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"This cross sectional study was carried out in Jakarta, among institutionalized elderly aged 60 - 74 years. Rabe study reported that there is a high prevalence of low body mass index (BMI) value among the elderly in Jakarta. Ferro-Luzzi et at (1992) and James et al (1988) stated that an adult person with BMI less than 18.5 kg/m2 was proposed being chronic energy deficient (CED) and had functioning and health impairment. General aim of this study is to investigate whether low BMI among elderly is associated with adaptation in energy expenditure and had negative consequences on health. Based on James and colleague classification of BMI, two groups of elderly with different BMI value represented this study. Twenty elderly subjects with BMI < 11.00 kg/m2 (low BMI group) and 20 elderly subjects with BMI 22.0 --25.00 kg/m2 (normal BMI group). To every subject in each group was conducted questionnaires, Hb level measurement, 2 days combined record and recall daily physical activity, 2 days combined food weighing and 24-hour food recall intake, and resting energy expenditure (REE). Body composition was assessed by skinfolds technique and bioelectrical impedance analysis (BIA) using Lukaski and Deurenberg equations. Result revealed that fat mass and fat free mass of low BMI subjects are significantly lower than the normal BMI subjects. The low BMI subjects had very low fat mass. However, both groups had same PAL [1.3 X basal Metabolic rate (BMR)]. The low BMI subjects who were considered as CED had similar level of activity of daily living (ADL) as those with normal BMI subjects. Both BMI group had no significant different on the number of health complaint. On the whole, findings indicated that the CED elderly had no physical adaptation and negative consequences on health. Anyway using the cut-off point to define CED proposed by Ferro-Luzzi and colleague for Indonesian elderly needs carefully consideration. "

"Hubungan antara kesepian dan adiksi smartphone tidak selalu ditemukan berkorelasi secara signifikan. Di sisi lain, Deficient Self-Regulation Model mengajukan disregulasi emosi sebagai mediator dalam hubungan antara adiksi smartphone dan kesepian. Penelitian ini bertujuan untuk menguji kembali hubungan positif antara kesepian dan adiksi smartphone, serta sejauh mana hubungan tersebut dapat dimediasi oleh disregulasi emosi. Sebanyak 158 dewasa muda (69% perempuan; Musia = 21,19, SD = 1,92) diukur menggunakan Smartphone Addiction Scale – Short Version, Revised UCLA Loneliness Scale, dan Brief Version of Difficulties in Emotion Regulation Scale. Hasil analisis korelasi menunjukkan bahwa kesepian berhubungan secara positif dan signifikan dengan adiksi smartphone. Hasil analisis PROCESS simple mediation (Model 4) menunjukkan bahwa hubungan kesepian dan adiksi smartphone dimediasi secara penuh oleh disregulasi emosi. Diskusi mengenai temuan-temuan dalam penelitian ini akan mengangkat peran penting dari disregulasi emosi dalam memahami bagaimana kesepian di kalangan dewasa muda dapat memicu perilaku adiksi smartphone dan berbagai dampak negatif yang mengikutinya.

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According to previous findings, the relationship between loneliness and smartphone addiction did not always show significant correlation. On the other hand, the Deficient Self-Regulation Model proposes emotional dysregulation as a mediator between loneliness and smartphone addiction. This study aimed to re-examine the positive relationship between loneliness and smartphone addiction and explore the extent to which emotional dysregulation mediates this relationship. A total of 158 Indonesian young adults (69% female; Musia=21,19, SD=1,92) were measured using the Smartphone Addiction Scale – Short Version, the Revised UCLA Loneliness Scale to assess loneliness, and the Brief Version of Difficulties in Emotion Regulation Scale. Results of the correlation analysis indicated a positive and significant relationship between loneliness and smartphone addiction. Notably, the findings of the PROCESS simple mediation analysis (Model 4) revealed that the relationship between loneliness and PSU is fully mediated by emotional dysregulation. The discussion of the current study's findings will emphasize the vital role ofemotional dysregulation in understanding how loneliness among young adults can trigger smartphone addiction and subsequent negative consequences."

