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"ABSTRAK Prevalensi Rinitis Akibat Kerja (RAK) berkisar antara 5-48%. Penyebab RAKantara lain adalah partikulat debu yang beterbangan di lingkungan kerja. Hal iniakan meningkatkan beban pembiayaan baik terhadap pekerja itu sendiri maupunperusahaan tempat ia bekerja. Penelitian ini bertujuan untuk mengetahuiprevalensi RAK serta hubungan antara kadar partikulat debu dengan kejadianRAK dengan populasi pekerja parkir basement di sebuah Hotel dan RSUD diJakarta dengan waktu pengumpulan sampel dilakukan selama bulan Desember 2014 hingga Maret 2015. Sampel penelitian adalah yang memenuhi kriteria inklusi yakni area kerja di parkir basement, usia 20-40 tahun, masa kerja lebihdari 1 tahun dan bersedia mengikuti prosedur penelitian. Subyek penelitian diwawancara dan diperiksa kadar eosinofil kerokan mukosa hidung sebelum dansesudah bekerja. RAK positif apabila terdapat gejala rinitis, memberat ketikabekerja dan ada peningkatan eosinofil kerokan mukosa hidung. Analisa penelitiandilakukan berdasarkan karakteristik usia, jenis kelamin, masa kerja, kebiasaanmerokok dan bagian kerja (terpapar langsung atau tidak dengan partikulat debu).Dari 57 subyek penelitian, 6 orang (10.5%) mengalami peningkatan eosinofildengan karakterisktik sebagai berikut: 4 orang memiliki masa kerja > 4 tahun; 4orang memiliki kebiasaan merokok; dan 3 orang bekerja di bagian kerja yangterpapar langsung dengan partikulat debu. Dari 6 orang tersebut terdapat 3 orang(5.2%) yang memenuhi kriteria RAK dengan karakteristik sebagai berikut: 2orang berusia 30-40 tahun, 2 orang adalah laki-laki, 2 orang mempunyai masakerja ≤ 4 tahun, dan 2 orang berasal dari bagian kerja yang terpapar tidaklangsung dengan partikulat debu. Terdapat hubungan bermakna antara riwayatatopi dengan peningkatan eosinofil (OR 23.33 dan 95%CI 2.40-224.62). Namuntidak ditemukan hubungan antara kadar partikulat debu dan masa kerja dengan RAK yang bermakna. ABSTRACT The prevalence of occupational rhinitis ranges between 5-48%. It is caused byparticulate dust in the workplace. It will increase financial burden both for theworkers themselves and the company. This study aims to determine theprevalence of OR and the relation between the levels of particulate dust with ORincident among workers who work in a hotel or hospital basement parking lot inJakarta, during December 2014 to March 2015. The sample inclusion criteriawere: age 20-40 years, working period of more than one year and are willing toparticipate in the study. The subjects were interviewed and nasal mucosal scrapings eosinophil levels were measured before and after work. OR was defined as has symptoms of rhinitis, increase during work and there is anincrease in eosinophils nasal mucosal scrapings. Analysis of the research carriedout based on the characteristics of age, sex, years of smoking and workingdirectly or indirectly exposed to dust particulates. Of the 57 subjects of the study,6 (10.5%) experienced an increase in eosinophils with the followingcharacteristics: 4 people has a work period > 4 years; 4 people smoke; and 3people work directly exposed to particulate dust. Three subjects (5.2%) meet allthe OR criteria with the following characteristics: 2 were aged 30-40 years, 2were male, 2 have a working period of ≤ 4 years and 2 were indirectly exposed toparticulate dust. There is a very significant association between history of atopywith increased eosinophils (, OR 23.3 and 95% CI 2.40-224.62). However, no association was found between levels of particulate dust and working period.;The prevalence of occupational rhinitis ranges between 5-48%. It is caused byparticulate dust in the workplace. It will increase financial burden both for theworkers themselves and the company. This study aims to determine theprevalence of OR and the relation between the levels of particulate dust with ORincident among workers who work in a hotel or hospital basement parking lot inJakarta, during December 2014 to March 2015. The sample inclusion criteriawere: age 20-40 years, working period of more than one year and are willing toparticipate in the study. The subjects were interviewed and nasal mucosal scrapings eosinophil levels were measured before and after work. OR was defined as has symptoms of rhinitis, increase during work and there is anincrease in eosinophils nasal mucosal scrapings. Analysis of the research carriedout based on the characteristics of age, sex, years of smoking and workingdirectly or indirectly exposed to dust particulates. Of the 57 subjects of the study,6 (10.5%) experienced an increase in eosinophils with the followingcharacteristics: 4 people has a work period > 4 years; 4 people smoke; and 3people work directly exposed to particulate dust. Three subjects (5.2%) meet allthe OR criteria with the following characteristics: 2 were aged 30-40 years, 2were male, 2 have a working period of ≤ 4 years and 2 were indirectly exposed toparticulate dust. There is a very significant association between history of atopywith increased eosinophils (, OR 23.3 and 95% CI 2.40-224.62). However, no association was found between levels of particulate dust and working period.;The prevalence of occupational rhinitis ranges between 5-48%. It is caused byparticulate dust in the workplace. It will increase financial burden both for theworkers themselves and the company. This study aims to determine theprevalence of OR and the relation between the levels of particulate dust with ORincident among workers who work in a hotel or hospital basement parking lot inJakarta, during December 2014 to March 2015. The sample inclusion criteriawere: age 20-40 years, working period of more than one year and are willing toparticipate in the study. The subjects were interviewed and nasal mucosal scrapings eosinophil levels were measured before and after work. OR was defined as has symptoms of rhinitis, increase during work and there is anincrease in eosinophils nasal mucosal scrapings. Analysis of the research carriedout based on the characteristics of age, sex, years of smoking and workingdirectly or indirectly exposed to dust particulates. Of the 57 subjects of the study,6 (10.5%) experienced an increase in eosinophils with the followingcharacteristics: 4 people has a work period > 4 years; 4 people smoke; and 3people work directly exposed to particulate dust. Three subjects (5.2%) meet allthe OR criteria with the following characteristics: 2 were aged 30-40 years, 2were male, 2 have a working period of ≤ 4 years and 2 were indirectly exposed toparticulate dust. There is a very significant association between history of atopywith increased eosinophils (, OR 23.3 and 95% CI 2.40-224.62). However, no association was found between levels of particulate dust and working period.;The prevalence of occupational rhinitis ranges between 5-48%. It is caused byparticulate dust in the workplace. It will increase financial burden both for theworkers themselves and the company. This study aims to determine theprevalence of OR and the relation between the levels of particulate dust with ORincident among workers who work in a hotel or hospital basement parking lot inJakarta, during December 2014 to March 2015. The sample inclusion criteriawere: age 20-40 years, working period of more than one year and are willing toparticipate in the study. The subjects were interviewed and nasal mucosal scrapings eosinophil levels were measured before and after work. OR was defined as has symptoms of rhinitis, increase during work and there is anincrease in eosinophils nasal mucosal scrapings. Analysis of the research carriedout based on the characteristics of age, sex, years of smoking and workingdirectly or indirectly exposed to dust particulates. Of the 57 subjects of the study,6 (10.5%) experienced an increase in eosinophils with the followingcharacteristics: 4 people has a work period > 4 years; 4 people smoke; and 3people work directly exposed to particulate dust. Three subjects (5.2%) meet allthe OR criteria with the following characteristics: 2 were aged 30-40 years, 2were male, 2 have a working period of ≤ 4 years and 2 were indirectly exposed toparticulate dust. There is a very significant association between history of atopywith increased eosinophils (, OR 23.3 and 95% CI 2.40-224.62). However, no association was found between levels of particulate dust and working period."

