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Abstrak :
ABSTRAK
Insulin-like growth factor (IGF)-1 adalah salah satu hormon yang berperan pada pertumbuhan remaja perempuan. Kadarnya akan meningkat pada masa pubertas dan mulai menurun saat akhir pubertas. Kadar IGF-1 yang tinggi saat dewasa berhubungan dengan kejadian kanker payudara. Penelitian ini bertujuan untuk mengetahui korelasi antara IGF-1 dengan indeks massa tubuh (IMT) pada remaja perempuan usia 13?15 tahun di Jakarta. Studi potong lintang ini dilakukan sejak bulan April?Mei 2016 dengan menggunakan data primer dari serum darah tersimpan berupa kadar IGF-1 yang diperiksa dengan metode ELISA dan data sekunder dari penelitian berjudul ?Faktor Determinan Kadar Estradiol, IGF-1, dan Menarche Dini pada Remaja Putri Usia 13?15 tahun di Jakarta: Studi Epidemiologi Gizi Terkait Faktor Risiko Kanker Payudara? berupa data antropometri, asupan makanan, dan aktivitas fisik dari 178 subjek yang didapat dengan metode total population sampling. Indeks massa tubuh pada remaja perempuan usia 13?15 tahun diukur dengan menggunakan kurva WHO 2007 dan CDC 2000. Tidak didapatkan korelasi antara IGF-1 dengan IMT pada remaja perempuan, namun terdapat kecenderungan nilai IGF-1 akan meningkat pada status gizi overweight dan menurun pada obesitas. Hendaknya para remaja perempuan menjaga status gizi dengan menjaga pola makan, memilih jenis makanan yang tepat dan seimbang, serta meningkatkan aktivitas fisik.

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ABSTRACT
The insulin-like growth factor (IGF)-1 is one of hormone that plays a role in the growth of adolescent girls. Its level will rise at puberty and begin to decline at the end of puberty. High IGF-1 levels in adult associated with the incidence of breast cancer. This study aimed to determine the correlation between IGF-1 and body mass index (BMI) in 13-15-years-old girls in Jakarta. This cross-sectional study was conducted in April-May 2016 by using primary data from stored blood serum to measure IGF-1 level byELISA method and secondary data from a study entitled "Determinant Factors of Levels of Estradiol, IGF-1, and Early Menarche in Adolescents Girls Aged 13-15 in Jakarta: Nutritional Epidemiology Study Related to Breast Cancer Risk Factors" such as anthropometric data, dietary intake, and physical activity were obtained from 178 subjects with a total population sampling method. Body mass index in girls aged 13-15 years were measured using WHO 2007 and CDC 2000 curves. There were no correlation between IGF-1 with a BMI in adolescent girls, however, there is a tendency value of IGF-1 will increase in overweight and decrease in obesity. Thus adolescent girls should maintain their nutritional status by maintain a diet, choose the right and balanced foods, as well as increased physical activity

Abstrak :
ABSTRAK
Background: a freshwater fish Ophiocephalus striatus or known locally to Indonesian as haruan,can potentially increases IGF-1 and albumin levels in elderly patients with hypoalbuminemia due to the contents of amino acids, fatty acids, vitamins, and minerals. This study was conducted to investigate the effect of Ophiocephalus striatus extract on the level of IGF-1 and albumin in elderly patients with hypoalbuminemia due to the contents of amino acids, fatty acids, vitamins, and minerals. This study was conducted to investigate the effect of Ophiocephalus striatus extract on the level of IGF-1 and albumin in elderly patients with hypoalbuminemia. Methods: the study is a double-blind randomized controlled trial involving malnourished elderly inpatients (≥60 years old) recovering from acute condition before hospital discharge, with Mini Nutritional Assessment score ≤23.5 and albumin level <3.5 g/dL. A total of 109 subjects were randomly divided into two groups: one group received 10 g Ophiocephalus striatus extract per day for 14 days and another group received placebo. Albumin and IGF-1 levels were obtained before and after intervention. Results: ninety subjects completed the study (extract group=45 subjects; placebo group =45 subjects) for 14 days. The median of age were 69 (64;75) years and the male to female ratio were 2 : 3. The changes of IGF-1 and albumin levels from before to after intervention between extract group compared to placebo group were 14.7 (0.30;31.5) ng/mL vs 1.0 (-6;13.15) ng/mL (p=0.002) and 0.5 (0.15;0.70) g/dL vs 0.10 (0.0;0.50) g/dL (p=0.003), respectively. There were significant differences in the improvement of IGF-1 and albumin levels between extract and placebo group. Conclusion: supplementation of Ophiocephalus striatus extract was associated with a significant increase in IGF-1 and albumin levels in elderly patients with hypoalbuminemia.

