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Abstrak :
Cacat tulang dapat terjadi dari berbagai macam penyebab seperti infeksi, tumor, trauma, pembedahan, etiologi bawaan/kongenital dan seterusnya. Bone graft digunakan untuk merawat kerusakan tulang tersebut. Di Indonesia bone graft berbasis Xenograft banyak digunakan, namun sayangnya kurang di resorbsi sehingga tulang yang terbentuk kurang optimal. Oleh karena itu perlu pengembangan kandidat material alternatif bone graft untuk bidang kedokteran gigi. Monetite diprediksi memiliki kemampuan mudah diresorbsi dan membentuk tulang dengan baik. Kelarutan berkaitan erat dengan kemampuan suatu material untuk diresorbsi. Tujuan penelitian ini adalah membuat granul monetite dengan menggunakan gipsum sebagai prekursor dengan metode hidrotermal, kemudian membandingkan kelarutan monetite hasil sintesis, dengan granul hidroksiapatit non-sinter (prototipe) dan granul xenograft hidroksiapatit komersial (Bio HA, BATAN). Perubahan fasa granul dianalisis menggunakan metode difraksi sinar-X (XRD). Analisis kelarutan dilakukan dengan menggunakan metode Atomic Absorption Spectrophotometry (AAS) dengan menggunakan larutan buffer asetat dan larutan buffer tris sebagai larutan simulasi. Selanjutnya, pengamatan mikrostruktur dan komposisi elemen menggunakan metode SEM-EDX. Hasil analisis XRD menunjukkan bahwa gipsum sudah berubah menjadi monetite pada suhu 100°C,125°C,150°C selama 24 jam. Impuritas ditemukan pada hasil sintesis suhu 100°C, sehingga granul hasil sintesis suhu 125°C digunakkan untuk pengujian kelarutan. Granul monetite memiliki kelarutan pada buffer asetat sebesar 92,70 mg/L dan pada buffer tris sebesar 11,16 mg/L. Granul xenograft memiliki kelarutan pada buffer asetat 15,94 mg/L dan pada buffer tris sebesar 5,02 mg/L. Sedangkan untuk granul HA non sinter memiliki kelarutan pada buffer asetat 189,1 mg/L dan pada buffer tris sebesar 150,04 mg/L. Hasil uji kelarutan menunjukkan granul monetite dan HA non sinter memiliki potensi diresorbsi oleh osteoklas lebih baik dari xenograft. Namun granul HA non sinter juga memiliki kelarutan yang tinggi pada larutan buffer tris (13 kali kelarutan monetite) sehingga kemungkinan akan cepat terlarut oleh cairan tubuh ketika nanti diimplankan dibandingkan dengan granul monetite. Berdasarkan hasil karakterisasi XRD dan pengujian kelarutan, granul monetite dapat dibuat dengan metode hidrotermal dan memiliki potensi kemampuan diresorbsi dan pembentukan tulang paling baik bila dibandingkan dengan granul kontrol. ......Bone defects can occur from various causes such as infection, tumor, trauma, surgery, congenital/congenital etiology and so on. Bone graft is used to treat the damaged bone. In Indonesia, Xenograft bone grafts are widely used, but unfortunately their low resorption hinder bone formation. Therefore, it is necessary to develop an alternative bone graft materials for dentistry. Monetite is predicted to have the ability to be easily resorbed and form a new bone. Solubility is closely related to bone graft degradability. The purpose of this study was to make monetite granules using gypsum as a precursor through hydrothermal method, then to compare the solubility of the synthesized monetite with non-sintered hydroxyapatite granules (prototype) and commercial hydroxyapatite xenograft granules (Bio HA, BATAN). The granules were characterized using X-ray diffraction (XRD) method. Solubility measurement was carried out using the Atomic Absorption Spectrophotometry (AAS) method in acetate buffer solution and tris buffer solution. Furthermore, the observation of the microstructure and elemental composition were done using the SEM-EDX method. The results of XRD analysis showed that the gypsum was into monetite at a temperature of 100°C, 125°C, 150°C for 24 hours. Impurities were found in the synthesis at 100°C, thus granules obtained at 125°C were used for further analysis. Monetite granules have a solubility of 92.70 mg/L in acetate buffer and 11.16 mg/L in tris buffer. Xenograft granules have a solubility of 15.94 mg/L in acetate buffer and 5.02 mg/L in tris buffer. As for the non-sintered HA granules, the solubility in acetate buffer is 189.1 mg/L and in tris buffer is 150.04 mg/L. The results of the solubility test showed that monetite granules and non-sintered HA had better potential for osteoclast resorption than xenografts. However, non-sintered HA granules also have high solubility in tris buffer solution (13 times the solubility of monetite) so they are likely to be quickly dissolved by body fluids when implanted later than monetite granules. Based on the results of XRD characterization and solubility testing, monetite granules can be prepared using the hydrothermal method and have the best potential for resorption and bone formation compared to control granules.

