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"Diesel particulate matter baik fine maupun ultrafine particulate berkontribusi terhadap pajanan personal harian pekerja. Pajanan diesel particulate matter dalam jangka waktu pendek maupun dalam jangka waktu panjang dapat mengganggu kesehatan. Gangguan kesehatan tersebut antara lain menyebabkan perubahan glukosa, HbA1c dan lipid. Penelitian ini merupakan penelitian analitik yang bertujuan menganalisis pajanan diesel particulate matter yang dikaitkan dengan peningkatan HbA1c dalam darah. Sampel penelitian adalah petugas uji mekanis berjumlah 18 orang dan 13 petugas administrasi di Unit Pengelola Pengujian Kendaraan Bermotor Cilincing dan 18 kelompok pembanding. Adapun variable penelitian adalah pajanan diesel particulate matter, kadar HbA1c, usia, Indeks Masa Tubuh (IMT), lama kerja, dan kebiasaan merokok. Pengukuran pajanan particulate matter menggunakan pompa Leland legacy dan Sioutas cascade impactor dan perhitungan konsentrasi pajanan menggunakan metode gravimetric. Penimbangan filter debu hasil sampling menggunakan alat Neraca Mikro Mettler Toledo. Pengukuran kadar HbA1c dalam darah bekerja sama dengan Laboratorium Kesehatan. Hasil penelitian menunjukan adanya hubungan yang kuat dan berkorelasi positif antara konsentrasi pajanan personal PM10, PM2.5, PM1, PM0.5 dan PM0.25 dengan tingkat kadar HbA1c dalam darah.

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Diesel particulate matter both fine and ultrafine particulate contribute to daily personal exposure of workers. Exposure to diesel particulate matter in the short term and in the long term can disrupt health. These health problems include changes in glucose, HbA1c and lipids. This study is an analytical study that aims to analyze the exposure of diesel particulate matter associated with increased HbA1c in the blood. The samples were mechanical test officer totaling 18 people and 13 administrative officers in Cilincing Motor Vehicle Testing Unit and 18 comparison groups. The research variables are diesel particulate matter exposure, HbA1c level, age, body mass index (BMI), length of service, and smoking habit. Measurement of particulate matter exposure using Leland legacy and Sioutas cascade impactor pumps and calculation of exposure concentration using gravimetric method. Weighing of sampling dust filter using Mettler Toledo Micro Balance tool. Measurements of HbA1c levels in the blood work in conjunction with the Health Laboratory. The results showed a strong and positively correlated relationship between the personal exposure concentrations of PM10, PM2.5, PM1, PM0.5 and PM0.25 with levels of HbA1c in the blood."

"Emisi mesin diesel (diesel exhaust) merupakan bahan yang karsinogenik terhadap manusia (grup 1 IARC). Sektor transportasi merupakan penyumbang terbesar diesel exhaust di udara. Polisiklik Aromatik Hidrokarbon (PAH) merupakan komponen yang banyak ditemukan dalam diesel exhaust. 1-Hidroksipirena (1-OHP) merupakan metabolit pyrene yang digunakan sebagai penanda adanya pajanan PAH. Penelitian ini bertujuan untuk mengetahui konsentrasi 1-OHP dalam urin terkait dengan pajanan diesel exhaust pada pekerja uji mekanis di Pusat Pengujian Kendaraan Bermotor Cilincing. Pajanan diesel exhaust diukur melalui konsentrasi personal PM2,5, PM1, PM0,5, dan PM0,25. Penelitian dilakukan pada 19 petugas uji mekanis dan 18 orang pembanding. Pengukuran partikulat dilakukan menggunakan pompa Leland Legacy dengan Sioutas Cascade Impactor. Analisis 1-OHP dalam urin dilakukan menggunakan HPLC dengan detektor fluoresensi. Distribusi frekuensi 1-OHP dalam urin berkisar antara 11,72 - 61,88 µg/gr kreatinin urin. Hasil analisis menunjukkan terdapat rata-rata konsentrasi 1-OHP petugas uji mekanis signifikan lebih tinggi dibandingkan dengan kelompok pembanding (p=0,001). Terdapat korelasi positif dengan derajat keeratan kuat antara konsentrasi partikulat pada semua ukuran dengan konsentrasi 1-OHP dalam urin. Partikulat yang dihasilkan dari emisi mesin diesel merupakan kontributor utama terhadap peningkatan konsentrasi 1-OHP dalam urin petugas uji mekanis PKB Cilincing.

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Diesel engine exhaust is categorized as carcinogenic to human (group 1) by IARC in 2012. Transportation is the biggest contributor of diesel exhaust pollutant. Polycyclic Aromatic Hydrocarbons (PAHs) are the major compound of diesel exhaust that can be found on gas and particle phases. 1-Hydroxypyrene (1-OHP), a metabolite of pyrene, has been used extensively as a biological monitoring of exposure to PAHs.

This study aimed to analyze the concentration of urinary 1-OHP related to diesel engine exhaust among vehicle testing mechanics at vehicle testing center Cilincing, Jakarta. Diesel exhaust exposure was measured by personal concentration of PM2,5, PM1, PM0,5, dan PM0,25. The subject was 19 vehicle testing mechanics and 18 non-mechanics as a comparator. Personal concentration of particulate matter collected using Leland Legacy pump and Sioutas Cascade Impactor and analyzed using gravimetric method. Urinary 1-OHP analyzed using High Performance Liquid Chromatography with fluorescence detector. Concentration of urinary 1-OHP ranging from 11,72 to 61,88 µg/gr creatinine.

The result show that mean concentration of 1-Hydroxypyrene of mechanic group is significant higher than non-mechanic group (p=0,001). There is a positive correlation between particulate matter concentration in all size and urinary 1-hydroxypyrene concentration. In this study, particulate related to diesel engine exhaust is the main contributor of the increasing of urinary 1-hydroxypyrene concentration among vehicle testing mechanics."