"Latar belakang: Penyakit kardiovaskular adalah salah satu masalah kesehatan di seluruh dunia, khususnya di negara berkembang. Dengan tingginya kejadian penyakit jantung koroner akan berakibat makin meningkatnya tindakan intervensi di bidang kardiovaskuler untuk mengurangi tingkat morbiditas dan mortalitas pada pasien. Pada akhir dekade ini intervensi koroner perkutan IKP digunakan secara luas untuk menangani penyakit arteri koroner dimana timbulnya restenosis masih menjadi hambatan utama. Beberapa penelitian menunjukkan bahwa inflamasi lokal dan sistemis mempunyai peranan penting pada terjadinya patogenesis in-stent restenosis ISR. Sejumlah penanda inflamasi telah diajukan untuk memprediksi angka mortalitas baik jangka pendek maupun jangka panjang terhadap sindroma koroner akut SKA, ISR dan trombosis stent, termasuk disini adalah eosinophil cationic protein ECP. Laporan mengenai korelasi antara kadar ECP dengan ISR belum pernah dilaporkan di Indonesia. Metode: Dilakukan studi potong lintang pada pasien jantung koroner yang mengalami ISR pasca dilakukan tindakan IKP yang berobat di unit Pelayanan Jantung Terpadu PJT Rumah Sakit Cipto Mangunkusumo pada bulan April-Mei 2018. Pasien yang diketahui mengalami ISR dimasukkan sebagai subyek penelitian dan dilakukan pemeriksaan kadar ECP dengan metode Enzyme-Linked Immunosorbent Assay Human Eosinophil Cationic Protein ELISA. Analisa data menggunakan Analisa Bivariat dan uji korelasi Spearman. Hasil: Penelitian mendapatkan 32 subyek yang terdiri dari 27 subyek laki-laki 84,4 dan 5 subyek perempuan 15,6. Rerata usia pasien adalah 60,69 tahun dengan simpang baku 10,17. Tidak terdapat korelasi antara kadar ECP dan ISR r=0,099 ; p=0,589. Simpulan: Tidak terdapat korelasi antara kadar ECP dan ISR pada pasien PJK pasca dilakukannya IKP.

