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Abstrak :
Sekitar 35% dari 901 orang dewasa yang menjalani pemeriksaan kesehatan secara rutin ditemukan mengalami NAFPD (nonalcoholic fatty pancreas disease). NAFPD berkaitan dengan manifestasi klinik (sindrom metabolik) MetS, adapun terapi yang diberikan sesuai dengan gejalanya seperti antihipertensi, statin, metformin dan faktor komorbid MetS, sehingga mungkin terjadi polifarmasi akibat multiterapi pengobatan. Dalam hal ini dibutuhkan obat tunggal yang dapat memperbaiki NAFPD pada tikus MetS salah satu kandidatnya yaitu 6-Gingerol. Tujuan dari penelitian ini untuk menganalisis efektifitas 6-Gingerol terhadap NAFPD akibat MetS melalui stress oksidatif pada organ pankreas tikus yang diinduksi HFD + Fruktosa 55% dan Streptozotocin 22mg/kg selama 8 minggu. Tikus yang mengalami sindrom metabolik diterapi dengan 6-Gingerol dosis 50,100 dan 200mg/kg selama 8 minggu. Setelah mencapai akhir terapi, serum dan jaringan pankreas di ambil dan di analisis kadar (tumor necrosis factor alpha) TNF-alpha, (interleukin-6) IL-6, (malondialdehyde) MDA, (glutathione peroxidase) GPx, amilase, akumulais lemak, ekspresi sel alfa dam beta pankreas sebagai parameter NAFPD. Hasil analisis menunjukan bahwa pemberian 6-Gingerol tidak dapat menurunkan aktivitas amilase serum, MDA, ekspresi mRNA IL-6, namun dapat meningkatkan aktivitas GPx, mengurangi akumulasi lemak, dan meningkatkan ekspresi insulin dan glukagon. Sehingga 6-Gingerol memiliki potensi sebagai agen terapeutik untuk memperbaiki NAFPD pada tikus MetS. ......About 35% of 901 adults who underwent routine health checks were found to have (nonalcoholic fatty pancreas disease) NAFPD. NAFPD is related to the clinical manifestations of (metabolic syndrome) MetS, while the therapy given is according to the symptoms. The therapies include: antihypertensives, statins, metformin, and MetS comorbid factors. Polypharmacy may occur as a result of multitherapy treatment. In this case, a single drug, namely 6-gingerol, is needed to improve NAFPD in the MetS rats. The aim of this study was to analyze the effectiveness of 6-Gingerol against MetS-induced NAFPD through oxidative stress in the pancreas of rats induced by HFD + Fructose 55% and Streptozotocin 22mg/kg for 8 weeks. Metabolic syndrome rats were treated with 6-gingerol doses of 50, 100, and 200 mg/kg for 8 weeks. After reaching the end of therapy, serum and pancreatic tissue were collected and analyzed for levels of (tumor necrosis factor alpha) TNF-α, (interleukin-6) IL-6, (malondialdehyde) MDA, (glutathione peroxidase) GPx, amylase, fat accumulation, cell expression pancreatic alpha and beta as parameters of NAFPD. The results of analysis showed that administering 6-gingerol did not significantly reduce serum amylase activity, MDA, the relative expression of IL-6, but it increased GPX activity, reduced fat accumulation, and increased insulin and glucagon expression in pancreatic tissue. Thus 6-Gingerol has the potential as a therapeutic agent to improve NAFPD in the MetS.

