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Abstrak :
"Readers are introduced to basic concepts related to the specific disciplines in the pharmaceutical sciences, including pharmacology, pharmaceutics, pharmacokinetics, and medicinal chemistry. In an easy-to-read writing style, the book provides readers with up-to-date information on pharmacogenomics and includes comprehensive coverage of industrial drug development and regulatory approval processes. Each chapter includes critical-thinking exercises, as well as numerous figures, tables, and graphs. Many chapters contain review questions, practice problems, and cases."--Publisher.

Abstrak :
Penelitian ini mengunakan model kompartemen model mammilary, satu dan dua kompartemen dengan pemberian satu jenis obat secara oral dan intravena. Model matematika yang dibentuk dari model farmakokinetik berupa persamaan diferensial. Solusi persamaan diferensial berupa variabel dan parameter farmakokinetik dapat diperoleh dengan metode matematika dan numerik seperti transformasi Laplace, residual, prinsip superposisi, dan metode-metode pemecahan lain pada persamaan diferensial. Untuk mengatasi kendala perhitungan manual dalam menyelesaikan persamaan diferensial dan membantu visualisasi dinamika obat dalam bentuk grafik, dibangun perangkat lunak simulasi komputer dengan bahasa Visual Basic.Hasil simulasi menunjukkan bahwa suatu data sampel plasma dapat ditentukan apakah pemberian secara oral atau injeksi dan memiliki kecenderungan mengikuti salah satu asumsi tubuh sebagai satu atau dua kompartemen. Jika diberikan data urin, perangkat lunak baru dapat menguji untuk data yang mengikuti asumsi tubuh 1 kompartemen. Data urin tersebut dapat dibedakan mana yang diberikan secara injeksi atau oral. Hasil simulasi mengisyaratkan bahwa variabel dan parameter farmakokinetik yang dihasilkan akan lebih bersifat individual.

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The Development of a Computer Simulation Software as a Tool in Pharmacokinetics Analisys. This research uses mammilary model (one compartment and two compartments) as compartment model in which a single drug administration is given via oral and intravenous. Mathematical modeling in differential equations can be derived from a pharmacokinetics model. The solutions are pharmacokinetics variables and parameters that can be solved using some mathematical and numerical methods such as Laplace transformation, residual method, superposition principle, trapezoidal rule and some solving methods in differential equations. To overcome manual calculation and to visualize a drug?s dynamics in the graph form, a computer simulation software based on Visual Basic has been built. The simulation results show that any particular sample data plasma can be checked whether it is given orally or injection and has a tendency to be compatible with an assumption of one compartment or two compartments. For urin data, the software capability is still limited only for one compartment. However, it can checked if the corresponding data is given via oral or injection. So the simulations show that pharmacokinetics variables and parameters will have individual effects.

Abstrak :
Buku yang berjudul "Clinical pharmacokinetics concepts and applications" ini ditulis oleh Malcolm Rowland, dan Thomas N. Tozer. Buku ini membahas tentang konsep-konsep klinis pharmacokinetik.

Abstrak :
Diminazen aseturat dilaporkan menghambat akyivitas balik enzim transkriptase melalui mekanisme aksi pengganjalan pada beberapa protozoa eukariyotparasitik seperti kerabat tripanosoma.

Abstrak :
Diminazen aseturat dilaporkan menghambat aktivitas balik enzim transkriptase melalui mekanisme aksi pengganjalan pada beberapa protozoa eukariyot parasitik seperti kerabat Tripanosoma. Telah dicari farmakokinetik plasma darah diminazen pada lima kambing terinfeksi yang diberi pengobatan 7 mg.kg-l berat badan dosis tunggal intra muskular. Konsentrasi obal ditetapkan melalui Kromatograji Cair Kinerja Tinggi fase lerbalik. Hasil menunjukan rerata <± galas baku) Absorbs}, Distribusi, Metabolisme, Ekskresi (ADME) berpola tri-eksponemial dengan Ka (menit'1) 5.1O2 ±26.1O\a (menif'), K!2 (menif1) dan K21 (menif1) 18.1O* ±J.10'2, 14.10'* ± 1.1O2 dan Lia3 ±LiaJ. Rerata harga fitments1) dan K13 (menit'') didapat 1.4.104 ±4. Iff* dan 3.10'* +2.W*. Rerata harga Tmtiks (menit) dan Kmaks (fig.mt1) didapat 53.71 ±30.61 and 13.40 ±8.13. Rerata harga Yds (L), Cl (ml.menif1), Tlfiffjam1) and Area di bawah kurva °-t~(fjg.L''.menit) didapat 4.91 ±3.12, 14.29 ±4.08, 94.91 ±33.23 dan 12.680 ±2.722. (MedJIndones 2006; 15:69-73).

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Diminazene aceturate has been reported to inhibit the reverse transcriptase activity by intercalating action mechanism of a number of protozoan eucaryol parasitic like Trypanosoma species. The phamacokinetics of diminazene in the blood plasma of five infected goaty treated with single intramuscular doses of 7 mg diminazen base kg body weight was investigated. The concentrations of the drug were determined by reverse phase high performance liquid chromatogmphy. Results show tlmt the mean (± SD) Absorption, Distribution, Metabolism and Excretion (ADME) of the drug plasma followed a tri-exponential process with Ka (minutes' ) were obtained at 5.10'' +26.10''. a (minutes' ), K12 (minutes') and K21 (minutes') were obtained at 18. /0"'f ± 1.10'2, 14. Iff* ± 1. !0'2 and 1./0~'! ± 1.Iff3. The mean values of fi (minutes' 1} and Kl3 (minutes') were obtained at 1.4.W4±4. JO* and 3.10~~f ±2.10''. The mean values of Tmax(minutes) and Cmax (fjg.m!'1) were obtained at 53.71 ±30.61 and 13.40 ±8.13. The mean values of Yds (L), Cl (ml .minutes''), Tl/2ff hours') and ALKf^fas.L''.minutes) were obtained at 4.91 ±3.12, 14.29 ±4.08,94.91 ±33.23 and 12.680 ±2.722. (MedJIndones 2006; 15:69-73).