Abstrak :
Ayam ketawa atau yang dikenal dengan nama manu gaga merupakan salah satu jenis ayam hias yang berasal dari Sidrap (Sidenreng - Rappang), Sulawesi Selatan. Tujuan dari penelitian ini adalah untuk melihat kekerabatan ayam ketawa tipe dangdut dan slow berdasarkan morfometrik pita suara dan analisis gen IGF-1. Penelitian dilakukan di Pinrang, Sulawesi Selatan sebagai tempat galur murni ayam gaga, terdiri dari lima daerah yaitu Kanie, Bullo, Macege, Rappang, dan Sidenreng. Sampel terdiri atas sepuluh ekor ayam ketawa tipe dangdut dan sepuluh ekor tipe slow. Data morfometrik pita suara dicatat dan dianalisis secara statistik. Analisis gen IGF-1 dilakukan isolasi dari darah. Korelasi antara data morfometrik organ pita suara dan variasi ayam ketawa tipe dangdut dan slow dilakukan menggunakan SPSS (versi 22) sedangkan analisis gen IGF-1 menggunakan metode Restriction Fragment Length Polymorphism (RFLP) dan High-resolution Melting (HRM). Untuk analisis morfometrik, nilai signifikansi () yang ditetapkan adalah 0,01. Berdasarkan Tabel Tests of Equality of Group Means, nilai Sig. untuk variabel syrinx adalah 0,016 > 0,010. Artinya, panjang syrinx tidak dapat menjelaskan perbedaan tipe ayam. Sedangkan untuk variabel trakea, otot trakea kanan, dan otot trakea kiri, nilai Sig. kurang dari 0,010. Artinya, masing-masing variabel tersebut dapat menjelaskan perbedaan tipe ayam. Sedangkan analisis molekuler menunjukkan bahwa target DNA gen IGF-1 berada pada posisi (632 bp), sedangkan hasil analisis polimorfisme menggunakan PCR-RFLP dan HRM diperoleh hasil bahwa ayam ketawa tipe dangdut dan slow merupakan homozigot. Hasil konfirmasi dengan menggunakan sekuensing diketahuai bahwa ayam ketawa tipe dangdut dan slow memiliki kekerabatan yang dekat. ......Gaga chicken, well-known as manu gaga is one type of ornamental chicken originating from Sidrap (Sidenreng - Rappang), South Sulawesi. The purpose of this study was to examine the relationship of dangdut and slow type gaga chicken based on morphometric vocal cords and IGF-1 gene analysis. The study was conducted in Pinrang, South Sulawesi as a pure strain of chicken gaga, consisting of five regions, namely Kanie, Bullo, Macege, Rappang and Sidenreng. The sample consisted of ten dangdut-type and ten slow-type. Morphometric data on vocal cords were recorded and analyzed statistically, while IGF-1 gene analysis was isolated from blood. The correlation between morphometric data of vocal cords and variations of dangdut and slow type of gaga chicken was done using SPSS (version 22) while IGF-1 gene analysis used Restriction Fragment Length Polymorphism (RFLP) and High-resolution Melting(HRM) methods. For morphometric analysis, the significance value (α) set is 0.01. Based on the Tests of Equality of Group Means Table, the Sig. for the syrinx variable is 0.016> 0.010. That is, the length of the syrinx cannot explain the difference in the type of chicken. As for the trachea, right tracheal muscle, and left tracheal muscle, the Sig. less than 0.010. That is, each of these variables can explain the different types of chickens. While molecular analysis shows that the IGF-1 genes DNA target is in position (632bp), while the results of the polymorphism analysis use PCR-RFLP and HRM obtained results that the gaga chicken type of dangdut and slow is homozygous. Confirmation results using sequenshing are known that the laughing type of dangdut and slow has a close relationship.

