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"Latar Belakang: Sklerosis multipel (multiple sclerosis/MS) merupakan penyakit inflamasi-demyelinasi sistem saraf pusat yang mengakibatkan atrofi struktur otak penderita. Indeks korpus kalosum (IKK) merupakan salah satu metode pengukuran morfometrik korpus kalosum yang cepat serta dengan reliabilitas interrater yang tinggi. Tujuan: Mengetahui korelasi antara hasil pengukuran IKK dengan volume korpus kalosum, substansi grisea kortikal, substansi grisea subkortikal, dan substansi alba serebri melalui MRI volumetri otak pada penderita MS. Metode : Hasil MRI kepala dari 30 penderita MS dilakukan pengukuran IKK. Nilai IKK kemudian dilakukan analisis korelasional dengan volume korpus kalosum, substansi grisea kortikal, substansi grisea subkortikal, dan substansi alba serebri yang diperoleh menggunakan perangkat lunak FreeSurfer©. Hasil : Terdapat korelasi yang sangat kuat antara IKK dengan volume korpus kalosum (R = 0,797 ; p = 0,001) dan volume substansi alba serebri (R = 0,813 ; p = 0,001). IKK juga berkorelasi kuat dengan volume substansi grisea kortikal (R = 0,642 ; p = 0,001) dan volume substansi grisea subkortikal (R = 0,696 ; p = 0,001). Kesimpulan : Metode pengukuran IKK dapat menjadi parameter morfometrik cepat dan sederhana yang menggambarkan volume korpus kalosum, substansi grisea kortikal, substansi grisea subkortikal, dan substansi alba serebri pada penderita MS.

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Background: Multiple sclerosis (MS) is an inflammatory-demyelinating disease of the central nervous system which results in atrophy of brain structure. Corpus callosum index (CCI) is a method of morphometric measurement of the corpus callosum using midsagittal slice from MRI which does not require additional sequences with fast processing time and high interrater reliability.

Objectives : To determine the correlation between the CCI measurements with corpus callosum, cortical gray matter, subcortical gray matter, and cerebral white matter volume through brain MRI volumetry in MS patients.

Methods : CCI measurements were obtained from head MRI from 30 MS patients according to the method conceived by Figueroa et al. Correlational analysis was carried out between CCI with corpus callosum, cortical gray matter, subcortical gray matter, and cerebral white matter volume obtained using FreeSurfer©.

Results : Very strong correlation was shown between CCI and corpus callosum volume (R = 0.797; p = 0.001) and cerebral white matter volume (R = 0.813; p = 0.001). CCI also shown strong correlation with cortical gray matter volume (R = 0.642; p = 0.001) and subcortical gray matter volume (R = 0.696; p = 0.001).

Conclusion : CCI can be a fast and simple morphometric parameter that describes the corpus callosum, cortical gray matter, subcortical gray matter, and cerebral white matter volume in MS patients."

"Latar Belakang: Parameter MRI difusi (ADC dan FA) otak pasien multipel sklerosis (MS) tidak hanya abnormal pada lesi, tetapi juga abnormal pada white matter yang bebas lesi dan terlihat normal pada MRI konvensional, atau disebut sebagai normal-appearing whitte matter (NAWM). Terdapat bukti perubahan mikrostruktural pada NAWM. Belum diketahui korelasi antara parameter MRI difusi NAWM dengan volume otak dan disabilitas neurologis pasien MS. Metode: Studi korelasi dengan desain cross-sectional. Terdapat 33 sampel yang dilakukan MRI otak dengan sekuens DTI. Dilakukan pengukuran nilai ADC dan FA pada struktur NAWM genu, korpus, dan splenium korpus kalosum masing-masing sampel, lalu dikorelasikan dengan volume otak yang diperoleh dari MRI volumetri, dan disabilitas klinis dalam bentuk EDSS. Hasil: Mean ADC korpus kalosum sampel 0,931 ×10−3 mm2/s (+ 0,131 SD), dan mean FA 0,717 (+ 0,116 SD). Terdapat korelasi kuat antara ADC dan FA NAWM korpus kalosum dengan rasio volume serebri tanpa ventrikel dengan volume intrakranial. Korelasi paling kuat adalah dengan FA (R= 0,78). Terdapat korelasi antara ADC dan FA NAWM korpus kalosum dengan EDSS, korelasi paling kuat dengan FA (R = -0,59). Kesimpulan: Terdapat korelasi antara ADC dan FA NAWM korpus kalosum dengan volume otak dan EDSS pasien MS. Diperlukan penelitian longitudinal untuk menilai kemampuan MRI difusi dalam evaluasi MS progresivitas MS.

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Background: Diffusion MRI parameters (ADC and FA) abnormalities in multiple sclerosis (MS) patients are not limited to the lesions, but also observed in the white matter that appears normal on conventional MRI sequences, known as normal-appearing white matter (NAWM). There are evidences of microstructural processes occurring in the NAWM. Correlation between diffusion MRI parameters of NAWM with brain volume and clinical disability in MS patients is not well established. Methods: This is a cross-sectional correlation study. Brain MRI with DTI sequence from 33 subjects were included. ADC and FA measurements of the genu, body, and splenium of corpus callosum (CC) were done. ADC and FA values were correlated with brain volume from MR volumetry and clinical disability represented by EDSS. Results: Mean ADC of CC NAWM is 0,931 ×10−3 mm2/s (+ 0,131 SD), and mean FA 0,717 (+ 0,116 SD). There was a strong correlation between ADC and FA of CC NAWM and the ratio of brain volume to intracranial volume. Strongest correlation observed was with FA (R= 0,78). There was a strong correlation between ADC and FA of CC NAWM and EDSS. Strongest correlation was also with FA (R = -0,59). Conclusion: There was a significant correlation between ADC and FA of CC NAWM with brain volume and EDSS of MS patients. Further longitudinal studies were needed to evaluate the potential of diffusion MRI in the evaluation of MS."