Hasil Pencarian  ::  Simpan CSV :: Kembali

Hasil Pencarian

Ditemukan 8 dokumen yang sesuai dengan query
cover
Thomas Agus Bayu Prasetyo
Studi kasus korosi pipa kondensat ASTM A53-B yang dilapisi material calcium silicate = Thermal insulation material affect in the surface corrosion of condensate pipe ASTM A53-B
"Korosi adalah sebuah produk yang dihasilkan oleh sebuah reaksi kimia antara mineral dengan oksigen dalam bentuk oksida yang sangat merugikan. Proses terjadinya korosi permukaan pada peralatan yang di bungkus isolasi tahan panas sulit dideteksi secara fisik dari luar sehingga kerusakan baru diketahui apabila sudah terjadi kegagalan pada saat peralatan atau sistim sudah mengalami kebocoran.
Penelitian terhadap produk korosi beserta material isolasi tahan panas di daerah produk korosi dilakukan untuk mengidentifikasi mekanisme korosi yang terjadi pada permukaan pipa. Dengan menggunakan alat uji laboratorium XRF, XRD dan TG-DTA dapat diketahui kandungan material pada produk korosi beserta material isolasi tahan panas yang terpasang serta perilaku peruraian kandungan material sehingga dapat dibandingkan dengan material aslinya.
Korosi permukaan pada pipa kondensat ASTM A53-B yang teijadi dilapangan adalah akibat adanya air (H2O) yang diserap oleh material isolasi tahan panas calcium silicate (CaSiOj) sehingga membentuk calcium hydroxide (Ca(OH)2), disamping itu kondisi operasional sistim yang mengalami perubahan temperatur berulang-ulang (cyclic) juga memiliki kontribusi mempercepat terjadinya proses korosi. Air yang masuk melalui celah pelapis luar material isolasi tahan panas akan menimbulkan senyawa baru dan mengakibatkan terjadinya korosi permukaan pipa seperti yang didapatkan dari pengujian sample didapatkan calcium yang terkandung dalam produk korosi.
Corrosion is product of a Chemical reaction between mineral and oxygen in term of destructive oxide. Visually, surface corrosion in most of equipment which covered by thermal insulation material are undetectable, consequently that any failures will be recognize only after leakage take in place.
Study of the corrosion product including thermal insulation material around corrosion product had been done to identify corrosion mechanism at pipe surface. By using laboratory test apparatus XRF, XRD and TG-DTA is able to identify corrosion Chemical product, thermal insulation material and thermal behavior as result of corrosion under insulation experiment.
Surface corrosion at existing condensate pipe ASTM A53-B is reaction product of water (H2O) and calcium silicate (CaSiO3) which produced calcium hydroxide (Ca(OH)i). In addition cyclic operation temperatures here proven to accelerate the corrosion process and water that found as absorbed by thermal insulation materials generates a new Chemical product which was found as calcium hydroxide at corrosion product."
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2009
T26350
UI - Tesis Open  Universitas Indonesia Library
cover
Thomas Agus Bayu Prasetyo
Studi Kasus Korosi Pipa Kondensat ASTM A53-B yang dilapisi Material Calcium Silicate
"Korosi adalah sebuah produk yang dihasilkan oleh sebuah reaksi kimia antara mineral dengan oksigen dalam bentuk oksida yang sangat merugikan. Proses terjadinya korosi permukaan pada peralatan yang di bungkus isolasi tahan panas sulit dideteksi secara fisik dari luar sehingga kerusakan baru diketahui apabila sudah terjadi kegagalan pada saat peralatan atau sistim sudah mengalami kebocoran.
Penelitian terhadap produk korosi beserta material isolasi tahan panas di daerah produk korosi dilakukan untuk mengidentifikasi mekanisme korosi yang terjadi pada permukaan pipa. Dengan menggunakan alat uji laboratorium XRF, XRD dan TG-DTA dapat diketahui kandungan material pada produk korosi beserta material isolasi tahan panas yang terpasang serta perilaku peruraian kandungan material sehingga dapat dibandingkan dengan material aslinya.
Korosi permukaan pada pipa kondensat ASTM A53-B yang teijadi dilapangan adalah akibat adanya air (H2O) yang diserap oleh material isolasi tahan panas calcium silicate (CaSiOj) sehingga membentuk calcium hydroxide (Ca(OH)2), disamping itu kondisi operasional sistim yang mengalami perubahan temperatur berulang-ulang (cyclic) juga memiliki kontribusi mempercepat terjadinya proses korosi. Air yang masuk melalui celah pelapis luar material isolasi tahan panas akan menimbulkan senyawa baru dan mengakibatkan terjadinya korosi permukaan pipa seperti yang didapatkan dari pengujian sample didapatkan calcium yang terkandung dalam produk korosi.
