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Abstrak :
[ABSTRAK
Tujuan : Mengevaluasi ada tidaknya perbedaan kualitas air mata pada penderita glaukoma yang mengalami mata kering antara yang diberi tetes mata sodium hialuronat 0,1% mengandung bahan pengawet benzalkonium klorida dan tetes mata sodium hialuronat 0,1% tanpa bahan pengawet. Metode : Penelitian ini merupakan penelitian prospektif terandomisasi. 30 pasien glaukoma yang mengalami mata kering dirandomisasi ke dalam kedua kelompok. Kelompok pertama,mendapatkan obat tetes mata artificial tear mengandung sodium hialuronat 0,1% dengan pengawet benzalkonium klorida, sedangkan kelompok II, mendapatkan obat tetes mata artificial tear mengandung sodium hialuronat 0,1% tanpa pengawet selama 1 bulan. Pemeriksaan Schirmer test, TFBUT, OPI, dan sitologi impresi dilakukan pada kedua kelompok baik sebelum dan sesudah 1 bulan penetesan obat tetes mata artificial tear. Results: Nilai median sitologi impresi sel goblet pasca penetesan artificial tear meningkat pada kelompok I (118,15-485) dan kelompok II (67.0-200), namun secara statistik tidak ada perbedaan bermakna. Nilai rata ? rata TFBUT pasca penetesan pada kelompok I (14,45±7,85) dan kelompok II (13,91±7,46) meningkat dibandingkan sebelum penetesan, serta secara statitstik memiliki perbedaan yang bermakna. Nilai Schirmer test dan OPI pasca penetesan pada kedua kelompok mengalami peningkatan secara klinis dibandingkan sebelum penetesan, namun tidak terdapat perbedaan bermakna secara statistik. Conclusions : Pemberian artificial tear mengandung sodium hialuronat 0,1% baik dengan pengawet maupun tanpa pengawet selama 1 bulan memberikan peningkatan Schirmer test, TFBUT,OPI dan sitologi impresi sel goblet.

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ABSTRACT
Objectives: To evaluate the difference of quality of tears between glaucoma patients suffering from dry eyes treated with 0.1% sodium hyaluronat eyedrops with preservative benzalconiumchloride and those treated with 0.1% sodium hyaluronat eyedrops without preservative. Methods: This is a randomized prospective study. Subjects were 30 glaucoma patients suffering from dry eyes, whom later randomized into two groups. Group I was treated with artificial tears eye drops, which contained 0.1% sodium hyaluronat and benzalconium chloride preservative, whereas Group II was treated with artificial tears eye drops, which contained 0.1% sodium hyaluronat without preservative for one-month duration. Before and after the treatment with artificial tears eyedrops, subjects of both groups were tested with Schirmer test, TFBUT, OPI, and impression cytology. Results: The median of goblet cells in impression cytology after treatment with artificial tears eye drops increased in group I (118, 15 ? 485) and group II (67, 0 ? 200), even though not statistically significant. Mean TFBUT after treatment was also higher in Group I (14.45±7.85) and Group II (13.91±7.46), yet not statistically significant. Schirmer test and OPI results after treatment showed a clinical improvement in both groups, however no statistic result was found to be significant. Conclusions: Treatment with artifical tears eye drops containing 0.1% sodium hyaluronat with or without preservative for one month will improve Schirmer test, TFBUT, OPI, and goblet cells impressions cytology result on glaucoma patients suffering from dry eyes.;Objectives: To evaluate the difference of quality of tears between glaucoma patients suffering from dry eyes treated with 0.1% sodium hyaluronat eyedrops with preservative benzalconiumchloride and those treated with 0.1% sodium hyaluronat eyedrops without preservative. Methods: This is a randomized prospective study. Subjects were 30 glaucoma patients suffering from dry eyes, whom later randomized into two groups. Group I was treated with artificial tears eye drops, which contained 0.1% sodium hyaluronat and benzalconium chloride preservative, whereas Group II was treated with artificial tears eye drops, which contained 0.1% sodium hyaluronat without preservative for one-month duration. Before and after the treatment with artificial tears eyedrops, subjects of both groups were tested with Schirmer test, TFBUT, OPI, and impression cytology. Results: The median of goblet cells in impression cytology after treatment with artificial tears eye drops increased in group I (118, 15 – 485) and group II (67, 0 – 200), even though not statistically significant. Mean TFBUT after treatment was also higher in Group I (14.45±7.85) and Group II (13.91±7.46), yet not statistically significant. Schirmer test and OPI results after treatment showed a clinical improvement in both groups, however no statistic