Abstrak :
Latar belakang: Penyebab stunting bersifat multifaktorial, salah satu faktor risikonya adalah malnutrisi kronis akibat kurangnya asupan protein. Kurangnya asupan protein dapat menyebabkan terjadi penurunan IGF-1, yaitu salah satu faktor pertumbuhan penting dalam pembangunan sel tubuh. IGF-1 juga memiliki peran dalam perkembangan kompleks dentoalveolar, terutama pada enamel, akar gigi, dentin, ligamen periodontal, dan jaringan pulpa gigi. Perlu dianalisis apakah gangguan perkembangan kompleks dentoalveolar akibat penuruan kadar IGF-1 pada anak stunting juga mempengaruhi waktu erupsi gigi. Tujuan: Menganalisis hubungan antara kadar IGF-1 dengan waktu erupsi gigi pada anak stunting. Metode: Pencarian literatur dilakukan dengan menggunakan pedoman alur Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) pada tiga electronic database, yaitu PubMed, EBSCO, dan Scopus. Penilaian kualitas literatur dilakukan dengan menggunakan QUADAS-2. Hasil: Terdapat 5 studi yang terpilih berdasarkan kriteria inklusi dan eksklusi. Hasil temuan penelitian menunjukkan bahwa kadar IGF-1 lebih rendah pada anak stunting dibandingkan dengan kelompok anak normal. Hal ini disebabkan karena kadar IGF-1 dalam darah dipengaruhi oleh banyak faktor, di antaranya yaitu nutrisi, status gizi, dan usia. IGF-1 yang rendah pada anak stunting berpotensi menyebabkan keterlambatan waktu erupsi gigi karena mengganggu mekanisme persinyalan molekul selama erupsi gigi, seperti BMP-2, Runx-2, dan TGF-. Kesimpulan: Terdapat korelasi positif antara kadar IGF-1 yang rendah dengan erupsi gigi pada anak stunting. Ekspresi IGF-1 yang rendah dapat menyebabkan terjadinya gangguan waktu erupsi gigi karena mengganggu proses maturasi gigi. ......Background: The causes of stunting are multifactorial, one of the risk factors causing stunting is chronic malnutrition due to lack of protein intake. Lack of protein intake can cause the decrease of IGF-1 level, which is one of the important growth factor supporting the growth and development of somatic cells. Furthermore, IGF-1 also has a role in the development of the dentoalveolar complex, especially enamel, tooth roots, dentin, periodontal ligament, and dental pulp tissues. It should be clarified whether the disturbances of dentoalveolar complex development due to decreased IGF-1 level in the stunted children would also affect the eruption time of the dentition. Objective: To analyze the relationship between IGF-1 level and the timing of tooth eruption in stunted children. Methods: Literature researches were done by using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines through three electronic databases, which were PubMed, EBSCO, and Scopus. Quality assessment of bias was examined using QUADAS-2 tool. Results: There were 5 selected studies based on inclusion and exclusion criteria. The results of the study showed that IGF-1 levels were lower in stunted children compared to normal children. The influencing factors of the level of IGF-1 in the blood, are nutritional status and age. Low level of IGF-1 in stunted children has the potential to cause delays in the timing of tooth eruption, by interrupting the activity of BMP-2, Runx-2, and TGF-β. Conclusion: There is a positive correlation between low IGF-1 level and the timing of tooth eruption in stunted children. Low IGF-1 expression can cause disturbances in the timing of tooth eruption because it interferes with the dental maturity process.