Corrosion is product of a Chemical reaction between mineral and oxygen in term of destructive oxide. Visually, surface corrosion in most of equipment which covered by thermal insulation material are undetectable, consequently that any failures will be recognize only after leakage take in place.
Study of the corrosion product including thermal insulation material around corrosion product had been done to identify corrosion mechanism at pipe surface. By using laboratory test apparatus XRF, XRD and TG-DTA is able to identify corrosion Chemical product, thermal insulation material and thermal behavior as result of corrosion under insulation experiment.
Surface corrosion at existing condensate pipe ASTM A53-B is reaction product of water (H2O) and calcium silicate (CaSiO3) which produced calcium hydroxide (Ca(OH)i). In addition cyclic operation temperatures here proven to accelerate the corrosion process and water that found as absorbed by thermal insulation materials generates a new Chemical product which was found as calcium hydroxide at corrosion product."
Universitas Indonesia, 2009
T40270
UI - Tesis Open  Universitas Indonesia Library
cover
Jennifer Fortiana
Efek penambahan steroid pada semen berbasis kalsium silikat terhadap viabilitas sel fibroblas = Effect of steroid addition in calcium silicate based cement on fibroblast cells viability
"ABSTRAK
Latar Belakang: Berbagai material kaping pulpa berbahan dasar kalsium silikat
terus dikembangkan, diantaranya semen berbasis kalsium silikat dengan
penambahan steroid. Tujuan: Menganalisis efek penambahan steroid pada semen
berbasis kalsium silikat terhadap viabilitas sel fibroblas. Metode: Sel fibroblas
embrio ayam direndam dalam ekstrak larutan semen berbasis kalsium silikat
dengan penambahan steroid dan MTA. Viabilitas sel dihitung dengan
menggunakan uji MTT. Hasil: Terdapat perbedaan bermakna (p ≤ 0,05)
viabilitas sel pada kelompok semen berbasis kalsium silikat dengan penambahan
steroid dibandingkan kelompok kontrol dan MTA. Kesimpulan: Penambahan
steroid menurunkan viabilitas sel. Terdapat peningkatan pada 72 jam, yang menandakan terjadinya proliferasi sel.ABSTRACT
Background: Calcium silicate based materials are being developed continuously,
one of them is calcium silicate based cement containing steroid. Objective: To
analyze the effect of steroid addition in calcium silicate based cement on
fibroblast cells viability. Methods: Chicken embryonic fibroblast cells were
immersed in extract solution of calcium silicate based cement containing steroid
and MTA. Viability was analyzed by MTT Assay. Results: Significant difference
(p ≤ 0,05) of viability on calcium silicate based cement containing steroid group
was found, compared to control and MTA group. Conclusion: Steroid addition
decrease viability. There was an increase in 72 hours, marking cells proliferation.;Background: Calcium silicate based materials are being developed continuously,
one of them is calcium silicate based cement containing steroid. Objective: To
analyze the effect of steroid addition in calcium silicate based cement on
fibroblast cells viability. Methods: Chicken embryonic fibroblast cells were
immersed in extract solution of calcium silicate based cement containing steroid
and MTA. Viability was analyzed by MTT Assay. Results: Significant difference
(p ≤ 0,05) of viability on calcium silicate based cement containing steroid group
was found, compared to control and MTA group. Conclusion: Steroid addition
decrease viability. There was an increase in 72 hours, marking cells proliferation.;Background: Calcium silicate based materials are being developed continuously,
one of them is calcium silicate based cement containing steroid. Objective: To
analyze the effect of steroid addition in calcium silicate based cement on
fibroblast cells viability. Methods: Chicken embryonic fibroblast cells were
immersed in extract solution of calcium silicate based cement containing steroid
and MTA. Viability was analyzed by MTT Assay. Results: Significant difference
(p ≤ 0,05) of viability on calcium silicate based cement containing steroid group
was found, compared to control and MTA group. Conclusion: Steroid addition
decrease viability. There was an increase in 72 hours, marking cells proliferation."