result was found to be significant. Conclusions: Treatment with artifical tears eye drops containing 0.1% sodium hyaluronat with or without preservative for one month will improve Schirmer test, TFBUT, OPI, and goblet cells impressions cytology result on glaucoma patients suffering from dry eyes., Objectives: To evaluate the difference of quality of tears between glaucoma patients suffering from dry eyes treated with 0.1% sodium hyaluronat eyedrops with preservative benzalconiumchloride and those treated with 0.1% sodium hyaluronat eyedrops without preservative. Methods: This is a randomized prospective study. Subjects were 30 glaucoma patients suffering from dry eyes, whom later randomized into two groups. Group I was treated with artificial tears eye drops, which contained 0.1% sodium hyaluronat and benzalconium chloride preservative, whereas Group II was treated with artificial tears eye drops, which contained 0.1% sodium hyaluronat without preservative for one-month duration. Before and after the treatment with artificial tears eyedrops, subjects of both groups were tested with Schirmer test, TFBUT, OPI, and impression cytology. Results: The median of goblet cells in impression cytology after treatment with artificial tears eye drops increased in group I (118, 15 – 485) and group II (67, 0 – 200), even though not statistically significant. Mean TFBUT after treatment was also higher in Group I (14.45±7.85) and Group II (13.91±7.46), yet not statistically significant. Schirmer test and OPI results after treatment showed a clinical improvement in both groups, however no statistic result was found to be significant. Conclusions: Treatment with artifical tears eye drops containing 0.1% sodium hyaluronat with or without preservative for one month will improve Schirmer test, TFBUT, OPI, and goblet cells impressions cytology result on glaucoma patients suffering from dry eyes.]

Abstrak :
Prevalensi populasi dan manifestasi penderita dry eye bervariasi. Aktivasi jalur pensinyalan stres pada permukaan epitel okuler, sel imun bawaan, dan sel imun adaptif akan meningkatkan produksi beberapa sitokin inflamatorik, seperti IFN-Y yang memicu apoptosis sel dan sekresi IL-17 yang melisis tight-junction, menginduksi perubahan epitel, mendestabilisasi lapisan air mata, mengamplifikasi inflamasi dan menciptakan siklus tak henti. Lutein merupakan golongan antioksidan Y-karotenoid yang terbukti memiliki efek protektif dan menghambat inflamasi yang diinduksi oleh berbagai stimulator in vitro dan in vivo. Pada penelitian ini dilakukan perbandingan kadar IFN-Y dan IL-17 pada model mencit dry eye tanpa diberi dan yang diberi suplementasi lutein selama 10 hari. Metode induksi dry eye dilakukan menggunakan kombinasi antara evaporatif dan insufisiensi lakrimal. Pengamatan kondisi akhir klinis dan perhitungan sel goblet didokumentasikan dan dihitung. Pengukuran kadar IFN-Y dan IL-17 dilakukan menggunakan ELISA. Hasil akhir menunjukkan adanya perbedaan signifikan kondisi klinis dan konsentrasi sel goblet model hewan coba antara kelompok tanpa lutein dan kelompok dengan pemberian lutein. Tidak ada perbedaan signifikan kadar IFN-Y dan IL-17 antar kelompok uji coba. Belum diketahui pasti efek langsung lutein terhadap kadar IFN-Y dan IL-17. Lutein memiliki tendensi untuk menurunkan inflamasi, melindungi jaringan permukaan okuler sel goblet, dan meregenerasi sel goblet. ......Population prevalence and manifestation of dry eye patient vary statistically. Activation of stress signaling pathways, residential immune cells, and adaptive immune cells on ocular epithelial surface will increase inflammatory cytokines, such as IFN-Y production which ignites cell apoptosis and IL-17 which lyses tight-junction, induces epithelial changes, destabilizes tear film, amplifies inflammation and creates an endless loop. Lutein is a Y-carotenoid antioxidant which has been proven to has protective and anti-inflammatory effect. This research compared IFN-Y and IL-17 levels between dry eye mice model without and with lutein supplementation for 10 days. Combination between evaporative and lacrimal insufficiency as dry eye induction method was choosen. Clinical condition and goblet cells concentration were documented and measured. IFN-γ and IL-17 measurements were done using ELISA. There were significant differences between clinical descriptions and goblet cell concentration between groups but there are no statistically significant differences in IFN-Y and IL-17 level between groups. There has been no specific direct effect of lutein on IFN-Y and IL-17 level. Lutein has tendencies to lower inflammation, protects ocular surface from dessication, and has potency to regenerates goblet cells.

