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Abstrak :
Di Indonesia, praktik radioterapi molekuler masih dilakukan dengan metode fixed dose. Sementara penelitian menyatakan bahwa metode fixed dose memiliki tingkat eror yang besar. Salah satu pemodelan yang dapat diandalkan untuk melakukan simulasi, fitting, dan menganalisis perbedaan kondisi fisiologis dan biodistribusi pada setiap individu pasien berdasarkan data pra-klinis pada Peptide-Receptor Radionuclide Therapy (PRRT) adalah pemodelan Physiologically-Based Pharmacokinetics (PBPK). Dalam penelitian ini dilakukan pengembangan sebuah in-house software berbasis General User Interface (GUI) untuk dapat mengaplikasikan pemodelan PBPK dalam proses dosimetri pada PRRT menggunakan perangkat lunak MATLAB r2018b beserta aplikasi bawaannya, yaitu Simbiology dan App Designer. Penulis menggunakan data sekunder dan data pasien virtual yang didapatkan dengan menambahkan eror sebesar 1%, 2%, dan 3% terhadap data sekunder secara acak. Metode estimasi yang digunakan dalam pengembangan in-house software ini adalah non-linear fit (nlinfit) dengan error model proportional karena memiliki persentase deviasi relatif (%RD) dan persentase Coefficient of Variation (%CV) yang paling baik. Secara kualitatif, In-house software yang dikembangkan menghasilkan grafik Area Under the Curve (AUC) yang saling berhimpit dengan literatur serta grafik hasil fitting yang baik, sementara secara kuantitatif menghasilkan nilai AUC dan Time-Integrated Activity Coefficient (TIAC) dengan rata-rata %RD di bawah 10% dan %CV di bawah 50%. Nilai %RD didapatkan dengan membandingkan nilai perhitungan AUC dan estimated parameters antara hasil dari in-house software dengan literatur. Dari hasil tersebut, in-house software berbasis GUI yang dibangun dalam penelitian ini telah berhasil dalam melakukan simulasi, fitting, menghitung besar nilai AUC serta nilai TIAC secara akurat pada PRRT dengan menggunakan pemodelan PBPK. ......In Indonesia, the practice of molecular radiotherapy is still carried out using the fixed-dose method. Meanwhile, research states that the fixed-dose method has a large error rate. One of the reliable models for simulating, fitting, and analyzing differences in physiological conditions and biodistribution in each individual patient based on pre-clinical data on Peptide-Receptor Radionuclide Therapy (PRRT) is Physiologically-Based Pharmacokinetics (PBPK) modeling. In this research, an in-house software based on General User Interface (GUI) was developed to be able to apply PBPK modeling in the dosimetry process on PRRT using the MATLAB r2018b software and its default applications, namely Simbiology and App Designer. The author uses secondary data and virtual patient data obtained by adding errors of 1%, 2%, and 3% to the secondary data randomly. The estimation method used in the development of this in-house software is non-linear fit (nlinfit) with proportional model error because it has the best percentage of relative deviation (%RD) and percentage of Coefficient of Variation (%CV). Qualitatively, the developed In-house software produces an Area Under the Curve (AUC) graph that coincides with the literature as well as a good fit graph, while quantitatively it produces AUC and Time-Integrated Activity Coefficient (TIAC) ​​values ​​with an average of % RD below 10% and CV below 50%. The %RD value is obtained by comparing the calculated AUC and estimated parameters between the results from the in-house software and the literature. From these results, the GUI-based in-house software built in this study has succeeded in performing simulations, fittings, calculating the AUC value and TIAC value accurately on PRRT using PBPK modeling.

