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Abstrak :
Coastal plant locally known as terong pungo (Solanum sp.) was used by Aceh community as traditional medicine for toothache. The objectives of this study were to isolate endophytic fungi from the leaves of terong pungo and determine the antibacterial activity of the fungi against bacteria causing dental caries and infection. Eight endophytic fungi were isolated. Antagonism test among the isolates was performed to select the most dominant fungus. TP6 was the selected fungus based on the antagonism assay. Crude extracts of the fungus were macerated from the culture broth using ethyl acetate. The strongest antibacterial activity of the extracts was obtained when the fungus was at 12 days of cultivation. The fungal crude extract was strongly active against Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa with inhibition zone diameter of 20, 21 and 23 mm, respectively.

Abstrak :
Plants have been the chief source of compounds of medicine for thousand of years. Plants die also the source of many medicines ft>r the majority of the world's population, The role of biotechnology is very important for multiplying, conserving the spesies, and enhancing the production of secondary metabolites. Endophytes of novel secondary metabolites offering the potensial for medical and industrial exploitation. Natural products from various endophytic microbes have been investigated. Some examples of natural products observed from endophytic microbes are antibiotics, antiviral compounda; anticancers; antimalarial compounds; antioxidants, antidiabetics nad immunosuppressive compounds.