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"Pendahuluan: Akumulasi zat besi berlebih, terutama pada pasien thalassemia yang menerima transfusi darah rutin, dapat memicu penyakit pernapasan seperti PPOK melalui pembentukan radikal bebas. Meskipun kelator besi seperti deferiprone efektif, deferiprone memiliki efek samping seperti neutropenia dan agranulositosis. Phaleria macrocarpa diketahui juga mengandung mangiferin yang bersifat antioksidan dan antiinflamasi. Tujuan penelitian ini untuk mengetahui efektivitas terapi kombinasi deferiprone dan ekstrak etanol P. macrocarpa sebagai alternatif untuk mengobati kondisi kelebihan zat besi dengan efek samping yang lebih rendah. Metode: Penelitian menggunakan tikus Sprague-Dawley (200-250 g) yang dibagi menjadi enam kelompok: Normal (N), Kontrol Negatif (KN), Deferiprone (D), Phaleria macrocarpa (PM), Kombinasi Dosis Penuh (DPM-1), dan Kombinasi Setengah Dosis (DPM-2). Tikus diinjeksi iron dextran 15 mg/x selama 8 minggu. Kelompok perlakuan menerima ekstrak etanol Phaleria macrocarpa (100 mg/kgBB) selama 4 minggu, sedangkan deferiprone diberikan dalam dosis penuh (462,5 mg/kgBB) atau setengah dosis (231,2 mg/kgBB) selama 4 minggu. Kadar zat besi dalam jaringan paru diukur menggunakan Atomic Absorption Spectrometry (AAS). Hasil: Kelompok PM menunjukkan penurunan kadar besi paling rendah di paru dibandingkan KN. Uji normalitas Shapiro-Wilk menunjukkan data terdistribusi normal (p>0,05). Uji One Way Anova tidak menemukan perbedaan signifikan antar kelompok (p>0,05), sehingga uji post hoc tidak dilakukan. Kesimpulan: Pemberian terapi deferiprone dan ekstrak Phaleria macrocarpa secara kombinasi tidak menunjukkan perbedaan yang signifikan dalam penurunan kadar besi di paru secara statistik. Namun, data menunjukkan kadar besi mengalami penurunan walaupun tidak signifkan pada kelompok PM dan DPM2.

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Introduction: Excessive iron accumulation, particularly in thalassemia patients who undergo regular blood transfusions, can lead to respiratory diseases like COPD, through free radical formation. Although iron chelators such as deferiprone are effective, they may cause side effects including neutropenia and agranulocytosis. Phaleria macrocarpa, containing mangiferin, has known antioxidant and anti-inflammatory properties. The study aims to evaluate the effectiveness of combining deferiprone with Phaleria macrocarpa extract for treating iron overload with fewer side effects. Methods: Sprague-Dawley rats (200–250 g) were divided into six groups: Normal (N), Negative Control (KN), Deferiprone (D), Phaleria macrocarpa (PM), Full-Dose Combination (DPM-1), and Half-Dose Combination (DPM-2). The rats were injected with 15 mg/x iron dextran for 8 weeks to induce iron overload. The treatment groups received ethanol extract of Phaleria macrocarpa (100 mg/kg body weight) for 4 weeks, while deferiprone was given at full dose (462.5 mg/kg body weight) or half dose (231.2 mg/kg body weight) for 4 weeks. Iron levels in lung tissues were measured using Atomic Absorption Spectrometry (AAS). Results: The PM group showed the lowest reduction in lung iron levels compared to KN. The Shapiro-Wilk test confirmed that the data were normally distributed (p>0.05). One-way Anova revealed no significant differences between groups (p>0.05), so post hoc tests weren’t conducted. Conclusion: Although the combination of deferiprone and Phaleria macrocarpa extract did not significantly reduce lung iron levels, The data showed that iron levels decreased, although not significantly, in the PM and DPM2 groups."