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Background Cardiovascular disease is one of the major health problems worldwide, especially in developing countries. With the high incidence of coronary heart disease will result in increased interventions in the field of cardiovascular to reduce the level of morbidity and mortality in patients. By the end of this decade percutaneous coronary intervention PCI is widely used to treat coronary artery disease where the onset of restenosis remains a major obstacle. Several studies have shown that local and systemic inflammation plays an important role in the development of in stent restenosis ISR pathogenesis. A number of inflammatory markers have been proposed to predict both short and long term mortality rates for acute coronary syndrome ACS, ISR and stent thrombosis, including here is eosinophil cationic protein ECP. Reports on the correlation between ECP and ISR levels have not been reported in Indonesia. Metods Cross sectional study was performed on coronary heart patients who had ISR after PCI performed treatment at Integrated Heart Service Unit of Cipto Mangunkusumo Hospital in April May 2018. Patients who were known to have ISR were included as research subjects and examined ECP levels by method of Enzyme Linked Immunosorbent Assay Human Eosinophil Cationic Protein ELISA. Data analysis using Bivariate Analysis and Spearman correlation test Result The study obtained 32 subjects consisting of 27 male subjects 84,4 and 5 female subjects 15,6. The average age of the patient is 60,69 years with standar deviation 10,17. There is no correlation between ECP and ISR levels r 0,09 p 0,589. Conclusion There was no correlation between ECP and ISR levels in CHD patients after PCI."

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Latar Belakang: Asma merupakan penyakit inflamasi kronik pada saluran napas. Menurut Global Initiative for Asthma (GINA) latihan fisis merupakan salah satu penatalaksanaan non farmakologi yang direkomendasikan. Tujuan penelitian ini untuk mengetahui pengaruh senam asma terhadap hormon kortisol yang meregulasi beberapa faktor sistem imun (IL-10, IL-5, IgE, eosinofil) dan parameter perbaikan fungsi paru.

Metode Penelitian: Rancangan penelitian adalah quasi eksperimen dengan pre post grup design. Jumlah sampel 39 kelompok asma atopi daari Rumah Sakit Prof. Dr. dr. Margono Soekarjo Purwokerto Jawa Tengah tahun 2017-2018 dan 26 sampel kelompok non asma non atopi. IL-10 dan IL-5 diambil dari supernatan dengan isolasi PBMC dengan stimulasi alergen Der p, kontrol negatif menggunakan medium Roswell Park Memorial Institute (RPMI) dan kontrol positif menggunakan medium phytohemagglutinin (PHA). Hormon kortisol dan IgE diambil dari plasma darah dan eosinofil dengan pemeriksaan darah rutin. IL-10, IL-5, hormon kortisol dan IgE dianalisis dengan ELISA, sedangkan VEP₁ dan VEP₁/KVP diukur dengan spirometri H-101 dengan penghitungan prediksi dengan Pneumobile 2009. Kualitas hidup diukur dengan kuesioner Asthma Quality of Life Questionnaire (AQLQ) dan kemampuan mengontrol asma diukur dengan kuesioner Asthma Control Questionnaire (ACQ). Analisis statistik dengan uji t-test berpasangan dan Wilcoxon untuk uji pengaruh sebelum dan setelah  senam asma, sedangkan Pearson untuk analisis hubungan antar variabel.

