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ABSTRAK Latar belakang. Hipertensi merupakan salah satu kondisi yang paling banyak
ditemukan pada pelayanan kesehatan primer yang dapat meningkatkan mortalitas dan
morbidita apabila tidak mendapatkan pengobatan yang tepat. Beberapa penelitian
menunjukkan respon penurunan tekanandarah pada ras kulit hitam berbeda dibanding
ras kulit putih dengan antihipertensi golongan penyekat EKA, hal ini ditunjang
dengan perbedaan PRA pada kedua kelompok ras ini. Belum terdapat data tentang
respon tekanan darah pasien hipertensi ras melanesiadengan pemberian penyekat
EKA yang ditunjang dengan pemeriksaan kadar PRA pada kelompok ras ini.
Objektif. Menilai apakah terdapat perbedaan respon terapi terhadap penyekat enzim
konversi angiotensin (EKA) pada pasien hipertensi ras melanesia dan ras non
melanesia.
Metode. Penelitian ini adalah penelitian kohort prospektif yangdilakukan di kota
Jayapura bulan September-November 2015terhadap 85 subyek usia 30 sampai 55
tahun dengan hipertensi yang belum pernah diobati sebelumnya. Subyek terbagi atas
2 grup yaitu ras Melanesia (n=34) dan ras Non Melanesia(n=51). Kedua grup tersebut
diberikan lisinopril dosis awal 5 mg. Pemeriksaan tekanan darah dilakukan pada awal
dan diulangi setiap 7 hari selama 4 minggu berturut-turut.
Hasil. Terdapat perbedaan respon tekanan darah pasien hipertensi ras Melanesia dan
ras Non Melanesia. Perbedaan tekanan darah sistolik sebesar 24,5 ± 9,4 mmHg pada
subyek ras Melanesia dan pada subyek Non Melanesia sebesar 34,5 ± 13,5 mmHg
(p<0,001). Perbedaan tekanan darah diastolik subyek ras Melanesia sebesar 13,3±5,5
mmHg dan pada subyek Non Melanesia sebesar 22,6±9,3 mmHg (p<0,001).
Perbedaan tekanan rerata arteri pada subyek ras Melanesia sebesar 17,1±5,6 mmHg
dan pada subek ras Non Melanesia sebesar 26,21±8,8 mmHg (p<0,001). Reratakadar
Plasma Renin Activity (PRA) pada subyek ras Melanesia sebesar 1,48[1,86]
ng/ml/jam dan pada subyek ras Non Melanesia rerata kadar PRA sebesar 1,1[1,47]
ng/ml/jam. Tidak terdapat hubungan yang bermakna rerata kadar PRA pada kedua
kelompok ras ini (p=0,564).
Kesimpulan. Terdapat perbedaan penurunan tekanan darah (sistolik, diastolik dan
tekanan rerata arteri) dengan pemberian penyekat EKA pada kelompok ras Melanesia
dan kelompok ras Non Melanesia dan hal ini tidak berhubungan bermakna dengan
rerata kadar PRA pada kedua kelompok ini sehingga kemungkinan terdapat faktor lain yang mempengaruhi respon penurunan tekanan darah dengan penyekat EKA.
ABSTRACT Hypertension is one of the most commonconditionsin primary health
care that increase mortality and morbidity if it does not receive appropriate therapy.
Several studies show that blacks response differently compared with white in
conjunction with a decrease of blood pressure in response to administer ACE
inhibitor. The studies supported by PRA differences in both group of race. There are
no data ofblood pressure response in hypertensive patientsinMelanesian race by
administeringACE inhibitor supported withPRA levels examination in thisgroup of
race.
Objective. To compare therapeutic response ofangiotensin converting enzyme
blockers (ACE)inhibitorinreducing blood pressure between MelanesianandNon
Melanesian hipertensive patients.
Method. This study is a prospective cohort study conducted in the city of
Jayapura September to November 2015. We found85 subjects aged 30 to 55 years
oldwith hypertensionnever be treated before. Subjects are divided into two
groups, namely the Melanesian race (n = 34) and non Melanesian race (n = 51).
Both groups were given an initial dose of 5 mg of lisinopril. Blood pressure
checks performed at baseline and repeated every 7 days for 4 weeks in a row.
Results. There are differences in the response of blood pressure in hypertensive
patientofMelanesian race and Non Melanesiarace. Reduction ofsystolic blood
pressure of 24.5 ± 9.4 mmHg in subject Melanesian race and on the subject of
Non Melanesian 34.5 ± 13.5 mmHg (p < 0.001). Reduction ofdiastolic blood
pressure of subjectsMelanesians of 13.3 ± 5.5 mmHg, and on the subject of Non
Melanesia 22.6 ± 9.3 mmHg (p<0.001). Reduction ofmean arterial pressure in
subjectMelanesian race at 17.1 ± 5.6 mmHg andNon Melanesian race at 26.21 ±
8.8 mmHg (p < 0.001). Mean Plasma Renin Activity (PRA) on the subject of the
Melanesian race at 1.48 [1.86] ng/ml/h and on the subject of nonMelanesian race
PRA average level of 1.1 [1.47] ng/ml/hr. There was no significant relationship
mean PRA levels in both these racial groups (p = 0.564).