Abstrak :
Sasaran dari studi ini adalah untuk mengetahui apakah laba bersih arus kas operasi mempunyai kemampuan dalam memprediksi arus kas masa depan pada perusahaan yang melaporkan laba dan perusahaan yang melaporkan rugi. Walaupun penelitian terdahulu menjelaskan tentang hubungan laba dan arus kas masa depan untuk perusahaan yang melaporkan laba dan rugi, sedangkan hubungan antara arus kas lancar dan arus kas masa depan baik yang meningkat maupun yang menurun, hasilnya adalah antara laba bersih dan arus kas mempunyai kemampuan memprediksi arus kas masa depan untuk perusahaan yang melaporkan laba. Di sisi lain, untuk perusahaan yang melaporkan rugi, tidak signifikan dalam memprediksi arus kas masa depan sedangkan arus kas operasi masih mempunyai kemampuan memprediksi arus kas operasi. Penelitian ini menggunakan pendekatan kuantitatif dan data yang diolah menggunakan analisis regresi linier berganda. Hasil dari penelitian adalah laba bersih dan arus kas memiliki kemampuan memprediksi arus kas masa depan.

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The objective of this study is to investigate whether earnings or operating cash flows have predictive ability to predict future operating cash flows between firms reporting profit and firms reporting loss. Although prior study indicates a strengthening relationship between earnings and future operating cash flows for both firms reporting profits and losses, while relationship between current and future operating cash flows is neither increasing nor decreasing, our result indicates that both net profit and cash flows have ability to predict future operating cash flow for firms reporting profit. On the other hand, for firms reporting loss, earnings are not significant to predict future operating cash flows while current operating cash flows still have ability to predict future operating cash flows. This research using double linier analyse. Result for this research is net profit and cash flow have predictive ability future cash flows.

Abstrak :
ABSTRAK
This research aims to analyze the influence of operating costs and sales volume to against net income of PT Aero Globe Indonesia, and to analyze how much effect from net income as intervening variabel of this research. The sampling technique used in this research is purposive sampling. The data in this research is secondary data which were obtained from 8 years financial statements years 2007 until 2014. The analyze methode of this research is path analysis. The result of this research show that operating cost and sales volume partially had negative significant effect to the net income. But after the research adding by the invervening variabel, the substructure 2 was show that operating cost, sales volume and net income simultaneously had positive significant effect to the net profit margin.

Abstrak :
[ABSTRAK
Gastro Entero Pancreatic Neuro Endocrine Tumor (GEP-NET) merupakan keganasan yang jarang dijumpai di dunia dibandingkan dengan keganasan gastrointestinal lainnya. Menurut data GEP-NET kadang sulit dibedakan dengan Irritabel Bowel Syndrome (IBS) dalam mendiagnosisnya. Keluhan GEP-NET antara lain nyeri perut, diare, flushing, sampai penurunan berat badan. Keluhan IBS antara lain nyeri perut, mual, diare atau dengan tanpa konstipasi. Saat ini telah dikembangkan pemeriksaan Chromogranin A (CgA) untuk membantu dalam pemeriksaan penapisan pasien yang menderita IBS maupun pasien yang dicurigai GEP-NET. Penelitian ini merupakan penelitian deskriptif untuk mengetahui kadar CgA pada kelompok normal, mengetahui kadar CgA pada pasien yang didiagnosis IBS, mengetahui kadar CgA pada pasien yang memiliki risiko GEP-NET dan mengetahui perbedaan kadar CgA pada pasien yang didiagnosis IBS dan pasien yang dicurigai menderita GEP-NET yang keduanya memiliki risiko GEP-NET. Pada penelitian ini didapatkan kadar CgA serum pada kelompok kontrol normal dengan nilai mean 50,70 μg/L, median 48,89 μg/L dengan rentang minimum-maksimum antara 42,66-80,62 μg/L. Pada penelitian ini didapatkan kadar CgA serum pada kelompok IBS dengan nilai mean 76,67 μg/L, median 64,82 μg/L dengan rentang minimum-maksimum antara 45,52-243,18 μg/L. Pada penelitian ini didapatkan kadar CgA serum pada kelompok yang dicurigai GEP- NET denga nilai mean median 66,23 μg/L dengan rentang minimum-maksimum antara 49,89-656,41 μg/L.Pada penelitian ini tidak terdapat perbedaan kadar CgA pada populasi pasien yang didiagnosa IBS maupun pada pasien yang dicurigai menderita GEP-NET yang keduanya memiliki risiko menderita GEP-NET dikemudian hari.