"Tujuan: Mengetahui dosis terapi vitamin D yang optimal untuk ibu hamil dengan defisiensi dan insufisiensi vitamin DMetode: Uji klinis acak terkontrol dilakukan Juni 2019–Desember 2022 di RSUPN Cipto Mangunkusumo dan RSUD Koja, Jakarta. Subjek adalah wanita hamil usia kehamilan ≤14 minggu dengan defisiensi atau insufisiensi vitamin D (25(OH)D<30 ng/ml). Subjek dibagi menjadi 2 kelompok, kelompok pertama mendapatkan terapi vitamin D3 50.000 IU/minggu dan kelompok kedua mendapatkan terapi vitamin D3 5.000 IU/hari. Intervensi diberikan selama 4 minggu. Pengukuran kadar 25(OH)D dan 1,25(OH)2D dilakukan pada awal dan akhir intervensi.Hasil: Subjek awal berjumlah 60 orang, dan 8 subjek mengalami drop out. Karakteristik dasar subjek pada kedua kelompok setara. Kadar awal 25(OH)D tidak menunjukkan perbedaan bermakna di antara kedua kelompok (p=0,552). Pemberian terapi vitamin D3 50.000 IU/minggu selama 4 minggu meningkatkan kadar 25(OH)D secara signifikan (dari 14,5±4,3 menjadi 27,9±9,3 ng/mL, p<0,001) dan meningkatkan kadar 1,25(OH)2D namun secara statistik tidak signifikan (p=0,257). Pemberian terapi vitamin D3 5.000 IU/hari selama 4 minggu meningkatkan kadar 25(OH)D secara signifikan (dari 15,3±4,7 ng/mL menjadi 26,9±6,1 ng/mL, p<0,001) dan juga meningkatkan kadar 1,25(OH)2D secara signifikan (p=0,042). Namun tidak didapatkan perbedaan yang bermakna baik pada delta 25(OH)D (p=0,694), maupun delta 1,25(OH)2D di antara kedua kelompok dosis (p=0,641).Kesimpulan: Terapi vitamin D3 50.000 IU/minggu selama 4 minggu sama efektifnya dengan vitamin D3 5.000 IU/hari dalam meningkatkan kadar 25(OH)D serum pada wanita hamil dengan defisiensi dan insufisiensi vitamin D. Kedua dosis tersebut juga aman dan dapat ditoleransi oleh ibu hamil.

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Objective: To determine the optimal therapeutic dose of vitamin D for pregnant women with insufficiency or deficiency of Vitamin D

Methods: A randomized controlled trial was conducted from June 2019 to December 2022 at Cipto Mangunkusumo National Center General Hospital and Koja District Hospital in Jakarta, Indonesia. Subjects were ≤14 weeks gestation pregnant women with insufficiency or deficiency of Vitamin D (25(OH)D<30 ng/ml]. Two intervention groups were randomly assigned: 5,000 IU vitamin D3 daily or 50,000 IU weekly. Maternal blood samples were collected before and after four weeks of interventions to assess changes in serum concentrations of 25(OH)D and 1,25(OH)2D).

Result: Sixty subjects were randomized into two groups, and eight subjects were dropped out. The basic demographics of subjects in both groups were equivalent. There were no differences in baseline levels of 25(OH)D between two groups (p=0.552). In the 50,000 group, 25(OH)D levels increased from 15.3 ± 4.7 ng/mL to 26.9 ± 6.1 ng/mL (p<0.001). The 1,25(OH)2D levels increased however, the increase is not statistically significant. While in the 5,000 group, the 25(OH)D levels increased from 14.5 ± 4.3 ng/mL to 27.9 ± 9.3 ng/mL (p<0.001) and the 1,25(OH)2D levels increased significantly (p=0.042). However, the increment 25(OH)D and 1,25(OH)2D were not statistically significant between two groups.

Conclusion: Vitamin D3 50,000 IU weekly is equally effective and safe as 5,000 IU daily in increasing 25(OH)D serum levels in pregnant women with insufficiency or deficiency of Vitamin D."