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"Perjalanan penyakit Neoplasma Ovarium Kistik (NOK) disebut sillent killer karena seringkali terdeteksi saat sudah membesar. Kista ovarium seringkali muncul sepanjangsiklus hidup perempuan. Kelainan ginekologis dianggap sebagai kondisi yang secara signifikan mempengaruhi kehidupan sehari-hari perempuan, hubungan sosial, seksualitas dan kesehatan psikologis. Penatalaksaan NOK meliputi tindakan konservatif dan suportif dengan pemberian asuhan keperawatan yang komprehesif. Metode yang digunakan adalah studi kasus dengan fokus penerapan teori adaptasi Roy dan teori ketidakpastian Mishel. Aplikasi teori adaptasi Roy dan teori ketidakpastian Mishel efektif diterapkan pada kelima kasus yang berfokus pada kemampuan klien untuk beradaptasi dengan berbagai perubahan fisik maupun psikologis, serta melihat penilaian yang muncul dari kondisi penyakit dan tindakan yang dilakukan serta mampu mengeksplorasi bagaimana mekanisme koping yang digunakan serta respon adaptif yang digunakan oleh klien dengan menggunakan intervensi keperawatan yang sesuai.

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Cystic Ovary Neoplasm (NOK) disease is called the sillent killer because it is detected when it is enlarged. Ovarian cysts appeaed throughout the life cycle of women. Gynecological abnormalities are considered a condition that significantly affects women's daily lives, social relations, sexuality and psychological health. NOK's

management includes conservative and supportive interventions by providing comprehensive nursing care. The method used is a case study with a focus on applying Roy's adaptation theory and Mishel's uncertainty theory. The application of Roy's adaptation theory and Mishel's uncertainty theory is effectively applied to the five cases that focus on the client's ability to adapt to various physical and psychological changes, as well as see the evaluations that arise from disease conditions and actions and are able to explore how coping mechanisms are used and adaptive responses used by clients by using appropriate nursing interventions."

"A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience. The first part of this book is unique in explaining the recent developments in the field in terms of their point of action in the natural history of cancer. The second and third sections contain a more straightforward description of practical aspects of chemotherapy, and the current place of drug treatment in everyday cancer management, including the outcomes of that treatment."

"Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers."