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"Updating the most comprehensive and complete guide to water treatment planning and design, this edition maintains the book's broad scope and reach, while reaching the working professional with additional worked problems and new treatment approaches. It covers both the principles and theory of water treatment as well as the practical considerations of plant design and distribution. The contents have been updated to cover changes to regulatory requirements, testing methodology, and design approaches, as well as the emergent topics of pharmacological agents in the water supply and treatment strategies"

"Summary:This text is an essential study guide for undergraduates studying microbiology modules on degree courses in pharmacy and the pharmaceutical sciences"

"Summary:With its concise and readable style, this book offers coverage of the concepts, including advances in immunology and genomics, while also ensuring that students have the knowledge and mastery of the fundamentals necessary to understand the advances of the future. It explains microbiology, providing a strong foundation in the fundamental concepts"

"ABSTRAKPendahuluan: Infeksi paru merupakan penyebab morbiditas dan mortalitas terbesar di Intensive Care Unit ICU. Pasien ICU umumnya dalam kondisi critically ill dan riwayat penggunaan antibiotic sebelumnya sehingga memiliki risiko resistensi terhadap antibiotik yang berpengaruh terhadap luaran pasien.Sistem skoring digunakan di ICU untuk menilai derajat keparahan penyakit dan luaran pasien. Penelitian ini menilai eta kuman pasien infeksi paru dan hubungannya dengan derajat keparahan penyakit yang dinilai dengan skor APACHE II. Metode: Penelitian ini menggunakan metode potong lintang yang dilaksanakan pada bulan Agustus-September 2017 di ICU RSUP Persahabatan. Total subjek terdiri atas 59 subjek dengan cara pengambilan sampel consecutive sampling. Semua pasien didiagnosis infeksi paru oleh dokter spesialis dan dikonfirmasi melalui foto toraks kemudian dinilai derajat keparahan penyakit dengan skor APACHE II dan dilakukan biakan dan resistensi mikroorganisme. Hasil: Kuman yang banyak ditemukan merupakan gram negative (37,2%) dengan risiko mortalitas tertinggi 75% jenis Acinetobacter pada skor (APACHE II 30-34). Rerata skor APACHE II 15,78+ 6,04 dengancut off point skor APACHE II 16,5 dan skor APACHE II >16 memiliki mortalitas terbesar (64%) (p=0,032). Diagnosis infeksi paru dengan mortalitas terbesar didapatkan pada CAP (56%). Kesimpulan: Acinetobacter baumanii merupakan kuman terbanyak yang menyebabkan kematian pada pasien infeksi paru dan skor APACHE II merupakan prediktor yang baik dalam menilai derajat keparahan penyakit dan luaran pasien.

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ABSTRACT<>br>Introduction: Lung infection are the most common cause of high mortality and morbidity in Intensive Care Unit (ICU). Patients in ICU mostly critically ill with history of antibiotic use and risk of drug resistant that will influence the outcome of the patients. Scoring system used in ICU to measure severity of the disease and the outcome of the patients. This study asseses the microbiological pattern of patients with lung infection and severity of the disease using APACHE II Score. Methods: This study used cross sectional methods that heldbetween August 2017-September 2017in Persahabatan Hospital Intensive Care Unit. Total subjects consisted of 59 patients with lung infection base on consecutive sampling. All of the patients diagnosed with lung infection from specialist and confirmed with radiological findings, measured the APACHE II Score and performed sputum culture and resistance. Results: The most common isolation found in lung infection patients was gram negative (37,2%) with mortality risk of Acinetobacter baumanii75% (APACHE II Score 30-34). Mean APACHE II Score was 15,78+ 6,04 with cut off point APACHE II Score 16,5 and APACHE II Score > 16 has the highest mortality (64%) (p=0,032). Diagnose of lung infection with the highest mortality found in patients with CAP (56%). Conclusions: Acinetobacter baumanii are the most common cause of mortality in lung infection patients. The APACHE II Score has good predictor in measure severity of the diseases and the outcome of the patients."

