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Abstrak :
Latar Belakang: Periodontitis merupakan salah satu kondisi periodontal yang dapat menyebabkan poket periodontal. Terdapat berbagai metode perawatan poket periodontal, salah satunya adalah Guided Tissue Regeneration. Penelitian mengenai persepsi dan preferensi Dokter Gigi Spesialis Periodonsia di Indonesia mengenai penggunaan membran GTRpada terapi regeneratif jaringan periodontal belum pernah dilakukan di Indonesia. Tujuan: Mendapatkan persepsi dan preferensi dokter gigi spesialis periodonsia di Indonesia mengenai penggunaan membran GTR. Metode: Penelitian deskriptif dengan pendekatan potong lintang menggunakan kuesioner kepada dokter gigi spesialis periodonsia di Indonesia. Hasil: 93 responden melakukan bedah regeneratif GTR dengan mayoritas 1-3 bedah setiap bulan dengan indikasi 2-3 wall defect. GTR dilakukan menggunakan membran resorbable collagen karena memberikan hasil perawatan yang lebih baik dengan parameter keberhasilan pertumbuhan tulang secara radiografi dan persentase kesuksesan sebesar 75%. Alasan responden tidak melakukan GTR karena biaya cukup tinggi. Responden puas dan percaya diri dengan teknik GTR dan setuju penggunaan material dari hewan, manusia dan sintetis. Jumlah bedah regeneratif periodontal GTR oleh dokter gigi spesialis periodonsia di Indonesia dipengaruhi oleh lama praktik dan tidak dipengaruhi oleh domisili daerah praktik. Kesimpulan: Terdapat perbedaan persepsi dan preferensi dokter gigi spesialis periodonsia di Indonesia dalam penggunaan teknik GTR pada terapi jaringan periodontal regeneratif dan terdapat perbedaan signifikan antara jumlah bedah regeneratif periodontal GTR oleh dokter gigi spesialis periodonsia dan lama praktik. ......Background: Periodontitis is one of the periodontal conditions that can cause periodontal pockets. There are various methods of treating periodontal pockets, one of which is Guided Tissue Regeneration. Research on the perceptions and preferences of Periodontists in Indonesia regarding the use of GTR membranes in periodontal tissue regenerative therapy has never been conducted in Indonesia. Objective: Obtain the perceptions and preferences of periodontists in Indonesia regarding the use of GTR membranes. Methods: Descriptive study with a cross-sectional approach using a questionnaire to periodontists in Indonesia. Results: 93 periodontists in Indonesia performed GTR with the majority of surgeries performed 1-3 times a month and indications of 2-3 wall defects. GTR is performed using a resorbable collagen membrane because it provides better treatment results with radiographic parameters of bone growth success and a treatment success rate of 75%. The reason respondents did not do the GTR was because the cost was quite high. Respondents were satisfied and confident with the GTR technique and agreed to use animal, human and synthetic materials. The number of GTR periodontal regenerative surgeries by periodontists in Indonesia is influenced by length of practice and not by domicile in the practice area. Conclusion: There are differences in the perceptions and preferences of periodontists in Indonesia regarding the use of the GTR technique in regenerative periodontal tissue therapy and there are significant differences between the number of GTR regenerative periodontal surgeries by periodontists and the length of practice.

Abstrak :
Latar Belakang : Konsep minimal intervention dentistry adalah membuang infected dentin dan meninggalkan affected dentin yang dapat mengalami remineralisasi. Berdasarkan cara terjadinya, remineralisasi affected dentin dapat melalui dua cara yaitu metode konvensional dan Guided Tissue Remineralization GTR . GTR adalah proses remineralisasi yang melibatkan Dentin Matrix Protein1 DMP1 . Peran DMP1 adalah mengikatAmorphous Calcium Phosphat ACP dalam skala nano, membentuk ikatan elektrostatik yang stabil menuju zona gap dalam fibril kolagen dan menghasilkan remineralisasi mineralisasi intrafibrilar.DMP 1 yang rusak oleh proses karies digantikan oleh protein analog Carboxymetil Chitosan/Amorphous Calcium Phosphate CMC/ACP . Tujuan: Melihat remineralisasi yang terjadi setelah peletakan CMC/ACP pada demineralized dentin dan diperiksa menggunakan micro-CTpada hari ke-7 dan hari ke-14.Metode: Dua kelompok dilakukan demineralisasi buatan, salah satunya diaplikasikan material CMC/ACP, evaluasi grey level dengan menggunakan micro-CT. Hasil: Terlihat remineralisasi pada permukaan demineralized dentin dengan naiknya grey level pada hari ke-7 dan hari ke-14. Kesimpulan: CMC/ACP berpotensi untuk remineralisasi metode Guided Tissue Regeneration pada demineralized dentin. Kata kunci : Carboxymethyl Chitosan/ Amorphous Calcium Phosphate, Remineralisasi Metode Guided Tissue Regeneration. ......Background. The concept of minimal intervention dentistry showed that only the lsquo infected rsquo dentine needed to be removed as part of the cavity preparation process, and that the lsquo affected rsquo dentine could remain. Remineralization of affected dentine was possible through two methods conventional remineralization techniques and Guided Tissue Remineralization GTR . GTR is a process of remineralization involving Dentin Matrix Protein 1 DMP1 . Dentin matrix protein 1 DMP1 is a non collagenous calcium binding protein that plays a critical role in biomineralization at the nanoscale, forming stable electrostatic bonds to the gap zone in collagen fibrils and resulting in remineralization of intrafibrillar mineralization. DMP1 is replaced by an analog protein Carboxymethyl Chitosan Amorphous Calcium Phosphate CMC ACP . Objective to evaluate demineralized dentin remineralization after application CMC ACP using micro CT. Methods Two groups performed artificial demineralisation, one of which applied CMC ACP material whereas, the other group was not applied CMC ACP. Evaluation of remineralization with micro CT. Result After 7 days and 14 days CMC ACP application, remineralization was obsrved.Conclusions CMC ACP has the potential to remineralize the demineralized dentin.Key words Carboxymethyl Chitosan Amorphous Calcium Phosphate, Guided Tissue Regeneration

Abstrak :
This volume presents a new contribution for the field of Tissue Engineering with a focus on the development of mathematical and computational methods that are relevant to understand human tissues, as well to model, design, and fabricate optimized and smart scaffolds.