Hasil Pencarian  ::  Simpan CSV :: Kembali

"Hiperurisemia merupakan faktor risiko independen dari sindroma metabolik. Kadar asam urat dikontrol dengan allopurinol. Akan tetapi, pemakaiannya pada pasien sindroma metabolik berisiko menimbulkan severe cutaneous adverse reactions SCAR . Oleh sebab itu, penelitian eksperimental ini bertujuan untuk membandingkan aktivitas anti-hiperurisemia allopurinol dengan ekstrak etanol akar Acalypha indica terhadap perubahan kadar asam urat tikus hiperurisemia yang diinduksi dengan diet tinggi fruktosa dan kolesterol DTFK selama tujuh minggu. Dua puluh lima tikus dibagi menjadi lima kelompok, yaitu kelompok kontrol normal, kelompok DTFK, kelompok allopurinol 30 mg/kgBB, kelompok Acalypha indica 250 mg/kgBB, dan kelompok kombinasi allopurinol dan Acalypha indica. Periode terapi empat minggu akan disertai dengan DTFK. Hasil penelitian menunjukkan bahwa kelompok allopurinol memiliki peningkatan kadar asam urat terkecil, yaitu 1,2944 mg/dL SD 0,6884 mg/dL, sedangkan kelompok Acalypha indica menunjukkan peningkatan kadar asam urat, 1,8388 mg/dL SD 1,4842 mg/dL, yang tidak jauh berbeda dari kelompok DTFK, 1,7632 mg/dL SD 1,2625 mg/dL. Kelompok kombinasi menunjukkan peningkatan kadar asam urat yang tertinggi yaitu 2,2825 mg/dL SD 2,1969 mg/dL. Meskipun demikian, perbedaan ini tidak bermakna secara statistik. Hal ini dapat disebabkan oleh faktor variasi genetik pada tikus dan kurangnya dosis terapi Acalypha indica.

---

Hyperuricemia is an independent risk factor of metabolic syndromes. Allopurinol is used to control uric acid level. However, usage in patients with metabolic syndrome is associated with the risk of severe cutaneous adverse reactions SCAR. Therefore, this experimental study aims to compare the anti hyperuricemic activity of allopurinol with etanol extract of Acalypha indica towards uric acid levels alteration in hyperuricemic rats induced by high fructose and high cholesterol diet. Twenty five rats are divided into five groups, that is group normal diet group, DTFK group, allopurinol 30 mg kg bw group, g Acalypha indica 250 mg.kg bw group, and combination of allopurinol and Acalypha indica group. Treatment is given in four weeks with continuity of the high fructose and high cholesterol diet.

Results shows allopurinol group have the smallest increase in uric acid level, 1.2944 mg dL SD 0.6884 mg dL. Acalypha indica group shows similar increase in uric acid level with DTFK group, 1.8388 mg dL SD 1.4842 mg dL, and 1.7632 mg dL SD 1.2625 mg dL respectively. Combination group shows the highest increase in uric acid level, 2.2825 mg dL SD 2.1969 mg dL. However, these differences are not significant. This could be caused by the small dose of Acalypha indica and the possibility of rats rsquo genetic variation in the study."