Fakultas Kedokteran Gigi Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
Stefani Astari Dewi Aryani
Perbedaan Kerapatan Siler Biokeramik Berbasis Kalsium Silikat Dengan Aktivasi Ultrasonik Terhadap Dinding Saluran Akar (Analisis Mikro-CT) = Differences on Sealing Ability of Bio-ceramic Calcium Silicate-Based Sealer with Ultrasonic Activation (Micro-CT Analysis)
"Latar Belakang: Pengisian saluran akar dengan teknologi terbaru siler premixed kalsium silikat pozolan dengan aktivasi ultrasonik dapat mengurangi porositas pengisian saluran akar. Reaksi pozolan menghasilkan siler dengan daya alir yang lebih baik dengan waktu pengerasan yang lebih cepat, terlebih dengan aktivasi ultrasonik yang akan mengurangi terbentuknya porositas dan meningkatkan kerapatan siler terhadap dinding saluran akar. Tujuan: Menganalisis perbedaan kerapatan siler berbasis kalsium silikat dan siler berbasis kalsium silikat pozolan dengan aktivasi ultrasonik dan tanpa aktivasi ultrasonik terhadap dinding saluran akar. Metode: Evaluasi kerapatan siler berbasis kalsium silikat dan kalsium silikat pozolan dengan aktivasi ultrasonik dan tanpa aktivasi ultrasonik terhadap dinding saluran akar pada 32 gigi premolar rahang bawah yang sudah diekstraksi yang dilihat dari persentase volume porositas pengisian saluran akar menggunakan dengan teknologi 3 dimensi Mikro-CT. Hasil: Siler berbasis kalsium silkat pozolan yang diaktivasi ultrasonik menunjukkan kerapatan siler saluran akar terhadap dinding saluran akar terbaik. Kesimpulan: Kerapatan siler berbasis kalsium silikat pozolan terhadap dinding saluran akar lebih baik dibandingkan siler berbasis kalsium silikat. Kerapatan siler yang diaktivasi ultrasonik terhadap dinding saluran akar juga lebih baik dibandingkan dengan yang tidak diaktivasi ultrasonik.
The latest technology of premixed calcium silicate pozzolan sealer with ultrasonic activation can reduce the porosity of root canal filling. Pozzolan reaction allows the sealer with better flow capacity with faster hardening time, especially with ultrasonic activation which will reduce the formation of porosity and increase sealing ability of root canal filling. Objective: Analyzing differences in sealing ability of calcium silicate-based sealers and calcium silicate pozzolan-based sealers with ultrasonic activation and without ultrasonic activation with 3D Micro-CT analysis. Methods: 32 samples of single rooted lower premolar were given root canal filling using gutta percha and calcium silicate-based sealers and with or without ultrasonic activation. Sealing ability was evaluated by measuring total porosity of the root canal filling. Group 1: calcium silicate-based sealer without ultrasonic activation, group 2: calcium silicate-based sealer with ultrasonic activation, group 3: calcium silicate pozzolan-based sealer without ultrasonic activation, and group 4: calcium silicate pozzolan-based sealer with ultrasonic activation. Result: Ultrasonic activated calcium silicate pozzolan-based showed the best sealing ability with lowest porosity. Conclusion: Calcium silicate pozzolan-based sealers have better sealing ability compared to calcium silicate-based sealers. The ultrasonic activated sealer groups also showed better sealing ability compared to the one that was not activated by ultrasonic."
