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Ditemukan 126 dokumen yang sesuai dengan query
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Figlin, Robert A., editor
"This book provides a comprehensive look at renal cell carcinoma, exploring its biology as well as current and future molecular targets for renal cancer carcinoma."
New York: Springer, 2012
e20401747
eBooks  Universitas Indonesia Library
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Chaidir Aulia
"Adenoid cystic carcinoma is an extremely rare case of the esophagus. We present a female patient, aged 76 years who present with dysphagia and weight loss for tire last three month. On endoscopy there was a luminal narrowing in the middle third of the esophagus. Diagnosis was challenging due to the stenosis and the tumor size. Histopathological confirmation was obtained by subcarinal fine-needle aspiration biopsy. This type of cancer is very aggressive with short survival time. Further studies are needed to define optimal treatment."
Jakarta: The Indonesian Journal of Gastroenterology Hepatology and Digestive Endoscopy, 2006
IJGH-7-2-Agt2006-51
Artikel Jurnal  Universitas Indonesia Library
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"At this time there is an increasing demand for an accurate pre operative staging in non small cell lung cancer. Chest Computed Tomography (CT) is one of the imaging modality of choice used for this purpose. This study evaluated the accuracy of the chest CT to determine the status of tumor and nodules in non small cell lung cancer. During the years 1998 and 1999 a descriptive prospective study of 32 patients undergoing a contact enhanced chest CT examination for non small cell lung cancer, stage I-IIIA, was conducted. Lobectomy, lu\ymph nodes dissection and postoperatice histo-pathological examination were done. CT findings were as followas a sensitivity of 100% , a specificity of 25% and an accuracy of 60% in the detection of the nodule stage were found. In 17 patients with adeno-carcinoma, the sensitivity, the specificity and the accuracy were 86.6%, 100% dan 88.2% respectively. The diagnosis of all patients was conformed histo-pathologically. Six patients with T2 dan 26 patients with T3 were detected by chest CT; the accuracy of the tumor status was 93.7% confirmed by surgical and histo-pathological examinations. It was concluded that th CT played an important role in determining the clinical stage of non small cell lung cancer. The specificity and accuracy were higher in adeno-carcinoma as compare with squamous cell carcinoma in detecting the nodal status."
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Persahabatan Hospital. Department of Radiology, 2003
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Artikel Jurnal  Universitas Indonesia Library
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"Incidences of pancreatic cancer worldwide have been known to be increased. It is the fifth leading cause of death in United State of America.Seventy percent accourts in the head of the pancreas...."
Artikel Jurnal  Universitas Indonesia Library
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Silitonga, Imelda Setiana
"Latar belakang: Karsinoma urotelial merupakan keganasan kandung kemih tersering pada laki-laki. Faktor risikonya adalah merokok, pajanan bahan kimia, radiasi, infeksi Schistosoma hematobium. Mutasi p53 merupakan mutasi tersering pada karsinoma urotelial kandung kemih yang menyebabkan akumulasi protein p53 di inti dan terlihat dengan imunohistokimia. Tujuan penelitian adalah untuk melihat perbedaan ekspresi p53 pada karsinoma urotelial kandung kemih derajat rendah dan derajat tinggi serta hubungan ekspresi p53 dengan: "stadium tumor. Bahan dan cara: Penelitian menggunakan desain potong lintang. Sampel terdiri atas 47 kasus yang terbagi menjadi 22 kasus karsinoma urotelial derajat rendah dan 25 kasus karsinoma urotelial derajat tinggi di Departemen Patologi Anatomik Fakultas Kedokteran Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo (FKUI/RSCM) tahun 2009-2017. Dilakukan pulasan imunohistokimia p53 dengan menggunakan cut off positif ≥ 20% berdasarkan penelitian Thakur et al, Ong et al, dan Saint et al. Hasil: Ekspresi p53 positif pada 33 sampel (70,21%), terbanyak pada karsinoma urotelial derajat tinggi 20 kasus (80%), sedangkan pada karsinoma urotelial derajat rendah terdapat 13 kasus (59,1%). Sebanyak 22 kasus (68,8%) Nonmuscle invasive bladder cancer dan 11 kasus (73,3%) Muscle invasive bladder cancer menunjukkan ekspresi positif. Ekspresi p53 cenderung lebih banyak ditemukan pada karsinoma urotelial derajat tinggi dan stadium tinggi. Kesimpulan: Tidak ada perbedaan ekspresi p53 pada karsinoma urotelial kandung kemih derajat rendah dan derajat tinggi. Tidak ada hubungan antara ekspresi p53 dengan stadium tumor.
