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"Latar belakang : Asma memengaruhi sekitar 300 juta orang di seluruh dunia dan menjadi masalah kesehatan global yang serius yang mempengaruhi semua kelompok umur. Asma alergi adalah fenotipe asma yang paling mudah dikenali dan sering dimulai sejak masa anak-anak. Sebagian besar asma alergi berhubungan dengan sensitisasi saluran napas akibat pajanan aeroalergen umum, terutama yang berasal dari tungau debu rumah. Proses inflamasi eosinofilik saluran napas menghasilkan produk akhir berupa nitrit oksida. Kadar nitrit oksida udara ekspirasi (FeNO) merupakan salah satu penanda hayati yang mengukur inflamasi saluran napas dan kadar FeNO yang tinggi pada pasien asma berhubungan dengan inflamasi saluran napas eosinofilik.Penilitian ini bertujuan mengetahui hubungan kadar IgE spesifik Der p dan Der f  dengan kadar FeNO pada pasien asma tidak terkontrol di RSUP Persahabatan.Metode : Penelitian ini merupakan studi potong lintang dengan jumlah sampel 86 subjek pasien asma tidak terkontrol berdasarkan asthma control test di RSUP Persahabatan. Metode pengumpulan subjek dilakukan dengan teknik consecutive sampling. Pemeriksaan IgE spesifik tungau debu rumah menggunakan protia Q96M. Pemeriksaan FeNO menggunakan Bedfont NObreath.Hasil : Dari 86 subjek asma tidak terkontrol didapatkan hasil rerata usia pasien asma tidak terkontrol di RSUP Persahabatan adalah  52,45 + 12,94 tahun, sebagian besar berjenis kelamin perempuan (84,9%).Proporsi pasien asma yang alergi terhadap tungau debu rumah  mencapai 64%. Prorporsi alergi Der p dan Der f 58%, alergi Der p 4,7% dan alergi Der f 1,2%. Median kadar IgE spesifik tungau debu rumah pada pasien asma tidak terkontrol di RSUP Persahabatan adalah 3,94 (0-100) IU/ml untuk Der p dan 4,47 (0-100) IU/ml untuk Der f. Median FeNO pasien asma tidak terkontrol adalah 26 (3-92) ppb. Dilakukan uji korelasi Spearman untuk kadar IgE spesifik dan kadar FeNO pasien asma tidak terkontrol. Terdapat hubungan bermakna antara kadar IgE spesifik Der p (nilai p = 0,009, r = 0,279, uji Spearman) dan Der f (nilai p = 0,001, r = 0,339, uji Spearman) dengan FeNO.Kesimpulan : Terdapat hubungan yang bermakna antara kadar IgE spesifik tungau debu rumah Der p dan Der f dengan FeNO pada pasien asma tidak terkontrol. Namun tingkat korelasi yang didapatkan lemah.

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Background : Asthma affects approximately 300 million people worldwide and is a serious global health problem affecting all age groups. Allergic asthma is the most easily recognized asthma phenotype and often begins in childhood. Most allergic asthma is associated with airway sensitization due to exposure to common aeroallergens, particularly those from house dust mites. The eosinophilic inflammatory process of the airways produces the final product in the form of nitric oxide. Fractional exhaled nitric oxide (FeNO) levels are one of the biomarkers that measure airway inflammation and high FeNO levels in asthma patients are associated with eosinophilic airway inflammation. This study aims to determine the relationship between Dermatophagoides pteronysinnus (Der p) and Dermatophagoides  farinae (Der f) specific IgE levels with FeNO levels in uncontrolled asthma patients at Persahabatan Hospital.

Method : This cross sectional study in 86 uncontrolled asthma patients based on asthma control test less than 24 points. The method of collecting subjects was done by consecutive sampling technique. House dust mite specific IgE assay using protia Q96M. FeNO examination using Bedfont NObreath.   

Result : From 86 subjects with uncontrolled asthma, the mean age of uncontrolled asthma patients at Persahabatan Hospital was 52.45 + 12.94 years, most of them were female (84.9%). The proportion of asthma patients who were allergic to house dust mites reached 64. %. The proportion of allergy to Der p and Der f 58%, allergy to Der p 4.7% and allergy to Der f 1.2%. The median level of specific IgE for house dust mites in patients with uncontrolled asthma at the Persahbatan Hospital was 3.94 (0-100) IU/ml for Der p and 4.47 (0-100) IU/ml for Der f. The median FeNO of uncontrolled asthmatic patients was 26 (3-92) ppb. Spearman correlation test was performed for specific IgE levels and FeNO levels in patients with uncontrolled asthma. There was a significant relationship between specific IgE levels Der p (p value = 0.009, r = 0.279) and Der f (p value = 0.001, r = 0.339) and FeNO.

