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Abstrak :
Dispepsia nonulseratif adalah suatu masalah gastrointestinal yang sering terjadi. Etiopatogenesisnya belum diketahui pasti. Tujuan penelitian ini adalah untuk mengetahui pengaruh faktor lingkungan seperti merokok, teh, alkohol, dan konsumsi NSAID terhadap dispepsia nonulseratif. Penelitian dilakukan di Bagian Gastroenterologi, Penyakit Dalam dan Radiologi IG Medical College, Shimla, India. Tiga ratus pasien dispepsia non ulseratif diteliti. Sebagai kelompok kontrol diambil dengan usia dan jenis kelamin yang sama. Riwayat merokok, teh, alkohol, dan konsumsi NSAID diteliti pada kedua kelompok. Konsumsi teh sebagai faktor lingkungan ternyata mempunyai pengaruh bermakna pada kelompok dispepsia nonulseratif, sedangkan faktor-faktor lain seperti merokok, alkohol, dan NSAID tidak mempunyai hubungan positif dengan dispepsia nonulseratif. (Med J Indones 2004; 14: 50-4)

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Non ulcer dyspepsia is a common gastrointestinal problem, the etiopathogenesis of which is not well established. This study was planned to see the effect of environmental factors like smoking, tea, alcohol, and NSAIDs consumption with non-ulcer dyspepsia. This study was conducted in the department of Gastroenterology, Medicine and Radiology of I.G. Medical College, Shimla, India. Three hundred patients of non-ulcer dyspepsia were included in the study. Each case was matched with community control of same age and sex. A detailed history of smoking, tea, alcohol, and NSAIDs consumption was taken from the patients and controls. Consumption of tea as an environmental factor was found to be statistically significant in non-ulcer dyspepsia patients as compared to controls using multivariate regression. In the present study, environmental factors like smoking, alcohol, NSAIDs consumption did not show positive co-relation with non-ulcer dyspepsia. (Med J Indones 2004; 14: 50-4)

Abstrak :
Penghambatan enzim siklooksigenase merupakan dasar efikasi dan toksisitas obat anti inflamasi non steroid. Penelitian ini bertujuan untuk mengevaluasi jenis obat anti inflamasi non steroid yang digunakan di poliklinik penyakit saraf Rumkital Dr. Mintohardjo Jakarta dan mengevaluasi tolerabilitas meloxicam 15 mg dengan natrium diklofenak 100 mg terhadap saluran cerna. Metode penelitian ini observasi cross-sectional dan cohort prospektif pada periode Desember 2010?Maret 2011. Pengambilan data mengenai keluhan dispepsia terkait penggunaan obat anti inflamasi non steroid terdiri dari nyeri abdomen atas, mual, muntah, kembung abdomen dan cepat kenyang dilakukan melalui wawancara berdasarkan kuesioner PADYQ (The porto alegre dyspeptic symptoms questionnaire) yaitu sebelum, setelah 2 minggu, dan setelah 4 minggu pengobatan. Hasil penelitian menyatakan obat anti inflamasi non steroid paling banyak diresepkan di poliklinik penyakit saraf Rumkital Dr. Mintohardjo adalah meloxicam (48,21%), selanjutnya natrium diklofenak (31,07%), asam mefenamat (15,36%), piroxicam (3,93%) dan asetaminofen (1,43%). Meloxicam secara bermakna menunjukkan resiko yang lebih kecil terhadap insiden saluran cerna daripada natrium diklofenak setelah 2 minggu pengobatan dalam hal keluhan nyeri abdomen atas dan kembung abdomen dengan nilai kebermaknaan pengujian masing-masing sebesar 0,020 dan 0,037. Berdasarkan hasil penelitian ini diketahui meloxicam memiliki tolerabilitas saluran cerna lebih baik daripada natrium diklofenak setelah 2 minggu pengobatan. ......Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a high incidence of gastrointestinal side-effects. Inhibition of the cyclooxygenase (COX) enzyme is the basis for both the efficacy and toxicity of NSAIDs. The aim of this study was to avaluate the nonsteroidal anti-inflammatory drugs were used in neuro polyclinic hospital of Dr. Mintohardjo Jakarta, and to evaluate gastrointestinal tolerability of meloxicam 15 mg compared with diclofenac sodium 100 mg. The methode of this study was cross-sectional observation and cohort prospective on December 2010-March 2011. The data of dyspepsia associated were used non-steroidal anti-inflammatory drugs consist of pain in upper abdomen, nausea, vomiting, upper abdominal bloating and early satiety collected with PADYQ (The porto alegre dyspeptic symptoms questionnaire) were assessed at baseline and after 2 and 4 weeks of treatment. The non-steroidal anti-inflammatory drugs used in neuro polyclinic hospital of Dr. Mintohardjo Jakarta were meloxicam (48.21%), diclofenac sodium (31.07%), mefenamic acid (15.36%), piroxicam (3.93%) dan acetaminophen (1.43%). Insiden of adverse event after 2 weeks treatment was significantly lower in the meloxicam group compared with diclofenac sodium group in pain in upper abdomen and upper abdominal bloating (p=0.020 and p=0.037). These result suggest that meloxicam was much better tolerated than diclofenac sodium after 2 weeks treatment.

Abstrak :
Non-steroidal anti-inflammatory drugs (NSAIDs) is a group of drugs used to treat pain, inflammation, and fever. High consumption of NSAIDs associated with high gastrointestinal side effects. Common complaint from patients, which ranging from mild heartburn to the onset of gastrointestinal bleeding, often complicates the adequate administration of NSAIDs. Various methods have been developed to reduce the likelihood of gastroenteropathy complication. Early diagnosis, appropriate prompt treatment, as well as adequate monitoring will reduce morbidity and mortality from complications due to NSAIDs. This paper will discuss the diagnosis and management of gastro-enteropathy NSAID through approaching the underlying pathophysiology.