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Abstrak :
This concise, pragmatic, pocket-sized book addresses neurological contributions to the diagnosis and management of dementia through a longitudinal examination of the work undertaken in a dedicated neurological dementia clinic. It covers the use of cognitive and non-cognitive screening instruments and their diagnostic utility and the use of other diagnostic investigations: neuroimaging, neurophysiology and neuropathology. The diagnostic mix is discussed in terms of both neuropsychological syndromes and neurological diagnoses, as is the use of conventional treatments for dementia and the impact of national directives (e.g. NICE, National Dementia Strategy) on day-to-day clinical practice. This book, is an illustrated, practical resource for medical professionals involved in the assessment and management of dementia patients.

Abstrak :
ABSTRAK
Latar belakang dan tujuan: Xerosis atau kulit kering merupakan masalah kesehatan yang sering dijumpai pada usia lanjut. Prevalensi xerosis pada usia lanjut berkisar antar 30 ? 58%. Salah satu faktor yang dijumpai pada kulit kering adalah penurunan ekspresi aquaporin-3 (AQP3). Bahan herbal pegagan atau Centella asiatica ekstrak etanol dalam nanopartikel kitosan (CAEENPK) secara in vitro diketahui dapat meningkatkan ekspresi AQP3 pada keratinosit yang berperan dalam hidrasi kulit. Penelitian ini bertujuan untuk membandingkan efektivitas dan keamanan krim pelembap yang mengandung Centella asiatica ekstrak etanol dalam nanopartikel kitosan 1%, Centella asiatica ekstrak etanol (CAEE) 1%, dan krim pelembap dasar pada populasi geriatri dengan kulit kering. Metode: Penelitian uji klinis acak tersamar buta ganda dilakukan pada 43 orang penghuni panti werdha di Jakarta. Evaluasi skin capacitance (SCap), specified symptom sum score (SRRC), derajat gatal, dan efek samping dilakukan pada awal terapi, minggu kedua, dan keempat. Setelah prakondisi selama satu minggu, setiap subjek penelitian mendapatkan tiga pelembap yang berbeda secara acak pada tiga lokasi di tungkai bawah.Hasil: Tidak didapatkan peningkatan nilai SCap yang berbeda bermakna antara ketiga kelompok pengobatan. Penurunan nilai SRRC setelah empat minggu tidak berbeda bermakna antara ketiga kelompok perlakuan. Derajat gatal pada minggu kedua menurun pada ketiga kelompok, hingga menjadi tidak gatal pada seluruh SP (100%) setelah minggu keempat. Tidak ditemukan efek samping subjektif dan objektif pada ketiga kelompok perlakuan. Kesimpulan: Efektivitas krim pelembap yang mengandung CAEENPK 1% tidak lebih tinggi dibandingkan dengan krim pelembap yang mengandung CAEE 1% atau krim pelembap dasar, serta memiliki keamanan yang sama dalam mengatasi kekeringan kulit pada populasi geriatri. Kata kunci: Centella asiatica, nanopartikel, aquaporin-3, hidrasi kulit, geriatri

