Hasil Pencarian  ::  Simpan CSV :: Kembali

"This book presents exact, that is minimal, solutions to individual steps in the design process for Digital Microfluidic Biochips (DMFBs), as well as a one-pass approach that combines all these steps in a single process. All of the approaches discussed are based on a formal model that can easily be extended to cope with further design problems. In addition to the exact methods, heuristic approaches are provided and the complexity classes of various design problems are determined."

"This book provides an insightful guide to the design, testing and optimization of micro-electrode-dot-array (MEDA) digital microfluidic biochips. The authors focus on the characteristics specific for MEDA biochips, e.g., real-time sensing and advanced microfluidic operations like lamination mixing and droplet shape morphing. Readers will be enabled to enhance the automated design and use of MEDA and to develop a set of solutions to facilitate the full exploitation of design complexities that are possible with standard CMOS fabrication techniques. The book provides the first set of design automation and test techniques for MEDA biochips. The methods described in this book have been validated using fabricated MEDA biochips in the laboratory. Readers will benefit from an in-depth look at the MEDA platform and how to combine microfluidics with software, e.g., applying biomolecular protocols to software-controlled and cyberphysical microfluidic biochips."

"Perkembangan teknologi microfluidic telah memberikan dampak signifikan dalam berbagai aplikasi biomedis. Perangkat microfluidic memungkinkan pemrosesan sampel dalam jumlah kecil dan mengurangi waktu pemrosesan. Salah satu aplikasi penting adalah dalam deteksi dini Ganoderma Boninense, patogen utama pada kelapa sawit. Teknologi deteksi DNA berbasis lab-on-chip telah dikembangkan untuk mendeteksi patogen ini secara cepat dan akurat di lapangan. Penelitian ini bertujuan untuk mengkarakterisasi micropump piezoelektrik dalam sistem microfluidic dengan berbagai variasi pembebanan menggunakan eksperimen langsung dan simulasi Computational Fluid Dynamics (CFD). Micropump piezoelektrik dipilih karena ukurannya yang kecil, ringan, dan mampu dikendalikan dengan presisi tinggi. Eksperimen dilakukan dengan menggunakan Bartel mp6 micropump dan variasi chip microfluidic seperti Rhombic Chamber Chip, Reaction Chamber Chip, dan Open Membrane Chip. Hasil penelitian menunjukkan bahwa micropump piezoelektrik memiliki hubungan linear antara flow rate dan amplitude voltage. Pada kasus pembebanan dengan Rhombic Chamber Chip dan Reaction Chamber Chip, flow rate yang dihasilkan lebih kecil dibandingkan hasil simulasi CFD. Perbedaan yang cukup besar ditemukan pada pembebanan menggunakan Open Membrane Chip. Faktor penyebab perbedaan ini termasuk pengabaian tekanan hidrostatik dan pemodelan parameter membran yang tidak akurat. Secara keseluruhan, penelitian ini berhasil menunjukkan performa micropump piezoelektrik dalam berbagai kondisi pembebanan dan memberikan dasar untuk pengembangan lebih lanjut dalam aplikasi biomedis lainnya.

---

The development of microfluidic technology has had a significant impact on various biomedical applications. Microfluidic devices allow for the processing of small sample volumes and reduce processing times. One important application is the early detection of Ganoderma Boninense, the main pathogen in oil palm. Lab-on-chip DNA detection technology has been developed to quickly and accurately detect this pathogen in the field. This research aims to characterize piezoelectric micropumps in a microfluidic system under various loading conditions using direct experiments and Computational Fluid Dynamics (CFD) simulations. Piezoelectric micropumps were chosen for their small size, lightweight, and high precision control. Experiments were conducted using the Bartel mp6 micropump and different microfluidic chip variations such as the Rhombic Chamber Chip, Reaction Chamber Chip, and Open Membrane Chip. The research results show that piezoelectric micropumps have a linear relationship between flow rate and amplitude voltage. In loading cases with the Rhombic Chamber Chip and Reaction Chamber Chip, the generated flow rate was smaller than the CFD simulation results. Significant differences were found in the loading using the Open Membrane Chip. Factors contributing to these differences include the neglect of hydrostatic pressure and inaccurate modeling of membrane parameters. Overall, this research successfully demonstrated the performance of piezoelectric micropumps under various loading conditions and provides a foundation for further development in other biomedical applications."