Abstrak :
ABSTRAK Insidensi kolitis ulseratif di Indonesia mulai meningkat. Sedangkan etiologi penyakit tersebut masih belum jelas sehingga pengobatan saat ini masih bersifat simptomatik, jangka panjang, dan menimbulkan banyak efek samping. Tujuan dari penelitian ini adalah untuk membuktikan efek antiinflamasi ekstrak daun Ficus deltoidea pada kolon mencit yang diinduksi dekstran sodium sulfat (DSS). Penelitian dilakukan dengan menggunakan 24 sampel materi biologik tersimpan dari penelitian sebelumnya yang dibagi menjadi empat kelompok: kontrol negatif (DSS), kontrol positif (aspirin), ekstrak daun Ficus deltoidea dosis 25 mg, dan ekstrak daun Ficus deltoidea dosis 50 mg. Preparat histologis jaringan kolon diwarnai dengan pewarnaan hematoksilin-eosin (HE) dan diamati pada perbesaran 400x. Terdapat peningkatan sel goblet secara signifikan (p < 0,001) pada kelompok ekstrak daun Ficus deltoidea dosis 50 mg dibandingkan dengan kelompok kontrol negatif. Namun tidak terdapat perbedaan bermakna pada parameter fokus inflamasi dan angiogenesis.

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ABSTRACT The incidence of ulcerative colitis in Indonesia is increasing. While its etiology is still unknown, the current treatment is still symptomatic, long term, and causes many side effects. The purpose of this study is to confirm that Ficus deltoidea leaf extract has an antiinflammatory effect on DSS-induced mice colon. This study was conducted using 24 stored tissue samples from previous study which are divided into four groups: negative control (DSS), positive control (aspirin), Ficus deltoidea leaf extract at a dose of 25 mg, and Ficus deltoidea leaf extract at a dose of 50 mg. Colon tissue histology sample is stained with hematoxylin-eosin (HE) staining and examined on magnification of 400x. There is a significant increase number of goblet cells (p < 0,001) on the Ficus deltoidea leaf extract group at a dose of 50 mg compared to negative control group. However, there is no significant effect of Ficus deltoidea leaf extract on inflammation focus and angiogenesis.