Abstrak :
Latar belakang: Pemfigus merupakan penyakit autoimun yang ditandai lepuh pada kulit dan/atau mukosa akibat adanya imunoglobulin terhadap permukaan sel keratinosit. Kortikosteroid KS merupakan pilihan terapi utama. Dipikirkan pemfigus berhubungan dengan sindrom metabolik SM secara langsung maupun tidak langsung. Tujuan: Mengetahui proporsi SM pada pasien pemfigus dan faktor-faktor yang berhubungan di Rumah Sakit Cipto Mangunkusumo RSCM. Metode: Studi potong lintang pada bulan September November 2016 di Poliklinik Kulit dan Kelamin RSCM. Subjek dianamnesis, dilakukan pengukuran tekanan darah dan lingkar abdomen, lalu dilanjutkan pengambilan darah untuk pemeriksaan kadar trigliserida, high density lipoprotein HDL, serta gula darah puasa. Hasil: Didapatkan 30 subjek dengan rerata usia 41,6 10,3 tahun dan sebagian besar perempuan. Sebanyak 23 subjek 76,7 terdiagnosis pemfigus vulgaris dan 7 subjek 23,3 pemfigus foliaseus. Median durasi penyakit adalah 31 bulan. Median lama penggunaan steroid adalah 16,5 bulan. Ditemukan SM pada 40 dari total SP. Didapatkan proporsi obesitas sentral adalah 63,3 , hipertensi 50, hipertrigliseridemia 50, hiperglikemia 23,3, dan hipo-HDL 43,3. Simpulan: Ditemukan proporsi yang sama antara laki-laki dan perempuan di kelompok SM. Tidak ditemukan perbedaan bermakna jenis kelamin, tipe pemfigus, usia, lama sakit, dan lama penggunaan steroid antara kelompok SM dan tidak SM. ......Background: Pemphigus is an autoimmune bullous disease characterized by blistering skin and or mucosa caused by presence of immunoglobulin against keratinocyte cell surface. Corticosteroid is the main therapy. Pemphigus has been related to metabolic syndrome MS lately. Objective: Determine MS proportion in pemphigus patients and its associated factors. Methods: This cross sectional study was conducted in September November 2016 in Dermatovenereology Outpatient Clinic in Cipto Mangunkusumo Hospital. Subjects history was taken then blood pressure, and abdominal circumference were measured. Patients trigliceryde, high density lipoprotein HDL, and fasting blood glucose level were also measured. Results: There are 30 subjects with age mean 41,6 10,3 years and mostly women, 23 patients 76,7 are diagnosed as pemphigus vulgaris while 7 patients 23,3 are pemphigus foliaceus. Disease duration mean in all patients is 31 months and steroid duration mean is 16.5 months. MS was found in 40 subjects. Proportion of central obesity is 63,3, hypertension 50, hypertriglyceridemia 50, hyperglycemia 23,3, and hipo HDL 43,3. Conclusion The same proportion of men and women are found in MS group. There is no statistically significant difference found in gender, pemphigus subtype, age, disease duration, and steroid usage duration between two groups.

Abstrak :
This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.

Abstrak :
Latar Belakang: Penyakit Jantung Koroner (PJK) sebagai masalah kesehatan di Indonesia. Terdapat peningkatan kejadian PJK dihubungkan dengan peningkatan sindrom metabolik. Sampai saat ini belum ada data prevalensi sindrom metabolik pada subyek dengan PIK di RSCM. Tujuan: Untuk melihat proporsi sindrom metabolik pads populasi penderita PAC, serta profil komponen sindrom metabolik. Metode Penelitian bersifat deskriptif, dilakukan pada bulan Maret-Nopember 2005 di Poli Kardiologi, Divisi Kardiologi Departemen Penyakit Dalam RSCM.. Subyek adalah penderita PIK di RSCM dengan jumlah responden 92 subyek. Hasil: Dari 92 responden didapatkan hasil yang mengalami sindrom metabolik pada PJK sebesar 45 (48,9%) lebih besar dibandingkan populasi umum (16,5%-31,1%), dengan komposisi laki-laki 30 (66,7%) clan perempuan 15 (33,3%). Rerata usia 59 tahun (1K 95% 55-63), rerata tekanan darah sistolik 133,9 mmHg (IK 95% 129,7-138,1), rerata tekanan darah diastolik 83,2 mmHg (IK 95% 80,8-85,6), rerata indeks massa tubuh 25 kg/m2 (IK 95% 24,3-25,7), rerata lingkar perut 86,5 cm (IK 84,6-88,4), rerata HDL 42,9 mg/dL (IK 95% 41,04,8), rerata LDL 133,7 mg/dL (IK 95% 126,3-141,1), rerata trigliserida 149,9 mgldL (1K 95% 131,6-168,2), rerata glukosa darah puasa 110,4 mg/dL (1K 95% 101,9-118,9). Simpulan Sindrom metabolik ditemukan pada sebagian besar populasi penderita PJK. Kata Kunci : PJK, sindrom metabolik, proporsi.