"ABSTRAKLatar belakang: Hiperurisemia asimtomatik seringkali dianggap kondisi yang tidak berbahaya dan belum perlu ditatalaksana. Kadar asam urat yang tinggi merupakan faktor independen terjadinya peningkatan tekanan darah. Tekanan darah memiliki parameter fisiologis yang ditandai oleh fluktuasi dinamis dan kontinyu. Fluktuasi ini dinyatakan sebagai variabilitas tekanan darah (VTD). Pada kondisi normotensi variabilitas tekanan darah juga berubah-ubah. Beberapa penelitian telah menunjukkan variabilitas tekanan darah berperan dalam kejadian kardiovaskular. Agen anti hiperurisemia seperti allopurinol telah terbukti berperan dalam penurunan rerata tekanan darah. Meskipun demikian peran allopurinol terhadap variabilitas tekanan darah pada subyek hiperurisemia asimtomatik yang normotensi belum banyak diketahui.Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan allopurinol dengan perubahan variabilitas tekanan darah pada subyek hiperurisemia asimtomatik normotensiMetode: Sebanyak 37 subyek hiperurisemia asimtomatik yang normotensimenjalani pemeriksaan home blood pressure monitoring (HBPM)sebelum dan sesudah pemberian allopurinol 1x300 mg selama 8 minggu. Dilakukan analisa variabilitas tekanan darah pagi dan malam baik sebelum maupun sesudah terapi.Hasil: Pemberian allopurinol terbukti tidak bermakna dalam menurunkan variabilitas tekanan darah sistolik pagi dari 4.4±3.0 menjadi 3.8±2.1 (p 0,357), variabilitas tekanan darah sistolik malam dari 5.1± 2.7 menjadi 4.2± 2.2 (p 0,129), variabilitas tekanan darah diastolik pagi dari 4.3± 2.2 menjadi 4.0± 2.0 (p 0,531) dan variabilitas tekanan darah diastolik malam dari 4.1±1.5 menjadi 3.3±2.0 (p 0,063).Kesimpulan: Sesudah terapi allopurinol terdapat penurunan variabilitas tekanan darah sistolik dan diastolik pagi dan malam, meskipun secara statistik tidak bermakna

---

ABSTRACTBackground:Asymptomatic hyperuricemia is often considered a harmless condition and does not need to be managed. High level of serum uric acid is an independent factor in an increase of blood pressure. Blood pressure has physiological parameters that are characterized by dynamic and continuous fluctuation. This fluctuation is expressed as blood pressure variability (BPV). In normotensive condition, BPVchanges dynamically. Several studies have shown that BPV plays a role in cardiovascular events. Antihyperuricemia agents, such as allopurinol, have been shown to decrease mean blood pressure. Howeverthe role of allopurinol in BPV in normotensive subjects has not been established yet in prior studies.Objective: The aim of this study is to evaluate the association of Allopurinol administration and changes in blood pressure variability in asymptomatic hyperuricemia subjects with normotension.Methods:A total of 37 normotensive asymptomatic hyperuricemia subjects underwent a home blood pressure monitoring (HBPM) before and after administration of allopurinol 1x300 mg for 8 weeks. Variability of blood pressure was analyzed both daytime and nighttime.Results: The administration of allopurinol proved not significant in reducing morning-time systolic blood pressure variability from 4.4±3.0 to 3.8±2.1 mmHg (p 0,357), night-time systolic blood pressure variability from 5.1±2.7 to 4.2±2.2 mmHg (p 0,129), morning-time diastolic blood pressure variability from 4.3±2.2 to 4.0±2.0 mmHg (p 0,531) and night-time diastolic blood pressure variability from 4.1±1.5 to 3.3±2.0 mmHg (p 0,063)Conclusion: After allopurinol administration, there was a decrease in the variability of morning-time and night-time systolic and diastolic blood pressure, although not statistically significant."

