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"[ABSTRAKTujuan: Untuk mengevaluasi perbandingan ketebalan kornea dan morfologi sel endotel penderita miopia sedang dengan pemakaian harian lensa kontak lunak hidrogel konvensional (nelfilcon A) terhadap silikon hidrogel (lotrafilcon B) selama 1 bulan.Metode: Penelitian ini merupakan uji klinis tersamar tunggal pada 17 pasien (34 mata) dengan miopia sedang yang dibagi secara acak untuk memakai lensa kontak lunak nelfilcon A atau Lotrafilcon B. Ketebalan kornea sentral (CCT), Coefficient of variation (CV), dan persentase sel heksagonal (6A) diukur menggunakan mikroskop spekuler non-con robo Konan sebelum penelitian (pre-fitting), 1 minggu serta 1 bulan setelah pemakaian lensa kontak lunak. Pasien juga dievaluasi mengenai adanya efek samping subyektif dan komplikasi selama memakai lensa kontak.Hasil: Terdapat 64,7% subyek dengan riwayat pemakaian lensa kontak lunak sebelumnya, dimana 52,9% diantaranya adalah pemakai hidrogel konvensional yang tidak teratur. Setelah evaluasi 1 bulan, tidak didapatkan perbedaan yang bermakna antara pemakai Nelfilcon A dengan Lotrafilcon B dalam hal: ketebalan kornea sentral (p=0,285; uji Mann Whitney), CV (p=0,587; uji t tidak berpasangan), dan 6A (p=0,353; uji t tidak berpasangan). Analisis general linear model terhadap waktu pengukuran mendapatkan perbedaan yang bermakna pada seluru subyek meliputi penurunan CCT (p=0,001) dan CV (p=0,001), serta peningkatan 6A (p=0,022) pada test within subject effect.Simpulan: Tidak terdapat perbedaan CCT, CV, dan 6A yang bermakna secara statistik antara pada pemakaian harian lensa kontak lunak Lotrafilcon B dan Nelficon A. Pasien dengan riwayat penggunaan lensa kontak sebelumnya mendapatkan manfaat dengan pemakaian nelfilcon A dan lotrafilcon B dalam hal perbaikan hipoksia jaringan berupa: penurunan ketebalan kornea dan perbaikan morfologi sel endotel.

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ABSTRACTObjective: To compare corneal thickness and endothelial cell morphology in myopic patients wearing 1 month hydrogel conventional and silicon hydrogel contact lenses in daily wear.Methods: This is a prospective, single blind, randomized study. Seventeen (34 eyes) myopic patients were randomly assigned to wearing either nelfilcon A or lotrafilcon B. Central corneal thickness (CCT), Coefficient of variation (CV), and percentage of six-sided cell (6A) were examined using specular microscope non-con robo Konan. Changes in CCT, CV, and 6A were evaluated before contact lenses fitting as well as 1 week and 1 month after the treatment. Patients were also evaluated for any subjective side effects and complications during the treatment period.Results: There were 64,7% subjects with history of contact lens weares and 52,9% of them was hydrogel wearers. After 1 month daily wear of nelfilcon A and lotrafilcon B, no statistically differences changes in CCT (p=0,285; Mann Whitney test), CV (p=0,587; unpaired t test) dan 6A (p=0,353; unpaired t test). General linear model analysis in follow up evaluation with test of within subject effect revealed decreased CCT(p=0,001) and CV (p=0,001), also increased 6A (p=0,022) in all subjects.Conclusions: There were no statistically difference CCT, CV, and 6A between daily wear of nelfilcon A and lotrafilcon B. Subjects with history of contact lens weares gained advantages in oxygen availability, which is decrease in corneal thickness and improvement of endothelial cell morphology., Objective: To compare corneal thickness and endothelial cell morphology in myopic patients wearing 1 month hydrogel conventional and silicon hydrogel contact lenses in daily wear.Methods: This is a prospective, single blind, randomized study. Seventeen (34 eyes) myopic patients were randomly assigned to wearing either nelfilcon A or lotrafilcon B. Central corneal thickness (CCT), Coefficient of variation (CV), and percentage of six-sided cell (6A) were examined using specular microscope non-con robo Konan. Changes in CCT, CV, and 6A were evaluated before contact lenses fitting as well as 1 week and 1 month after the treatment. Patients were also evaluated for any subjective side effects and complications during the treatment period.Results: There were 64,7% subjects with history of contact lens weares and 52,9% of them was hydrogel wearers. After 1 month daily wear of nelfilcon A and lotrafilcon B, no statistically differences changes in CCT (p=0,285; Mann Whitney test), CV (p=0,587; unpaired t test) dan 6A (p=0,353; unpaired t test). General linear model analysis in follow up evaluation with test of within subject effect revealed decreased CCT(p=0,001) and CV (p=0,001), also increased 6A (p=0,022) in all subjects.Conclusions: There were no statistically difference CCT, CV, and 6A between daily wear of nelfilcon A and lotrafilcon B. Subjects with history of contact lens weares gained advantages in oxygen availability, which is decrease in corneal thickness and improvement of endothelial cell morphology.]"