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2019
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
cover
Raissa Ardelia Ahimsa
Adaptasi Siler Berbahan Dasar Kalsium Silikat dan Resin Epoksi pada Sepertiga Tengah Dinding Saluran Akar = Adaptation of Calcium Silicate and Epoxy Resin Sealers in Middle Third of Root Canal Wall
"

Latar Belakang: Siler kalsium silikat bersifat hidrofilik, berikatan secara kimia ke dentin,  membentuk hidroksiapatit, memiliki waktu kerja dan settingideal, dan tidak terjadi penyusutan. Siler resin epoksi yang banyak digunakan saat ini memiliki kekurangan berupa adanya penyusutan saat mengeras. Evaluasi adaptasi siler dapat menentukan kemampuan kerapatan suatu siler. Salah satu metode untuk mengevaluasi kemampuan kerapatan siler adalah dengan Scanning Electron Microscopy (SEM). Tujuan: Menganalisis perbedaan adaptasi siler pada sepertiga tengah dinding saluran akar antara siler berbahan dasar kalsium silikat dengan resin epoksi.Metode: Tiga puluh dua sampel gigi premolar mandibula dibagi menjadi dua kelompok, yaitu kelompok 1: siler resin epoksi dan kelompok 2: siler kalsium silikat. Sampel dipreparasi dan diobturasi dengan siler berbahan dasar kalsium silikat dan resin epoksi. Selanjutnya, gigi dipotong vertikal dan disiapkan untuk analisis adaptasi siler menggunakan SEM. Data tersebut dianalisis secara statistik dengan uji Chi-square. Hasil Penelitian: Tidak terdapat perbedaan bermakna antara adaptasi siler kalsium silikat dan resin epoksi secara statistik (p>0.05). Partikel resin epoksi secara keseluruhan tampak berukuran lebih besar dibandingkan dengan kalsium silikat. Kesimpulan: Tidak terdapat perbedaan adaptasi siler secara statistik antara siler berbahan dasar kalsium silikat dengan resin epoksi pada sepertiga tengah dinding saluran akar, namun secara klinis sampel siler kalsium silikat lebih sedikit menunjukkan gap/ celah dan lebih banyak yang berpenetrasi ke dalam tubuli dentin dinding saluran akar.

Background: Calcium silicate sealer is hydrophilic, chemically bonded to dentin, forms hydroxyapatite, has an ideal working and setting time, and does not shrink. The epoxy resin sealer that is widely used today has the disadvantage of shrinkage when hardening. Evaluation of the adaptation of the sealer can determine the sealing ability of a sealer. One of the method for evaluating the sealing ability of a sealer is Scanning Electron Microscopy (SEM). Objective: To analyze differences in the adaptation of sealers in middle third of root canal wall between the calcium silicate and epoxy resin based sealer. Methods: Thirty-two mandibular premolar teeth samples were divided into two groups, that are group 1: epoxy resin sealer and group 2: calcium silicate sealer. Samples were prepared and obturated with calcium silicate and epoxy resin based sealer. Next, the teeth were cut vertically and prepared for analysis of the sealer adaptation using SEM. The data was analyzed statistically by Chi-square test. Results: There was no significant difference between the adaptation of calcium silicate and epoxy resin sealer statistically (p> 0.05). Overall epoxy resin’s particles appear larger than calcium silicate. Conclusion: There was no statistical difference in the adaptation of sealers between calcium silicate and epoxy resin based sealer in middle third of root canal wall, but clinically fewer calcium silicate sealer samples showed gaps and more penetrated into dentinal tubules of root canal wall.

 

"
Depok: Fakultas Kedokteran Gigi Universitas Indonesia , 2019
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
cover
Indira Larasputri
Perbedaan Kemampuan Adhesi Siler Berbasis Kalsium Silikat Dan Resin Epoksi Terhadap Permukaan Dentin Saluran Akar = A Comparative Analysis of Adhesion Abilities between Calcium Silicate and Epoxy Resin based Sealers on Root Canal Dentine Surfaces
"Latar Belakang: Kemampuan adhesi siler terhadap dentin merupakan faktor penting dalam kesuksesan perawatan endodontik. Siler resin epoksi sebagai gold standart memiliki kemampuan adhesi yang superior, tetapi tidak memiliki sifat bioaktif sehingga berkembang siler kalsium silikat. Tujuan: Membandingkan kekuatan push-out bond strength dan failure mode siler AH Plus® Bioceramic dan Ceraseal dengan siler AH Plus®. Metode: Tiga puluh gigi premolar dibagi menjadi tiga kelompok untuk preparasi dan pengisian saluran akar menggunakan siler AH Plus® Bioceramic (kelompok 1), Ceraseal (kelompok 2) dan siler AH Plus® (kelompok 3). Sampel diinkubasi selama tujuh hari pada suhu 37oC, kemudian dipotong pada area sepertiga apikal dan medial. Nilai push-out bond strength dan failure mode dianalisis. Hasil: AH Plus® Bioceramic memiliki perbedaan nilai push-out bond strength dan failure mode yang signifikan dibanding AH Plus® dan Ceraseal. Ceraseal dan AH Plus® tidak memiliki perbedaan nilai secara signifikan. Analisis gambaran failure mode oleh dua orang observer menunjukkan reliabilitas data yang tinggi. AH Plus® Bioceramic memiliki dominasi kegagalan campuran, sedangkan Ceraseal dan AH Plus® memiliki persentasi kegagalan campuran dan kohesif yang seimbang. Kesimpulan: Seluruh kelompok siler menunjukkan kemampuan adhesi yang baik terhadap permukaan dentin, meskipun nilai push-out bond strength siler AH Plus® Bioceramic paling rendah diantara seluruh kelompok.