"Introduction. Thalassemia is one of the hemoglobin disorders with high prevalence worldwide and in Indonesia. A continuous red blood cells transfusion can result in accumulation of iron in the body and stored as ferritin. The excessive iron is removed using iron chelation therapy where a good compliance to iron chelators is required for desirable outcomes. Hence, this study aims to find the association between patients’ compliance to oral iron chelators (Deferasirox and Deferiprone) and serum ferritin level in adolescent thalassemia patients as they have been known to be non-compliant towards their medication.Methods. Questionnaire and patient diary card were distributed to adolescent thalassemia patients who had fulfilled exclusion and inclusion criteria. Subjects were divided into poor and good compliance based on the result of patient diary card which were filled for 30 days. Based on Adherence Barrier Questionnaire (ABQ), high and low ABQ score were obtained. The serum ferritin level pre- and post-study was obtained from patients’ medical record. The association between patients’ compliance from the diary card report was assessed using SPSS along with identification of adherence barriers and questionnaire’s total score from the ABQ result.Results. Out of 29 subjects, from the result of patient diary card, there were 72% subjects with poor compliance and 28% subjects with good compliance. Based on ABQ result, there were 4.8% subjects with high ABQ score and 55.2% subjects with low ABQ score. There was a statistically significant correlation between ABQ score and serum ferritin level difference pre- and post-study (ρ = -0.394, p = 0.034). The correlation between patient’s compliance from diary card and serum ferritin level was insignificant (ρ = -0.040, p = 0.838). Based on ABQ result, it was found that forgetfulness, patients’ attitude towards their regiments, and fear of side effects are barriers towards patients’ compliance for iron chelators.Conclusion. There is a correlation between patients’ compliance and serum ferritin level based on the result of ABQ.

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Pendahuluan. Talasemia adalah salah satu kelainan hemoglobin dengan prevalensi tinggi di dunia dan di Indonesia. Transfusi darah dalam jangka waktu panjang menyebabkan penumpukan zat besi dalam tubuh yang disimpan sebagai feritin serum. Zat besi yang berlebihan dikeluarkan dengan terapi kelasi besi, dimana dibutuhkan kepatuhan yang baik terhadap obat kelasi besi agar hasil pengobatan baik. Studi ini bertujuan untuk mencari hubungan antara kepatuhan pasien terhadap obat kelasi besi oral (Deferasiroks dan Deferipron) dengan jumlah feritin serum pada pasien talasemia remaja karena remaja dikenal sering tidak patuh terhadap pengobatan mereka.

Metode. Kuesioner dan buku diari disebarkan untuk mengumpulkan data dari pasien talasemia remaja yang memenuhi kriteria eksklusi dan inklusi. Subjek dibagi menjadi kepatuhan baik dan buruk berdasarkan hasil buku diari yang diisi selama 30 hari. Berdasarkan hasil Adherence Barrier Questionnaire (ABQ), didapatkan skor ABQ tinggi dan rendah. Jumlah feritin serum sebelum dan sesudah studi diambil dari rekam medik pasien. Hubungan antara kepatuhan pasien berdasarkan buku diari dinilai menggunakan SPSS bersamaan dengan identifikasi penghambat kepatuhan dan skor total kuesioner berdasarkan hasil ABQ.

Hasil. Dari 29 subjek, berdasarkan hasil buku diari, terdapat 72% subjek dengan kepatuhan yang baik dan 28% subjek dengan kepatuhan yang buruk. Berdasarkan hasil ABQ, terdapat 44.8% subjek dengan skor ABQ tinggi dan 55.2% subjek dengan skor ABQ rendah. Terdapat hubungan yang bermakna secara statistik antara skor ABQ dan perbedaan feritin serum sebelum dan sesudah studi (ρ = -0.394, p = 0.034). Sementara itu, hubungan antara kepatuhan pasien bedasarkan buku diari dengan perbedaan jumlah feritin serum tidak bermakna (ρ = -0.040, p = 0.838). Ditemukan bahwa lupa, sikap pasien terhadap obatnya, dan ketakutan terhadap efek samping adalah penghalang kepatuhan pasien terhadap obat kelasi besi berdasarkan hasil respon dari ABQ.

Kesimpulan. Terdapat hubungan antara kepatuhan pasien dengan jumlah feritin serum berdasarkan hasil ABQ.

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