Conclusion. There aredifferences in blood pressure reduction (systolic, diastolic
pressure and mean arterial pressure) with administer of ACE inhibitor in
Melanesianand Non Melanesiagroup of race. There is no significant relation with
averagePRAlevels in both group of race. Another factors affectsresponses of reduction blood pressure with administer ofACEinhibitor may be considered.;Background. Hypertension is one of the most commonconditionsin primary health
care that increase mortality and morbidity if it does not receive appropriate therapy.
Several studies show that blacks response differently compared with white in
conjunction with a decrease of blood pressure in response to administer ACE
inhibitor. The studies supported by PRA differences in both group of race. There are
no data ofblood pressure response in hypertensive patientsinMelanesian race by
administeringACE inhibitor supported withPRA levels examination in thisgroup of
race.
Objective. To compare therapeutic response ofangiotensin converting enzyme
blockers (ACE)inhibitorinreducing blood pressure between MelanesianandNon
Melanesian hipertensive patients.
Method. This study is a prospective cohort study conducted in the city of
Jayapura September to November 2015. We found85 subjects aged 30 to 55 years
oldwith hypertensionnever be treated before. Subjects are divided into two
groups, namely the Melanesian race (n = 34) and non Melanesian race (n = 51).
Both groups were given an initial dose of 5 mg of lisinopril. Blood pressure
checks performed at baseline and repeated every 7 days for 4 weeks in a row.
Results. There are differences in the response of blood pressure in hypertensive
patientofMelanesian race and Non Melanesiarace. Reduction ofsystolic blood
pressure of 24.5 ± 9.4 mmHg in subject Melanesian race and on the subject of
Non Melanesian 34.5 ± 13.5 mmHg (p < 0.001). Reduction ofdiastolic blood
pressure of subjectsMelanesians of 13.3 ± 5.5 mmHg, and on the subject of Non
Melanesia 22.6 ± 9.3 mmHg (p<0.001). Reduction ofmean arterial pressure in
subjectMelanesian race at 17.1 ± 5.6 mmHg andNon Melanesian race at 26.21 ±
8.8 mmHg (p < 0.001). Mean Plasma Renin Activity (PRA) on the subject of the
Melanesian race at 1.48 [1.86] ng/ml/h and on the subject of nonMelanesian race
PRA average level of 1.1 [1.47] ng/ml/hr. There was no significant relationship
mean PRA levels in both these racial groups (p = 0.564).
Conclusion. There aredifferences in blood pressure reduction (systolic, diastolic
pressure and mean arterial pressure) with administer of ACE inhibitor in
Melanesianand Non Melanesiagroup of race. There is no significant relation with
averagePRAlevels in both group of race. Another factors affectsresponses of reduction blood pressure with administer ofACEinhibitor may be considered.;Background. Hypertension is one of the most commonconditionsin primary health
care that increase mortality and morbidity if it does not receive appropriate therapy.
Several studies show that blacks response differently compared with white in
conjunction with a decrease of blood pressure in response to administer ACE
inhibitor. The studies supported by PRA differences in both group of race. There are
no data ofblood pressure response in hypertensive patientsinMelanesian race by
administeringACE inhibitor supported withPRA levels examination in thisgroup of
race.
Objective. To compare therapeutic response ofangiotensin converting enzyme
blockers (ACE)inhibitorinreducing blood pressure between MelanesianandNon
Melanesian hipertensive patients.
Method. This study is a prospective cohort study conducted in the city of
Jayapura September to November 2015. We found85 subjects aged 30 to 55 years
oldwith hypertensionnever be treated before. Subjects are divided into two
groups, namely the Melanesian race (n = 34) and non Melanesian race (n = 51).
Both groups were given an initial dose of 5 mg of lisinopril. Blood pressure
checks performed at baseline and repeated every 7 days for 4 weeks in a row.
Results. There are differences in the response of blood pressure in hypertensive
patientofMelanesian race and Non Melanesiarace. Reduction ofsystolic blood
pressure of 24.5 ± 9.4 mmHg in subject Melanesian race and on the subject of
Non Melanesian 34.5 ± 13.5 mmHg (p < 0.001). Reduction ofdiastolic blood
pressure of subjectsMelanesians of 13.3 ± 5.5 mmHg, and on the subject of Non
Melanesia 22.6 ± 9.3 mmHg (p<0.001). Reduction ofmean arterial pressure in
subjectMelanesian race at 17.1 ± 5.6 mmHg andNon Melanesian race at 26.21 ±
8.8 mmHg (p < 0.001). Mean Plasma Renin Activity (PRA) on the subject of the
Melanesian race at 1.48 [1.86] ng/ml/h and on the subject of nonMelanesian race
PRA average level of 1.1 [1.47] ng/ml/hr. There was no significant relationship
mean PRA levels in both these racial groups (p = 0.564).
Conclusion. There aredifferences in blood pressure reduction (systolic, diastolic
pressure and mean arterial pressure) with administer of ACE inhibitor in
Melanesianand Non Melanesiagroup of race. There is no significant relation with
averagePRAlevels in both group of race. Another factors affectsresponses of reduction blood pressure with administer ofACEinhibitor may be considered."