Hasil: Terdapat peningkatan bermakna antara kadar hormon kortisol, IL-10, VEP₁, VEP₁/KVP, kualitas hidup, kemampuan mengontrol asma dan penurunan IL-5, IgE dan eosinofil setelah senam asma pada pasien asma atopi persisten ringan-sedang dibandingkan sebelumnya. Terdapat hubungan bermakna antara peningkatan hormon kortisol dengan perbaikan fungsi paru (VEP₁ dan KVP) dan peningkatan hormon kortisol dengan penurunan IL-5, sedangkan peningkatan hormon kortisol berhubungan tidak bermakna dengan peningkatan IL-10 dan penurunan IgE.

Kesimpulan: Senam asma meningkatkan kadar hormon kortisol, IL-10, perbaikan fungsi paru, kualitas hidup dan kemampuan mengontrol asma serta dapat menurunkan IL-5, IgE, eosinofil pada asma atopi persisten.

 

 

Kata Kunci : Hormon Kortisol, IL-10, IL-5, IgE, Eosinofil, Fungsi paru, Asma Atopi Persisten

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Background: Asthma is a chronic inflammatory disease of the airways. One of the management of non-pharmacological asthma recommended by the Global Initiative for Asthma (GINA) is physical exercise. The purpose of this study was to investigate the role of exercise on cortisol which regulates several immune system factors (IL-10, IL-5, IgE, eosinophil) and lung function improvement parameters.

Methods: This study was a quasi-experiment with pre-post group design. The number of samples was 39 atopic asthma groups conducted at Prof. Dr. dr. Margono Soekarjo Hospital Purwokerto Central Java 2017-2018 and 26 non-atopy non-asthma groups which the inclusion criteria. Cortisol hormone and IgE were taken from blood plasma and eosinophil by routine blood test. IL-10, IL-5, cortisol and IgE were analyzed by Enzyme-Linked Immunosorbent Assay (ELISA), while Force Expiration Volume in 1 second / FEV₁ and FEV₁ / FVC (Force Vital Capacity) were measured by H-101 spirometry with predictive calculations with Pneumobile 2009. Quality of life was assessed by the Asthma Quality of Life Questionnaire (AQLQ) and asthma control ability by the Asthma Control Questionnaire (ACQ). Statistical analysis was conducted using paired t-test and Wilcoxon before and after asthma exercise, and Pearson method for the analysis of relationships between variables.

 Results: There were a significant increases in blood cortisol level, IL-10, FEV₁, FEV₁ / FVC, quality of life and the ability to control asthmatic attack and significant decreases in IL-5, IgE and eosinophil blood counts after compared to before asthma exercise. There were correlation among increases cortisol hormone with improving pulmonal function (FEV₁ and FVC), IL-5, eosinophil with increased FEV₁ and FEV₁ / FVC volume. The incerases in hormone cortisol was associated with no significant increases in IL-10 and decreased IgE.

Conclusion: Asthma exercise increases levels of cortisol, IL-10, pulmonary functions, quality of life and control ability, and reduces IL-5, IgE, eosinophil in atopic asthma persistent

 

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"ABSTRAKLatar belakang: Asma dan rinitis alergi merupakan penyakityang disebabkan oleh inflamasi saluran napas.United airway adalah hipotesis terdapatnya kesatuan morfologi dan fungsi sistem saluran napas atas dan bawah yang memiliki kesamaan dalam histologi, fisiologi dan patologi. Penilaian respons inflamasi pada saluran pernapasan diharapkan mampumemperbaiki derajat berat penyakit asma maupun rinitis alergi sehingga derajat penyakit terkontrol baik.Metode: Penelitian ini menggunakan metode potong lintang pada 31 pasien asma yang berobat ke RSUP Persahabatan. Subjek penelitian dinilai derajat berat penyakitnya berdasarkan derajat asma stabil, derajat kontrol asma dan derajat rinitis. Penilaian inflamasi saluran napas atas menggunakan eosinofil mukosa hidung dan inflamasi saluran napas bawah menggunakan FeNO Subjek dibagi menjadi kelompok asma dengan rinitis alergi dan asma tanpa rintis alergi menggunakan pemeriksaan alergi uji cukit kulit.Hasil: Terdapat hubungan dengan korelasi yang bermakna antara peningkatan kadar FeNO dengan asma yang tidak terkontrol (r=0,39, p = 0,02).Terdapat perbedaan yang bermakna antara jumlah eosinofil mukosa hidung (p = 0,02) dan FeNO (p = 0,01)pada subjek asma dengan rinitis alergidan asma tanpa rinitis alergi. Terdapat hubungan dengan korelasi yang bermakna antara kadar FeNO dengan jumlah eosinofil mukosa hidung. (r = 0,378, p= 0,04).