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Background: Coronary heart disease (CHD) has become one of health problems in Indonesia. The increment in CHD incidence is associated with increment in metabolic syndrome. Currently, there is no data about metabolic syndrome in patient with CHD at Dr. Cipto Mangunkusumo hospital. Purpose_ (1) To find out the proportion of metabolic syndrome among CHD patients. (2) To find out the profiles of the components of metabolic syndrome. Methods: We conducted a descriptive study during March - November 2005 in Cardiology outpatient unit, Dr. Cipto Mangunkusumo hospital. The subjects for this study were CHD patients who came to the outpatient unit. The numbers of subjects included were 92 people. Results: From 92 subjects who participated in this study, we found 45 subjects (48.9%) had metabolic syndrome more than general population 16.5%-31.1%). Thirty six subjects (66.7%) were male. Mean age was 59 years old (95% CI = 55 - 63 years old)_ Mean systolic pressure was 133.9 mmHg (95% CI = 1293 - 138.1 mmHg). Mean diastolic pressure was 83,2 mmHg (95% CI = 80.8 --- 85.6 mmHg). Mean Body Mass Index was 25 kglm2 (95% CI = 24.3 - 25.7 kglm2). Mean waist circumference was 86.5 cm (95% CI = 84.6 - 88.4 cm). Mean HDL level was 42.9 mg/dL (95% CI = 41,0 - 44.8 mg/dL). Mean LDL level was 133.7 mg/dL (95% CI = 126.3 - 141.1). Mean triglyceride level 149.9 mg/dL (95% CI = 131.6 - 168.2 mg/dL). Mean fasting blood glucose level was 110.4 mg/dL (95% CI = 101.9 -118.9). Conclusion. Metabolic syndrome was found in the majority of CHD patients. Keywords : coronary heart disease, metabolic syndrome.

Abstrak :
Sindrom metabolik merupakan kumpulan faktor risiko penyakit kardiovaskular yang ditandai oleh obesitas sentral, kadar gula darah tinggi, kadar kolesterol HDL rendah, tingginya kadar trigliserida, dan tekanan darah tinggi. Prevalensi sindrom metabolik di Indonesia tergolong tinggi. Penelitian ini bertujuan untuk mengetahui faktor dominan dan faktor-faktor yang berhubungan dengan sindrom metabolik pada penduduk Indonesia usia >15 tahun. Penelitian ini merupakan penelitian kuantitatif dengan desain studi potong lintang dengan menggunakan data Riskesdas 2018. Analisis data yang digunakan adalah analisis univariat, analisis bivariat menggunakan chi square, dan analisis multivariat menggunakan regresi logistik berganda. Hasil penelitian menunjukkan bahwa, dari 30.563 subjek, 32% memiliki sindrom metabolik. Analisis bivariat juga menunjukkan hasil yang signifikan antara jenis kelamin, usia, tingkat pendidikan, tempat tinggal, status pekerjaan, konsumsi alkohol, riwayat merokok (0,000), konsumsi makanan berisiko (makanan dan minuman manis, makanan asin), konsumsi sayur dan buah, aktivitas fisik, kondisi mental emosional, dan status gizi dengan sindrom metabolik (p value = 0,05). Analisis multivariat menunjukkan bahwa usia lansia merupakan faktor dominan yang berhubungan dengan sindrom metabolik (p value = 0,000; OR 8,94 ; 95% CI : 5,98 – 13,36)