Background: The adhesion of sealers to dentin is important for successful endodontic treatment. As the gold standard, epoxy resin sealers have superior adhesion, but lack bioactive properties, hence the development of calcium silicate sealers. Objective: To compare the push-out bond strength and failure mode of AH Plus® Bioceramic and Ceraseal sealers with AH Plus® Sealer. Methods: Thirty premolars were divided into three groups for root canal preparation and obturation with AH Plus® Bioceramic (group 1), Ceraseal (group 2), and AH Plus® (group 3). The samples were incubated at 37°C for seven days, then cut at the apical and medial third. Push-out bond strength and failure mode were analyzed. Results: AH Plus® Bioceramic demonstrated significant differences in push-out bond strength and failure mode values compared to AH Plus® and Ceraseal. Ceraseal and AH Plus® were not significantly different. Analysis of failure mode descriptions by two observers showed high data reliability. AH Plus® Bioceramic had a predominance of mixed failures, whereas Ceraseal and AH Plus® had equal percentages of mixed and cohesive failures. Conclusion: All sealer groups showed good adhesion to the dentin surface, although the push-out bond strength value of AH Plus® Bioceramic sealer was the lowest among the groups."
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2023
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
cover
Swesty Mahardhini
Perbedaan Kekuatan Adhesi Pasak Fiber Pada Perawatan Saluran Akar Menggunakan Siler Berbasis Resin Epoksi Dan Kalsium Silikat = The Difference of Fiber Post Adhesion Strength in Endodontic Treatment Using Epoxy Resin and Calcium Silicate-based Root Canal Sealer
"Latar Belakang: Penggunaan bahan semen (siler) saluran akar dengan kandungan dan karakteristik berbeda diduga dapat memengaruhi retensi pasak fiber terhadap dinding saluran akar pasca perawatan endodontik. Tujuan : Mengetahui perbedaan kekuatan adhesi pasak fiber pada perawatan saluran akar yang menggunakan siler berbasis resin epoksi dan kalsium silikat. Metode: 30 gigi premolar bawah akar tunggal didekoronasi, dilakukan preparasi saluran akar, lalu dibagi menjadi 3 kelompok; Kelompok 1 (kontrol): gigi tanpa pengisian saluran akar, Kelompok 2: gigi yang menggunakan siler resin epoksi (AH-Plus), dan Kelompok 3: gigi yang menggunakan siler berbasis kalsium silikat (Ceraseal). Setelah pengisian saluran akar, preparasi, dan pemasangan pasak fiber. Selanjutnya gigi dipotong pada area sepertiga tengah akar setebal 2 mm kemudian dilakukan uji push-out bond strength menggunakan Universal Testing Machine. Data dianalisis dengan tes One-way Anova dan post hoc Bonferroni. Hasil: Terdapat perbedaan bermakna nilai push-out bond strength antar kelompok semen resin resin epoksi dan kalsium silikat. Kesimpulan: Gigi yang melalui perawatan saluran akar menggunakan siler resin epoksi memberikan kekuatan adhesi pasak fiber yang lebih baik dibandingkan gigi yang menggunakan siler kalsium silikat.
Background: The use of root canal sealers with different composition and characteristics is thought to effect the retention of fiber post in root canal walls after endodontic treatment. Objective: To evaluate the difference of the fiber post adhesion strength after endodontic treatment using epoxy resin and calcium silicate based root canal sealer. Methods: 30 samples of single-rooted lower premolar were decoronated, got the root canal prepared, then divided into 3 groups; Group 1 (the controls): samples without root canal filling, Group 2 and 3, the canals were filled with gutta percha using epoxy resin (AH-Plus), and calcium silicate (Ceraseal)-based root canal sealer. After root canal obturation, the gutta percha were partly removed, prepared for post space, and then cemented with the fiber posts. Then 2 mm thick disk were cut from the middle root section and subjected to a push-out bond strength test. Data were analysed using the one-way ANOVA and post hoc Bonferroni test. Result: There was a significant difference in the push-out bond strength value between the epoxy resin and calcium silicate-based root canal sealer groups. Conclusion: The endodontic treated tooth previously using epoxy resin root canal sealer gave better fiber post adhesion strength compared to tooth that used calcium silicate based root canal sealer."