Abstrak :
Pendahuluan: Kolitis ulserativa (UC) adalah peradangan kronis pada usus besar yang menyebabkan menyebabkan sakit perut, diare, dan perdarahan saluran cerna. Secara global, sekitar 1,2- 20,3 per seratus ribu penduduk mengalami UC. Pasien yang mengalami UC memiliki potensi Kekambuhan adalah 50% dan 20-30% di antaranya memerlukan operasi pengangkatan usus besar (kolektomi). Sampai saat ini, obat lini pertama yang digunakan untuk mengobati UC ringan sampai sedang adalah asam 5-asetil-salisilat (5-ASA). Namun, penggunaan obat-obatan Ini memiliki sejumlah efek samping seperti diare, mual, muntah dan demam. Oleh Oleh karena itu, penelitian ini ingin menguji efek anti inflamasi dari ekstrak daun mahkota dewa (Phaleria macrocarpa), yang telah lama dikenal untuk mengobati peradangan, untuk menjadi solusi alternatif untuk mengatasi UC. Metode: Sampel diperoleh dari penelitian Suprapti et al berupa preparat jaringan kolon distal mencit Balb/c yang diinduksi DSS/AOM. Selanjutnya mencit diberi ekstrak daun P. macrocarpa 25 mg dan 50 mg dengan perbandingan asetosal. Perlakuan diberikan selama 20 minggu sebelum mencit dikorbankan. Pemeriksaan histopatologi (pewarnaan hematoxylin-eosin) dilakukan dengan mengamati jumlah sel goblet, fokus inflamasi dan angiogenesis. Hasil dan Pembahasan : Ekstrak daun P. macrocarpa mampu mencegah penurunan jumlah sel goblet pada kolon distal (p<0,05) karena induksi DSS/AOM. Tidak ada penurunan yang signifikan dalam jumlah fokus peradangan (p>0,05) dan angiogenesis (p>0,05) pada kolitis setelah pemberian P. makrokarpa. Kesimpulan: Ekstrak daun P. macrocarpa mampu menghambat proses radang usus distal dengan mencegah penurunan jumlah sel goblet rata-rata, tetapi tidak mengurangi jumlah fokus peradangan atau angiogenesis.
Introduction: Ulcerative colitis (UC) is a chronic inflammation of the large intestine that causes abdominal pain, diarrhea, and gastrointestinal bleeding. Globally, about 1.2-20.3 per hundred thousand people experience UC. Patients who experience UC have a recurrence potential of 50% and 20-30% of them require surgical removal of the colon (colectomy). To date, the first-line drug used to treat mild to moderate UC is 5-acetyl-salicylic acid (5-ASA). However, the use of these drugs has a number of side effects such as diarrhea, nausea, vomiting and fever. Therefore, this study wanted to test the anti-inflammatory effect of the extract of the leaves of the crown god (Phaleria macrocarpa), which has long been known to treat inflammation, to be an alternative solution to treat UC. Methods: Samples were obtained from Suprapti et al's research in the form of tissue preparations of the distal colon of Balb/c mice induced by DSS/AOM. Furthermore, the mice were given P. macrocarpa leaf extract 25 mg and 50 mg with a ratio of acetosal. The treatment was given for 20 weeks before the mice were sacrificed. Histopathological examination (hematoxylin-eosin staining) was performed by observing the number of goblet cells, foci of inflammation and angiogenesis. Results and Discussion : Leaf extract of P. macrocarpa was able to prevent the decrease in the number of goblet cells in the distal colon (p<0.05) due to DSS/AOM induction. There was no significant reduction in the number of foci of inflammation (p>0.05) and angiogenesis (p>0.05) in colitis after administration of P. macrocarpa. Conclusion: P. macrocarpa leaf extract was able to inhibit the distal intestinal inflammatory process by preventing a decrease in the average goblet cell count, but did not reduce the number of foci of inflammation or angiogenesis.