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ABSTRACT
Gastro Entero Pancreatic Neuro Endocrine Tumors (GEP-NET) is a malignancy that is rarely found in the world compared to other gastrointestinal malignancies. According to data registration data The Surveillance, Epidemiology and End Results (SEER) an increase in the incidence of sharp from 1973 (from 0.92 to 1.28 in 100,000 population per year), to 2004 (from 5.09 to 5.42 in 100,000 population per year). GEP-NET is difficult to distinguish from Irritabel Bowel Syndrome (IBS) in diagnose sometimes. GEP-NET complaints include abdominal pain, diarrhea, flushing, until the weight loss. Complaints of IBS include abdominal pain, nausea, diarrhea or with no constipation. We have been developed examination Chromogranin A (CgA) to assist in the screening examination of patients who suffer from IBS and patients who are suspected of suffering from GEP-NET.This study is a descriptive study to determine levels of CgA in the normal group, knowing CgA levels in patients diagnosed IBS, knowing CgA levels in patients who have a risk of GEP-NET and know the difference CgA levels in patients diagnosed with IBS and patients suspected of suffering from GEP- NET who both have risk GEP-NET. In this study, serum levels of CgA in the normal control group with a mean of 50,70 μg/L, median 48,89 μg / L with a minimum-maximum range between 42,66 to 80,62 μg/L. In this study, serum levels of CgA in the IBS group with a mean of 76,67μg /L, median 64,82 μg/L with a minimum-maximum range between 45,52 to 243,18 μg/L. In this study, serum levels of CgA in the group suspected of GEP-NET premises mean median value 66,23 μg/L with a minimum-maximum range between 49.89 to 656.41 g / L. In this study there was no difference in the levels of CgA IBS patients diagnosed population and in patients suspected of suffering from GEP-NET are both at risk of suffering from GEP-NET in the future., Gastro Entero Pancreatic Neuro Endocrine Tumors (GEP-NET) is a malignancy that is rarely found in the world compared to other gastrointestinal malignancies. According to data registration data The Surveillance, Epidemiology and End Results (SEER) an increase in the incidence of sharp from 1973 (from 0.92 to 1.28 in 100,000 population per year), to 2004 (from 5.09 to 5.42 in 100,000 population per year). GEP-NET is difficult to distinguish from Irritabel Bowel Syndrome (IBS) in diagnose sometimes. GEP-NET complaints include abdominal pain, diarrhea, flushing, until the weight loss. Complaints of IBS include abdominal pain, nausea, diarrhea or with no constipation. We have been developed examination Chromogranin A (CgA) to assist in the screening examination of patients who suffer from IBS and patients who are suspected of suffering from GEP-NET.This study is a descriptive study to determine levels of CgA in the normal group, knowing CgA levels in patients diagnosed IBS, knowing CgA levels in patients who have a risk of GEP-NET and know the difference CgA levels in patients diagnosed with IBS and patients suspected of suffering from GEP- NET who both have risk GEP-NET. In this study, serum levels of CgA in the normal control group with a mean of 50,70 μg/L, median 48,89 μg / L with a minimum-maximum range between 42,66 to 80,62 μg/L. In this study, serum levels of CgA in the IBS group with a mean of 76,67μg /L, median 64,82 μg/L with a minimum-maximum range between 45,52 to 243,18 μg/L. In this study, serum levels of CgA in the group suspected of GEP-NET premises mean median value 66,23 μg/L with a minimum-maximum range between 49.89 to 656.41 g / L. In this study there was no difference in the levels of CgA IBS patients diagnosed population and in patients suspected of suffering from GEP-NET are both at risk of suffering from GEP-NET in the future.]