Abstrak :
Latar Belakang: Periodontitis merupakan penyakit inflamasi pada jaringan pendukung gigi dan angka penyakit ini bertambah setiap tahunnya di Inonesia. Pada terapi periodontal regeneratif, graft tulang digunakan untuk menggantikan jaringan tulang yang hilang dan memiliki berbagai sumber. Setiap jenis memiliki kelebihan dan keterbatasannya, pemilihan bergantung pada faktor tertentu. Literatur tentang persepsi dan preferensi pasien dalam pemilihan bahan graft tulang sudah banyak ditemukan, tetapi survei mengenai evaluasi klinis serta preferensi pemakaian graft tulang menurut dokter gigi terbatas, khususnya di Indonesia. Tujuan: Mengetahui tingkat pengetahuan, persepsi dan preferensi Dokter Gigi Spesialis Periodonsia dan mahasiswa Peserta Program Dokter Gigi Spesialis (PPDGS) Periodonsia di Indonesia dalam penggunaan graft tulang pada terapi regeneratif periodontal. Metode: Penelitian dilakukan menggunakan kuisioner via Google Form dengan desain penelitian deskriptif dan observasional dengan metode cross-sectional. Hasil: Seluruh responden memiliki pengetahuan dan preferensi yang beragam terkait penggunaan graft tulang pada terapi regeneratif periodontal. Oral Hygiene dan gambaran radiografis merupakan parameter yang harus dievaluasi sebelum prosedur regeneratif. Jenis graft tulang xenograft paling banyak dipilih karena hasil, biokompatibilitas, dan bioaktivitas material yang baik. Biaya merupakan alasan tidak digunakannya graft tulang. Graft tulang seringkali dikombinasikan dengan Teknik GTR dan membran, dan bentuk granul adalah sediaan yang paling sering digunakan. Graft tulang paling sering digunakan pada kasus periodontitis dengan kehilangan tulang vertikal diikuti pemasangan implan. Kesimpulan : Xenograft menjadi bahan graft tulang yang paling banyak dipakai. Tidak terdapat perbedaan statistik yang bermakna antara persepsi kedua kelompok dalam penggunaan graft tulang pada terapi regeneratif periodontal. Responden merasa puas dengan penggunaan graft tulang untuk terapi regeneratif periodontal dibandingkan dengan bahan lain ......Background: Periodontitis is an inflammatory disease of the supporting tissues of the teeth and the number of this disease increases every year in Indonesia. In regenerative periodontal therapy, bone grafts are used to replace lost bone tissue and it comes from various sources. Each type has its own advantages and limitations, the selection depends on certain factors. Literature on patient perceptions and preferences in the selection of bone graft material has been found, but surveys regarding clinical evaluation and preference for using bone grafts according to dentists are limited, especially in Indonesia. Objective: Evaluating the level of knowledge, perceptions and preferences of periodontists and periodontist resident students in Indonesia on the use of bone grafts in periodontal regenerative therapy. Method: A cross-sectional descriptive study using questionnaires given to Periodontists in Indonesia. Result: All of the respondents had various knowledge and preferences regarding the use of bone grafts in periodontal regenerative therapy. Oral hygiene and radiographic appearance are parameters that must be evaluated prior to regenerative procedures. The most widely chosen graft is the xenograft, due to better results, biocompatibility, and bioactivity of the material. Cost is the main reason for the respondents not using bone grafts. Bone grafts are often combined with the GTR and membrane techniques, and the granular form is the most frequently used form of graft. Bone grafts are most often used in periodontitis cases with a vertical bone loss followed by implant placement.Conclusion : Xenograft are the most widely used bone graft material in Indonesia. There was no statistically significant difference between the perceptions of the two groups regarding the use of bone grafts in periodontal regenerative therapy. Respondents were satisfied with the use of bone grafts for periodontal regenerative therapy compared to other materials.