Kata kunci: Karsinoma urotelial, kandung kemih, p53, imunohistokimia.

Background : Urothelial carcinoma is the most common malignancy in the bladder and mainly occurs in older men. Risk factors for bladder cancer include smoking, exposure to chemicals, radiation and schistosoma hematobium infection. P53 is a tumor suppressor gene that is involved in the cell cycle and plays a role in the occurrence of apoptosis in response to DNA damage. P53 gene mutation is one of the most common genetic changes in urothelial bladder carcinoma. The p53 gene mutation will cause accumulation of p53 protein in the nuclei which can be detected through immunohistochemical examination. The aim of this study is to see differences of p53 expression in low grade and high grade urothelial carcinoma and to see the association of p53 expression with tumor stage. Material and method : This study uses a cross sectional study design. The sample consisted of 47 cases of urothelial bladder carcinoma divided into 22 cases of low grade urotelial carcinoma and 25 cases of high grade urotelial carcinoma originating from the archives of the Anatomical Pathology Department Faculty Medicine of Universitas Indonesia/Cipto Mangunkusumo Hospital (FKUI/ RSCM) in 2009-2017. The study was carried out by p53 immunohistochemical examination and assessment of p53 expression using a percentage with a positive cut off value of ≥ 20%. Result : This study obtained positive p53 expression in 33 samples from 47 samples studied (70,21%). Most are found in high grade urothelial carcinoma as many as 20 cases (80%). Whereas in low grade urothelial carcinoma there are 13 cases (59,1%) with positive p53 expression. As many as 22 cases (68,8%) of Non muscle invasive bladder cancer (NMIBC) and 11 cases (73,3%) of Muscle invasive bladder cancer (MIBC) showed positive p53 expression. There was no difference between p53 expression in low grade and high grade bladder urothelial carcinoma (p=0,118). This study also showed no association between p53 expression with tumor stage (p=1,000). Conclusion : P53 expression was not significantly different with tumor grade. P53 expression was not significantly associated with the tumor stage."
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
T57631
UI - Tesis Membership  Universitas Indonesia Library
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Agustinus Gatot Dwiyono
"Latar Belakang: Kanker Nasofaring (KNF) merupakan keganasan yang sering di Indonesia. Molekul terkait imun yang banyak diteliti adalah Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1). Penelitian ini bertujuan untuk mengetahui profil PD-L1 dari spesimen KNF di Indonesia.
Metode: Spesimen biopsi massa nasofaring diambil untuk pemeriksaan konsentrasi protein PD-L1 dengan metode Enzyme-Linked Immunosorbent Assay (ELISA). Pada spesimen yang terbukti secara histologis KNF dilakukan pemeriksaan Imunohistokimia (IHK) untuk mengetahui ekspresi PD-L1.
Hasil: Lima puluh empat spesimen biopsi nasofaring diperoleh. Tiga puluh lima dari 54 spesimen dikonfirmasi secara histologis KNF yang tidak berdiferensiasi dengan usia rerata 51 tahun. Selebihnya, 19 spesimen lainnya secara histologis bukan KNF dengan usia rerata 37 tahun. Pada pemeriksaan ELISA, median konsentrasi PD-L1 dari spesimen KNF adalah 2100,73 ± 3689,52 pg/mg protein, dan spesimen bukan KNF adalah 1010,88 ± 1082,37 pg/mg protein. Pada pemeriksaan IHK 30 sampel KNF untuk pemeriksaan ekspresi PD-L1, semuanya mengekspresikan PD-L1 positif, dengan rincian; skor 1 sebanyak 7%, skor 2 sebanyak 30%, dan skor 3 sebanyak 63%.
Kesimpulan: Protein PD-L1 dari spesimen KNF dengan pemeriksaan ELISA signifikan meningkat dibandingkan dengan bukan KNF. Semua spesimen KNF dengan pemeriksaan IHK mengeskspresikan PD-L1 positif dengan mayoritas skor 3.

Background: Nasopharyngeal Carcinoma (NPC) is a common malignancy in Indonesia. Immune-related molecules that have been studied are Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1). This study aims to determine the profile of PD-L1 from NPC specimens in Indonesia.
Method: A nasopharyngeal biopsy specimen was taken to examine the concentration of PD-L1 protein by the Enzyme-Linked Immunosorbent Assay (ELISA). Immunohistochemistry (IHC) examinations were conducted to determine the PD-L1 expression.
