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Abstrak :
Pendahuluan: Pergerakan gigi ortodonti akan merangsang terjadinya proses inflamasi sehingga mengeluarkan mediator inflamasi. Prostaglandin E2 (PGE2) adalah salah satu mediator inflamasi yang dikeluarkan selama pergerakan ortodonti dan berperan dalam resorpsi tulang. Proses inflamasi ini terjadi pada semua pergerakan ortodonti termasuk pada penggunaan sistem self-ligating. Walaupun sistem self-ligating diklaim banyak memiliki keuntungan, termasuk efeknya pada ligamen periodontal, akan tetapi belum ada penelitian secara biomolekular yang membandingkan mediator inflamasi dalam ligamen periodontal. Metode: Duabelas pasien dari klinik ortodonti, FKG-UI, dengan kasus nonekstraksi dan indeks iregularitas pada insisif mandibula sebesar 4-9 mm, mendapatkan perawatan ortodonti dengan sistem self-ligating pasif (Damon Q, Ormco) dan sistem konvensional preskripsi MBT (Agile, 3M). Cairan krevikular gingiva diambil dari sisi labial regio insisif mandibula pada 0 jam (sebagai kontrol), 24 jam, dan 4 minggu. Kadar PGE2 diperiksa menggunakan ELISA. Hasil: Walaupun secara statistik tidak terdapat perbedaan kadar PGE2 pada pemakaian braket self-ligating dibandingkan dengan konvensional pada 0 jam, 24 jam (p=0,815), dan 4 minggu (p=0,534), namun secara deskriptif kelompok selfligating memiliki kadar PGE2 lebih tinggi dari konvensional secara konsisten pada 0, 24jam, dan 4 minggu. Pada waktu 24 jam, kadar PGE2 meningkat dibandingkan saat 0 jam, pada kedua sistem, dan kadar PGE2 pada kelompok self-ligating pasif (302,55±26,33 pg/ mL) lebih besar daripada kelompok konvensional (264,43±83,08 pg/mL). Pada waktu 4 minggu, kadar PGE2 menurun dibandingkan dengan waktu pengambilan 0 jam dan 24 jam, pada kedua kelompok sistem, dan kadar PGE2 pada kelompok self-ligating (236,17±42,63 pg/mL) lebih besar dari kelompok konvensional (208,267±81,83 pg/mL). Kesimpulan: Penelitian kami menyimpulkan bahwa sistem self-ligating memberikan respon selular yang berbeda dibandingkan sistem konvensional. ......Introduction: Inflammation process, as a result of orthodontic tooth movement, will trigger the release of inflammatory mediator. Prostaglandin E2 (PGE2) is one of the inflammatory mediator that is released during the orthodontic movement and plays an important role in bone resorption. These inflammatory process occurred in all orthodontic movement included in orthodontic treatment using self-ligating system. Although self-ligating system?s advantages have been claimed, including the effect of the system in periodontal ligament, there are still no research in biomolecular level comparing the mediator release in periodontal ligament. Objective: The purpose of this study was to examine PGE2 concentration in gingival crevicular fluid (GCF) during initial alignment of anterior mandible, using two different system brackets, passive self-ligating and conventional bracket. Methods: Twelve patients with mandibular incisor irregularities of 4 to 9 mm and prescribed nonextraction cases, from orthodontic clinic, faculty of dentistry, Universitas Indonesia, were having orthodontic treatment. They were divided into 2 groups, each group were using Damon passive self-ligating system (Damon Q, Ormco), and conventionally ligated bracket with MBT?s prescription (Agile, 3M). GCF were taken from labial site of mandibular incisors at 0 hour (served as control), 24 hours, and 4 weeks. PGE2 level was determined using ELISA kit. Results: There was no statistically difference in PGE2 level in self-ligating system group compared with conventional group, at 0, 24 hours, and 4 weeks, but from descriptive view self-ligating group had higher PGE2 levels than conventional at 0, 24 hours, and 4 weeks. At 24 hours, mean of PGE2 level was elevated from 0 hour, in both groups, and mean of PGE2 level was higher in self-ligating group (302,55±26,33 pg/ mL) than conventional group (264,43±83,08 pg/mL). At 4 weeks, mean of PGE2 level was decrease from 0, and 24 hours in both groups, and mean of PGE2 level was still higher in self-ligating group (236,17±42,63 pg/mL) than conventional group (208,267±81,83 pg/mL). Conclusion: Our findings suggest that self-ligating giving difference cellular response than conventional systems during orthodontic tooth movement