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Metabolic syndrome refers to the presence of a cluster of risk factors specific for cardiovascular disease. The cluster of metabolic factors includes central obesity, impaired fasting blood glucose, low HDL cholesterol, high triglyceride levels, and high blood pressure. This study aims to identify the dominant factor and related factors associated with metabolic syndrome in the Indonesian population aged 15 and over years old. This research is a quantitative research with cross-sectional study design and the data was obtained from the Indonesia Basic Health Research (RISKESDAS) 2018. The association between risk factors and metabolic syndrome were measured through chi-square bivariate analysis and binary logistic regression. Multivariate analysis was done using multiple logistic regression. The prevalence of metabolic syndrome was 32%. The results demonstrates that age, sex, level of education, residence type, occupation status, smoking habit, alcohol consumption, fruits and vegetable intake, sweet food intake, sugar sweetened beverages intake, physical activity, mental and emotional disturbance, and nutritional status were significantly associated with metabolic syndrome (p value <0,05). Elderly was the most dominant risk factor for metabolic syndrome (p value = 0,000; OR 8,94 ; 95% CI : 5,98 – 13.36)

Abstrak :
ABSTRAK
Sindrom metabolik MetS adalah kumpulan faktor yang kompleks dan saling berhubungan, yang meningkatkan risiko penyakit jantung dan diabetes mellitus tipe 2. Resistensi insulin dan obesitas sentral dianggap sebagai penyebab utama dari sindrom metabolik, sehingga penurunan resistensi insulin menjadi tujuan klinis yang penting saat ini. Beberapa studi menyimpulkan bahwa akupunktur dapat meningkatkan sensitivitas insulin, karena itu efektif untuk mengatasi gangguan metabolik Uji klinis acak tersamar tunggal dengan pembanding dilakukan pada 50 penderita sindrom metabolik yang dibagi secara acak ke dalam dua kelompok, kelompok elektroakupunktur dan medikamentosa n = 25 serta kelompok elektroakupunktur sham dan medikamentosa n=25 . Elektroakupunktur dilakukan 2 kali seminggu sebanyak 10 kali tindakan di titik CV12 Zhongwan, CV4 Guanyuan, ST25 Tianshu, ST36 Zusanli, ST40 Fenglong, SP6 Sanyinjiao, dan MA-IC3 Endokrin. Dilakukan pemeriksaan gula darah puasa dan insulin puasa untuk mengukur HOMA-IR sebagai luaran primer. Hasilnya terdapat perbedaan bermakna secara statistik perubahan HOMA-IR antara kelompok elektroakupunktur dan medikamentosa dengan kelompok elektroakupunktur sham dan medikamentosa -1,66 2,187 dan -0,29 2,388, p = 0,044 . Terapi kombinasi elektroakupunktur dan medikamentosa efektif untuk menurunkan resistensi insulin pada penderita sindrom metabolik.

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ABSTRACT
The metabolic syndrome is a complex disorder defined by a cluster of interconnected factors that increase the risk of cardiovascular diseases and diabetes mellitus type 2. Insulin resistance and central obesity are considered significant factors as the underlying cause of the metabolic syndrome, since reduction of insulin resistance is an important clinical goal today. Several studies have concluded that acupuncture can improve insulin sensitivity, as it is effective against metabolic disturbances. A single blind randomized controlled trial involved 50 patients randomly allocated into two groups electroacupuncture with medication group n 25 or sham electroacupunture with medication group n 25 . Electroacupuncture therapy was given twice a week for ten times at CV12 Zhongwan, CV4 Guanyuan, ST25 Tianshu, ST36 Zusanli, ST40 Fenglong, SP6 Sanyinjiao, and MA IC3 Endocrine. Fasting blood glucose and fasting insulin serum were assessed to measure HOMA IR as the primary outcome. There was a statistically significant difference in changing of HOMA IR between electroacupuncture with medication group and sham electroacupunture with medication group 1,66 2,187 and 0,29 2,388, p 0.044 . Electroacupuncture with medical treatment effectively decreased insulin resistance of metabolic syndrome patients.