Results: Fifty-four nasopharyngeal biopsy specimens were obtained. Thirty-five of 54 specimens were confirmed histologically for undifferentiated NPC with an average age of 51 years. The rest, 19 other specimens are histologically non NPC with an average age of 37 years. On ELISA examination, the median PD-L1 concentration of the NPC specimen was 2100.73 ± 3689.52 pg/mg protein, and the non-KNF specimen was 1010.88 ± 1082.37 pg/mg protein. At the IHC examination of 30 NPC samples for PD-L1 expression examination, all of them expressed PD-L1 positive, with details; score 1 is 7%, score 2 is 30%, and score 3 is 63%.
Conclusion: PD-L1 protein from NPC specimens by ELISA examination was significantly increased compared to non-NPC. All NPC specimens with IHC examination expressed PD-L1 positive with a majority score of 3.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
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UI - Tesis Membership  Universitas Indonesia Library
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Deby
"Karsinoma hepatoselular memiliki prognosis yang buruk akibat keterbatasan terapi seperti terlambat diagnosis, kurangnya biomarker spesifik, dan ketidakpekaan terhadap agen tumor ini. Imunoterapi berbasis sel NK autologus dengan stimulasi eksosom menjadi modalitas pengembangan imunoterapi berbasis sel NK untuk pasien karsinoma hepatoseluler. Sel NK pasien karsinoma hepatoseluler diisolasi dari darah vena perifer dan eksosom diisolasi dari serum darah donor sehat. Karakterisasi eksosom dengan particle size analyzer dan flow cytometry. Stimulasi eksosom ke sel NK selama 24 jam kemudian evaluasi ekspresi reseptor NKp44, NKp46, NKp30, NKG2D, KIR2D, dan NKG2A serta ekspresi perforin dan granzyme B. Visualisasi interaksi sel NK dengan fraksi sel mononuklear lainnya (CD4, CD8, CD11c, dan CD19) dengan imunofluorens. Ukuran partikel < 100 nm, muatan listrik negatif dan CD63+CD81+ (positif ganda) hasil isolasi eksosom. Terjadi peningkatan ekspresi reseptor NKp44, NKp46, NKp30, NKG2D, penurunan ekspresi NKG2A, serta peningkatan ekspresi perforin dan granzyme B pada sel NK terinduksi eksosom. Tidak ada interaksi sel berupa sinapsis imun antara sel NK terstimulasi eksosom dengan fraksi sel mononuklear lain pasien karsinoma hepatoseluler. Stimulasi eksosom ke sel NK pasien karsinoma hepatoseluler memulihkan kemampuan sitotoksik sel NK.

Hepatocellular carcinoma has a poor prognosis due to limitations of therapy such as late diagnosis, lack of specific biomarkers, and insensitivity to this tumor agent. Autologous NK cell-based immunotherapy with exosome stimulation is a modality for developing NK cell-based immunotherapy for hepatocellular carcinoma patients. NK cells from hepatocellular carcinoma patients were isolated from peripheral venous blood, and exosomes were isolated from the blood serum of healthy donors. Exosome characterization with a particle size analyzer and flow cytometry. Stimulation of exosomes on NK cells for 24 hours, then evaluation of expression of NKp44, NKp46, NKp30, NKG2D, KIR2D, and NKG2A receptors, as well as perforin and granzyme B expression. Visualization of interactions of NK cells with other mononuclear cell fractions (CD4, CD8, CD11c, and CD19) by immunofluorescence. Particle size < 100 nm, negative electric charge, and CD63+CD81+ (double positive) exosome isolated results. There was increased expression of receptors NKp44, NKp46, NKp30, NKG2D, decreased expression of NKG2A, and increased expression of perforin and granzyme B in exosome-induced NK cells. There was no cell interaction in the form of immune synapses between exosome-stimulated NK cells and other mononuclear cell fractions in hepatocellular carcinoma patients. Stimulation of exosomes into NK cells of hepatocellular carcinoma patients restores the cytotoxic ability of NK cells."
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2023
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Fina Widia
"ABSTRAK
Karsinoma sel ginjal terhitung sekitar 3% dari kanker pada orang dewasa dan 85% dari semua keganasan primer ginjal. Tumor ini biasanya tidak memberikan gejala hingga penyakit sudah berada pada stadium lanjut. Metastasis pada kelenjar getah bening dan metastasis jauh diketahui merupakan faktor prognostik yang penting pada karsinoma sel ginjal. Parameter klinis diperlukan untuk memprediksi metastasis sebelum operasi. Penelitian ini merupakan penelitian prospektif dengan mengambil data dari rekam medis dari Januari 1995 hingga Desember 2015 di Rumah Sakit Cipto Mangunkusumo. Penelitian ini mengevaluasi faktor prediktif klinis untuk kejadian metastasis pada karsinoma sel ginjal.

