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ABSTRAK Hipertensi merupakan kelainan yang umum dijumpai pada kehamilan.
Sekitar 70% wanita hamil mengalami gestational hypertension dan preeklampsia.
Disfungsi endotel pada preeklampsia menyebabkan permukaan endotel yang
nontrombogenik menjadi trombogenik sehingga dapat terjadi aktivasi koagulasi.
Preeklampsia meningkatkan keadaan hiperkoagulabel yang sudah ada pada
kehamilan normal. Gestational hypertension pada wanita hamil adalah hipertensi
yang tidak memenuhi kriteria preeklampsia. Hampir setengah dari pasien dengan
gestational hypertension akan berkembang menjadi preeklampsia. Fibrin
monomer merupakan petanda aktivasi koagulasi yang digunakan pada keadaan
pretrombotik oleh karena terbentuk terlebih dahulu pada keadaan hiperkoagulabel
daripada D-dimer yang terbentuk setelah fibrinolisis. Tujuan penelitian adalah
mendapatkan gambaran fibrin monomer pada gestational hypertension dan
preeklampsia. Penelitian ini adalah penelitian potong lintang pada 30 wanita
hamil gestational hypertension dan 30 wanita hamil preeklampsia yang dilakukan
pada Oktober sampai November 2015. Pemeriksaan FM menggunakan reagen
STA-Liatest memakai koagulometer STA Compact Analyzer. Kadar fibrin
monomer pada gestational hypertension didapatkan mean 4,61 µg/mL dengan
standar deviasi 0,86 µg/mL. Kadar fibrin monomer pada preeklampsia didapatkan
median 10,5 µg/mL dengan mean 11.99 µg/mL dan rentang 6,12 ? 23,26 µg/mL.
Didapatkan perbedaan bermakna kadar fibrin monomer pada gestational
hypertension dan preeklampsia dengan nilai p<0,001.
ABSTRACT Hypertension is a common disorder in pregnancy. Approximately 70% of
pregnant women is gestational hypertension and preeclampsia. Endothelial
dysfunction in preeclampsia causes the endothelial surface of the nonthrombogenic
be thrombogenic so it can activated coagulation. Preeclampsia
increase hypercoagulability state in normal pregnancy. Gestational hypertension is
a hypertension in pregnancy who do not meet the criteria of preeclampsia. Nearly
half of patients with gestational hypertension develop into preeclampsia. Fibrin
monomers are used for coagulation activation marker on the prethrombotic state
therefore formed before on hypercoagulability state hiperkoagulabel than D-dimer
formed after fibrinolysis. The objective of this study is to gain description of
fibrin monomer levels and it was a cross-sectional study 30 pregnant women with
gestational hypertension and 30 pregnant women with preeclampsia. The study
was conducted in October and November 2015. Examination of fibrin monomer
using the reagent STA-Liatest and analyzer STA Compact. Mean of fibrin
monomer in gestational hypertension was 4.61 µg/mL with standard deviation
was 0.86 µg/mL. Median of fibrin monomer in preeclampsia was 10.5 µg / mL
with range was 6.12 to 23.26 µg/mL. Fibrin monomer levels found significant
differences in gestational hypertension and preeclampsia with p <0.001.
;Hypertension is a common disorder in pregnancy. Approximately 70% of
pregnant women is gestational hypertension and preeclampsia. Endothelial
dysfunction in preeclampsia causes the endothelial surface of the nonthrombogenic
be thrombogenic so it can activated coagulation. Preeclampsia
increase hypercoagulability state in normal pregnancy. Gestational hypertension is
a hypertension in pregnancy who do not meet the criteria of preeclampsia. Nearly
half of patients with gestational hypertension develop into preeclampsia. Fibrin
monomers are used for coagulation activation marker on the prethrombotic state
therefore formed before on hypercoagulability state hiperkoagulabel than D-dimer
formed after fibrinolysis. The objective of this study is to gain description of
fibrin monomer levels and it was a cross-sectional study 30 pregnant women with
gestational hypertension and 30 pregnant women with preeclampsia. The study
was conducted in October and November 2015. Examination of fibrin monomer
using the reagent STA-Liatest and analyzer STA Compact. Mean of fibrin
monomer in gestational hypertension was 4.61 µg/mL with standard deviation
was 0.86 µg/mL. Median of fibrin monomer in preeclampsia was 10.5 µg / mL
with range was 6.12 to 23.26 µg/mL. Fibrin monomer levels found significant
differences in gestational hypertension and preeclampsia with p <0.001.
