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ABSTRAK Latar belakang dan tujuan. Penggunaan antibiotik pada akne vulgaris (AV) saat ini
dihadapi permasalahan resistensi Propionibacterium acnes (PA) dan bakteri lain
yang berperan pada AV. Data pola resistensi AVS dan AVB di RS Cipto
Mangunkusumo (RSCM) tahun 2006 menunjukkan adanya resistensi PA terhadap
eritromisin (63,2%), klindamisin (57,9%), dan tetrasiklin (47,4%). Tidak ditemukan
PA yang resisten terhadap doksisiklin maupun minosiklin. Penggunaan antibiotik
pada AV dapat menyebabkan perubahan pola resistensi sehingga penelitian ini
bertujuan memberikan data terbaru mengenai pola bakteri dan resistensinya terhadap
antibiotik lini pertama pada AVS dan AVB di Departemen Ilmu Kesehatan Kulit dan
Kelamin RSCM, yaitu tetrasiklin, doksisiklin, minosiklin, klindamisin dan
eritromisin.
Metode. Penelitian ini merupakan penelitian deskriptif dengan desain potong lintang.
Spesimen untuk kultur dan uji resistensi didapatkan dari ekstraksi komedo tertutup
yang selanjutnya dibiakkan secara aerob dan anaerob. Pemeriksaan uji resistensi
dilakukan secara kuantitatif dengan menggunakan MIC strip test.
Hasil. Dari 91 subjek, bakteri yang ditemukan terdiri atas PA 11,0%, Staphylococcus
epidermidis (SE) 50,5%, Staphylococcus aureus (SA) 7,7% dan bakteri lain sebesar
40,7% (aerob) dan 19,8% (anaerob). Sebagian kecil PA (10%) resisten terhadap
tetrasiklin, klindamisin, dan eritromisin. Tidak ditemukan PA yang resisten terhadap
doksisiklin dan minosiklin. Bakteri SE resisten terhadap eritromisin (65,2%),
klindamisin (52,2%), tetrasiklin (32,6%), dan doksisiklin (4,3%). Tidak ditemukan
SE yang resisten terhadap minosiklin. Sebagian kecil SA resisten terhadap
eritromisin (28,6%), doksisiklin (14,3%) dan klindamisin (14,3%). Tidak ditemukan
SA yang resisten terhadap tetrasiklin dan minosiklin.
Kesimpulan. Bakteri yang ditemukan pada pasien AVS dan AVB antara lain,
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, dan
Staphylococcus aureus 7.7%. Bakteri paling banyak ditemukan resisten terhadap
eritromisin dan ketiga bakteri tersebut seluruhnya masih sensitif terhadap minosiklin.
ABSTRACT Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
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