Abstrak :
Latar belakang: Obesitas dan sindrom metabolik (SM) yang terjadi pada usia dini akan menjadi faktor risiko diabetes melitus tipe 2 dan penyakit jantung koroner. Prevalens SM meningkat secara paralel dengan peningkatan obesitas. Penelitian mengenai SM pada anak dan remaja sangat terbatas. Tujuan: Mengetahui prevalens SM pada remaja obes usia 12-16 tahun dan faktor-faktor yang memengaruhinya. Metode: Sebuah penelitian potong lintang pada tiga sekolah menengah pertama negeri di Jakarta yang dipilih secara purposive sampling (remaja dan obes). Dilakukan pengukuran antropometri, tekanan darah dan pemeriksaan laboratorium darah. Diagnosis SM ditentukan sesuai kriteria International Diabetes Federation (IDF), yaitu lingkar pinggang > persentil 90 menurut usia dan jenis kelamin, dan memenuhi > 2 kriteria sebagai berikut: trigliserida > 150 mg/dl, HDL > 40 mg/dl, glukosa darah puasa > 100 mg/dl atau terdiagnosis diabetes melitus tipe 2 (DMT2), tekanan darah > 130/85 mmHg. Penyakit kardiovaskular atau DMT2 orangtua, riwayat diabetes pada ibu selama kehamilan, bayi berat lahir rendah (BBLR), pola makan tinggi lemak dan gula, aktivitas sedentari, orangtua obes, dan pajanan asap rokok diduga meningkatkan kejadian SM. Data diolah dengan tes Pearson atau Fisher untuk menentukan faktor-faktor yang memengaruhi dan angka kejadian SM ditampilkan dalam prevalens. Hasil: Prevalens obes pada penelitian ini adalah 5,9%. Penelitian dilakukan pada 95 subyek obes usia 12-16 tahun. Sebanyak 35,8% subyek memiliki IMT >p95-p97 dan 64,2% memiliki IMT >p97, semuanya telah mengalami pubertas. Prevalens SM adalah 15,8% dan meningkat hingga 21,3% pada kelompok super-obes. Terdapat perbedaan bermakna prevalens SM pada kedua kelompok IMT (p=0,048). Hipertrigliseridemia dan kadar HDL rendah adalah kriteria diagnosis terbanyak pada remaja obes dengan SM. Tidak ditemukan hubungan yang bermakna antara faktor-faktor yang memengaruhi terhadap kejadian SM. Simpulan: Prevalens SM pada penelitian ini 15,8% dan meningkat hingga 21,3% pada remaja super-obes. Tidak ditemukan hubungan yang bermakna antara faktor-faktor yang memengaruhi dengan kejadian SM. Dislipidemia adalah perubahan metabolik yang paling sering dijumpai pada remaja obes dengan SM.

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Background: Obesity and metabolic syndrome (MS) beginning in childhood lead to a substansial risk for type 2 diabetes mellitus and coronary heart disease. Prevalence of MS increases accordingly with the incidence of obesity. The study of the MS among children and adolescents were limited. Aim: The purpose of this study is to define the prevalence and factors that affect the incidence of MS among obese adolescents. Methods: A cross-sectional study selected by purposive sampling was conducted on three junior high school in Jakarta. The anthropometric, blood pressure, lipid profile, and glucose serum level from venous blood sample were taken. The definition of MS was made according to criteria of IDF. Parental history of cardiovascular disease or type 2 diabetes mellitus, history of maternal diabetes during pregnancy, low birth weight, high-fat and sugar diet, sedentary lifestyle, obese parents, and cigarette smoke expossure are considered as the factors affected the incidence of MS. Pearson or Fisher test was used to determine the factors that affect MS and the prevalence of MS were described as descriptive data. Results: Prevalence of obese were 5.9%. A total of 95 subjects with median age 12-16 years, were enrolled into the study. All subjects were obese, and 64.3% of them were superobese (BMI >p97 for age and sex). The prevalence of MS was 15.8% and increased to 21.3% among superobese group. There was a significant difference in the prevalence of MS in obese and super-obese (p = 0.048). Hypertriglyceridemia and low HDL levels are the diagnostic criteria found the most in MS subjects. There was no significant association between factors affecting MS. Conclusion: The prevalence of MS was 15.8% and increased to 21.3% among superobese. There was no significant association between factors affecting MS in adolescents. Dyslipidemia is the most common metabolic change in obese adolescents with MS.