Abstrak :
Beberapa studi epidemiologi maupun studi metaanalisis menunjukkan faktor seperti jenis kelamin dan usia, obesitas, dan resistensi insulin, pada diabetes mellitus tipe 2 memiliki hubungan dengan risiko terjadinya kanker. Hiperinsulinemia dapat mempengaruhi risiko kanker tidak hanya melalui efek mitogenik langsung dari insulin tetapi juga secara tidak langsung melalui peningkatan produksi IGF-1. Metformin yang merupakan terapi lini pertama untuk pasien diabetes melitus tipe 2 telah dikaitkan dengan risiko berkurangnya berbagai sel kanker. Penelitian ini merupakan penelitian cross-sectional yang bertujuan untuk membandingkan dan menganalisis hubungan antibodi anti-p53 dengan beberapa penanda metabolik HbA1c, insulin, dan IGF-1 pada pasien diabetes melitus yang menerima terapi antidiabetes metformin n=47 , non-metformin n=31 , dan subjek sehat n=16 di Puskesmas Pasar Minggu. Sampel yang digunakan adalah serum darah yang kemudian diuji menggunakan metode ELISA untuk menganalisis antibodi anti-p53, IGF-1, dan Insulin. Nilai antibodi anti-p53, yaitu 0,26 0,06 dan pada kelompok metformin tunggal/kombinasi dan 0,24 0,08 pada kelompok non-metformin. Nilai pada kedua kelompok memiliki perbedaan yang bermakna p< 0,001 jika dibandingkan dengan subjek sehat. Terdapat korelasi negatif menengah antara antibodi anti-p53 dengan HbA1c r = -0,407; p= 0,023 dan dengan IGF-1 r = - 0,571; p = 0,021 pada kelompok non-metformin. Tidak terdapat hubungan yang bermakna antara antibodi anti-p53 dengan kadar insulin pada ketiga kelompok. ...... Either epidemiological studies or meta analysis has shown that several factors such as gender, age, obesity, and insulin resistance are related to cancer incidents. Hyperinsulinemia affect cancer progression not only trough insulin mitogenic activities but also trough inducing IGF 1 production. Metformin as a first line therapy for patients with type 2 diabetes mellites has been associated with a reduced risk of various cancer cells. Aside from its insulin sensitizer mechanism, several studies showed other mechanism related to cancer treatment. This cross sectional study compares and analyzes the correlation between effect of antidiabetic treatment in the group of metformin combination n 47 and non metformin n 31 against anti p53 antibody and their relation to HbA1c, IGF 1, and insulin in type 2 diabetes mellitus patients in Pasar Minggu Primary Health Center. Patient rsquo s blood serum was collected then analyzed with ELISA kit to measure the value of anti p53 antibody, IGF 1, and insulin. The average of anti p53 antibody were 0.26 0.06 and 0.24 0.08 in metformin combination group and non metformin group, respectively. There was a statistically significant difference anti p53 antibody level between the two groups against age and sex match 16 apparently healthy subjects.

Abstrak :
Latar Belakang : Stunting merupakan salah satu manifestasi dari malnutrisi kronis yang ditandai dengan tinggi badan yang lebih rendah dari standar tinggi badan untuk usia individu tersebut. Salah satu faktor penyebab stunting adalah kurangnya asupan nutrisi. Kurangnya asupan nutrisi dapat menyebabkan berkurangnya kadar Hb dan IGF-1. Berkurangnya asupan nutrisi juga dapat mengganggu proses pertumbuhan dan perkembangan gigi yang dapat mempengaruhi watu erupsi gigi. Perlu dilakukan analisis untuk melihat hubungan antara stunting dengan kadar Hb, IGF-1, dan erupsi gigi. Tujuan : Menganalisis hubungan antara kadar Hb, IGF-1, dan erupsi gigi dengan kondisi stunting. Metode : Penelusuran literatur dilakukan dengan menggunakan pedoman Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) pada tiga electronic database, yaitu : PubMed, EBSCO, dan SCOPUS. Kualitas dari literatur dinilai menggunakan QUADAS-2 tool. Hasil : Terdapat 27 artikel yang terpilih berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan. 19 artikel menyatakan bahwa terdapat hubungan antara kadar Hb dengan stunting, dimana anak dengan kondisi stunting lebih memungkinkan untuk memiliki kadar Hb yang rendah (anemia). 4 artikel menyatakan bahwa terdapat hubungan antara kadar IGF-1 dengan stunting, dimana anak dengan kondisi stunting memiliki kadar IGF-1 yang lebih rendah dibandingkan dengan anak non-stunting. 3 artikel menyatakan bahwa terdapat hubungan antara stunting dengan erupsi gigi, dimana anak dengan kondisi stunting mengalami keterlambatan erupsi gigi. 1 artikel menyatakan bahwa tidak ada hubungan antara stunting dengan pertumbuhan dan perkembangan gigi. Kesimpulan : Terdapat korelasi positif antara stunting dengan kadar Hb dan IGF-1. Korelasi antara stunting dengan erupsi gigi belum dapat ditentukan dengan pasti ......Background : Stunting is a manifestation of chronic malnutrition which is characterized by a lower height than the individual's age standard. One of the primary cause of stunting is the lack of nutritional intake. Lack of nutritional intake can cause reduced Hb and IGF-1 levels. Lack of nutritional intake can also interfere with the process of growth and development of the teeth which can affect the timing of tooth eruption. An analysis is needed to see the relationship between stunting and levels of Hb, IGF-1, and the timing of tooth eruption. Objective : To analyze the relationship between Hb levels, IGF-1 levels, and the timing of tooth eruption with stunting. Method : Literature research was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines on three electronic databases, namely: PubMed, EBSCO, and SCOPUS. The quality of the literature was assessed using the QUADAS-2 tool. Results : There are 27 articles that were selected based on predetermined inclusion and exclusion criteria. 19 articles state that there is a relationship between Hb levels and stunting, where stunted children are more likely to have low Hb levels (anemia). 4 article states that there is a relationship between IGF-1 levels and stunting, where stunted children have lower IGF-1 levels compared to non-stunted children. 3 The article states that there is a relationship between stunting and tooth eruption, where stunted children experience delays in tooth eruption. 1 article states that there is no relationship between stunting and dental growth and development Conclusion : There is a positive correlation between stunting and Hb and IGF-1 levels. The correlation between stunting and tooth eruption cannot be determined with certainty.