Abstrak :
ABSTRAK
Pati adalah polimer alam yang memiliki sifat sebagai termoplastik. Kekurangan dari pati sebagai bahan plastik yaitu getas dan menyerap air. Guna meningkatkan sifat pati, dalam penelitian ini dilakukan proses grafting pati dengan methylacrylat, dengan inisiator ceric ammonium nitrat. Proses grafting dalam penelitian ini dilakukan pada konsentrasi inisiator 1x10-3, 3x10-3, 4x 10-3, dan 6x10-3, mol/L. Ekstraksi dan hidrolisa asam dilakukan pada hasil grafting untuk mengetahui prosentase polimethylacrylat homopolimer dan polimethylacrylat yang tergrafting.

Untuk mengukur berat molekul polimethylacrylat yang tergrafting digunakan GPC. Untuk menganalisa kualitas dari hasil grafting maka dilakukan beberapa pengujian antara lain spectra mapping dengan FTIR microspectroscopy, Uji tarik dengan alat uji tarik instron, dan sifat ketahanan terhadap air dengan uji sudut kontak. Proses grafting dilakukan dalam sebuah labu dengan 5 leher. Pati sebanyak 20 gram direaksikan pada temperatur kamar dengan 40 gram methylacrylat dalam 500 ml air dengan dialiri nitrogen dan digunakan ceric ammonium nitrat sebagai inisiator. Hasil grafting setelah dilakukan ekstraksi dan hidrolisa asam menunjukkan bahwa pada konsentrasi ceric ammonium nitrat yang meningkat menghasilkan meningkatnya persentase PMA homopolirner, sedangkan persentase PMA tergrafting, dan berat molekul dari PMA tergrafting menurun. Hasil ini berpengaruh terhadap sifat mekanik produk S-g-PMA, dimana untuk S-g-PMA yang dihasilkan dengan konsentrasi ceric ion 4x 10-3 mol/L memiliki sifat mekanik yang mirip elastomer. S-g-PMA yang dihasilkan pada konsentrasi ceric ion yang lain polimer yang dihasilkan merupakan plastik yang kuat dan ulet. Proses grafting jugs meningkatkan kwalitas pati dalam ketahanannya terhadap air, dari hasil uji sudut kontak menunjukkan bahwa pati setelah grafting pada kontak dengan air tidak mengalami penggelembungan (swelling).

