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"This study aimed to assess the dietary changes of overweight and obese subjects and its relation to the body weight changes during 24 week of orlistat study. This study was an observational study as part of an open-labelled, randomised, parallel﷓group, real life study of the efficacy of orlistat for 36 weeks. However, this observational study followed the subjects until 24 weeks. The subjects were 64 overweight and obese Indonesian adults with body mass index 25.08 - 37.4 kglm2 and mean weight 76.7 kg (58,2 - 106.7 kg). Subjects were being prescribed a nutritionally balanced mild hypocaloric low fat diet. Caloric levels prescribed were a deficit of 500 kcal/day from daily caloric requirement (BMR corrected with physical activity level). 32 subjects were given orlistat 120 mg tid. On week-24, data of 38 subjects were being pooled and analyzed together. Until week-24, the subjects had lost an average of 7.8% of their initial body weight and 5.9% of their initial waist circumference. Total energy (p<0.05), protein (p<0.05), fat (p<0.001), carbohydrate (p<0.001) and PUFA intake (p<0.005) significantly reduce from week-0 to week-24.

The mean percentage reduced were 19.3% of energy intake, 32.7% of fat intake, 17.4% of carbohydrate intake and 7.5% of protein intake. Several predictors that may influence the body weight changes were treatment (orlistat), carbohydrate, and PUFA intake changes. In conclusion the dietary intake changes might influence the body weight reduction and waist circumference reduction, regardless the treatment, especially because typical Indonesian diet the energy source mostly from carbohydrate."

"Obesitas merupakan masalah kesehatan yang diprediksi terus bertambah hingga tahun 2050. Obesitas ditandai dengan nilai Indeks Massa Tubuh ≥ 30. Penelitian ini dimulai dari studi bioinformatika dibandingkan Orlistat. Gallocatechin gallate berpotensi sebagai anti obesitas yang terdapat dalam kandungan ekstrak daun yang diperoleh dari hasil bioinformatika. Penelitian secara in vivo menggunakan tikus putih betina galur Wistar yang diawali dengan uji induksi dengan 2 kelompok yaitu kelompok non HFD (High Fat Diet) dan HFD dengan pemberian secara oral. Semua tikus diinduksi dengan pakan standar dan pakan diet tinggi lemak selama 10 minggu hingga kenaikan berat badan mencapai 50% dan setelah itu diberi perlakuan dengan pembagian kelompok yaitu A (normal dengan pakan standar), B (HFD), C (HFD+Orlistat 30 mg/KgBB), D (HFD+Ekstrak 10 mg/KgBB), E (HFD+Ekstrak 20 mg/KgBB), dan F (HFD+Ekstrak 40 mg/KgBB) selama 4 minggu. Parameter yang diukur adalah berat badan, indeks lee, food intake, berat lemak viseral, % indeks adipositas, ukuran sel adiposa, profil darah (kolesterol, trigliserida, HDL, LDL, glukosa darah, dan uji toleransi glukosa), pengukuran kadar protein adiponektin, leptin, dan PNLIP dengan metode ELISA sandwich. Berdasarkan penelitian, ekstrak dosis 3 (40 mg/KgBB) memberikan pengaruh signifikan terhadap penurunan berat badan, kontrol nafsu makan dan mengurangi berat lemak viseral, mengurangi ukuran sel adiposa, memperbaiki nilai profil darah, meningkatkan kadar protein adiponektin dan leptin serta mengurangi kadar protein PNLIP.

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Obesity is a health problem that is predicted to increase until 2050. Obesity is characterized by a Body Mass Index value ≥ 30. This research started from a bioinformatics study compared to Orlistat. Gallocatechin gallate has potential as an anti-obesity contained in leaf extracts obtained from bioinformatics results. The next stage was to carry out in vivo research using wistar female white rats which divided into non High Fat Diet (HFD) and HFD group with oral administration. All rats were induced with standard feed and high fat diet for 10 weeks until body weight gain reached 50% and after that they were treated according to 6 groups, A (normal with standard feed), B (HFD), C (HFD+Orlistat 30 mg/KgBW), D (HFD+Extract 10 mg/ KgBW), E (HFD+Extract 20 mg/KgBW), and F (HFD+Extract 40 mg/KgBW) for 4 weeks. The parameters measured were body weight, lee index, food intake, visceral fat weight, % adiposity index, adipose cell size, blood profile (cholesterol, triglycerides, HDL, LDL, blood glucose, and glucose tolerance test), measurement of adiponectin, leptin, and PNLIP protein level using the sandwich ELISA method. Based on this research, Extract dose 3 (40 mg/KgBW) has an significant effect on weight loss, appetite control and reduce visceral fat weight, reduce adipose cell size, improve blood profile values, increase adiponectin and leptin protein levels and decrease PNLIP protein level."