Depok: Fakultas Kedokteran Gigi Universitas Indonesia, 2020
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
cover
Adrian Himawan Singgih
Pengaruh dosis kumulatif metotreksat dan steroid terhadap kejadian osteoporosis sekunder pada anak dan remaja dengan leukemia limfoblastik akut = Influence of methorexate and steroid cumulative doses in secondary osteoporosis in children and adolescents with acute lymphoblastic leukemia
"Latar belakang. Anak dan remaja dengan leukemia limfoblastik akut (LLA) berisiko mengalami osteoporosis sekunder, salah satunya karena pemberian obat kemoterapi metotreksat dan steroid. Saat ini belum terdapat data prevalens osteoporosis sekunder pada anak dengan LLA di Indonesia dan bukti keterkaitan dosis kumulatif metotreksat dan steroid terhadap kejadian osteoporosis sekunder pada anak dengan LLA.
Tujuan. Mengetahui ada tidaknya kaitan antara dosis kumulatif metotreksat dan/atau steroid terhadap kejadian osteoporosis sekunder pada anak dan remaja dengan LLA.
Metode. Penelitian ini merupakan studi potong lintang terhadap 52 anak dan remaja dengan LLA yang sedang menjalani kemoterapi di Rumah Sakit dr. Cipto Mangunkusumo (RSCM). Pengambilan darah dan foto polos tulang belakang dilakukan untuk menilai parameter kesehatan tulang, serta pemeriksaan dual energy X-ray absorptiometry (DEXA) untuk menilai densitas mineral tulang. Analisis regresi logistik digunakan untuk menganalisis keterkaitan dosis kumulatif metotreksat dan steroid terhadap kejadian osteoporosis sekunder.
Hasil. Median usia subyek adalah 10 (7-14) tahun dengan lelaki 54% (n=52). Didapatkan kejadian osteoporosis sekunder 6/52 (11,5%) dan densitas mineral tulang rendah 11/52 (21,2%). Tidak didapatkan kaitan antara dosis kumulatif steroid (adjusted RP 0,474 [0,057-3,935], p = 0,489) dan dosis kumulatif metotreksat (adjusted RP 0,083 [0,006-1,126], p = 0,061)  dengan kejadian osteoporosis sekunder. Pasien berusia di bawah 10 tahun, memiliki kadar vitamin D rendah, dan status prepubertas memiliki kecenderungan mengalami osteoporosis sekunder.
Kesimpulan. Tidak didapatkan hubungan yang bermakna secara statistik antara dosis kumulatif steroid dan/atau metotreksat terhadap osteoporosis sekunder pada anak dan remaja dengan LLA.
Background. Children and adolescents with acute lymphoblastic leukemia (ALL) are at risk of secondary risk, one of which is the administration of chemotherapy drugs (methotrexate and steroids). Currently, there are no data on the prevalence of secondary osteoporosis in children with ALL in Indonesia and evidence about association between methotrexate and steroids with the incidence of secondary osteoporosis with ALL.
Objective. To determine whether there is an association between the cumulative dose of methotrexate and/or steroids on the incidence of secondary osteoporosis in children and adolescents with ALL.
Methods. This study was a cross-sectional study of 52 children and adolescents with ALL who were undergoing chemotherapy at the Cipto Mangunkusumo Hospital (CMH). Blood sampling and plain radiographs of the spine were performed to assess bone health parameters, as well as dual energy X-ray absorptiometry (DEXA) examination to assess bone mineral density. Logistic regression analysis was used to analyze the association between the cumulative dose of methotrexate and steroids on the incidence of secondary osteoporosis.
Result. The median age of the subjects was 10 (7-14) years with 54% men (n=52). The incidence of secondary osteoporosis was 6/52 (11.5%) and low bone mineral density 11/52 (21.2%). There was no association between the cumulative dose of steroids (adjusted PR 1.501 [0.124-18.124], p=0.75) and the cumulative dose of methotrexate (adjusted PR 0.071 [0.005-0.951], p=0.05) and the incidence of secondary osteoporosis. None of the confounding factors (pubertal status, vitamin D levels, income level, age, and sex) were associated with secondary osteoporosis. Patient aged below 10 years old, have prepubertal status, and with low vitamin D serum tends to have osteoporosis more likely.
Conclusion. There was no statistically significant relationship between the cumulative dose of steroids and/or methotrexate on secondary osteoporosis in children and adolescents with ALL."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library