Abstrak :
Latar Belakang: Penyakit radang usus merupakan penyakit yang memerlukan pengobatan yang terus menerus, sementara pengobatan yang saat ini diterapkan memiliki berbagai efek samping yang cukup berat jika dikonsumsi dalam jangka panjang. Tanaman tabat barito (Ficus deltoidea) adalah tanaman herbal tradisional Kalimantan yang memiliki kandungan fitokimia seperti flavonoid yang berpotensi untuk menjadi agen antiinflamasi dan menangani penyakit radang usus. Tujuan: Membuktikan bahwa ekstrak daun tabat barito memiliki efek antiinflamasi terhadap usus halus mencit yang diinduksi inflamasi oleh dextran sodium sulfate (DSS). Metode: Penelitian ini menggunakan metode penelitian eksperimental dengan DSS untuk menginduksi kolitis pada mencit. Mencit kemudian diberi ekstrak daun tabat barito dengan dosis 25 mg dan 50 mg per mencit untuk dibandingkan dengan mencit yang diberi aspirin. Mencit diamati gambaran histopatologi usus halusnya (pewarnaan hematoxylin-eosin) untuk mengetahui variabel inflamasi usus meliputi infiltrasi sel inflamatorik, angiogenesis, dan hilangnya sel goblet. Gambaran histopatologi diamati pada 5 lapang pandang tiap preparat dengan perbesaran 400x. Hasil: Uji statistik menyatakan bahwa tidak terdapat perbedaan signifikan dari ekstrak daun tabat barito terhadap infiltrasi sel radang (p=0,681), angiogenesis (p=0,073), dan jumlah sel goblet (p=0,121) pada usus halus mencit yang DSS. Kesimpulan: Ekstrak daun tabat barito 25 mg dan 50 mg per mencit tidak memiliki efek anti inflamasi pada usus halus yang diinduksi oleh DSS pada usus halus mencit...... Background: Inflammatory bowel disease is a disease that requires continuous treatment, while the current treatment has various side effects which are quite severe if consumed in the long term. Tabat barito (Ficus deltoidea) is a traditional Kalimantan herbal plant that has phytochemical contents such as flavonoid that has antiinflammatory properties to treat inflammatory bowel disease. Objective: To prove that Ficus deltoidea leaf extract has an anti-inflammatory effect on the small intestine of mice induced by dextran sodium sulfate (DSS). Methods: This study used an experimental research method with DSS to induce colitis in mice. Mice were then given Ficus deltoidea leaf extract with a concentration of 25 mg and 50 mg for each mice to compare with mice given aspirin. Histopathological features of the small intestine are observed (hematoxylin-eosin staining) to determine intestinal inflammatory variables including infiltration of inflammatory cells, angiogenesis, and loss of goblet cells. Histopathological features were observed in 5 visual fields for each preparation with 400x. Results: Statistical tests revealed that there was no significant effect of tabat barito leaf extract on inflammatory cell infiltration (p = 0,681), angiogenesis (p = 0.067), and the number of goblet cells (p = 0.121) in the small intestine of mice induced by dextran sodium sulfate . Conclusion: Tabat barito leaf extract 25 mg and 50 mg has no significant antiinflammation effect on the small intestine of mice induced by DSS.

Abstrak :
Latar Belakang: Meningkatnya tren kasus kolitis ulseratif (KU) di Asia, komplikasi penyakit, dan efek samping terapi yang digunakan saat ini menyebabkan munculnya ide untuk memberdayakan tanaman herbal sebagai terapi alternatif. Penelitian ini bertujuan untuk membuktikan efektivitas ekstrak daun mahkota dewa (Phaleria macrocarpa) terenkapsulasi nanopartikel kitosan sebagai agen antiinflamasi yang dapat memperbaiki deplesi sel Goblet pada mencit yang diinduksi dekstran sodium sulfat (DSS). Metode: Pada penelitian ini dilakukan analisis histopatologi, dengan pewarnaan hematoksilin-eosin (HE), untuk menilai deplesi sel Goblet pada 24 sampel jaringan kolon