Abstrak :
Latar Belakang: IGF-1 adalah growth factor yang sangat poten bukan hanya untuk pertumbuhan somatik tetapi juga pada sistem saraf pusat. Sekitar 70% IGF-1 di sirkulasi diproduksi di hati dan disekresikan ke aliran darah menuju organ target. IGF-1 memiliki peran penting dalam neurogenesis dewasa. Proses penuaan diasosiasikan dengan penurunan konsentrasi IGF-1. Kekurangan IGF-1 diasosiasikan dengan gangguan kognitif, penyakit Alzheimer, osteoporosis dan diabetes. Literatur terkini menunjukkan olahraga aerobik meningkatkan serum IGF-1, Environmental Enrichment (EE) juga meningkatkan neuron positif IGF-1. Namun, efek kombinasi kedua perlakuan ini belum banyak diobservasi. Penelitian ini bertujuan untuk mengamati efek olahraga aerobik dan EE secara kontinu pada IGF-1 di hati dan plasma. Metode: Penelitian ini merupakan studi data sekunder berdasarkan data yang diambil pada eksperimen in-vivo dengan tikus sebagai hewan uji. Dua puluh empat tikus wistar jantan umur tujuh bulan dibagi secara acak ke empat grup, Kontrol, Aerobik, EE dan Kombinasi. Perlakuan dilakukan selama 8 minggu. Setiap kelompok diuji kadar IGF-1 pada awal dan akhir eksperimen untuk plasma dan pada akhir eksperimen untuk hati. Pengujian IGF-1 menggunakan ELISA dengan kit Qayeebio (QY-E10935). Analisis data menggunakan one-way ANOVA untuk plasma dan Kruskall-Wallis untuk hati dengan program SPSS20. Hasil: Hasil uji IGF-1 plasma tidak menunjukkan perbedaan signifikan antar perlakuan (p=0.17) sementara hasil uji IGF-1 hati menunjukkan perbedaan signifikan antara perlakuan Aerobik dengan EE (p=0.006) dan antara perlakuan Aerobik dengan Kombinasi (p=0.042). Kesimpulan: Studi analisis data menggunakan 24 sampel tidak menunjukan peningkatan IGF-1 yang signifikan secara statistik di tikus dengan perlakuan kombinasi olahraga aerobik dan EE secara kontinu baik di plasma maupun di hati. Hal ini kemungkinan disebabkan oleh banyaknya interaksi IGF-1 dengan growth factors lain dan posibilitas bahwa IGF-1 bukan fator tunggal yang mempengaruhi dampak olahraga aerobik dan EE. ......Introduction: IGF-1 is a potent growth factor not only for bodily growth but also in central nervous system. Around 70% of total circulating IGF-1 is produced in the liver, it is also secreted into the bloodstream to reach target tissue. IGF-1 has a vital role in adult neurogenesis. Normal aging is associated with reduced IGF-1 concenctration. IGF-1 deficiency is associated with cognitive impairment, Alzheimer’s disease, osteoporosis and diabetes. Recent literatures suggest aerobic exercise increases serum IGF-1, Environmental Enrichment (EE) also increases IGF-1 positive neurons. However, the effect of combination of these treatments to plasma and liver IGF-1 has not been observed. This study aims to examine the effect of aerobic exercise and continuous EE on plasma and liver IGF-1. Method: This study is a secondary data research based on the data acquired in an experiment classified as in vivo experimental research using rats as subjects. Twenty-four 7-month-old month male Wistar rats are randomly divided into four groups which are Control, Aerobic Exercise, Environmental Enrichment and Combination group. The duration of experiment is 8 weeks. Every group has its plasma IGF-1 measured before and after the experiment and after the experiment for liver IGF- 1. IGF-1 plasma and liver levels are analyzed using ELISA method with Qayeebio (QYE10935) kit. The data is analyzed using one-way ANOVA for the plasma and Kruskall- Wallis for the liver using SPSS20 software. Results: There’s no significant statistical difference between groups in plasma IGF-1 (p=0.17) meanwhile there’s statistically significant difference between Aerobic and EE groups (p=0.006) and between Aerobic and Combination groups (p=0.042). Conclusion: Study data analysis using 24 samples did not show statistically significant increase of IGF-1 levels in rats treated with combination of aerobic exercise and continuous environmental enrichment both in plasma and liver. This may suggest the versatility and multiple interaction of IGF-1 and other growth factors and indicating that IGF-1 is not the sole growth factors/ substance mediating the effect of aerobic exercise and environmental enrichment.