Abstrak :
Many persons have a constellation of major risk/actors, life-habit risk factors, and emerging risk factors that constitute a condition called the Metabolic Syndrome. Eight components characteristic of the Metabolic Syndrome are: I. insulin resistance (with or without glucose intolerance), 2. hyperinsulinemia, 3. abdominal obesity, 4. raised blood pressure, 5. atherogenic dyslipidemia (T Triglyceride, T Postprandial lipemia, Small dense LDL or Type B pattern), 6. procoagulant state (t Fibrinogen, T PAI-1), 7. hyperuricemia, 8. endothelial dysfunction ft Albumin excretion rate, etc). Among the single etiologic factors being considered are: 1. a genetic defect in one or more components of the insulin action cascade leading to insulin resistance, 2. malnutrition during fetal development, and 3. abdominal obesity. It is possible that these three factors could be in some way interrelated. Several mechanisms implicated in the development of insulin resistance in obesity can be shortly postulated below. TNF-a oversecreted by the enlarged fat cells impairs insulin action by inhibiting insulin receptor signaling, possibly by increasing IRS-l serine phosphorylation GLUT-4 expression and translocation to the cell surface will be impaired by TNF-a. Leptin released from visceral adipocytes may inhibit insulin action in the liver by impairing insulin receptor signaling, leading to reduced down-regulation of PEPCK, the rate-limiting enzyme in gluconeogenesis. Glucose-stimulated insulin released from pancreatic fi-cell is also impaired by leptin through STAT-3 production stimulated by leptin via leptin receptor on the surface membrane of fl-cell, and then STAT-3 stimulates the opening of K+Arp-channels, and consequently insulin release will be inhibited. Resistin, as well as TNF-a and leptin released by adipocytes, decrease insulin sensitivity and to be suggested to inhibit adipogenesis; insulin administration rapidly increases resistin levels to normal in adipose tissue. Potential therapeutic beneficial effects of metformin for obesity and insulin resistance may be selectively categorized into 3 groups. In carbohydrate metabolism, metformin prevents pancreatic j3-cellfrom gluco-and lipotoxicity, increases insulin receptor binding, and increases insulin receptor tyrosine kinase (IRTK) activity. Metformin increases oral glucose-induced GLP-l amide levels in obese non-diabetic subjects; metformin is able to inhibit GLP-l degradation induced by dipeptidyl-peptidase IV. GLP-l is a gastrointestinal hormone, which stimulates insulin secretion and promotes satiety, and hence GLP-l and dipeptyl-peptidase IV-inhibitor can be proposed as therapeutic goals for the treatment of patients with Type 2-DM (T2DM) and obesity. In lipid metabolism, metformin may improve lipid profile. Several vasoprotective effects also belong to Metformin, f.e. 4. Hyperinsulinemia, J- Fibrinogen, -I PAl-I, -I FactorXHIa which functions to stabilize fibrin, 4- Platelet aggregation, i Capillary permeability, -I SMC-Fibroblast activity, and i Carbonyl stress (pathway to AGE formation). Conclusion: Obesity and insulin resistance are two major components of the metabolic syndrome, which predispose individuals to the development of T2DM and coronary heart disease. TNF-a and leptin, which are oversecreted by enlarged fat cells, play pivotal roles in the molecular defects of insulin action in obesity-linked insulin resistance. Pleio-tropic properties (vasoprotective effects) of metformin beyond carbohydrate and lipid effects may contribute to the beneficial therapeutic tools for obesity-linked insulin resistance.