mencit dari penelitian sebelumnya. Mencit dibagi menjadi 6 kelompok: normal (N), kontrol negatif (NC)—diinduksi kolitis dengan DSS 2%, MD25—diinduksi kolitis dan diberikan 25 mg/kg berat badan (BB) larutan ekstrak daun Phaleria macrocarpa, MD12,5—diinduksi kolitis dan diberikan 12,5 mg/kgBB larutan ekstrak daun Phaleria macrocarpa, NPMD12,5—diinduksi kolitis dan diberikan 12,5 mg/kgBB larutan ekstrak daun Phaleria macrocarpa terenkapsulasi nanopartikel kitosan, dan NPMD6,25—diinduksi kolitis dan diberikan 6,25 mg/kgBB larutan ekstrak daun Phaleria macrocarpa terenkapsulasi nanopartikel kitosan. Jumlah sel Goblet dihitung secara manual dan dianalisis secara statistik. Hasil: Seluruh perlakuan dengan ekstrak daun Phaleria macrocarpa dapat memperbaiki deplesi sel Goblet secara signifikan terhadap kontrol negatif (NC) [MD25 (p=0,021), MD12,5 (p=0,043), NPMD12,5 (p=0,021), and NPMD6,25 (p=0,021)]. Kesimpulan: Ekstrak daun Phaleria macrocarpa, baik terenkapsulasi maupun tidak terenkapsulasi nanopartikel kitosan, dapat memperbaiki deplesi sel goblet pada kolon yang diinduksi DSS ......Background: The increasing cases of ulcerative colitis (UC) in Asia, its intestinal and extraintestinal complications, and side effects of current therapy urges the search of alternative therapy with minimal side effects. The study aims to prove the antiinflammatory effect of mahkota dewa (Phaleria macrocarpa) leaf extract encapsulated in chitosan nanoparticles to ameliorate goblet cell depletion in dextran sodium sulphate (DSS)-induced mice colon. Methods: 24 previously-made tissue samples, stained with hematoxylin-eosin (HE), underwent histopathological examination to analyze Goblet cell depletion. Mice were divided into 6 groups: normal (N), negative control (NC)—given DSS 2% treatment to induce colitis, MD25—given DSS 2% and 25 mg/kg body weight (BW) of Phaleria macrocarpa leaf extract, MD12,5—given DSS 2% and 12,5 mg/kgBW of Phaleria macrocarpa leaf extract, NPMD12,5—given DSS 2% and 12,5 mg/kgBW of Phaleria macrocarpa leaf extract encapsulated in chitosan nanoparticle, and NPMD6,25—given DSS 2% and 6,25 mg/kgBW of Phaleria macrocarpa leaf extract encapsulated in chitosan nanoparticle. Goblet cell was counted manually and statistically analyzed. Results: Phaleria macrocarpa leaf extract treatment, in both forms, improve Goblet cell depletion in all groups compared to negative control [MD25 (p=0,021), MD12,5 (p=0,043), NPMD12,5 (p=0,021), and NPMD6,25 (p=0,021)]. Conclusion: Phaleria macrocarpa leaf extract, either encapsulated or not encapsulated by nanoparticle chitosan, is able to ameliorate Goblet cell depletion in DSS-induced mice colon.

Abstrak :
ABSTRAK
Kanker kolon merupakan penyebab kematian terbesar keempat di dunia. Penelitian inibertujuan untuk melihat efek hambatan ekstrak biji kedelai dan bungkil padatahap awal karsinogenesis kolon. Mencit Swiss Webster berusia 12 minggudiinduksi dengan azoksimetan 10 mg/kg BB diikuti dengan pemberian dextransodium sulfat 2 melalui air minum. Ekstrak biji kedelai dosis 75, 150, dan 200mg, bungkil dosis 75, 150, dan 200 mg, dan aspirin 0,39 mg diberikan per oralselama 4 minggu. Efek hambatan karsinogenesis dinilai dengan mengkuantifikasijumlah radang, rerata sel goblet, rerata angiogenesis pada jaringan kolon yangdiwarnai hematoksilin-eosin. Aktifitas proliferasi dihitung sebagai mean AgNOR.Penurunan bermakna jumlah radang terjadi pada pemberian ekstrak biji kedelaidosis 150 maupun 200 mg, bungkil dosis 150 mg, dan aspirin p

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ABSTRACT