"Dalam peneliatian ini telah dibuat dan dirancang sistem electrospinning berbasis mikrokontroler. Electrospinning umumnya digunakan untuk membuat nanofibers secara elektrostatik yang kemudian menghasilkan polimer nanofiber dengan diameter dalam skala nm dari larutan polimer yang diberi tegangan tinggi. Jika dibandingkan dengan teknologi konvensional, electrospinning adalah teknik yang serbaguna dan sangat efisien. Untuk dapat menerapkan teknik electrospinning ini, instrumen yang diperlukan adalah microfluidic syringe pump, kolektor, dan tegangan tinggi. Sistem syringe pump dibuat modular dan independent satu sama lain. Setiap syringe pump memiliki motor stepper yang menggerakkan lead screw, yang menggerakkan penyangga untuk piston pada suntikan. Drum kolektor memiliki efek yang signifikan pada produktivitas dan pengaturan nanofibers dan struktur akhir. Kecepatan rotasi atau RPM dari drum kolektor harus dikontrol untuk mendapatkan membran nanofibrous yang optimal. Tegangan tinggi yang diberikan akan menghasilkan peregangan tetesan larutan polimer yang dapat ditingkatkan dengan memberikan tegangan yang lebih tinggi. Pengaturan tegangan yang diterapkan juga merupakan faktor penting dalam teknik electrospinning, oleh karena itu perlu untuk mengontrol tegangan tinggi yang diberikan. Mikrokontroler yang digunakan dalam sistem ini adalah Atmega16. Untuk mengendalikan stepper motor digunakan driver a4988. Komunikasi antara mikrokontroler dan PC menggunakan komunikasi serial dengan baud rate 9600. Fungsi transfer kalibrasi dari microfluidic syringe pump dengan Sistem syringe pump dapat atur hingga 0,0043 mL/detik atau 15480 uL/jam dengan kesalahan Fungsi transfer kalibrasi dari drum kolektor  dengan. Drum kolektor dapat diatur dengan kecepatan maksimum 208 RPM dengan kesalahan.

---

This research describes the design development of electrospinning system based on microcontroller. Electrospinning is commonly used to make nanofibers electrostatically which then produces nanofiber polymers with a diameter in the nm scale from a high voltage polymer solution. When compared with conventional technology, electrospinning is a versatile and very efficient technique. To be able to apply this electrospinning technique, the required instruments are microfluidic syringe pump, collector, and high voltage. The syringe pump system is modular and independent of each other. Each pump has a stepper motor that drives the lead screw, which in turn moves the sled (mounted on a linear ball bearing) which pushes (inserts) or pulls (sucks) the syringe. Collectors have a significant effect on the productivity and arrangement of nanofibers and the final structure. The rotation speed or RPM of the drum collector must be controlled to obtain the optimal nanofibrous membranes. The applied voltage will result in stretching of the polymer solution droplets which can be increased by giving a higher voltage. The voltage regulation applied is also an important factor in this electrospinning technique, therefore it is necessary to control the applied high voltage. The microcontroller used in this system is ATmega16. Communication between the microcontroller and PC uses serial communication with a baud rate of 9600. Calibration transfer function of a microfluidic syringe pump  with. The system flow-rate can be set up to 0.0043 mL/second or 15480 uL/hour with error 0,674%. Calibration transfer function of microfluidic syringe pump  with. The collector drum can be set with a maximum speed of 208 RPM with an error of 0.277%."