"[Latar belakang : Fibrilasi atrium merupakan aritmia yang paling sering terjadipasca bedah pintas arteri koroner. Peningkatan stress oksidatif, inflamasi, aktivitasneurohormonal memiliki peran terhadap kejadian fibrilasi atrium pasca bedahpintas arteri koroner. Berbagai strategi farmakologis seperti antiaritmia,antiinflamasi, dan antioksidan sudah dipelajari untuk menurun risiko kejadianfibrilasi atrium pasca bedah pintas arteri koroner namun kejadian fibrilasi atriummasih tinggi. Allopurinol memiliki efek antioksidan, namun belum ada uji klinisyang mempelajari efek allopurinol terhadap kejadian fibrilasi atrium. Penelitianini bertujuan untuk menilai efek allopurinol terhadap kejadian fibrilasi atriumpasca bedah pintas arteri koronerMetode : Uji klinis randomisasi tersamar ganda dilakukan di Rumah SakitPembuluh Darah Harapan Kita (RSJPDHK) pada periode April ? Mei 2015.Pasien BPAK on-pump elektif yang diseleksi secara consecutive samplingkemudian dibagi menjadi dua kelompok yaitu kelompok allopurinol dankelompok plasebo dengan randomisasi blok. Subyek diberikan allopurinol 600 mg/ plasebo dosis tunggal sejak 1 hari sebelum operasi sampai hari ke-5 pascaoperasi. Dilakukan pengamatan kejadian fibrilasi atrium pasca operasi sampaipasien pulang dari perawatan.Hasil : Sebanyak 90 subyek diikutsertakan dalam penelitian, 45 subyek padamasing-masing kelompok. Kejadiaan fibrilasi atrium lebih rendah secarabermakna pada kelompok allopurinol (12 (26,7%) vs 22 (48,9%) p 0,030). Kesimpulan : Pemberian allopurinol perioperatif menurunkan kejadian fibrilasi atrium pasca bedah pintas arteri koroner.;Background : Atrial fibrillation is the most common arrhythmias after coronaryartery bypass surgery. Increased oxidative stress, inflammation, neurohormonalactivity has a role on the incidence of atrial fibrillation after coronary arterybypass surgery. Various pharmacological strategies such as antiarrhythmias, antiinflammatory,and antioxidant have been studied to decrease atrial fibrillationincident after coronary artery bypass surgery, but the incidence of atrialfibrillation is still high. Allopurinol has antioxidant effects, but there was noclinical trials that studied the effect of allopurinol on atrial fibrillation incidence.The aim of this study to assess allopurinol effect on the atrial fibrillation incidenceafter coronary artery bypass surgery. Methods: A double-blind randomized clinical trial conducted at the NationalCardiovascular Center Harapan Kita in Jakarta from April to May 2015. Electiveon-pump CABG patients were selected by consecutive sampling then divided intotwo groups: allopurinol and placebo groups with block randomization. Subjectsgiven allopurinol 600 mg / placebo single dose since 1 day before surgery untilthe 5th day post-surgery. The incidence of atrial fibrillation was observedpostoperatively.Results: A total of 90 subjects were included in the study, 45 subjects in eachgroup. Occurrence of atrial fibrillation was significantly lower in the allopurinolgroup (12 (26.7%) vs 22 (48.9%) p 0,030). Conclusion: Perioperative allopurinol reduced the incidence of atrial fibrillation after coronary artery bypass surgery., Background : Atrial fibrillation is the most common arrhythmias after coronaryartery bypass surgery. Increased oxidative stress, inflammation, neurohormonalactivity has a role on the incidence of atrial fibrillation after coronary arterybypass surgery. Various pharmacological strategies such as antiarrhythmias, antiinflammatory,and antioxidant have been studied to decrease atrial fibrillationincident after coronary artery bypass surgery, but the incidence of atrialfibrillation is still high. Allopurinol has antioxidant effects, but there was noclinical trials that studied the effect of allopurinol on atrial fibrillation incidence.The aim of this study to assess allopurinol effect on the atrial fibrillation incidenceafter coronary artery bypass surgery. Methods: A double-blind randomized clinical trial conducted at the NationalCardiovascular Center Harapan Kita in Jakarta from April to May 2015. Electiveon-pump CABG patients were selected by consecutive sampling then divided intotwo groups: allopurinol and placebo groups with block randomization. Subjectsgiven allopurinol 600 mg / placebo single dose since 1 day before surgery untilthe 5th day post-surgery. The incidence of atrial fibrillation was observedpostoperatively.Results: A total of 90 subjects were included in the study, 45 subjects in eachgroup. Occurrence of atrial fibrillation was significantly lower in the allopurinolgroup (12 (26.7%) vs 22 (48.9%) p 0,030). Conclusion: Perioperative allopurinol reduced the incidence of atrial fibrillation after coronary artery bypass surgery.]"