Abstrak :
[ABSTRAK
Latar Belakang Delayed graft function (DGF) adalah komplikasi yang umum dijumpai pada transplantasi dari mayat. Berdasarkan studi terdahulu, DGF dan factor resikonya memiliki hasil yang bervariasi pada donor nefrektomi hidup Metode Peneliti melakukan analisis retrospektif dari rekam medic donor dan resipien transplantasi ginjal pada 100 kasus laparoskopi donor nefrektomi hidup di Rumah Sakit Cipto Mangunkusumo dari November 2011 hingga Februari 2014. Kriteria DGF adalah pasien didialisis pada 1 minggu post operasi dan/ atau kreatinin lebih dari 2.5 mg/dl pada hari ke 7 post operasi. Pasien yang tidak masuk dalam kriteria tersebut didefinisikan memiliki renal allograft yang berfungsi normal Hasil Prevalensi DGF pada penelitian ini adalah 14%. Indeks massa tubuh resipien, cold ischemia time, waktu anastomosis vaskular, dan total ischemia time lebih tinggi pada grup DGF, tetapi tidak ditemukan faktor resiko DGF yang signifikan secara statistic saat dilakukan analisis multivariat Kesimpulan Insidensi DGF pada studi ini masuk dalam rentang yang diamati pada studi-­‐ studi sebelumnya. Faktor resiko yang dilaporkan sebagai faktor resiko DGF pada laparoskopi donor nefrektomi hidup tidak signifikan secara statistik dengan DGF pada studi kali ini.

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ABSTRACT
Background Delayed graft function (DGF) is a common complication affecting deceased donor renal transplantation. Based on previous studies, DGF and its risk factors in live donor nephrectomy (LDN) have a various results. Methods We retrospectively analyzed the medical records of donor and recipient from our first 100 cases of laparoscopic LDN in Cipto Mangunkusumo Hospital from November 2011 to February 2014. The criteria used to define DGF were the requirement for dialysis in postoperative week 1 and/or serum creatinine greater than 2.5 mg/dl at postoperative day 7. Patients who did not match any of these criteria were define as having normal renal allograft function. Results The overall prevalence of DGF was 14%. Recipients body mass index, cold ischemia time, vascular anastomosis time, and total ischemia time were higher among the delayed graft function group, but no risk factors for DGF were significantly associated after multivariate analysis. Conclusions The incidence of DGF in our study was in the range of that observed in previous studies. The factors that previously reported and believed as risk factors of DGF in laparoscopic LDN were not significantly associated with the development of DGF in our study.;Background Delayed graft function (DGF) is a common complication affecting deceased donor renal transplantation. Based on previous studies, DGF and its risk factors in live donor nephrectomy (LDN) have a various results. Methods We retrospectively analyzed the medical records of donor and recipient from our first 100 cases of laparoscopic LDN in Cipto Mangunkusumo Hospital from November 2011 to February 2014. The criteria used to define DGF were the requirement for dialysis in postoperative week 1 and/or serum creatinine greater than 2.5 mg/dl at postoperative day 7. Patients who did not match any of these criteria were define as having normal renal allograft function. Results The overall prevalence of DGF was 14%. Recipients body mass index, cold ischemia time, vascular anastomosis time, and total ischemia time were higher among the delayed graft function group, but no risk factors for DGF were significantly associated after multivariate analysis. Conclusions The incidence of DGF in our study was in the range of that observed in previous studies. The factors that previously reported and believed as risk factors of DGF in laparoscopic LDN were not significantly associated with the development of DGF in our study.;Background Delayed graft function (DGF) is a common complication affecting deceased donor renal transplantation. Based on previous studies, DGF and its risk factors in live donor nephrectomy (LDN) have a various results. Methods We retrospectively analyzed the medical records of donor and recipient from our first 100 cases of laparoscopic LDN in Cipto Mangunkusumo Hospital from November 2011 to February 2014. The criteria used to define DGF were the requirement for dialysis in postoperative week 1 and/or serum creatinine greater than 2.5 mg/dl at postoperative day 7. Patients who did not match any of these criteria were define as having normal renal allograft function. Results The overall prevalence of DGF was 14%. Recipients body mass index, cold ischemia time, vascular anastomosis time, and total ischemia time were higher among the delayed graft function group, but no risk factors for DGF were significantly associated after multivariate analysis. Conclusions The incidence of DGF in our study was in the range of that observed in previous studies. The factors that previously reported and believed as risk factors of DGF in laparoscopic LDN were not significantly associated with the development of DGF in our study., Background Delayed graft function (DGF) is a common complication affecting deceased donor renal transplantation. Based on previous studies, DGF and its risk factors in live donor nephrectomy (LDN) have a various results. Methods We retrospectively analyzed the medical records of donor and recipient from our first 100 cases of laparoscopic LDN in Cipto Mangunkusumo Hospital from November 2011 to February 2014. The criteria used to define DGF were the requirement for dialysis in postoperative week 1 and/or serum creatinine greater than 2.5 mg/dl at postoperative day 7. Patients who did not match any of these criteria were define as having normal renal allograft function. Results The overall prevalence of DGF was 14%. Recipients body mass index, cold ischemia time, vascular anastomosis time, and total ischemia time were higher among the delayed graft function group, but no risk factors for DGF were significantly associated after multivariate analysis. Conclusions The incidence of DGF in our study was in the range of that observed in previous studies. The factors that previously reported and believed as risk factors of DGF in laparoscopic LDN were not significantly associated with the development of DGF in our study.]