Abstrak :
ABSTRAK
Pendahuluan: Pergerakan gigi pada perawatan ortodontik merupakan kombinasi proses resorbsi dan aposisi sehingga terjadi remodelling tulang. Gaya ortodontik menyebabkan keluarnya mediator inflamasi seperti interleukin-1β dari ligamen periodontal dan tulang alveolar sehingga merangsang resorbsi tulang. Salah satu tren ortodontik saat ini adalah pemakaian braket self-ligating, yang dianggap memiliki keunggulan dibandingkan dengan braket konvensional. Penelitian klinis menunjukkan bahwa dengan braket self-ligating waktu perawatan lebih cepat, nyeri berkurang, dan kerusakan periodontal minimal dibandingkan dengan braket konvensional. Saat ini belum pernah ada penelitian dari aspek biologi molekuler yang membandingkan kedua sistem braket ini dengan indikator interleukin-1β. Tujuan dari penelitian ini adalah untuk mengetahui kadar IL-1 β pada perawatan ortodontik menggunakan self-ligating dan konvensional. Metode: 12 pasien baru klinik ortodonti FKG-UI, dengan derajat crowding 4- 9mm pada anterior mandibula, dibagi menjadi 2 kelompok menggunakan selfligating dan konvensional. Subyek tidak memiliki penyakit periodontal dan penyakit sistemik yang terkait dengan kerusakan tulang. Sampel diambil dari cairan krevikular gingiva pada 0, 24jam, dan 4minggu setelah pemberian gaya, kemudian diperiksa konsentrasi total IL-1 β menggunakan ELISA. Hasil: Tidak terdapat perbedaan kadar IL-1β yang bermakna secara statistik pada pemakaian braket self-ligating dibandingkan dengan braket konvensional pada 0 jam (p=0,093), 24 jam (p=0,327), dan 4 minggu (p=0,077), namun kelompok braket self-ligating secara konstan memiliki rata-rata kadar IL-1β yang lebih tinggi dibanding kelompok braket konvensional pada 24 jam (73,27±27,80 pg/ml dan 56,45±28,76 pg/ml), dan 4 minggu (62,27±25,46 pg/ml dan 37,29±17,13 pg/ml)

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Abstract
Introduction: Tooth movement in orthodontic treatment resulting from resorption and apposition process that leads to bone remodeling. Orthodontic force will trigger the release of inflammatory mediators such as interleukin-1β from the periodontal ligament and alveolar bone to stimulate bone resorption. One current trend is the use of self-ligating bracket, which is considered to have more advantages compared with conventional bracket. Clinical studies have shown that the using of self-ligating bracket will reduce treatment time, causing less pain, and minimal periodontal damage compared with the conventional bracket. Until date, none of the research comparing IL-β as an indicator of inflammation between two bracket systems were done. The purpose of this research is to detect the IL-1 β level on orthodontic treatment using self-ligating and conventional brackets. Methods: 12 patients from orthodontic clinic faculty of dentistry Universitas Indonesia, with the degree of crowding 4-9mm in the anterior mandible, divided into 2 groups using self-ligating and conventional. The subjects did not have periodontal disease and systemic diseases associated with bone destruction. Samples taken from gingival crevicular fluid at 0, 24h, and 4week after giving force, and then examined the concentration and total IL-1 β using ELISA. Results: There were no statistically differences found in IL-1β level beetween self-ligating compared with conventional brackets in 0 hour (p=0,093), 24 hour (p=0,327), and 4 weeks (p=0,077) but self-ligating group contantly had higher levels of IL-1β than the conventional at 24h (73,27±27,80 pg/ml versus 56,45±28,76 pg/ml), and 4 weeks (62,27±25,46 pg/ml versus 37,29±17,13 pg/ml) Conclusion: There are differences in the cellular response beetween the use of self-ligating brackets and conventional brackets