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"Tunas berganda dapat dibentuk pada nodus kotiledon dari kecambah kacang tanah (Arachis hypogaea L.) varietas Lokal, Kelinci dan Pelanduk pada medium B5 dengan penambahan [(2-isopentenyl) adenosine] (2,iP), Kinetin dan 6-benzylaminopurine (BAP) sebanyak 50 mg/1. Frekuensi pembentukan tunas berganda bervariasi diantara varietas dan zat pengatur tumbuh yang dipergunakan. Namun demikian hanya varietas lokal yang pembentukan tunas bergandanya sangat efektif pada medium B5 dengan penambahan BAP sebanyak 50 mg/1. Perbanyakan tunas tampaknya telah diinduksi oleh adanya diferensiasi dari pemula tunas aksilar yang tersembunyi. Dari hasil penelitian ini menunjukan bahwa daerah nodus kotiledon kacang tanah memiliki potensi morfogenetik yang dapat diaktifkan dengan penggunaan BAP secara in vitro.

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Multiple shoot were formed on cotyledonary nodes of seedlings in peanut (Arachis hypogaea L.) Local, Kelinci and Pelanduk varieties on B5 medium supplemented with [(2-isopentenyl) adenosine] (2,iP), Kinetin and 6-benzylaminopurine (BAP) at 50 mgl1. The frequency of multiple shoots formation varied among the varieties and plant growth hormones tested. However, only mutiple shoots of Lokal variety seedlings were formed effectively on the B5 medium supplemented with 50 mg/1 of BAP. Multiplication of buds was induced by the differentiation of auxiliary buds from initially emerged buds. This results indicate that cotyledonary node region of peanut has high morphogenetic potential which could be activated by in vitro BAP application."

"Bayi prematur sangat rentan mengalami gangguan integritas kulit berupa lukatekan terutama pada telinga. Tujuan penelitian ini adalah untuk mengetahuiefektivitas penggunaan bantal kacang untuk pencegahan luka tekan grade I padatelinga bayi prematur. Desain penelitian ini menggunakan “quasi experimentposttest only with control group”, yang melibatkan 30 bayi prematur di ruangperinatologi. Hasilnya menunjukkan tidak ada perbedaan yang bermakna proporsikejadian luka tekan grade I pada telinga bayi prematur pada kelompok intervensidan kelompok kontrol (p value=0,65, α=0,05). Rekomendasi dari penelitian iniadalahperawatan dengan bantal tetap bermanfaat namun perlu dilakukanoptimalisasi alih baring.

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Preterm baby was very vulnerable to get skin integrity breakdown as pressure

ulcer particularly on the ear. The purposed of this study was to identify the

effectiveness using peanut pillow to prevent pressure ulcer on ears of preterm

baby. The design of this study was “experiment posttest only with control group”,

involving 30 preterm baby in the neonatology unit. The result showed there was

no significant differences proportion of pressure ulcer in the intervention group

and control group (p value=0,65, α=0,05). This study recommended that using

peanut pillow give the advantages but it is needed to optimize changing position."

"Atherosclerosis is a degenerative disease of large and medium arteries which loss their elasticity and the arterial walls are thickened which may cause coronary heart disease. Atherosclerosis is related to hyperlipidemia and concentration of serum lipoprotein cholesterol which are influenced by the intake of certain dietary lipids. The polyunsaturated fatty acid (PUFA), particularly linoleic acid is believed to have a lowering effect, saturated fatty acid (SAFA) increase, and mono-unsaturated fatty acid (MUFA) is neutral or has no effect on serum triglyceride that PUFA especially when given ia a large amount besides HDL-c. MUFA seems to have a similar effect as PUFA but without lowering effect on HDL-c. Low LDL-c and high HDL-c levels have positive effect on preventing and curing atherosclerosis and contrary of high LDL-c and low HDL-c.In this study, 60 albino, 2 month old male rats were put in separate cages and divides randomly into 6 groups. Each group received proportionally the first phase diet rich in margarine (40% of total energy) and cholesterol (10% w/w) for 3 months with additional oralforced feeding of proplythiouracil treated with the second phase diet with additional different types of fat source. The control group receieved normal diet. Determination of serum TG, total cholesterol, LDL-c, HDL-c and microscopic pathological examination of the aorta were carried out after treatment with the first and second phase diets.Analysis of variance showed that there were significant differences in serum TG, total cholesterol and LDL-c levels, the amount of diet consumed and the body weight changes between the treatment serum TG, total cholesterol and LDL-c as peanut oil. Serum HDL-c appeared not to be influenced by the different types of dietary fat. Pathological examination did not reveal any identifiable atherosclerosis signs in the aorta of the rats."

"ABSTRAKResveratrol 3,5,4 -trihidroksistilben merupakan suatu senyawa fitoaleksin stilben yang terdapat pada kulit kacang tanah Arachis hypogaea L., yang memiliki banyak khasiat seperti kardioprotektif, antioksidan, antidiabetes, dan antihiperkolesterolemia melalui mekanisme penghambatannya terhadap HMG-CoA reduktase. Terdapat banyak cara ekstraksi resveratrol yang dapat diterapkan. Penelitian ini bertujuan untuk mengevaluasi kemampuan Natural Deep Eutectic Solvents NADES -Ultrasound Assisted Extraction UAE untuk ekstraksi resveratrol dari kulit kacang tanah dan dibandingkan dengan metode konvensional maserasi. Hasil ekstraksi diuji dengan Kromatografi Cair Kinerja Tinggi KCKT . Hasil penelitian menunjukkan senyawa resveratrol berhasil diekstraksi dengan NADES-UAE. Hasil tertinggi diperoleh pada NADES campuran kolin klorida dan asam oksalat, pada kondisi rasio sampel-pelarut 1:20 g/ml dan waktu ekstraksi 15 menit, dengan perolehan kadar 0,0485 mg/g simplisia. Namun, metode maserasi memberikan kadar resveratrol yang lebih tinggi dibandingkan hasil NADES-UAE yaitu 0,2212 mg/g simplisia.

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ABSTRACTResveratrol 3,5,4 trihydroxystilbene is a naturally occurring stilbene phytoalexin compound found in peanut Arachis hypogaea L. pericarp and has known for many biological activities including cardioprotective, antioxidant, antidiabetic, and anti hypercholesterolemia through its HMG CoA reductase inhibitory activity. There are many methods can be applied to extract resveratrol. The aim of this study was to evaluate natural deep eutectic solvents NADES based ultrasound assisted extraction UAE for their potential to obtain resveratrol from peanut pericarp and compared with the conventional maceration method. The extracts were analysed by High Performance Liquid Chromatography HPLC . The results showed, resveratrol successfully extracted by NADES UAE, with highest resveratrol content obtained by NADES composed of choline chloride and oxalic acid 0,0485 mg g dry weight , under conditions solid liquid ratio 1 20 g ml and extraction time of 15 minutes. However, maceration method gives the higher amount of resveratrol content 0,2212 mg g dry weight than NADES UAE result."