"Allopurinol sebagai purin analog dari hipoksantin dan merupakan inhibitor dari xanthine oksidase (XO) yang dapat menjadi salah satu obat hipertensi dengan menurunkan tekanan darah sistolik, diastolik, dan tekanan arteri rata-rata. Allopurinol pada tikus hipertensi yang diinduksi diet tinggi lemak. Penelitian ini menggunakan 30 ekor tikus yang dikelompokkan menjadi 6 kelompok. Lima kelompok tikus jantan Sprague-Dawley memberi makan makanan tinggi lemak selama enam minggu dan satu kelompok diberi pakan standar. Obat yang diberikan selama tujuh hari, satu kelompok hanya diberi diet tinggi lemak dan CMC 0,5% secara oral, satu kelompok diberi lemak tinggi dan ISDN 3,6 mg/200 g BB per oral, satu kelompok diberi diet tinggi lemak dan dosis Allopurinol 9 mg/200 g BB per oral, satu kelompok diberi diet tinggi lemak dan dosis Allopurinol 18 mg/200 g BB per oral, dan satu kelompok diberi diet tinggi lemak dan dosis Allopurinol 36 mg/200 g BB per oral. Diet tinggi lemak diberikan melalui pakan dengan komposisi terdiri dari pakan standar: kuning telur puyuh: HFCS: mentega (5: 3: 1: 1). Allopurinol mengurangi signifikansi darah pada tiga kelompok dosis (p <0,05). Semua dosis Allopurinol dan ISDN memberikan hasil yang relevan pada parameter tekanan darah dan kadar glukosa yang diperlukan pada hari terakhir pemberian obat. Berdasarkan hasil ini, Allopurinol memiliki efek potensial sebagai agen antihipertensi.

---

Allopurinol as a purine analogous to hypoxanthine and is an inhibitor of xanthine oxidase (XO) which can be one of the drugs for hypertension by lowering systolic, diastolic, and mean arterial blood pressure. Allopurinol in hypertensive rats induced by a high-fat diet. This study used 30 rats which were grouped into 6 groups. Five groups of Sprague-Dawley male rats fed high-fat foods for six weeks and one group was given standard feed. Drugs given for seven days, one group was only given a high-fat diet and 0.5% CMC orally, one group was given high fat and ISDN 3.6 mg/200 g BW orally, one group was given a high-fat diet and a dose of Allopurinol 9 mg/200 g BW orally, one group was given a high-fat diet and a dose of Allopurinol 18 mg/200 g BW orally, and one group was given a high-fat diet and Allopurinol dose 36 mg/200 g BW orally. A high-fat diet is provided through feeds with a composition consisting of standard feed: quail egg yolk: HFCS: butter (5: 3: 1: 1). Allopurinol reduced blood significance in three dose groups (p <0.05). All doses of Allopurinol and ISDN give relevant results on blood pressure parameters and glucose levels needed on the last day of drug administration. Based on these results, Allopurinol has a potential effect as an antihypertensive agent."

"Allopurinol merupakan obat golongan inhibitor enzim xanthine oksidase yang dijadikan sebagai agen terapi lini pertama dalam mengobati hiperurisemia dan gout. Namun, allopurinol dilaporkan memberikan efek samping berupa reaksi hipersensitivitas pada beberapa pasien yang mengonsumsi obat tersebut. Antosianin, salah satu senyawa turunan flavonoid diketahui memiliki peran penting terhadap penghambatan enzim xantin oksidase. Ubi jalar ungu yang memiliki nama latin Ipomoea batatas diketahui merupakan sumber antosianin yang tinggi. Pada penelitian sebelumnya, telah ditemukan bahwa antosianin terasilasi merupakan senyawa spesifik pada ubi jalar yang memiliki efek penghambatan terhadap enzim xantin oksidase. Pada karya tulis ini akan dijelaskan efek dan potensi antosianin terasilasi yang berasal dari Ipomoea batatas terhadap kerusakan ginjal dan inflamasi ginjal yang disebabkan akibat hiperurisemia yang diinduksi potasium oksonat yang berasal dari penelitian sebelumnya. Hasil penelitian sebelumnya, baik in vitro maupun in vivo menunjukkan hasil positif terhadap penurunan kadar asam urat dan perbaikan inflamasi ginjal oleh antosianin terasilasi yang dikombinasikan dengan allopurinol. Sehingga Ipomoea batatas disimpulkan memiliki potensi sebagai suplemen pendamping untuk terapi hiperurisemia dan gout. Kedepannya, dalam rangka merealisasikan suplemen Ipomoea batatas, masih terdapat hal yang harus diteliti dan dikembangkan lebih lanjut.

