Latar Belakang: Orang tua yang merawat anak dengan kanker sering mengalami tingkat stres yang tinggi dan gejala depresi. Koping religius berfungsi sebagai metode bagi orang tua mengelola beban emosional mereka. Metode: Penelitian ini menggunakan metode kuantitatif dnegan pendekatan cross-sectional. Penelitian ini menggunakan kuesioner demografi, Perceived Stress Scale (PSS), dan BRIEF R-COPE. Hasil: Analisis data dari 154 responden orang tua yang mengisi kuesioner mengungkapkan tujuh variabel yang secara signifikan terkait stress orang tua: koping religius, status pernikahan, tingkat pendidikan pendapatan bulanan, tempat tinggal saat ini, lama rawat inap di rumah sakit, dan terutama jenis kanker. Kesimpulan: Koping religius yang positif menunjukkan korelasi positif dengan tingkat stres orang tua yang tinggi. Hal ini menggaris bawahi pentingnya memasukkan pendekatan religius ke dalam asuhan keperawatan, terutama bagi family caregivers.< ......Background: Parents caring for children with cancer often experience high levels of stress and symptoms of depression. Religious coping serves as a method for parents to manage their emotional burden. Methods: This study employed quantitative methods with a cross-sectional approach. It utilized demographic questionnaires, the Perceived Stress Scale (PSS), and BRIEF R-COPE. Results: Analysis of data from 154 parent respondents completing the questionnaires revealed seven variables significantly associated with parental stress: religious coping, marital status, education level, monthly income, current residence, length of hospital stay, and notably, the type of cancer. Conclusion: Positive religious coping shows a positive correlation with high levels of parental stress. This underscores the importance of incorporating religious approaches into nursing care, particularly for family caregivers.