Colon cancer is the fourth cause of cancer death worldwide. The present studywas aimed to investigate the effect of soybean and soybean meal extract on earlycolon carcinogenesis.In this study, male Swiss Webster mouse was induced byazoxymethane 10 mg kg body weight followed by administration of 2 dextransodium sulfate during a week. Soybean, soybean meal extract at each dose of 75,150, and 200 mg daily and aspirin 0,39 mg kg body weight daily administeredorally for 4 weeks. Histopathological examination of the colon tissue hematoxyllin eosin staining was done by counting the number of inflammationspot, goblet cells and angiogenesis. Proliferation activity was calculated as meanAgNOR. Soybean extract 150 and 200 mg , soybean meal extract 150 mg andaspirin are significantly reduce the number of inflammation spot p

Abstrak :
Penyakit paru obstruktif kronis (PPOK) adalah penyakit yang ditandai dengan hambatan aliran udara akibat dari kombinasi dua penyakit pernapasan, yaitu bronkitis kronis dan emfisema. Pada penelitian sebelumnya ditemukan bahwa piroksikam mengikat reseptor formil peptida-1 (FPR-1) untuk menghambat aktivasi neutrofil dan mengurangi pelepasan anion superoksida dari neutrofil yang diinduksi N-Formil-L-metionin-L-leusil-L-fenilalanin (fMLF) secara in vitro. Pada penelitian ini, dilakukan eksperimen secara in vivo pada antagonis FPR-1 yaitu piroksikam terhadap histologi paru. Penelitian ini menggunakan mencit betina DDY yang dibagi menjadi 6 kelompok: kontrol dan kontrol negatif yang diberikan CMC Na 0,5% secara oral, kontrol positif diberikan inhalasi budesonid 1mg/kg BB/hari, serta 3 kelompok variasi dosis piroksikam 0,026mg/20gBB mencit/hari; 0,052mg/20gBB mencit/hari; 0,104mg/20gBB mencit/hari secara oral. Mencit dipaparkan asap rokok (6 batang rokok/hari selama 8 minggu), kemudian diobati baik dengan piroksikam atau budesonid selama 3 minggu. Dalam studi histologi, dilakukan pewarnaan Periodic acid–Schiff (PAS) dan masson’s trichrome. Berdasarkan penelitian, Dosis 0,026mg/20gBB piroksikam memberikan perbedaan bermakna pada penebalan dinding bronkus (p<0,05). Dosis 0,026mg/20gBB piroksikam memberikan perbedaan bermakna pada jumlah sel goblet (p<0,05). Dosis 0,104mg/20gBB piroksikam memberikan perbedaan bermakna pada proporsi fibrosis (p<0,05). Berdasarkan hasil penelitian, aktivitas anti-inflamasi piroksikam dapat dikaitkan dengan penurunan penebalan dinding bronkus, jumlah sel goblet, dan proporsi fibrosis. ......Chronic Obstructive Pulmonary Disease (COPD) is given by the symptoms of airway limitation of two respiratory disease, chronic bronchitis and emphysema. On the previous experiment found that piroxicam binds to formyl peptide receptor-1 (FPR-1) to inhibit neutrophil activation and reduce superoxide anion that released from neutrophil induced by N-Formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF) with in vitro method. In this study, in vivo experiments were conducted on the FPR-1 antagonist piroxicam on lung histology. This experiment is done by using female DDY mice, divided into 6 different groups: control and negative control were given CMC Na 0,5% orally, positive control was given 1mg/kg BW/day of budesonide inhalation, and three variation dose groups of piroxicam 0,026mg/20gBW mice/day; 0,052mg/20gBW mice/day; 0,104mg/20gBW mice/day orally. Mouse were exposed to CS (6 cigarettes/day for 8 weeks), then treated with piroxicam either budesonide for 3 weeks. In lung histological studies, Masson’s trichrome and Periodic acid–Schiff (PAS) staining were performed. Doses 0,026mg/20gBW piroxicam significantly reduced bronchial wall thickening (p<0,05). Doses 0,026mg/20gBW piroxicam significantly reduced number of goblet cells (p<0,05). Doses 0,104mg/20gBW piroxicam significantly reduced fibrosis proportion (p<0,05). Based on this result, the anti-inflammation activity of piroxicam may be attributed to the reduction of bronchial wall thickening, number of goblet cells, and fibrosis proportion.