---

Allopurinol is a drug group of enzyme inhibitors of xanthine oxidase which is used as the first-line therapy agent in treating hyperuricemia and gout. However, Allopurinol is reported to provide side effects of hypersensitivity reactions in some patients who consume the drug. Antosianin, one of the known flavonoids derivative compounds has an important role in inhibition of xanthine oxidase enzyme. Purple sweet potato (Ipomoea batatas) is known to be a high source of anthocyanins. In previous studies, it has been found that acylated anthocyanin is a specific compound in sweet potato which has an inhibitory effect on the xanthine oxidase enzyme. In this paper will be described the effect and potential of acylated anthocyanin derived from Ipomoea batatas toward kidney injury and kidney inflammation caused by the potassium oxonate-induced hyperuricemia that originated from previous research. The results of previous studies, both in vitro and in vivo showed positive results against decreased uric acid levels and improved renal inflammation by the acylated anthocyanin combined with allopurinol. Ipomoea batatas deduced has the potential as an companion supplement to hyperuricemia and gout therapy. In the future, in order to realize the supplement of Ipomoea batatas, there are still things to be researched and developed further."

"Latar Belakang: Cedera reperfusi akibat dilepaskannya reactive oxygen species(ROS) saat penggunaan Cardiopulmonary bypass(CPB) dan kembalinya mengalir darah yang kaya oksigen pada miokard yang iskemia, dapat menyebabkan kerusakan miokard. Allopurinol sebagai penghambat xanthine oksidase, telah diteliti sebelumnya mengenai efektivitas dalam mengurangi cedera reperfusi pada bedah jantung terbuka yang belum menunjukkan hasil yang konklusif, meskipun pada beberapa penelitian memberikan hasil yang cukup baik pada pemulihan dari stunningmiokard, biomarker cedera reperfusi maupun kejadian atrial fibrilasi pascabedah (AFPB). Metilprednisolon juga dipakai untuk mengurangi efek inflamasi dan cedera reperfusi pada pasien bedah jantung terbuka karena perannya dalam menghambat secara indirek pengaktifan enzim NADPH oksidase.Tujuan penelitianini adalah untuk membandingkan efektifitas pemberian allopurinol peroral 600 mg pada malam hari dan 1 jam sebelum pembedahan dengan metilprednisolon intravena 15 mg/kgbb saat induksi anestesi dalam mengurangi cedera reperfusi pada bedah pintas arteri koroner.Metode: Telah dilakukan penelitian uji klinis acak tersamar ganda pada 42 pasien yang menjalani bedah pintas arteri koroner menggunakan CPB antara bulan Oktober 2019 hingga Maret 2020, yang dialokasikan ke dalam kelompok allopurinol atau kelompok metilprednisolon.Pemeriksaan biomarker cedera reperfusi dilakukan dengan pemeriksaan sampel darah malondialdehyde(MDA) yang dilakukan sesaat setelah pemasangan kateter vena sentral (basal) dan 5 menit setelah klem jepit aorta dilepas (pascareperfusi). Pemeriksaan MDA dilakukan dengan metode ELISA. Penilaian skor inotropik dan vasoaktif (SIV) dilakukan pada 24 jam pertama perawatan pascabedah. Sedangkan penilaian kejadian atrial fibrilasi pascabedah dilakukan selama 48 jam pertama pascabedah. Data yang diperoleh dianalisis dengan uji statistik yang sesuai dengan piranti lunak program SPSS 21. Uji hipotesis pada variabel kadar MDA akan menggunakan uji T tes tidak berpasangan bila sebaran data normal. Pada variabel skor inotropik dan vasoaktif akan menggunakan uji T test tidak berpasangan (bila sebaran data normal) atau dengan uji mann whitney(bila sebaran data tidak normal). Dan uji hipotesis untuk variabel kejadian AFPB menggunakan uji chi-squared(bila syarat x2terpenuhi) atau dengan uji fisher(bila syarat x2tidak terpenuhi).Hasil : 42 pasien yang menjalani bedah pintas arteri koroner yang memenuhi kriteria penerimaan, 40 pasien dianalisis karena 2 pasien meninggal sebelum 48 jam pertama pascabedah. Karakteristik demografi dan kadar MDA basal seimbang pada kedua kelompok. Peningkatan kadar MDA pascareperfusi lebih rendah pada pemberian allopurinol, namun secara statistik tidak berbeda bermakna (p=0,379). Nilai SIV pascabedah pada pemberian allopurinol secara statistik lebih rendah bermakna (median 6 vs 22, p=0,009). Kejadian AFPB pada kedua kelompok menunjukkan perbedaan yang tidak bermakna secara statistik (p=0,231).Simpulan : Allopurinol tidak lebih efektif daripada metilprednisolon dalam upaya mengurangi cedera reperfusi pada bedah pintas arteri koroner.

