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"Penelitian ini adalah diketahuinya pengarub pemberian jus anggur 300 gram per hari selama dua minggu terhadap kadar NO serum laki-laki dan perempuan dengan kadar kolesterol total batas tinggi. Penelitian ini merupakan sebuab field trial, membandingkan Ul subyek dalam kelompok yang mendapatkan jus anggur disertai penyuluhan TIC (P) dengan 17 subyek dalam kelompok yang hanya mendapatkan penyuluhan 1LC (K). Subyek yang memenuhi kriteria penelitian dibagi menjadi dua kelompok dengan randomisasi sederhana. Data yang diambil melipoti usia, jenis kelamin, riwayat hiperkolesterolemia dalam keluarga, akrivitas fisik, indeks massa tubuh (IMT), asupan energi, lernak, kolesterol, serat, dan polifenol dengan food record. Pemeriksaan kadar kolesterol total dan NO serum dilekukan di awal dan ekhir perlekuan. Analisis data menggunakan uji t tidak berpasangan dan uji Mann Whitney dengan batas kernaknaan 5%. Sebanyak 18 subyek pada kelompok P dan 14 subyek pada kelompok K, dengan rerata usia 35,57±5,20 tahun mengikuti penelitian secara lengkap. Indeks akrivitas fisik subyek kedua ke!ompok termasuk di bawah rata-rata. Data awal tidak didapatkan perbedaan bermakna (p>O,OS). Setelah dua minggu perlakuan, didapatkan persentase asupan energi terbadap kebutuhan energi total termasuk kategori cukup pada kelompok perlakuan dan kurang pada kontrol. Asupan lemak total dan kolesterol kadua kelompok adalah tergolong cukup. Asupan serat tergolong kurang. Terdapat perbadaan bermakna asupan polifenol pada kedua kelompok selama perlakuan (p<0,05). Terdapat peningkatan kadar NO serum sesudab perlekuan pada kedua kelompok yang tidak berbeda bermakna (p>O,OS), bahkan terdapat penurunan kadar kolesterol total serum pada kedua kelompok sesudah perlekuan meskipun tidak berbeda bermakna (p>0,05) dan masih dalam kategori batas tinggi. Pemberian jus anggur 300 gram per han tidak didapatkan perbedaan bermakna peningkatan kadar NO serum antara kelompok perlakuan dan kontrol.

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The aim of this study was to investigate the effect of grape juice (that made from 300 grams of grapes per day) during two weeks on serum NO level in male and female subjects with borderline high total cholesterol level. The study was a field trial Thirty five subjects were selected using certain criteria and randomly (simple randomization) divided into two groups. The treatment group (n=18) received grape juice and nutrition counseling; the control group (n=l7) received nutrition counseling. Data obtained directly from the subjects were age, gender, history of hypercholesterolemia in .subject's family, physical activity, and body mass index, intake of energy, fat, cholesterol~ fiber and polyphenol using food record. Laboratory findings of serum NO level and total cholesterol level were done before and after intervention. For statistical analysis, unpaired t-test and Mann Whitney were used with the level of significance was S%. Eighteen subjects in the treatment group and fourteen subjects in the control group completed the study and analyzed. Mean of age was 35.57±5.20 years old. The physical activity index of bath groups were low. The characteristics of the two groups were closely matched at base line (p>O.OS). After two weeks intervention, subjects? energy consumed in the treatment group achieved the recommended diet, while in the control group was below. The average intake of total fat and cholesterol in both groups achieved the recommended diet, but the fiber intake were below. The average intake of polyphenol in the treatment group was increased significantly than the control group (pQ.05). There were decreased on serum total cholesterol level in bath groups, although not statistically significant (p>O.OS). The effect of gyape juice for two weeks did not significantly increase serum NO level in the treatment group."