"Dengan tingginya jumlah orang yang bepergian di seluruh dunia setiap harinya, membuat penyakit yang hanya tersedia di bagian dunia tertentu menyebar sangat cepat, seperti: Malaria, HIV, dan TB (TBC) - yang dikategorikan sebagai penyakit trifecta di negara tropis. Indonesia saat ini menghadapi beban penyakit yang sangat tinggi. Oleh karena itu sangat penting untuk menegaskan deteksi dini dan mudah semua penyakit itu, untuk memastikan tindakan penyembuhan yang tepat secepat mungkin. Kebutuhan ini dapat dicakup oleh ketersediaan kit In Vitro Diagnostic (IVD). IVD yang baru dikembangkan akan memiliki kualitas untuk menjadi point-of-care-testing (POCT), dengan lab-on-a-chip (LOC), memberikan hasil analisis cepat dan akurat dengan kebutuhan volume rendah untuk analisis sampel. Proyek ini sedang menyelesaikan masalah dengan, mengembangkan saluran Microfluidic plastik sebagai salah satu komponen kit In Vitro Diagnostic (IVD). Pembuatan mikro saluran Microfluidic menggunakan teknik Hot Embossing membutuhkan parameter yang terkontrol secara tepat dan keseragaman terkontrol di setiap siklus, dan membutuhkan cetakan dengan spesifikasi mikro-fabrikasi. Hasil karena alat minimal mekanisme Embossing Panas menghasilkan penyimpangan kecil dalam set parameter dan keseragaman. Memproduksi bagian produk dari dimensi chip Microfluidic untuk menyimpang dari cetakan dan membengkokkan atau membelokkan menciptakan cacat produk.

---

With a high number of people traveling across the world everyday, it has made the diseases which was only available in certain part of the world spreading very fast e.g. Malaria, HIV, and TB (tuberculosis) – which categorized as trifecta disease in tropical countries. Indonesia is currently facing a high burden of those diseases. It is therefore very important to affirm earlier and easier detections of all those diseases, to ensure the right curing actions as quick as possible. These needs could be covered by the availability of In Vitro Diagnostic (IVD) kit. The newly develop IVD will have the quality to be point-of-care-testing (POCT), with lab-on-a-chip (LOC), giving rapid analysis result and accurately with low volume requirement for samples analysis. This project is solving the problem by, developing plastic Microfluidic channel as one of In Vitro Diagnostic (IVD) kit components. Micro-fabricating of Microfluidic channel using Hot Embossing technique demands precisely controlled parameter and controlled uniformity in each cycle, and needs a mold with micro-fabrication specification. Results due to minimal tools of Hot Embossing mechanism resulting minor deviations in the parameter set and uniformity. Producing product part of Microfludic chip dimensions to deviate from the mold and to bent or deflected creating a product defect."

"The book is mainly focused on micromachining of transparent materials which, due to the nonlinear absorption mechanism of ultrashort pulses, allows unique three-dimensional capabilities and can be exploited for the fabrication of complex microsystems with unprecedented functionalities."

"Nanophotonics has emerged rapidly into technological mainstream with the advent and maturity of nanotechnology available in photonics and enabled many new exciting applications in the area of biomedical science and engineering that were unimagined even a few years ago with conventional photonic engineering techniques. Handbook of Nanophotonics in Biomedical Engineering is intended to be a reliable resource to a wealth of information on nanophotonics that can inspire readers by detailing emerging and established possibilities of nanophotonics in biomedical science and engineering applications. This comprehensive reference presents not only the basics of nanophotonics but also explores recent experimental and clinical methods used in biomedical and bioengineering research. Each peer-reviewed chapter of this book discusses fundamental aspects and materials/fabrication issues of nanophotonics, as well as applications in interfaces, cell, tissue, animal studies, and clinical engineering. The organization provides quick access to current issues and trends of nanophotonic applications in biomedical engineering. All students and professionals in applied sciences, materials, biomedical engineering, and medical and healthcare industry will find this essential reference book highly useful."

"This book covers the recent developments in the production of micro and nano size products, which cater to the needs of the industry. The processes to produce the miniature sized products with unique characteristics are addressed. Moreover, their application in areas such as micro-engines, micro-heat exchangers, micro-pumps, micro-channels, printing heads and medical implants are also highlighted. The book presents such microsystem-based products as important contributors to a sustainable economy. The recent research in this book focuses on the development of new micro and nano manufacturing platforms while integrating the different technologies to manufacture the micro and nano components in a high throughput and cost effective manner. The chapters contain original theoretical and applied research in the areas of micro- and nano-manufacturing that are related to process innovation, accuracy, and precision, throughput enhancement, material utilization, compact equipment development, environmental and life-cycle analysis, and predictive modeling of manufacturing processes with feature sizes less than one hundred micrometers. "