Conclusion : There is a significant relationship between the levels of specific IgE for house dust mites Der p and Der f with FeNO in patients with uncontrolled asthma. However, the correlation level obtained is weak."

"Latar Belakang: Asma telah menjadi masalah kesehatan masyarakat di berbagai negara. Kekambuhan asma melibatkan banyak sel yang berperan dalam proses reaksi peradangan kronik terutama sel mast, eosinofil, limfosit T, makrofag, neutrofil dan sel epitel. Peradangan yang terus menerus pada saluran napas dapat menyebabkan proses remodeling pada asma. Mekanisme remodeling disebabkan ketidakseimbangan produksi matriks ekstraselular dan degradasi kolagen. Penelitian ini bertujuan untuk melihat korelasi kadar matriks metalloproteinase-9 dengan derajat kontrol pada pasien asma.Metode: Penelitian ini merupakan penelitian potong lintang yang dilakukan Poliklinik Asma RS Persahabatan dari April-Desember 2023. Subjek penelitian adalah pasien asma yang berkunjung ke Poliklinik Asma dan memenuhi kriteria penelitian. Subjek penelitian dilakukan anamnesis, pemeriksaan MMP-9, hitung jenis neutrofil sputum, hitung jenis eosinofil sputum, pengukuran FeNO dan asthma control test (ACT).Hasil: Pada penelitian ini didapatkan 40 subjek penelitian. Nilai median MMP-9 pada pasien asma 0,74 ng/ml (0,33-17,82 ng/ml). Nilai median hitung jenis eosinofil sputum 3% (0-92%). Nilai rerata hitung jenis neutrofil sputum 59,62%  31,34%. Nilai median FeNO 67 ppb (13-184 ppb), rerata skor ACT 16,37  5,67. Terdapat perbedaan bermakna rerata kadar MMP-9 berdasarkan derajat kontrol pasien asma (p < 0,03). Terdapat perbedaan bermakna rerata hitung jenis neutrofil berdasarkan derajat kontrol pasien asma (p < 0,029). Terdapat perbedaan bermakna rerata nilai FeNO berdasarkan derajat kontrol pasien asma (p < 0,001). Terdapat korelasi bermakna kadar MMP-9 dengan skor ACT pada pasien asma (r = - 0,32, p < 0,047).Kesimpulan: Terdapat korelasi negatif kadar MMP-9 dengan skor ACT pada pasien asma.

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Background: Asthma has become a public health problem in various countries. Asthma recurrence involves many cells that play a role in the chronic inflammatory reaction process, especially mast cells, eosinophils, T lymphocytes, macrophages, neutrophils and epithelial cells. Continuous inflammation of the airways can cause a remodeling process in asthma. The remodeling mechanism is caused by an imbalance in extracellular matrix production and collagen degradation. The aim of this study was to know the correlation between matrix metalloproteinase-9 levels and the degree of asthma control patients.

Methods: This is a cross-sectional study conducted by the Asthma Polyclinic at Persahabatan Hospital from April-December 2023. The research subjects were asthma patients who visited the Asthma Polyclinic and met the inclusion criteria. The research subjects underwent anamnesis, MMP-9 examination, sputum neutrophil count, sputum eosinophil count, FeNO measurement and asthma control test (ACT).

Results: In this study, there were 40 research subjects. The median MMP-9 value in asthma patients was 0.74 x 102 ng/ml (0.33-17.82 ng/ml). The median value of sputum eosinophil count was 3% (0-92%). The mean value of sputum neutrophil count was 59.62%  31.34%. Median FeNO value 67 ppb (13-184 ppb), mean ACT score 16.37  5.67. There was a significant difference in mean MMP-9 levels based on the degree of control of asthma patients (p < 0.03). There was a significant difference in the mean count of neutrophil types based on the degree of control of asthma patients (p < 0.029). There was a significant difference in the mean FeNO value based on the degree of control of asthma patients (p < 0.001). There was a significant correlation between MMP-9 levels and ACT scores in asthma patients (r = - 0.32, p < 0.047).

Conclusion: There is a negative correlation between MMP-9 levels and ACT scores in asthma patients."