---

Background: Reperfusion injury due to the release of reactive oxygen species (ROS) when using cardiopulmonary bypass (CPB) and the return of oxygen-rich blood flow to ischemic myocardium after the release of aortic clamps, can cause myocardial damage. Allopurinol as an inhibitor of xanthine oxidase, has been studied previously about its effectiveness in reducing reperfusion injury in open heart surgery which shows inconclusive results, although in some studies it has given quite good results in recovery from myocardial stunning, biomarkers of reperfusion injuries and postoperative atrial fibrilation (POAF). Methylprednisolone is also used to reduce the effects of inflammation and reperfusion injury in open heart surgery patients because of its role in indirectly inhibiting the activation of the enzyme NADPH oxidase. The aim of this study was to compare the effectiveness of oral administration of allopurinol 600 mg at night and 1 hour before surgery with 15 mg/kg intravenous methylprednisolone during anesthesia induction in reducing reperfusion injury in coronary artery bypass surgery.

Methods: A double-blind randomized clinical trial study was conducted on 42 patients undergoing coronary artery bypass surgery using CPB between October 2019 and March 2020, which was allocated to the allopurinol group or the methylprednisolone group. Examination of biomarkers of reperfusion injury is carried out by examination of a blood sample of malondialdehyde (MDA) which is performed shortly after the installation of a central venous catheter (basal) and 5 minutes after the aortic clamp are removed (post-reperfusion). MDA examination is done by the ELISA method. Assessment of vasoactive-inotropic scores (VIS) was carried out in the first 24 hours of post-surgical treatment. While the assessment of the incidence of POAF was performed during the first 48 hours after surgery. The data obtained were analyzed by the appropriate statistical tests using SPSS 21 software program. Hypothesis testing on MDA variables will use the T test unpaired if the data distribution is normal. In the VIS variables will use the T test unpaired (if the data distribution is normal) or with the Mann Whitney test (if the data distribution is not normal). And hypothesis testing for POAF variables will use the chi-square test (if the x2 requirement are met) or with the fisher test (if the x2requirements are not met).

Results:42 patients who underwent coronary artery bypass surgery who met the admission criteria, 40 patients were analyzed because 2 patients died before the first 48 hours after surgery. Demographic characteristics and basal MDA levels were balanced in both groups. The increased levels of MDA post-reperfusion were lower in allopurinol administration, but the statistics were not significantly different (p = 0.379). The postoperative VIS value in the administration of allopurinol was significantly lower than in the administration of methylprednisolone (median 6 vs 22, p = 0.009). The incidence of AFPB in the two groups showed no differences were statistically significant (p = 0.231).

Conclusion:Allopurinol is not more effective than methylprednisolone in an effort to reduce reperfusion injury in coronary artery bypass surgery. "

