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Ni Made Hustrini
"Background: optimal hydration represents adequate total daily fluid intake to compensate for daily water losses, ensure adequate urine output to reduce the risk of urolithiasis and renal function decline, and also avoid the production of arginine vasopressin (AVP). Twenty four hour urine osmolality has been used to assess hydration status, but it is challenging because of the possibility of spilling urine and limitation of daily activities. This study is aimed to determine the performance of the afternoon urine osmolality to assess the optimal hydration status compared with 24 hour urine osmolality.
Methods: a cross sectional study was conducted on healthy employees aged 18-59 years at Universitas Indonesia Medical Faculty/Cipto Mangunkusumo Hospital, with consecutive sampling method. The ROC curve was analyzed to obtain the optimal cut off point and the accuracy of the afternoon urine osmolality in assessing the optimal hydration status.
Results: between August-September 2016 there were 120 subjects (73.8% female, median age 32 years) who met the study criteria with a median 24 hour urine osmolality 463.5 (95% CI, 136-1427) mOsm/kg H2O and median afternoon urine osmolality 513 (95% CI, 73-1267). We found moderate correlation (r=0.59; p<0.001) between afternoon urine osmolality and a 24 hour urine osmolality. Using ROC curve, the AUC value was 0.792 (95% CI, 0.708-0.875) with the cut off 528 mOsm/kg H2O. To assess the optimal hydration status, the afternoon urine osmolality had the sensitivity of 0.7 (95% CI, 0.585-0.795) and the specificity of 0.76 (95% CI, 0.626-0.857), Likelihood Ratio (LR) (+) 2.917 (95% CI, 1.74-4.889) and LR (-) 0.395 (95% CI, 0.267-0.583).
Conclusion: afternoon urine osmolality can be used as a diagnostic tool to assess the optimal hydration status in healthy population with cut off 528 mOsm/kg H2O, sensitivity of 0.7, and specificity of 0.76."
Lengkap +
Jakarta: Faculty of Medicine University of Indonesia, 2017
616 UI-IJIM 49: 2 (2017)
Artikel Jurnal  Universitas Indonesia Library
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Ni Made Hustrini
"ABSTRAK
Latar Belakang: Hidrasi optimal merupakan hidrasi yang mencukupi untuk menggantikan kehilangan cairan, menjamin produksi urin cukup untuk mengurangi risiko urolitiasis dan penurunan fungsi ginjal, serta mencegah keluarnya arginin vasopresin AVP . Osmolalitas urin 24 jam diketahui dapat mengukur status hidrasi seseorang, namun dirasakan memberatkan karena kemungkinan urin tercecer dan membatasi aktivitas kerja. Oleh karena itu, dibutuhkan metode yang lebih sederhana untuk menggantikan pemeriksaan tersebut. Penelitian sebelumnya menunjukkan osmolalitas urin sore memiliki nilai terdekat dengan osmolalitas urin 24 jam. Namun, belum ada penelitian yang mengukur kemampuan urin sore hari sebagai penentu status hidrasi optimal.
Tujuan: Mengetahui peranan pemeriksaan osmolalitas urin sore hari untuk menilai status hidrasi optimal dibandingkan dengan osmolalitas urin 24 jam.
Metode: Studi diagnostik dengan desain studi potong lintang terhadap subjek sehat berusia 18-59 tahun dengan menganalisa kurva ROC untuk mendapatkan titik potong dan akurasi osmolalitas urin sore hari dalam menilai status hidrasi optimal.
Hasil: Antara bulan Agustus-September 2016 terkumpul 120 subjek 73,8 perempuan, median usia 32 tahun yang memenuhi kriteria penelitian dengan median osmolalitas urin 24 jam 463,5 95 IK, 136-1427 mOsm/kg H2O dan median osmolalitas urin sore hari 513 95 IK, 73-1267 mOsm/kg H2O. Pada analisis didapatkan korelasi sedang r= 0,59; p

ABSTRACT
Background: Optimal hydration representing adequate total daily fluid intake to compensate for daily water losses, ensure urinary output to reduce the risk of urolithiasis and renal function decline, and also avoid production of arginine vasopressin AVP . Twenty four hour urine osmolality has known to assess hydration status, but it is challenging because of the possibility of spilling urine and limiting time for daily activities. So that, we need easier method to determine optimal hydration status to replace 24 hour urine osmolality. Previous studies showed afternoon urine osmolality have an association with 24 hour urine osmolality. However, no studies measure the performance of afternoon urine osmolality to assess optimal hydration status.
Objective: To determine the performance of afternoon urine osmolality to assess the optimal hydration status compared with 24 hour urine osmolality.
Methods: Diagnostic study with cross sectional study design was conducted to healthy subjects aged 18 59 years by analyzing the ROC curve to obtain the optimal cutt off point and accuracy of afternoon urine osmolality in assessing the optimal hydration status.
Results: Between August September 2016 there were 120 subjects 73.8 female, median age 32 years who met the study criteria with a median 24 hour urine osmolality 463.5 95 CI, 136 1427 mOsm kg H2O and median afternoon urine osmolality 513 95 CI, 73 1267 mOsm kg H2O. From the analysis, we found the correlation was moderate r 0.59 p
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Lengkap +
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2016
T58714
UI - Tesis Membership  Universitas Indonesia Library