Abstrak :
ABSTRAK
Indikasi kinerja perbankan yang memiliki kecenderungan kurang stabil, dilihat dari profitabilitas yang naik turunnya laba bersih, dikhawatirkan akan terus berlanjut yang dapat menyebabkan tidak tumbuhnya perusahaan. GWM merupakan suatu instrument makro prudential yang yang dapat meningkatkan atau menurunkan tingkat likuiditas suatu bank. Penelitian ini dilakukan pada perusahaan sektor perbankan bank umum konvensional yang ada di seluruh Indonesia, dengan menggunakan data triwulan periode 2012 sampai 2017 untuk mengetahui pengaruh perubahan GWM terhadap kinerja perbankan yang diukur dengan laba bersih. Metode penelitian yang digunakan adalah analisis regresi data panel yang akhirnya menyimpulkan bahwa perubahan GWM berpengaruh negatif dan signifikan pada kategori Buku 1, Buku 2, dan Buku 3, sedangkan untuk kategori Buku 4 tidak terlalu terpengaruh oleh perubahan GWM.

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ABSTRACT
Indications of banking performance that have a tendency to be less stable, seen from the profitability of the up and down of net income, it is feared will continue that can cause the growth of the company. CRR Cash Reserve Ratio is a macro prudential instrument that can increase or decrease a bank's liquidity level. This study was conducted in conventional banking sector throughout Indonesia, using quarterly data from 2012 to 2017 to determine the effect of CRR changes on bank performance as measured by net income. The research method used is panel data regression analysis which finally concludes that the change of CRR has negative and significant effect on the categories of Book 1, Book 2, and Book 3, while for Book 4 category is not too affected by GWM change.

Abstrak :
Penelitian ini bertujuan untuk menganalisis determinan dari Net Foreign Investment Flows pada Pasar Keuangan Indonesia. Terdapat dua model, dengan variabel indepeden dari Set Faktor Global dan Set Faktor Domestik. Penelitian ini menggunakan metode Ordinary Least Square Regresi Linear Majemuk. Hasil dari penelitian ini menunjukkan bahwa Faktor Domestik memiliki pengaruh signifikan terhadap Net Foreign Investment Flows pada Pasar Keuangan Indonesia, dan Faktor Global memiiki pengaruh yang tidak signifikan terhadap Net Foreign Investment Flows pada Pasar Keuangan Indonesia. ...... This study aims to analyze the determinants on Net Foreign Investment Flows in Indonesia Financial Market. There are two proposed models, with variable independents from Global Drivers Set and Domestic Drivers Set. This study uses Ordinary Least Square Multiple Regression methodology. This study proved that Domestic Drivers has significant impact on Net Foreign Investment Flows on Indonesia?s Financial Market, while Global Drivers has no significant impact on on Net Foreign Investment Flows on Indonesia?s Financial Market.

Abstrak :
Penelitian ini bertujuan melihat pengaruh spesifikasi bank terhadap net interest margin NIM perbankan di Indonesia. Industri perbankan Indonesia diharuskan beroperasi secara efisien. Nilai net interest margin mencerminkan seberapa efisien bank dalam menjalankan kegiatan usahanya. Dengan menggunakan data panel bank umum di Indonesia yang beroperasi pada periode tahun 2011 hingga 2015 ditemukan bahwa non performing loan NPL, risk aversion, ukuran, dan biaya operasional mempengaruhi net interest margin. ...... The focus of study is to analyze how bank spesification affect on net interest margin of Indonesian. Indonesian banking industry have to operate efficiently. Net interest margin value represent how effective the operational process. Employing pooled data from commercial banks operating in Indonesia period 2011 2015, This research finds that net interest margin is being influenced by non performing loan, risk aversion, size, and operational cost.