an increase in the severity of NEC (p > 0.05) or the time of the increase in the severity of NEC (p > 0.05).

Conclusion: Based on this study, it can be concluded that in the population of neonatal patients with NEC I and II at RSCM, the examined internal and external factors are not significantly associated with the incidence or time of the increase in the severity of NEC."

"ABSTRAKTujuan: Mengetahui batasan nilai PSA untuk memprediksi adanya metastasis tulang pada pasien kanker prostat di RS Sardjito. Metode: Penelitian retrospektif, dengan mengumpulkan rekam medis pasien kanker prostat telah dilakukan bone scintigraphy di RS Sardjito tahun 2006 - 2011.Hasil: Dari 83 pasien kanker prostat yang telah dilakukan bone scintigraphy, terdapat 55 pasien (66%) mengalami metastasis tulang dan terdapat 28 pasien (34 %) yang tidak mengalami metastasis tulang. Dari 55 pasien yang mengalami metastasis tulang, terdapat 11 pasien (20 %) dengan PSA kurang dari 20 ng/ml dan terdapat 44 pasien (80 %) yang memiliki PSA lebih dari 20 ng/ml. Cut-off point PSA 17.65 ng/ml memiliki sensitivitas terbesar yaitu 85.5% dan spesifisitas 53.6%.Kesimpulan: Pemeriksaan bone scintigraphy dianjurkan pada pasien dengan PSA > 17.65 ng/ml, sedangkan pada pasien dengan PSA < 17.65 dianjurkan pada pasien dengan gejala klinis nyeri tulang.

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ABSTRACTObjective: Prostate cancer shows a strong predilection to spread to the bones, with bone metastases identified at autopsy in up to 90 % of patients dying from prostate cancer. Serum prostate specific antigen (PSA) concentration has been widely applied as a biomarker to diagnose and monitor prostate cancer. Technetium-99m methylene diphosphate (Tc—99m MDP) whole body bone scintigraphy is currently a well-accepted diagnostic procedure for bone metastasis in malignancy. The aim of this study was to establish a useful serum PSA cut-off value to predict the presence of bone metastasis in men with prostate cancer. Material and Methods: Consecutive male patients diagnosed with prostate cancer were retrospectively analyzed. All of the subjects had received Tc-99m MDP whole body bone scintigraphy and had their serum PSA concentration measured at Sardjito Hospital, Yogyakarta. The proper cut-off value was established based on statistical analysis in order to predict the possibility of bone metastasis among prostate cancer patients.Results: In total, 83 consecutive male patients with prostate cancer were enrolled, and 55 patients (66 %) were confirmed by scintigraphic findings to have bone metastases. A serum PSA concentration of 17,65 ng/ml gave the best sensitivity (78,33 %) and specificity (65,21 %). The positive predictive value, negative predictive value were 85,45 % and 53,57 %, respectively (p<0,05).Conclusion: A cut-off value of 17,65 ng/ml appears to be an appropriate benchmark for stratifying metastatic bone disease in prostate cancer patients at Sardjito Hospital, Yogyakarta, such that if a patient with newly diagnosed prostate cancer and without any skeletal symptoms has a serum PSA concentration of less than 17,65 ng/ml,we suggest that they would not need to undergo bone scintigraphy."