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Abstrak :
ABSTRAK
Senyawa turunan pirimidin telah berhasil disintesis dengan mereaksikan benzaldehida, etil asetoasetat, dan urea melalui reaksi kondensasi Biginelli. Produk yang terbentuk dikarakterisasi menggunakan alat FTIR, UV-Vis, dan GC-MS. Pada sintesis senyawa ini digunakan nanokatalis CuFe2O4 yang berhasil disintesis dengan metode kopresipitasi dan dikonfirmasi dengan FTIR, XRD, TEM dan PSA. Berdasarkan optimasi (senyawa 1) dengan nama IUPAC 5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin2(1-)one diperoleh kondisi optimum dengan waktu 4 jam reaksi, suhu 70°C, dan 7,5% berat katalis dengan yield sebesar 71,57%, untuk (senyawa 2) 5-(ethoxy carbonyl)-4- (phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)thione diperoleh kondisi optimum selama waktu 4 jam reaksi, suhu 50°C, dan 7,5% berat katalis dihasilkan yield sebesar 76,84% sedangkan untuk (senyawa 3) pada waktu 4 jam reaksi, suhu 70°C, dan 7,5% berat katalis dengan yield sebesar 73,69% belum berhasil membentuk senyawa 5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)imine dari reaktan benzaldehida, etil asetoasetat dan guanidin.

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ABSTRACT
Pyrimidine derivatives have been synthesized by reacting benzaldehyde, ethyl acetoacetate, urea through Biginelli condensation reaction using CuFe2O4 nanocatalyst . Characterization of the three of product were performed by using FTIR, UV-Vis and GC-MS. In the synthesis of these compounds using CuFe2O4 nanocatalyst were successfully synthesized by coprecipitation method and characterized by FTIR, XRD, PSA, TEM. Optimum conditions for producing (compound 1) 5-(ethoxy carbonyl)-4- (phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)one were 4 hours reaction, temperature 70° C and 7.5% weight catalyst with yield 71.57% , (compound 2) 5-(ethoxy carbonyl)- 4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)thione was at 4 hours reaction, 50° C and 7.5% weight catalyst with yield 76.84% and compound 3 were 4 hours reaction, temperature 70° C and 7.5% weight catalyst with yield 73.69% has not succeeded in forming a 5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)imine.

Abstrak :
Turunan naftokuinon dilaporkan memiliki berbagai aktivitas farmakologis yang baik seperti antioksidan, antibakteri, antikanker dan antiinflamasi. Pada penelitian ini senyawa turunan naftokuinon telah berhasil disintesis melalui metode multikomponen melalui reaksi Mannich dengan bantuan nanokatalis . Nanokatalis telah berhasil disintesis dengan metode menggunakan ekstrak daun murbei. Senyawa metabolit sekunder yang terkandung dalam daun murbei seperti alkaloid berperan sebagai agen penghidrolisis (sumber basa lemah) dan saponin sebagai agen penstabil untuk mencegah aglomerasi. Katalis dikarakterisasi dengan spektroskopi FT-IR, XRD, PSA, SEM-EDX, TEM dan VSM. Hasil XRD menunjukkan bahwa nanopartikel memiliki struktur spinel. Nanopartikel memiliki bentuk dengan ukuran rata-rata 33,63 nm. Sifat magnetik dari nanopartikel ditinjau dari nilai koersivitas (Hc), remanensi (Mr), dan magnetisasi saturasi (Ms) yaitu masing-masing sebesar 175,44 Oe; 1,63 emu/g dan 14,10 emu/g. Senyawa turunan naftokuinon dilakukan pada kondisi optimum yaitu menggunakan pelarut etanol:air (1:1) selama 8 jam pada suhu ruang dengan jumlah katalis 10% mol. Senyawa tersebut disintesis dengan mereaksikan lawson, benzaldehida dan variasi amina aromatik (anilin, 4-kloroanilin dan 4-nitroanilin). Senyawa yang telah terbentuk dikonfirmasi dengan uji titik leleh, kromatografi lapis tipis, spektroskopi FT-IR, spektrofotometer UV-Vis dan GC-MS. Senyawa 1 (2-hidroksi-3-(fenil(fenilamino)metil)naftalena-1,4-dion) berhasil disintesis dengan massa produk campuran sebesar 0,3127 gram dengan kemurnian sebesar 6,78%. Senyawa 2 (2-(((4-klorofenil)amino)(fenil)metil)-3-hidroksinaftalen-1,4-dion) dan senyawa 3 (2-hidroksi-3-(((4-nitrofenil)amino)(fenil)metil)naftalen-1,4-dion) belum berhasil terbentuk dengan massa campuran masing-masing sebesar 0,3014 gram dan 0,2599 gram. Aktivitas farmakologis antioksidan diuji dengan menggunakan metode DPPH. Uji aktivitas antioksidan senyawa 1, 2 dan 3 memiliki IC masing-masing yaitu 5,95; 7,21 dan 14,41 ppm.
Naphthoquinone derivatives reported have a variety of good pharmacological activities such as antioxidants, antibacterial, anticancer and anti-inflammatory. In this research, the naphthoquinone derivatives have been successfully synthesized through Mannich reaction using nanocatalyst. nanocatalyst has been successfully synthesized by green synthesis method using mulberry leaf extract. Secondary metabolite compounds contained in mulberry leaves such as alkaloids as hydrolyzing agents (weak base sources) and saponins as stabilizing agents to prevent agglomeration. The catalyst was characterized by FT-IR spectroscopy, XRD, PSA, SEM-EDX, TEM and VSM nanoparticles have a spherical shape with an average size of 33.63 nm. The magnetic properties of CuFe nanoparticles such as coercivity (Hc), remanence (Mr), and saturation magnetization (Ms) values were respectively 175.44 Oe; 1.63 emu/g and 14.10 emu/g. Naphthoquinone derivative was carried out under optimal conditions using ethanol : water (1:1) solvent for 8 hours at room temperature with a catalyst amount of 10% mol. The compound was synthesized by reacting lawsone, benzaldehyde and aromatic amine variations (aniline, 4-chloroaniline and 4-nitroaniline). The compounds were confirmed by melting point test, thin layer chromatography, FT-IR spectroscopy, UV-Vis spectrophotometer and GC-MS. Compound 1 (2-hydroxy-3-(phenyl(phenylamino)methyl)naphthalene-1,4-dione) was successfully synthesized with mixed mass 0.3127 gram and purity 6.78%, compound 2 (2-(((4-chlorophenyl)amino)(phenyl)methyl)-3-hydroxynaphthalene-1,4-dione) and compound 3 (2-hydroxy-3-(((4-nitrophenyl)amino)(phenyl)methyl)naphthalene-1,4-dione) have not been successfully formed with mixed mass 0.3014 gram and 0.2599 gram, respectively. In naphthoquinone derivatives, the results of synthesis were tested by antioxidant activity using DPPH method. The antioxidant activity test of compound 1, 2 and 3 have IC 5.95; 7.21 and 14.41 ppm, respectively.