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"Research on agents and multi-agent systems has matured during the last decade and many effective applications of this technology are now deployed. PAAMS provides an international forum to present and discuss the latest scientific developments and their effective applications, to assess the impact of the approach, and to facilitate technology transfer. PAAMS started as a local initiative, but has since grown to become the international yearly platform to present, to discuss, and to disseminate the latest developments and the most important outcomes related to real-world applications. It provides a unique opportunity to bring multi-disciplinary experts, academics and practitioners together to exchange their experience in the development and deployment of Agents and Multi-Agent Systems. PAAMS intends to bring together researchers and developers from industry and the academic world to report on the latest scientific and technical advances on the application of multi-agent systems, to discuss and debate the major issues, and to showcase the latest systems using agent based technology. It will promote a forum for discussion on how agent-based techniques, methods, and tools help system designers to accomplish the mapping between available agent technology and application needs. Other stakeholders should be rewarded with a better understanding of the potential and challenges of the agent-oriented approach. This edition of PAAMS brings together past experience, current work, and promising future trends associated with distributed computing, artificial intelligence and their application in order to provide efficient solutions to real problems."

"Reformasi birokrasi di Indonesia menjadi titik balik dari perbaikan sistem birokrasi di Indonesia yang dinilai buruk oleh masyarakat. Hadirnya Peraturan Menteri Pendayagunaan Aparatur Negara Nomor 27 Tahun 2014 tentang pedoman pembentukkan agen perubahan di instansi pemerintah menjadi kebijakan untuk mendukung percepatan pelaksanaan reformasi birokrasi di instansi pemerintah. Skripsi ini membahas tentang peran change agent dalam tahapan manajemen perubahan reformasi birokrasi di Bappenas. Peneliti menggunakan konsep yang dikemukakan oleh Lewins (1951) untuk menggambarkan tahapan manajemen perubahan serta peran agen perubahan yang dikemukakan oleh Havelock dan Havelock (1971). Pendekatan penelitian ini adalah penelitian postpositivist dengan jenis penelitian deskriptif, dan teknik pengumpulan data primer melalui wawancara. Hasil penelitian menunjukan bahwa peran agen perubahan sudah terpenuhi karena agen perubahan aktif terlibat dari proses unfreeze hingga refreeze. Selain itu, agen perubahan telah memenuhi tiga peran yang dikemukakan oleh Havelock dan Havelock (1971) dari unfreeze hingga refreeze yang terdiri dari peran agen perubahan sebagai katalisator, sebagai pemberi solusi, dan sebagai pihak yang membantu proses perubahan. Selain itu, agen perubahan perlu memiliki atribut – atribut untuk menunjang peranannya dalam melaksanakan perubahan dimana dalam pemilihan agen perubahan di Bappenas memenuhi dua atribut agen perubahan yang dikemukakan Weiss (2003) yaitu skills dan behavior. Kehadiran agen perubahan di Bappenas dinilai membantu proses percepatan reformasi birokrasi di Bappenas dikarenakan agen perubahan menjadi pihak yang menginternalisasikan dan memberikan pengaruh mengenai pentingnya perubahan di unit kerja

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Bureaucratic reform in Indonesia is a turning point in improving the bureaucratic system in Indonesia which is considered bad by the public. The presence of Regulation of the Minister of State Apparatus Empowerment Number 27 of 2014 concerning guidelines for the formation of agents of change in government agencies has become a policy to support the acceleration of the implementation of bureaucratic reform in government agencies. This thesis discusses the role of change agents in the management stage of change in bureaucratic reform at Bappenas. Researchers used the concept proposed by Lewins (1951) to describe the stages of change management and the role of change agents proposed by Havelock and Havelock (1971). This research approach is postpositivist research with descriptive research type, and primary data collection techniques through interviews. The results showed that the role of change agents has been fulfilled because change agents are actively involved from the unfreeze to refreeze process. In addition, change agents have fulfilled the three roles proposed by Havelock and Havelock (1971) from unfreeze to refreeze, which consist of the role of change agents as catalysts, as solution givers, and as process helper. In addition, change agents need to have attributes to support their role in implementing change, where the selection of change agents at Bappenas fulfills two attributes of change agents as stated by Weiss (2003), namely skills and behavior. The presence of agents of change at Bappenas is considered to be helping the process of accelerating bureaucratic reform at Bappenas because change agents become parties who internalize and give influence on the importance of change in work units"

"This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the book provides a unique opportunity to study, understand and apply discovery and development principles and learning without the need for an individual to research, analyze and synthesize all immense sourcing references. Topics showcase challenges and solutions of issues encountered, offeringtremendous experience accumulated over many years of research that will be particularly useful to basic and bench scientists as well as clinicians as they continue discovering and developing new drugs and therapies."

"Hingga saat ini masalah depresi masih tetap merupakan topik yang menarik dan hangat. Hal ini disebabkan karena masalahnya yang besar dan kompleks; meliputi antara lain gambaran klinis, klasifikasi diagnosis, distribusi kasus dan penanganannya.Penelitian yang dilakukan di Eropa dan Amerika menunjukkan sekitar 8-11 % pria dan 18-23 % wanita akan mengalami episode depresi disuatu saat dalam perjalanan hidupnya (5,22). WHO (World Health Organi zation) memperkirakan depresi dialami oleh 3 % penduduk dunia - 100.000.000 jiwa - dan menurut Sartorius (1979), dari tahun ke tahun angka tersebut akan terus meningkat (12,16).Khusus di Indonesia, penderita depresi secara klinis diperkirakan minimal 3.000.000 jiwa (Kusumanto S., Iskandar Y., 1985). Namun bila ditinjau menurut data yang ada, baik di Rumah Sakit Umum maupun Rumah Sakit Jiwa, ternyata angka depresi sangat kecil. Hal ini mungkin disebabkan karena masih banyak pasien, atau bahkan para dokter yang tidak mengenal dan menyangkal bahwa seseorang menderita depresi (15). Dalam pada itu data menunjukkan bahwa dari seluruh pasien yang berkunjung ke dokter, 10 % diantaranya terdiri dari pasien depresi dan separuhnya merupakan depresi dalam bentuk tersamar (12,18,21)."

"Agen penghambat beta telah menunjukkan penurunan resiko perawatan atau kematian pasien dengan gagal jantung ringan sampai sedang, tetapi hanya sedikit diketahui mengenai manfaat atau keamanan agen ini pada gagal jantung berat. Dilaporkan satu kasus penggunaan penghambat beta pada gagal jantung berat dengan fraksi ejeksi kurang dari 25%. Laporan manfaat penghambat beta terhadap kesakitan dan kematian pasien dengan gagal jantung ringan sampai sedang juga ditemukan pada pasien dengan gagal jantung berat seperti yang dilaporkan pada kasus ini. (Med J Indones 2002; 11: 174-5)

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Beta-blocking agents have been shown to reduce the risk of hospitalization and death in patients with mild to moderate heart failure, but little is known about the efficacy or safety of these agents in severe heart failure. A case of beta blocker administration in severe heart failure with ejection fraction less than 25% is reported. The reported benefits of beta blockers with regard to morbidity and mortality in patients with mild to moderate heart failure were also found in the patient with severe heart failure as reported in this case. (Med J Indones 2002; 11: 174-5)"