Abstrak :
Sindrom metabolik mempakan sekumpulan gangguan metabolik yang dialami seseorang, meliputi obesitas, dislipidemia (rendahnya kadar I-IDL kolestcrol dan tingginya kadar trigiliserida), gangguan metabolisme glukosa serta hipertensi, yang dapat meningkadcan risiko tcrhadap pényakit kardiovaskuler. Penelitian ini bertujuan untuk mengetahui prevalensi dan hubungan antam karalcteristik individu, asupan makan dan faktor lainnya terhadap sindrom metabolik pada pegawai negeri sipil (PNS) yang mengikuti pemeriksaau kesehatan di Rumah Sakit Balcd Yudha Kota Depok. Studi potong lintang ini berlangsung pada bulan Mamet-Mei 2009, menggunakan data sekunder terhadap 164 responden dari RS Bakti Yudha, meliputi data kadar kolesterol total, HDL kolesterol, trigliserida diukur dcngan metode enzimatik colorimen-ik, kadar gula darah puasa menggunakan glucose dehydrogenase oxidize phosphate (GO D-PAP). Tekanan darah diukur dengan Nova Presameter air raksa (manual) can IMT mmggumim mocks BB/TB2 Bam badan dan finggi badan cliukur menggunakan alat Weighing Machine Mode? ZT-I20. Untuk data primer meliputi karakteristik responden, kebiasaan merokok, kehiasaan olahraga, dan riwayat penyaldt keluarga, diperoleh melalui wawancara menggunakan kuesioner. Asupan makan dan pola konsumsi makanan indeks glikemik tinggi diperoleh melalui wawancara menggunakan food recall lx 24 jam dan food jiequency questionnaire. Analisis data dengan uji kai kuadrat, uji T- independcn Lmtuk analisis bivariat dan regrcsi logistik ganda model prediksi untuk analisis multivariat. Hasil siudi menunjukkan prevalensi sindrom metabolik sebesar 23,8%. Hasil analisis multivariat model prediksi diperoleh ada hubungan antara umur (p value =0,027 95% CI l,l 1-5,55), kadar total kolestcrol (p value =0,o4s 95% Cl 1,01- 2l,48), kebiasaan olahraga (p value =0,010 95% CI 1,50-20,26) dan pola konsumsi makanan indeks glikemik tinggi (p value =0,009 95% CI 1,31-6,59) dengan kejadian sindrom metabolik. Faktor paling dominan berhubungan dengan sindrom metabolik adalah olahraga, dengan nilai OR = 5,5, dapat diartikan rcsponden yang tidak olahraga berisiko sebesar 5,5 kali uniuk rnengalami sindrom metabolik dibandingkan responden yang berolahraga setelah dikontrol oleh umur, kadar kolesterol total dan iiekuensi konsumsi makanan indeks glikemik.

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The metabolic syndrome is a constellation of metabolic disturbances in persons, it typically includes obesity, dyslipidemia (characterized by reduced HDL cholesterol and elevated triglyceride concentration), elevated fasting glucose and raised blood pressure which increase the risk of developing cardiovascular disease. The objective of this study was to assess prevalence of metabolic syndrome and the associations between individual characteristic, dietary intake and the other related factors to metabolic syndrome among civil servant who attended health examination at Balcti Yudha Hospital Depok City. Cross sectional study conducted in March - May 2009. This study used secondary data fiom 164 subject at Bakti Yudha Hospital which included information of cholesterol total, HDL cholesterol, triglyceride concentration using the enzymatic colorimetric method, fasting glucose using glucose dehydrogenase oxidize phosphate (GO D-PAP). Blood pressure were measured with a standard mercmy sphygmomanometer and BMI expressed in weight/height (kg/mz). Weight and height was measured use Weighing Machine Model ZT-120. Primary data such as characteristic of study participants, smoking habits, physical exercise dan family history of disease, was obtained from interview by using questiormaire guidelines. Dietary intake and high glicemic index dietary habits data 'dom 24-h recall and food frequency questionnaire. Statistical analysis used were chi-square, independent T-test for bivariate analysis and multiple logistic regression prediction model for multivariat analysis. The results of study shows prevalence of metabolic syndrome was 23,8%. From multivariat analysis results, age (p value =0,027; 95%CI 1,11-5,55), total cholesterol (p value =0,048; 95%CI 1,01-2I,48), physical exercise (p value =0,0l0; 95%CI l,50~20,26) and high glicemic index dietary habits (p value =0,009; 95%CI 1,31-6,59) was assocciated with syndrome metabolic. Dominant factor was assocciated with syndrome metabolic is physical exercise and largest OR = S,5, means that the respondents who do not physical exercise have risk of 5,5 times for the metabolic syndrome than respondents do physical exercise, after controlling age, total cholesterol and high glicemic index dietary habits.