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ABSTRACTBackground:Asthma and allergic rhinitis are diseases caused by airway inflammation. The united airways hypothesis suggests a similarity of morphology and function betweenthe upper and lower airway systems. Thus, the assessment of inflammatory activities in the united airway systems should reflect the severity and the degree of disease control in asthma and allergic rhinitis.Methods:This cross-sectional study included 31 asthma patients treated in National Respiratory Referral Center Persahabatan Hospital Jakarta, Indonesia, as subjects. Subjects were grouped into asthma with allergic rhinitis and asthma without allergic rhinitis based on the skin test examination. The degrees of stable asthma, asthma control, and rhinitis of the subjects were recorded. The nasal eosinophil counts and fractional concentration of exhaled nitric oxide (FeNO) level examinations were performed to assess the lower and upper airway inflammation, respectively.Results:There was a moderate correlation between FeNO levels and degree of asthma control (r=0.39, p=0.02).Subject grouping resulted in different nasal eosinophil counts and FeNO levels (p=0.02 and p=0.01, respectively). There was a moderate correlation between nasal eosinophil counts and FeNO levels (r=0.378, p= 0.04)."

"Latar belakang: Rinosinusitis kronik (RSK) merupakan sebuah masalah kesehatan global. Berdasarkan keberadaan polip hidung, RSK dikategorikan menjadi RSK dengan dan tanpa polip hidung. Rinosinusitis yang memiliki gejala persisten walaupun mendapatkan tata laksana yang tepat disebut sebagai rinosinusitis refrakter. Kondisi ini dapat menyebabkan tatalaksana berlebih terkait kegagalan dalam tindakan pembedahan. Terdapat banyak faktor yang berperan dalam patogenesis RSK refrakter, seperti infiltrasi eosinofil, biofilm dan asma.Tujuan penelitian: Mengetahui pengaruh infiltrasi eosinofil, biofilm dan asma terhadap RSK dengan polip hidung bilateral refrakter.Metode: Penelitian ini menggunakan desain cross-sectional dan melibatkan 37 pasien RSK dengan polip hidung bilateral di RSUPN Cipto Mangunkusumo. Data diambil dari rekam medis (jenis kelamin, usia, atopi, dan asma) dan hasil pemeriksaan preparat blok paraffin polip hidung (infiltrasi eosinofil dan biofilm). Analisis data dilakukan menggunakan Statistical Program for Social Science (SPSS) for Windows versi 20.Hasil: Kejadian refrakter ditemukan pada 29 subjek (78,4%). Berdasarkan analisis bivariat, tidak terdapat asosiasi yang bermakna antara infiltrasi eosinofil, biofilm, asma, atopi, usia, dan jenis kelamin dengan kejadian RSK dengan polip hidung bilateral refrakter (p>0,05). Kesimpulan: Tidak terdapat pengaruh signifikan dari infiltrasi eosinofil, biofilm dan asma terhadap RSK dengan polip hidung bilateral refrakter.

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Background: Chronic rhinosinusitis (CRS) is a global health issue. Based on the existence of nasal polyps, CRS is further categorized into CRS with and without nasal polyps. Rhinosinusitis that show persistent symptoms despite suitable treatment is referred to as refractory rhinosinusitis. This condition could cause over-treatment due to failed surgery. There are a lot of factors that contribute towards the pathogenesis of refractory CRS, such as eosinophil infiltration, biofilm, and asthma

Aim: To assess the impact of eosinophil infiltration, biofilm, and asthma towards refractory CRS with bilateral nasal polyps.

Methods: This is a cross-sectional study involving 37 CRS with bilateral polyp nasal patients at Dr. Cipto Mangunkusumo National General Hospital. Data were obtained from medical records (sex, age, atopy, and asthma) and nasal polyp paraffin block examination (eosinophil infiltration and biofilm). Data analysis was performed using Statistical Program for Social Science (SPSS) for Windows version 20.

Results: 29 subjects (78,4%) had refractory CRS with bilateral nasal polyps. Based on bivariate analysis, no significant association was shown between eosinophil infiltration, biofilm, and asthma, age, and sex and refractory CRS with bilateral nasal polyps."