ABSTRACT
Renal cell carcinoma (RCC) accounts for about 3% of cancers in adults as well as 85% of all primary malignancies arising from the kidney. RCC is commonly large at presentation and symptoms may not occur until relatively late in the disease. Lymph node and distant metastases were known as the prognostic factor in renal cell carcinoma. Clinical parameters are needed to predict the metastases preoperatively. This is a prospective-analytic using medical record data from January 1995 - December 2015 at Cipto Mangunkusumo Hospital. This study evaluate clinical predictive factors for metastatic renal cell carcinoma incidence;"
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UI - Tugas Akhir  Universitas Indonesia Library
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Hafizar
"Pendahuluan dan tujuan: Renal cell carcinoma (RCC) adalah tumor paling umum kedua pada sistem urologi. Sampai saat ini, satu-satunya pendekatan kuratif bagi mereka yang memiliki RCC lokal adalah operasi radikal; namun, kejadian rekurensi setelah nefrektomi memadai telah dilaporkan terjadi sebanyak 20 hingga 40% dari pasien dengan RCC lokal. Penelitian ini bertujuan untuk menyelidiki karakteristik dan kesintasan hidup pasien dengan RCC yang menjalani nefrektomi.
Metode: Kami menggunakan desain studi retrospektif dengan mengevaluasi rekam medis pasien yang didiagnosis dengan RCC yang menjalani tindakan bedah di Rumah Sakit Cipto Mangunkusumo, Rumah Sakit Kanker Dharmais, Rumah Sakit Medistra, dan Rumah Sakit Metropolitan Medical Centre, Jakarta, Indonesia selama periode Januari 1994 hingga Desember 2016.
Hasil: Usia rata-rata pasien saat operasi dilakukan adalah 52,92 ± 14,85, dan 114 (71,7%) subyeknya adalah laki-laki. Lima puluh dua (32,7%) subyek dengan pT2 RCC, dan tiga puluh lima (22%) subyek dengan patologis stadium 2. Seratus empat puluh tujuh (92,4%) subyek memiliki clear cell RCC. Kesintasan hidup rata-rata adalah 8,37 (0,1-143) bulan.
Kesimpulan: Angka median kesintasan pasien karsinoma sel ginjal (RRC) yang menjalani nefrektomi adalah 8,37 bulan, yang menunjukkan bahwa perawatan lebih lanjut diperlukan untuk meningkatkan tingkat kelangsungan hidup populasi ini. Namun, penelitian ini dibatasi oleh sifat studi retrospektif dan jumlah subjek yang terbatas. Studi acak, terkontrol, multicenter, yang lebih besar diperlukan untuk mengevaluasi angka kesintasan pasien RCC.

Introduction and objectives: Renal cell carcinoma (RCC) is the second most common urologic tumour. To this date, the only curative approach for those with localised RCC is radical surgery; yet, the development of disease recurrence after adequately performed nephrectomy has been reported in 20 to 40% of those with localised RCC. The present study aims to investigate the characteristics and survival of those with RCC undergoing nephrectomy.
Methods: We used retrospective study design by evaluating the medical records of patients diagnosed with RCC who were treated surgically at Cipto Mangunkusumo Hospital, Dharmais Cancer Hospital, Medistra Hospital, and Metropolitan Medical Centre Hospitals, Jakarta, Indonesia during the period from January 1994 to December 2016.
Results: The mean age at surgery of the subjects was 52.92 ± 14.85, and 114 (71.7%) subjects were male. Fifty-two (32.7%) subjects had pT2 RCC, and thirty-five (22%) of the subjects had pathologic stage of 2. One hundred and forty-seven (92.4%) subjects had clear cell RCC. The median survival was 8.37 (0.1-143) months.
Conclusion: The median survival of those with renal cell carcinomas (RCCs) who underwent nephrectomy was 8.37 months, which demonstrate that further treatment is required to increase the survival rate of these population. However, this study was limited by its retrospective nature and limited subjects. Larger multicenter controlled randomised studies are required to evaluate the survival of those with RCC.
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Jakarta: Fakultas Kedokteran Univesitas Indonesia, 2021
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UI - Tugas Akhir  Universitas Indonesia Library
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