"Latar Belakang: Reperfusi koroner sangat penting untuk menyelamatkan miokardium yang mengalami iskemia namun tindakan ini ternyata juga dapat mengakibatkan cedera miokardium yang dikenal sebagai jejas reperfusi Manifestasi klinisnya berupa komplikasi pasca BPAK diantaranya aritmia penurunan curah jantung dan perioperatif infark miokard Stres oksidatif merupakan salah satu inisiator utama kejadian jejas reperfusi Allopurinol sebagai inhibitor efektif enzim xantin oksidase dapat menurunkan stres oksidatif dengan menghambat pembentukan reactive oxygen species Sehingga diharapkan pemberian allopurinol pada pasien PJK dengan disfungsi ventrikel kiri yang akan menjalani BPAK dapat menurunkan kejadian komplikasi pasca operasiTujuan: Mengetahui efek allopurinol terhadap komplikasi pasca operasi BPAK low cardiac output syndrome yang dinilai dengan penggunaan inotropik dan IABP pasca operasi kematian dalam masa rawat perioperatif infark miokard dan aritmia pada pasien PJK dengan disfungsi ventrikel kiriMetode: Penelitian ini adalah uji klinis tersamar ganda 34 subjek dipilih secara konsekutif pada September November 2015 Subjek dibagi menjadi dua kelompok yaitu 16 orang mendapat allopurinol 600mg dan 18 orang mendapat plasebo Obat per oral diberikan 1 hari sebelum dan 6 jam sebelum operasi Pengamatan kejadian komplikasi pasca operasi dimulai sejak pelepasan klem silang aorta hingga pasien selesai perawatanHasil: Penggunaan inotropik dan IABP pasca operasi menunjukkan perbedaan yang bermakna pada kedua kelompok p 0 047 Ini berarti penggunaan allopurinol berpotensi mengurangi penggunaan inotropik dan IABP pasca operasi BPAK Proporsi kematian dalam masa rawat pasca operasi BPAK pada kedua kelompok tidak berbeda bermakna yaitu 6 25 vs 5 6 p 1 000 Sedangkan untuk kejadian aritmia pada kedua kelompok terdapat perbedaan bermakna dengan total proporsi 31 vs 66 p 0 039 dengan jumlah aritmia terbanyak pada kedua kelompok adalah fibrilasi atrium Kejadian perioperatif infark miokard tidak didapatkan pada penelitian ini sehingga efek pemberian allopurinol terhadap kejadian tersebut tidak dapat dinilaiKesimpulan: Pemberian allopurinol sebelum operasi pada pasien PJK dengan disfungsi ventrikel kiri berpotensi menurunkan kejadian low cardiac output syndrome LCOS yang terlihat dari rendahnya penggunaan obat inotropik dan IABP pasca operasi dan menurunkan kejadian aritmia pasca operasi BPAK

---

Background: Reperfusion of coronary blood flow is important to resuscitate the ischemic or hypoxic myocardium However the return of blood flow to the ischemic area can result paradoxical cardiomyocyte dysfunction this is referred to as ldquo reperfusion injury rdquo Clinical manifestations of reperfusion injury post CABG surgery are arrhythmias decrease cardiac output and perioperative myocardial infarct Oxidative stress has been confirmed as one of the main initiator in myocardial injury at ischemic and reperfusion state Allopurinol as an effective inhibitor of xanthine oxidase XO can reduce the oxidative stress by blocking the formation of reactive oxygen species ROS Pre operative allopurinol on CAD's patient with LV dysfunction is expected reduce the complications of post CABG surgery

Objective: To analyze effects of pre operative administration of allopurinol on complications of post CABG surgery low cardiac output syndrome which is measured by the use of post surgery inotropic and IABP hospital mortality perioperative myocardial infarction and arrhythmias in CAD's patient with LV dysfunction

Methods: This study is a double randomized clinical trial 34 CAD's patients with LV dysfunction were randomly selected by consecutive sampling methods from September November 2015 They were divided into two groups Sixteen patients were given 600 mg dose of allopurinol per oral one day before and 6 hours before surgery and the rest received placebo Complications of post CABG surgery were observed since the aortic cross clamp off until discharged

Results: The use of post surgery inotropic and IABP found significantly lower in allopurinol group p 0 047 There was no significant difference in proportion of death in post operative hospitalization period in both groups 6 25 vs 5 6 p 1 000 While for the incidence of arrhythmias was found significantly different in the two groups 31 vs 66 p 0 039 with atrial fibrillation as the most common arrhythmia No perioperative myocardial infarction was found in this study therefore effects of allopurinol to the event is unknown

Conclusions: Pre operative administration of allopurinol may reduce the complications of post CABG especially the use of inotropic and IABP and occurrence of arrhythmias"