"Tujuan: Evaluasi pengaruh penggunaan cairan irigasi dingin pada fakoemulsifikasi terhadap ketebalan kornea dan jumlah suar bilik mata depan pasca bedah.Tempat: Perjan Rumah Sakit Ciptomangunkusumo dan Jakarta Eye Center, Jakarta. Bahan dan cara: Prospektif, tersamar ganda, randomisasi pada 33 mata katarak senilis gradasi 3-4. Dilakukan fakoemulsifikasi menggunakan BSS® 10°C (n=16) atau BSS® suhu karnar (n=17) dengan prosedur dan terapi pasca bedah yang sama. Pra bedah, pasca bedah hart pertama dan hari ke-7 dilakukan pengukuran ketebalan komea, jumlah suar dan tekanan intraokular, masing-masing dengan OrbscanTM, laser flare-meter Kowa FM-500, dan tonometer non-kontak. Parameter intrabedah; waktu fako efektif (EPT) dan besarnya tenaga ultrasonik(UIS) direkam dalam mesin fako. Subjek yang mengalami komplikasi intrabedah maupun pasca bedah dikeluarkan dari penelitian.Hasil: Prabedah kedua kelompok memiliki karakteristik yang setara pada umur, gradasi katarak, ketebalan kornea, jumlah suar dan TIO. Tidal( terdapat perbedaan bermakna pada E. dan U/S. Fasca bedah hari pertama, ketebalan kornea pada kelompok BSSQ dingin 548,87±48,31}im, pada kelompok BSS® suhu kamar 582,47±35,48p.m (p0,022). Ketebalan kornea hari ke-7 tidak berbeda bermakna. Tidak terdapat perbedaan bermakna jumlah soar sampai tindak lanjut hari ke-7, namun peningkatan jumlah suar pada kelompok BSS® dingin lebih sedikit dan telah mencapai nilai prabedah pada hari ke-7. Hasil pengukuran tekanan intraokular sesuai dengan pengukuran ketebalan kornea.Simpulan: Cairan irigasi dingin dapat mempertahankan fungsi endotel komea dan stabilitas sawar darah akuos, sehingga menghambat penambahan ketebalan kornea dan jumlah suar di bilik mata depan pasca fakoemulsifikasi.

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Purpose: To evaluate the effect of cooled intraocular irrigating solution during phacoemulsification on postoperative central corneal thickness (CCT) and anterior chamber flare (AC flare).

Setting: Cipto Mangunkusumo Hospital and Jakarta Eye Center, Jakarta

Methods: In a prospective, double masked, randomized study, 33 eyes of third and fourth grade density cataract had phacoemulsification with irrigating solutions cooled to approximately 10°C (n=16) or at room temperature (n=17). Surgical procedure and postoperative therapy were otherwise identical in both groups. lntraoperative parameters; effective phaco time (EPT) and ultrasound energy (U/S) were recorded by phaco machine. Postoperative CCT, AC flare and intraocular pressure (IOP) were assessed respectively with Orbscan pachymetry, Kowa FM-500 laser flare-meter and non-contact tonometry on days 1 and 7. Complicated cases were excluded.

Results: Both groups were well matched characteristic in age, cataract density, preoperative CCT, AC flare and IOP. Intraoperative parameters were not different significantly. C.1the first postoperative day, CCT (cooled irrigation 548,87±48,31µm, control 582,47±35,48µm; p0,022) was significantly lower in the group with cooled irrigating solution. There was no significant difference in CCT on the 7th postoperative day. Despite no significant between-group difference in AC flare on any postoperative days, AC flare was lower in the group with cooled irrigating solution. Intraocular pressure measurement was well related to corneal thickness.

Conclusions: Cooled intraocular irrigating solution preserved corneal endothelial function and blood aquas barrier, showed with reducing immediate postoperative CCT and AC flare."