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ABSTRACT
Background and objectives: Xerosis or dry skin is a common health issue found in the elderly. The prevalence rate of xerosis in the elderly ranges between 30 - 58%. One of the factors found on dry skin is decreased expression of aquaporin-3 (AQP3). The herbal plant Centella asiatica ethanol extract in chitosan nanoparticle (CAEENPK) has been found to increase the expression of AQP3 on keratinocytes in vitro which plays a role in skin hydration. This study aims to compare the effectiveness and safety of moisturizing cream containing 1% Centella asiatica ehanol extract in chitosan nanoparticle, 1% Centella asiatica ethanol extract (CAEE), and moisturizing cream base in geriatric population with dry skin. Methods: A double-blind randomized controlled trial was conducted on 43 residents of a nursing home in Jakarta. The evaluation of skin capacitance (SCap), specified symptom sum score (SRRC), pruritic degree, and side effects were measured at baseline, week-2, and week-4 after therapy. After a week of preconditioning, each test subject received three different randomized moisturizing creams to be applied on three separate locations on the lower limbs.Results: There was no significant increase in SCap value among the three treatment groups. The decrease in SRRC value after four weeks did not differ among the three treatment groups. The pruritic degree decreased at the second week of treatment in all three groups and completely diminished after the fourth week among all the test subjects (100%). No objective and subjective side effects were found among the three treatment groups. Conclusion: The efectiveness of moisturizing cream containing 1% CAEENPK is not higher when compared to moisturizing cream containing 1% CAEE or moisturizing cream base. It is also as safe in treating dry skin of geriatric population;;ABSTRAK
Latar belakang dan tujuan: Xerosis atau kulit kering merupakan masalah kesehatan yang sering dijumpai pada usia lanjut. Prevalensi xerosis pada usia lanjut berkisar antar 30 ? 58%. Salah satu faktor yang dijumpai pada kulit kering adalah penurunan ekspresi aquaporin-3 (AQP3). Bahan herbal pegagan atau Centella asiatica ekstrak etanol dalam nanopartikel kitosan (CAEENPK) secara in vitro diketahui dapat meningkatkan ekspresi AQP3 pada keratinosit yang berperan dalam hidrasi kulit. Penelitian ini bertujuan untuk membandingkan efektivitas dan keamanan krim pelembap yang mengandung Centella asiatica ekstrak etanol dalam nanopartikel kitosan 1%, Centella asiatica ekstrak etanol (CAEE) 1%, dan krim pelembap dasar pada populasi geriatri dengan kulit kering. Metode: Penelitian uji klinis acak tersamar buta ganda dilakukan pada 43 orang penghuni panti werdha di Jakarta. Evaluasi skin capacitance (SCap), specified symptom sum score (SRRC), derajat gatal, dan efek samping dilakukan pada awal terapi, minggu kedua, dan keempat. Setelah prakondisi selama satu minggu, setiap subjek penelitian mendapatkan tiga pelembap yang berbeda secara acak pada tiga lokasi di tungkai bawah.Hasil: Tidak didapatkan peningkatan nilai SCap yang berbeda bermakna antara ketiga kelompok pengobatan. Penurunan nilai SRRC setelah empat minggu tidak berbeda bermakna antara ketiga kelompok perlakuan. Derajat gatal pada minggu kedua menurun pada ketiga kelompok, hingga menjadi tidak gatal pada seluruh SP (100%) setelah minggu keempat. Tidak ditemukan efek samping subjektif dan objektif pada ketiga kelompok perlakuan. Kesimpulan: Efektivitas krim pelembap yang mengandung CAEENPK 1% tidak lebih tinggi dibandingkan dengan krim pelembap yang mengandung CAEE 1% atau krim pelembap dasar, serta memiliki keamanan yang sama dalam mengatasi kekeringan kulit pada populasi geriatri. Kata kunci: Centella asiatica, nanopartikel, aquaporin-3, hidrasi kulit, geriatri

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ABSTRACT
Background and objectives: Xerosis or dry skin is a common health issue found in the elderly. The prevalence rate of xerosis in the elderly ranges between 30 - 58%. One of the factors found on dry skin is decreased expression of aquaporin-3 (AQP3). The herbal plant Centella asiatica ethanol extract in chitosan nanoparticle (CAEENPK) has been found to increase the expression of AQP3 on keratinocytes in vitro which plays a role in skin hydration. This study aims to compare the effectiveness and safety of moisturizing cream containing 1% Centella asiatica ehanol extract in chitosan nanoparticle, 1% Centella asiatica ethanol extract (CAEE), and moisturizing cream base in geriatric population with dry skin. Methods: A double-blind randomized controlled trial was conducted on 43 residents of a nursing home in Jakarta. The evaluation of skin capacitance (SCap), specified symptom sum score (SRRC), pruritic degree, and side effects were measured at baseline, week-2, and week-4 after therapy. After a week of preconditioning, each test subject received three different randomized moisturizing creams to be applied on three separate locations on the lower limbs.Results: There was no significant increase in SCap value among the three treatment groups. The decrease in SRRC value after four weeks did not differ among the three treatment groups. The pruritic degree decreased at the second week of treatment in all three groups and completely diminished after the fourth week among all the test subjects (100%). No objective and subjective side effects were found among the three treatment groups. Conclusion: The efectiveness of moisturizing cream containing 1% CAEENPK is not higher when compared to moisturizing cream containing 1% CAEE or moisturizing cream base. It is also as safe in treating dry skin of geriatric population. Keywords: Centella asiatica, nanoparticle, aquaporin-3, skin hydration,geriatrics

Abstrak :
The volume provides an introduction to the concept of active surveillance in oncology in general and prostate cancer specifically. The primary focus is to provide a comprehensive guide to the management of patients on surveillance. The volume covers the many complexities and nuances to this approach including, patient selection, risk assessment, how to overcome 'cancer hysteria' when counseling patients, identifying appropriate triggers for intervention, use of PSA kinetics and MR imaging information, technique and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy.

Abstrak :
This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.

Abstrak :
This book is concerned with the general issues of ageing, learning and education for the elderly and then with the more specific issues of why, how and what elders want to learn. This monograph consists of 10 chapters written by various internationally renowned researchers and scholar-practitioners in the field.