"Kualitas udara luar ruangan, khususnya kualitas udara mikrobiologis, belum menjadi perhatian khusus di Indonesia. Kualitas udara mikrobiologis seharusnya mendapat perhatian khusus karena pencemaran oleh mikroorganisme ke udara dapat memicu persebaran infeksi dan penyakit-penyakit lain. Penelitian ini dilakukan terhadap kualitas udara di TPA Cipayung, Depok, Jawa Barat, dan udara di permukiman sekitar TPA untuk mengetahui konsentrasi mikroorganisme dan jangkauan persebarannya di udara. Tujuan penelitian ini adalah: (1) menganalisis besarnya konsentrasi jamur Aspergillus fumigatus di area TPA Cipayung Depok; (2) menganalisis tingkat penyebaran jamur A. fumigatus pada kawasan permukiman di sekitar TPA Cipayung Depok; (3) menganalisis faktor-faktor yang mempengaruhi persebaran jamur A. fumigatus di udara di sekitar TPA Cipayung Depok. Pengambilan sampel udara dilakukan di 5 titik di TPA dan 5 titik lainnya di permukiman pada jarak 50, 100, 250, 500, dan 1.000 meter. Sampel udara diambil menggunakan alat EMS Bioaerosol Single Stage Sampler dengan debit aliran udara sebesar 28,3 L/menit. Pengambilan sampel udara untuk parameter jamur dilakukan selama satu menit pada media Malt Extract Agar dan diinkubasi pada temperatur 29-30C selama ± 48-72 jam. Parameter utama yang diteliti merupakan jamur A. fumigatus. Koloni yang tumbuh dihitung sebagai Colony-forming Units (CFU/m3). Hasil penelitian menunjukkan hasil angka kuman (konsentrasi A. fumigatus), temperature, kelembaban udara, dan kecepatan angin di TPA Cipayung pada rentang 43+13,5-1151.6+484,2 CFU/m3, 27-42oC, 40-83,8%, dan 0,4-3 m/s. Hasil pengukuran konsentrasi jamur A. fumigatus diuji secara statistik menggunakan uji non-parametrik untuk menunjukkan korelasinya dengan jumlah truk yang beraktivitas dan hasil menunjukkan korelasi (A>¼ >0,05) pada konsentrasi jamur A. fumigatus dengan jumlah truk yang beroperasi. Berdasarkan pengukuran dan perhitungan, nilai kecepatan jatuh dari spora A. fumigatus sesuai dengan Hukum Stokes, yaitu sebesar 0,000576-2,556 x10-3 m/jam dan termasuk ke dalam jenis submicroscale transport. Besarnya konsentrasi jamur yang ditemukan dapat dipengaruhi oleh suhu, kelembaban udara, dan kecepatan angin. Sementara itu, jumlah truk yang lewat serta melakukan kegiatan unloading sampah dapat mempengaruhi penambahan jumlah konsentrasi jamur karena dapat dikategorikan menjadi sumber garis (launching).

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Indonesia has yet to pay a serious attention to study about outdoor air quality, especially microbial air quality. It is a subject that must be seriously studied because microorganism-sponsored air pollution could cause the spread of infection and other diseases. This study aims to assess air quality at Cipayung Landfill in Depok, West Java, and the air in the vicinity of the facility so that the concentration and the dispersion in the air of microorganism could be detected. This study aims to: (1) analyze the concentration of Aspergillus fumigatus inside the Cipayung Landfill area; (2) analyze the movement rate of A. fumigatus in air inside the Cipayung Landfill area; (3) analyze the factors influencing the movement of A. fumigatus in air inside the Cipayung Landfill area. The air sampling for the study was conducted in five points at the Cipayung Landfill area and in five points at the neighborhood around the landfill. The author obtained the air sample through using the EMS Bioaerosol Single Stage Sampler with air flow rate at 28.3 liter/minute. The air sampling, used for fungi parameter, was conducted for one minute using the Malt Extract Agar medium, which was then incubated at temperatures between 29 and 30 degree Celcius for 48 to 72 hours. The primary parameter of the study is the A. fumigatus. The grown colony is counted as colony-forming units (CFU/m3). The results show that the concetration of A. fumigatus, temperature, humidity level and wind speed at Cipayung Landfill are, 43+13,5-1151.6+484,2 CFU/m3, 27-42oC, 40-83,8%, dan 0,4-3 m/s. The measurement results of A. fumigatus concentration is assessed by a non-parametric assessment to show its correlation with the number of trucks conducting activities at the facility. The results show the correlation (A>¼>0,05) between the two. Based on measurement and calculation, the downward velocity of the spores of A. fumigatus is inline with the Stokes Law at 0,000576-2,556 x10-3 m/hour and is part of submicroscale transport. The amount of fungi concentration found at the facility is influenced by temperature, humidity and wind speed. Meanwhile, the number of trucks passing at the facility and unloading waste there could influence the rise of concentration of fungi because it can be categorized as a linear source (launching)."