;Hypertension is a common disorder in pregnancy. Approximately 70% of
pregnant women is gestational hypertension and preeclampsia. Endothelial
dysfunction in preeclampsia causes the endothelial surface of the nonthrombogenic
be thrombogenic so it can activated coagulation. Preeclampsia
increase hypercoagulability state in normal pregnancy. Gestational hypertension is
a hypertension in pregnancy who do not meet the criteria of preeclampsia. Nearly
half of patients with gestational hypertension develop into preeclampsia. Fibrin
monomers are used for coagulation activation marker on the prethrombotic state
therefore formed before on hypercoagulability state hiperkoagulabel than D-dimer
formed after fibrinolysis. The objective of this study is to gain description of
fibrin monomer levels and it was a cross-sectional study 30 pregnant women with
gestational hypertension and 30 pregnant women with preeclampsia. The study
was conducted in October and November 2015. Examination of fibrin monomer
using the reagent STA-Liatest and analyzer STA Compact. Mean of fibrin
monomer in gestational hypertension was 4.61 µg/mL with standard deviation
was 0.86 µg/mL. Median of fibrin monomer in preeclampsia was 10.5 µg / mL
with range was 6.12 to 23.26 µg/mL. Fibrin monomer levels found significant
differences in gestational hypertension and preeclampsia with p <0.001.
;Hypertension is a common disorder in pregnancy. Approximately 70% of
pregnant women is gestational hypertension and preeclampsia. Endothelial
dysfunction in preeclampsia causes the endothelial surface of the nonthrombogenic
be thrombogenic so it can activated coagulation. Preeclampsia
increase hypercoagulability state in normal pregnancy. Gestational hypertension is
a hypertension in pregnancy who do not meet the criteria of preeclampsia. Nearly
half of patients with gestational hypertension develop into preeclampsia. Fibrin
monomers are used for coagulation activation marker on the prethrombotic state
therefore formed before on hypercoagulability state hiperkoagulabel than D-dimer
formed after fibrinolysis. The objective of this study is to gain description of
fibrin monomer levels and it was a cross-sectional study 30 pregnant women with
gestational hypertension and 30 pregnant women with preeclampsia. The study
was conducted in October and November 2015. Examination of fibrin monomer
using the reagent STA-Liatest and analyzer STA Compact. Mean of fibrin
monomer in gestational hypertension was 4.61 µg/mL with standard deviation
was 0.86 µg/mL. Median of fibrin monomer in preeclampsia was 10.5 µg / mL
with range was 6.12 to 23.26 µg/mL. Fibrin monomer levels found significant
differences in gestational hypertension and preeclampsia with p <0.001.
;Hypertension is a common disorder in pregnancy. Approximately 70% of
pregnant women is gestational hypertension and preeclampsia. Endothelial
dysfunction in preeclampsia causes the endothelial surface of the nonthrombogenic
be thrombogenic so it can activated coagulation. Preeclampsia
increase hypercoagulability state in normal pregnancy. Gestational hypertension is
a hypertension in pregnancy who do not meet the criteria of preeclampsia. Nearly
half of patients with gestational hypertension develop into preeclampsia. Fibrin
monomers are used for coagulation activation marker on the prethrombotic state
therefore formed before on hypercoagulability state hiperkoagulabel than D-dimer
formed after fibrinolysis. The objective of this study is to gain description of
fibrin monomer levels and it was a cross-sectional study 30 pregnant women with
gestational hypertension and 30 pregnant women with preeclampsia. The study
was conducted in October and November 2015. Examination of fibrin monomer
using the reagent STA-Liatest and analyzer STA Compact. Mean of fibrin
monomer in gestational hypertension was 4.61 µg/mL with standard deviation
was 0.86 µg/mL. Median of fibrin monomer in preeclampsia was 10.5 µg / mL
with range was 6.12 to 23.26 µg/mL. Fibrin monomer levels found significant
differences in gestational hypertension and preeclampsia with p <0.001.
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