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Abstrak :
Latar Belakang: Apendisitis masih merupakan salah satu masalah kesehatan di Indonesia dengan insidensi yang cukup tinggi. Salah satu parameter yang dapat dinilai dari apendisitis adalah reaktivitas dari folikel limfoid. Penelitian ini bertujuan mencari hubungan antara reaktivitas folikel limfoid dengan tipe radang apendiks pada pasien yang didiagnosis apendisitis secara histopatologis di RSUPNCM antara tahun 2005 hingga 2007. Metode: Penelitian dilakukan pada 50 sediaan apendisitis akut dan 50 sediaan apendisitis kronik yang dipilih secara acak. Penelitian dilakukan dengan metode analitik desain potong lintang yaitu dengan memperoleh data sekunder dari departemen Patologi Anatomi FKUI-RSUPNCM, mengamati sediaan dengan mikroskop, serta menganalisis data yang diperoleh dengan uji statistik. Hasil: Pada apendisitis akut, ditemukan hiperplasia folikel limfoid sebanyak 32%, sedangkan pada apendisitis kronik ditemukan hiperplasia folikel limfoid sebanyak 42%. Kesimpulan: Berdasarkan uji non-parametrik Chi square, didapatkan kesimpulan bahwa tidak terdapat perbedaan proporsi yang bermakna antara hiperplasia folikel limfoid pada apendisitis akut maupun kronik pada pasien yang didiagnosis apendisitis secara histopatologis di RSUPNCM tahun 2005 hingga 2007. ......Background: Appendicitis is still causing health problem in Indonesia with high incidency. One of the parameter that can be studied in appendicitis is lymphoid follicle hyperplasia. Objective of this study is to know whether there is relationship between lymphoid follicle reactivity and type of inflammation in patients who are diagnosed histopathologically suffering appendicitis in Cipto Mangunkusumo National General Hospital in 2005-2007. Method: This study evaluated 50 speciments of acuteappendicitis and 50 speciments of chronic appendicitis selected by random sampling. This study is a cross sectional analitic study done by analizing secondary data and observing preparates of appendix. Result: In this study, 32% of acute appendicitis have lymphoid follicle hyperplasia, and 42% of chronic appendicitis have lymphoid follicle hyperplasia. Conclusion: Based on Chi square non-parametric test, it is concluded that there are no significant difference of lymphoid follicle hyperplasia between acute and chronic appendicitis in patients who are diagnosed histopathologically suffering appendicitis in Cipto Mangunkusumo National General Hospital in 2005-2007.

Abstrak :
The abnormality or disease of ihe small intestine may cause chronic diarrhea. The tests required to investigate the abnormality of the small intestine are difficult and expensive. In this study we studied the small intestine in chronic diarrhea cases, to discover any abnormality. The chronic diarrhea patients presenting from 1996 to 2000(5 years) at Cipto Mangunkusumo General Central National Hospital were included in the study. Patients were excluded if unable to co-operate. All of the patients were given blood and stool lexis in addition to colonoscopy, ileoscopy and duodeno-jejunoscopy with biopsy. Small intestinal examination could only be performed on 78patients witii chronic diarrhea. The most frequent characteristic were: aged 30-39 or 50-59 years (25.6% of all canes in the study), male(57.7%), non-bloody non steatorrhoeic tvpe of diarrhea(74.4%), and 4 to 48 weeks-duration of diarrhea(68.0%). Small intestine abnormalities were endoscopically and/or histopathologically found in 65 cases(S2.6%), while the rest of the patients were found to have normal small intestine. The abnormalities were found to he infective non-tuberculosis ileitis (in 20 patients, or 26% of all cases), Infective non-tuberculosis duodenitis(20 or 26%), non-infective jejtinitixf 14, or 18.2%), villous aft phy of the jejunum(3, or 3.9%), lymphoid nodular/follii hyperplasia of the terminal Heutn(l2, or 15.6%) etc. LOT intestinal abnormalities were found in 67 or S3.7% of t chronic diarrhea cases. The frequent small intestinal abnormalities were infe tive ileitis, duodenitis and lymphoid nodular/follicle hype plasiaofthe terminal ileum. The small intestinal abnormal ties were found less than the large intestinal abnormalitie

Abstrak :
Background: The incidence of chronic non-infectious diarrhea cases is increasing in line with the developments of medical technology and science. The objective of this study was to uncover the histopathologic abnormalities of the small bowel in cases of chronic non-infectious diarrhea. Materials and Methods: All chronic non-infectious diarrhea patients in Cipto Mangunkusumo Hospital from 1996 until 2000 were included in this study. For the control group, we used 37 endoscopically-normal patients with junctional dyspepia with the some characteristics (sex and age). All of the patients underwent gastroduodeno-jejunoscopic and ileocolonoscopic examinations. Patients with infection were excluded from this study. Biopsies were taken from the duodenal bulb, descending duodenum, jejenum near the Treitz ligament, terminal ileum, and colon. Histopathological tests were performed on all of the biopsies. Result: Histopathological examination was carried out on 31 patients and 37 control patients. In the duodenal bulb, the width of villi, lymphocyte infiltration, cosinophil infiltration, stage of inflammation, and polymorphonuclear cells infiltration were all lower in the chronic non-infectious diarrhea group than in the control group (p< 0.0l). ln the descending part of duodenum and jejunum, lymphocyte infiltration, the stage of inflammation, and polymorphonuclear cell infiltration were found to be higher in the chronic non-infectious diarrhea group than in the control group (p< 0.01). Within the terminal ileum, lymphocyte infiltration, the stage of inflammation and lymphoid follicle hyperlasia were found to be higher in the chronic non-infectious diarrhea group than in the control group (p< 0.01). Conclusion: Histopathologically, increased lymphocyte infiltration, inflammation and lymphoid follicle hyperplasia were discovered in specified areas of small intestine in chronic non-infectious diarrhea patients.