"Background: diagnostic of pulmonary TB in HIV patients is a problem due to non specific clinical features, or radiological appearance. HIV patients with CD4≤200 cells/mL infected with M. tuberculosis have less capacity in containing M. tuberculosis, developing granulomas, casseous necrosis, or cavities. This condition is caused by weakend inflammatory which later reduced sputum production and may cause false negative result. This study aimed to assess differences in the positivity level of acid fast bacilli (AFB) and cultures of M. tuberculosis from non-bronchoscopic sputum (spontaneous and induced sputum) compared to bronchoscopic sputum (bronchoalveolar lavage) in HIV positive patients suspected pulmonary tuberculosis with CD4<200 cells/μL.Methods: this cross sectional study was conducted in adult HIV patients treated in Hasan Sadikin Hospital with CD4≤200 cells/μL suspected with pulmonary tuberculosis by using paired comparative analytic test. All patients expelled sputum spontaneously or with sputum induction on the first day. On the next day, bronchoalveolar lavage (BAL) was performed. The two samples obtained from two methods were examined by AFB examination with staining Ziehl Neelsen (ZN) and cultured of M. tuberculosis on solid media Ogawa on all patients. Positivity, sensitivity and increased sensitivity of AFB and culture of M. tuberculosis in the non bronchoscopic and bronchoscopic groups were compared.Results: there were differences in the positivity level of AFB with ZN staining between non-bronchoscopic and bronchoscopic groups which were 7/40 (17.5%) vs 20/40 (50.0%) (p<0.001). The differences between the cultures of non-bronchoscopic and bronchoscopic groups were 16/40 (40.0%) vs 23/40 (57.5%) (p=0.039). Bronchoscopic sputum increased the positivity level of the ZN AFB examination by 32.5% (from 17.5% to 50.0%) as well as on culture examination by 17.5% (from 40.0% to 57.5%).Conclusion: Bronchoalveolar lavage can improve the positivity level of smears and cultures in patients suspected of pulmonary TB in HIV patients with CD4<200 cells/μL.

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Latar belakang: diagnosis TB paru pada pasien HIV merupakan suatu tantangan karena fitur klinis atau tampilan radiologis yang tidak spesifik. Pasien HIV dengan sel CD4 <200 sel/mL yang terinfeksi M. tuberculosis memiliki kapasitas yang lebih rendah dalam menampung M. tuberculosis, membentuk granuloma, nekrosis, atau kavitas. Kondisi ini disebabkan oleh melemahnya inflamasi yang kemudian mengurangi produksi sputum dan dapat menyebabkan hasil negatif palsu. Penelitian ini bertujuan menilai perbedaan tingkat positivitas basil tahan asam (BTA) dan kultur M. tuberculosis dari sputum non-bronkoskopi dibandingkan dengan sputum bronkoskopi (bronkoalveolar) pada pasien tersangka tuberkulosis (TB) paru HIV dengan CD4≤200 sel/μL.

Metode: penelitian potong lintang dilakukan pada pasien HIV dewasa yang dirawat di Rumah Sakit Hasan Sadikin dengan CD4 ≤200 sel/μL yang disangka memiliki TB paru dengan uji analitik komparatif berpasangan. Semua pasien diminta memberikan dahak secara spontan atau dengan induksi sputum pada hari pertama. Pada hari berikutnya dilakukan pemeriksaan bronkoskopi dengan bilasan bronkoalveolus. Bahan yang diperoleh dari kedua cara diperiksa secara mikroskopis dengan pewarnaan Ziehl Neelsen (ZN) dan kultur M. tuberculosis dengan media padat Ogawa. Positivitas, sensitivitas dan peningkatan sensitivitas BTA dan kultur M. tuberculosis pada kelompok non-bronkoskopik dan bronkoskopik kemudian dibandingkan.

Hasil: terdapat perbedaan tingkat positivitas ZN pada kelompok non-bronkoskopi dibandingkan bronkoskopi yaitu 7/40 (17,50%) vs 20/40 (50,00%) (p<0.001). Perbedaan antara kultur kelompok non-bronkoskopi dengan kelompok bronkoskopi yaitu 16/40 (40,00%) vs 23/40 (57,50%) (p=0,039). Bilasan bronkoalveolus menunjukkan tingkat positivitas pemeriksaan dahak BTA lebih tinggi sebesar 32,5% (dari 17,5% menjadi 50%) dan juga kultur sebesar 17,5% (dari 40,0% menjadi 57,5%)."

"ABSTRAKA study on microbiological quality of Nasi Rames was carried out ifrom December 1996 to January 1997. One hundred and two samples of Nasi Rames were collected and 102 food handler were interviewed. The microbiological contamination was assessed by using the method of enumeration of Indicator organisms (Aerobic Plate Count, Coliforms, and Escherichia coli) in PetrifilmTM at SEAMEO TROPMED Laboratory, Jakarta. High microbial counts were found in food samples. More than 21 % of food samples contained APC higher than 106 CFUIg food. Coliform counts higher than 102 CFUIg was found in 75.5% of Nasi Rames and 42.2% of the samples were contaminated with E. coll. The study did not find geographical pattern of microbiological contamination in studied area or any significant differences between districts as well as environment. Statistical analysis showed there was significant difference in microbial counts between vendor 1 and vendor 2. Further statistical analysis on risk factors contribute to microbial contamination showed that water source was associated with high counts of APC (p=0.016) and that the manner of waste disposal was associated with E. coli contamination (p=0.025). The study has suggested that the basic facilities were essential in the street vending operation. Considering that street food cater for numerous people, there are urgent needs to improve the microbiological quality of street foods. Actions should be taken to provide basic facilities and introduce the knowledge on food hygiene to street food vendors as well as the consumer."