Abstrak :
ABSTRACK
Transplantasi ginjal dapat mengalami komplikasi delayed graft function yang merupakan salah satu bentuk gangguan ginjal akut. Terdapat banyak faktor yang dapat memengaruhi delayed graft function, yakni faktor intraoperatif dan ekstraoperatif. Studi ini meneliti faktor-faktor yang dapat menyebabkan delayed graft function pada faktor ekstraoperatif khususnya dari segi donor dan resipien. Tujuan: Mengetahui hubungan antara faktor donor (usia, hubungan kekerabatan dengan resipien) dan faktor resipien (usia, penyebab gagal ginjal) dengan kejadian delayed graft function pada resipien. Metode: penelitian ini menggunakan metode studi potong lintang dan melibatkan 483 sampel yang merupakan pasien transplantasi ginjal di RSCM periode November 2011-September 2018. Hasil: chi square dan fisher menunjukkan bahwa terdapat hubungan yang bermakna antara usia donor (p=0,023), usia resipien (p=0,006), dan hubungan kekerabatan donor dan resipien (p=0,008) dengan delayed graft function. Tidak terdapat hubungan antara penyebab gagal ginjal diabetes mellitus, hipertensi, infeksi, penyakit autoimun, dan penyebab lain gagal ginjal. Diskusi: Dari analisis multivariat didapatkan adanya hubungan bermakna antara hubungan kekerabatan donor dan resipien dengan delayed graft function (p= 0,011. Disimpulkan bahwa hubungan kekerabatan donor dan resipien merupakan faktor yang paling berhubungan dengan terjadinya delayed graft function pada resipien transplantasi ginjal RSCM dibandingkan dengan faktor usia donor, usia resipien, dan penyebab gagal ginjal resipien. ABSTRACT
Background: Kidney transplant patients may have complications, such as delayed graft function which is one of acute kidney injury. There are a lot of factors that can affect delayed graft function, such as intraoperative and extraoperative factors. In this study we discussed more about extraoperative factors, specifically from donor and recipient factors. Objective: To determine the association between donor factors (age, relation with recipien)t, recipient factors (age, cause of kidney failure) and delayed graft function in transplant recipient. Methods: Cross-sectional study design was used in this study  by collecting 483 patient data of medical record from data recapitulation of renal transplant by Departement of Urology, Cipto Mangunkusumo National Hospital, from November 2011-September 2018. Results: Bivariat analysis with chi square and fisher test result showed that there was a significant association between donor age (p=0,023), recipient age (p=0,006) and donor and recipient relation status (p=0,008) with delayed graft function. There were no significant association between recipient age, and causes of kidney failure. Discussion: From the multivariate analysis it was found that there was a significant association between donor and recipient relation status (p=0,011) with delayed graft function.From these result we concluded that donor and relation status are the most  associated factor with delayed graft function in recipients.