Abstrak :
Pendahuluan : Muatan besi berlebih merupakan masalah utama pada pasien thalassemia beta bergantung transfusi karena menyebabkan toksisitas pada jaringan atau organ. Laporan mengenai korelasi antara muatan besi berlebih dengan fungsi endokrin pada pasien dewasa TDT beta yang mengalami retardasi pertumbuhan di Indonesia belum pernah dilaporkan. Tujuan: Mendapatkan profil muatan besi dengan fungsi endokrin pada pasien dewasa TDT beta yang mengalami retardasi pertumbuhan.Metode: Dilakukan studi potong lintang pada pasien thalassemia beta mayor homozigot dan beta HbE usia dewasa yang mendapat transfusi darah di Poliklinik Thalassemia RSCM Jakarta pada Desember 2017. Muatan besi berlebih diwakili oleh feritin serum FS dan saturasi transferin ST, fungsi endokrin yang diperiksa adalah TSHs, fT4, dan IGF-1. FS, fT4 dan TSHs diperiksa dengan metode ELISA. IGF-1 diperiksa berdasarkan metode Solid-Phase ECLIA. Hasil: Proporsi hipotiroid subklinis sebesar 32,7 , kadar IGF-1 rendah pada 79,3 subjek penelitian. Terdapat korelasi negatif lemah FS dengan fT4 r = -0,361; p=0,003 , dan IGF-1 r=-0,313; p=0,008 , tidak terdapat korelasi FS dengan kadar TSHs r=0,074; p=0,29 . Tidak terdapat korelasi ST dengan TSHs r =0,003; p=0,492 , fT4 r=0,018; p=0,448 , dan IGF-1 r=-0,142; p=0,143. Simpulan: Terdapat korelasi negatif antara muatan besi berlebih yang dinilai dari feritin serum dengan fungsi endokrin yang dinilai dengan fT4 dan IGF-1.

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Introduction. Iron overload is a major problem in patients with transfusion dependent beta thalassemia, because it causes toxicity to tissues or organs. The correlation between iron overload and endocrine function in adult TDT beta patients in Indonesia have not been reported. This study aims to obtain a profile of iron load and endocrine function of adult TDT beta patients with growth retardation.Methods Cross sectional study was performed on beta homozygous beta and adult HbE beta patients receiving blood transfusions at the Thalassemia Kiara RSCM Jakarta Clinic, December 2017. Iron overload was represented by serum ferritin FS and transferrin saturation ST, and the endocrine functions are TSHs, fT4 by ELISA method and IGF 1 by the Solid Phase ECLIA method. Results Subclinical hypothyroid proportion was 32,7 and low IGF 1 level was found in 79.3 of subjects. There is a weak negative correlation between FS and fT4 r 0.361 p 0.003, and IGF 1 r 0.313 p 0.008 . No correlation was found between ST with TSHs r 0,003 p 0,492, fT4 r 0,018 p 0,448, and IGF 1 r 0,142 p 0,143. Conclusion There was negative correlation between iron overload based on serum ferritin with endocrine function based on fT4 and IGF 1.