"[ABSTRAKTelah dilakukan penelitian untuk mengetahui pengaruh pemberian simplisia Alphitobius sp. terhadap konsentrasi kolesterol total plasma darah tikus putih (Rattus norvegicus L.) jantan galur Sprague-Dawley. Dua puluh empat ekor tikus dibagi dalam 6 kelompok perlakuan yang terdiri atas kelompok kontrol normal yang hanya diberi pakan standar, kelompok kontrol perlakuan yang diberi diet tinggi lemak, dan 4 kelompok perlakuan yang diberi diet tinggi lemak dan bahan uji simplisia Alphitobius sp. dengan dosis 2,25 mg/kg bb, 4,5 mg/kg bb, 6,75 mg/kg bb dan 9 mg/kg bb. Pemberian bahan uji dan diet tinggi lemak dilakukan selama 14 hari berturut-turut. Hasil uji Anava satu arah (P < 0,05) menunjukkan terdapat pengaruh yang nyata terhadap konsentrasi kolesterol total akhir pada semua dosis perlakuan. Penurunan konsentrasi kolesterol terbesar dicapai oleh kelompok dosis 4,5 mg/kg bb yang juga merupakan dosis efektif dalam menurunkan konsentrasi kolesterol total yang mendekati nilai kelompok kontrol normal.ABSTRACTA research was done in to determine the effect of simplicia Alphitobius sp. intake on plasma total cholesterol concentration in white male rat Sprague-Dawley (Rattus norvegicus L.). Twenty-four male rats were separated into six treatment groups consisting of normal control group that were given a standard diet, treatment control group fed a high fat diet , and four treatment groups that were given a high fat diet and simplicia Alphitobius sp. with a different dose (2,25 mg/kg bw, 4,5 mg/kg bw, 6,75 mg/kg bw and 9 mg/kg bw). Provision of test material was done every day for 14 consecutive days. The result of one-way Anava test (P < 0,05) indicates that there is a significant effect on total cholesterol concentration at all treatment doses, showed that provision of simplicia Alphitobius sp. lower total cholesterol potentially. The biggest decrease of total cholesterol concentrations was achieved by dose 4,5 mg/kg bw, which is also an effective dose in lowering total cholesterol concentrations approached normal value.;A research was done in to determine the effect of simplicia Alphitobius sp. intake on plasma total cholesterol concentration in white male rat Sprague-Dawley (Rattus norvegicus L.). Twenty-four male rats were separated into six treatment groups consisting of normal control group that were given a standard diet, treatment control group fed a high fat diet , and four treatment groups that were given a high fat diet and simplicia Alphitobius sp. with a different dose (2,25 mg/kg bw, 4,5 mg/kg bw, 6,75 mg/kg bw and 9 mg/kg bw). Provision of test material was done every day for 14 consecutive days. The result of one-way Anava test (P < 0,05) indicates that there is a significant effect on total cholesterol concentration at all treatment doses, showed that provision of simplicia Alphitobius sp. lower total cholesterol potentially. The biggest decrease of total cholesterol concentrations was achieved by dose 4,5 mg/kg bw, which is also an effective dose in lowering total cholesterol concentrations approached normal value.;A research was done in to determine the effect of simplicia Alphitobius sp. intake on plasma total cholesterol concentration in white male rat Sprague-Dawley (Rattus norvegicus L.). Twenty-four male rats were separated into six treatment groups consisting of normal control group that were given a standard diet, treatment control group fed a high fat diet , and four treatment groups that were given a high fat diet and simplicia Alphitobius sp. with a different dose (2,25 mg/kg bw, 4,5 mg/kg bw, 6,75 mg/kg bw and 9 mg/kg bw). Provision of test material was done every day for 14 consecutive days. The result of one-way Anava test (P < 0,05) indicates that there is a significant effect on total cholesterol concentration at all treatment doses, showed that provision of simplicia Alphitobius sp. lower total cholesterol potentially. The biggest decrease of total cholesterol concentrations was achieved by dose 4,5 mg/kg bw, which is also an effective dose in lowering total cholesterol concentrations approached normal value.;A research was done in to determine the effect of simplicia Alphitobius sp. intake on plasma total cholesterol concentration in white male rat Sprague-Dawley (Rattus norvegicus L.). Twenty-four male rats were separated into six treatment groups consisting of normal control group that were given a standard diet, treatment control group fed a high fat diet , and four treatment groups that were given a high fat diet and simplicia Alphitobius sp. with a different dose (2,25 mg/kg bw, 4,5 mg/kg bw, 6,75 mg/kg bw and 9 mg/kg bw). Provision of test material was done every day for 14 consecutive days. The result of one-way Anava test (P < 0,05) indicates that there is a significant effect on total cholesterol concentration at all treatment doses, showed that provision of simplicia Alphitobius sp. lower total cholesterol potentially. The biggest decrease of total cholesterol concentrations was achieved by dose 4,5 mg/kg bw, which is also an effective dose in lowering total cholesterol concentrations approached normal value., A research was done in to determine the effect of simplicia Alphitobius sp. intake on plasma total cholesterol concentration in white male rat Sprague-Dawley (Rattus norvegicus L.). Twenty-four male rats were separated into six treatment groups consisting of normal control group that were given a standard diet, treatment control group fed a high fat diet , and four treatment groups that were given a high fat diet and simplicia Alphitobius sp. with a different dose (2,25 mg/kg bw, 4,5 mg/kg bw, 6,75 mg/kg bw and 9 mg/kg bw). Provision of test material was done every day for 14 consecutive days. The result of one-way Anava test (P < 0,05) indicates that there is a significant effect on total cholesterol concentration at all treatment doses, showed that provision of simplicia Alphitobius sp. lower total cholesterol potentially. The biggest decrease of total cholesterol concentrations was achieved by dose 4,5 mg/kg bw, which is also an effective dose in lowering total cholesterol concentrations approached normal value.]"