Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :
Penelitian ini bertujuan untuk mengetahui karakteristik dosimetri film EBT3 pada berkas elektron lapangan kecil dengan mengimplementasikannya pada kasus karsinoma nasofaring dan sinonasal. Penelitian ini dilakukan menggunakan Linac Synergy Platform yang memproduksi berkas elektron dengan energi 6, 8, 10, 12, 15 MeV. Film EBT3 dengan ukuran 3.2×2.5 cm2 diiradiasi menggunakan range dosis 0-500 cGy. Penelitian ini menggunakan lapangan radiasi 1×1, 2×2, 3×3, 5×5, 8×8 dan 10×10 cm2. Film dipindai menggunakan flatbed scanner Epson Perfection V700 dalam evaluasi pixel value. Perhitungan dan plot antara netOD dan dosis untuk mendapatkan kurva kalibrasi. Evaluasi uncertainty dan sensitivitas film EBT3 dilakukan dengan ImageJ dan MatLab. Hasilnya menunjukkan uncertainty tertinggi pada lapangan 1x1 cm2 dengan nilai 4.6%. Nilai sensitivitas film EBT3 konstan ketika dosis yang diberikan >100 cGy, namun berbeda untuk lapangan kecil yang sensitivitasnya sangat dipengaruhi oleh energi yang diberikan. Selain itu, pixel value yang diperoleh dipengaruhi oleh selang waktu antara iradiasi dengan pemindaian dan rotasi film EBT3 pada saat pemindaian. Namun, pixel value film EBT3 tidak dipengaruhi oleh pembalikan (flipped) film EBT3. Homogenitas scanner Epson V700 arah longitudinal lebih tinggi daripada arah transversal. Berdasarkan hasil pengujian menggunakan persamaan kalibrasi lapangan 10×10 cm2 dapat digunakan untuk membaca dosis sampai lapangan 5×5 cm2, dan khusus untuk energi 15 MeV dapat digunakan sampai lapangan 2×2 cm2. Pada kasus karsinoma nasofaring, semakin kecil lapangan berkas elektron maka nilai presentase diskrepansi dosisnya semakin besar dengan nilai terbesarnya -16.47% (6 MeV) pada lapangan 1×1 cm2. Sedangkan pada OAR spinal cord pada energi rendah dan lapangan kecil nilai nilai dosis yang terukur 0 cGy atau berkas elektron jangkauannya tidak sampai pada spinal cord (OAR). Namun untuk kasus sinonasal selain ukuran lapangan, nilai diskrepansi dosis juga dipengaruhi oleh ketidakhomogenan pada target dengan nilai terbesarnya 10.66% (12 MeV) pada lapangan 2×2 cm2. Hasil koreksi matriks pada scanner rata-rata dapat meningkatkan pembacaan dosis pada implementasi energi berkas elektron lapangan kecil pada kasus karsinoma nasofaring dan sinonasal. ...... This study aimed to determine the dosimetry characteristics of the EBT3 film on a small field electron beam and implementation in nasopharyngeal carcinoma and sinonasal case. The experiments were done using Linac Synergy-Platform which produces an electron beam with the energy of 6, 8, 10, 12, 15 MeV. EBT3 films with the size of 3.2×2.5 cm2 was irradiated using dose in the range of 0 to 500 cGy. We did the experiments using radiation field size of 1×1, 2×2, 3×3, 5×5, 8×8 and 10×10 cm2. The irradiated film was scanned using Epson Perfection V700 flatbed scanner to evaluate the pixel value. We calculated the NetOD (NOD) and plotted the characteristics curve between dose and NOD. We compared the uncertainty and sensitivity of characteristics curve of the EBT3 film between MatLab and ImageJ software. The results show the largest Uncertainty of characteristics curve around of 4.6% at 1×1 cm2. Sensitivity value was constant when film irradiated with >100 cGy, it's influenced much by the energy for small field. In addition, the pixel value obtained is influenced by the time interval between irradiation by scanning and rotation EBT3 film at the time of scanning. However, the pixel value is not influenced by the film EBT3 flipped. Epson V700 scanner homogeneity in the longitudinal direction is higher than the transverse direction. Based on the results of field testing using calibration equation 10×10 cm2 can be used to read the dose until 5×5 cm2 field, and specifically to the energy 15 MeV can be used to read doses a 2×2 cm2. In cases of nasopharyngeal carcinoma, the smaller the field of electron beam then the value of the dose the greater the percentage of discrepancy with the greatest value of -16.47% (6 MeV) on 1×1 cm2 field size. While in OAR spinal cord at low energy and small field values measured dose of 0 cGy or electron beam not coverage to the spinal cord (OAR). But for cases of sinonasal with addition of field size, dose discrepancy value is also affected by irregularities on the target with the greatest value of 10.66% (12 MeV) in 2×2 cm2 field size. The result of the matrix correction increase accuration on implementing electron small field beam in the case of nasopharyngeal carcinoma and sinonasal.

Abstrak :
ABSTRAK
Penelitian ini bertujuan untuk memverifikasi distribusi dosis pada teknik 3D-CRT dan IMRT dengan menggunakan dosimeter TLD rod dan film gafchromic EBT3 pada kasus payudara yang telah dibuat di TPS berdasarkan data klinis di Siloam Hospital TB Simatupang. Penelitian ini dilakukan menggunakan Linac Trilogy dengan TPS menggunakan modul Eclipse versi 11 yang memproduksi berkas foton dengan radiasi 6 dan 10 MV. Film EBT3 dengan ukuran 4 4 cm2 diiradiasi menggunakan energi 6 MV dalam variasi dosis 0 - 260 cGy. Penelitian ini menggunakan lapangan radiasi 10 10 cm2. Film dipindai menggunakan flatbed scanner Epson V700 dalam evaluasi pixel value. Perhitungan dan plot antara netOD dan dosis untuk mendapatkan kurva kalibrasi yang digunakan untuk memperoleh dosis pengukuran pada pasien. TLD rod dengan ukuran 3 mm diiradiasi dengan energi 6 MV dalam dosis 200 cGy. TLD dibaca menggunakan TLD reader Harshaw dalam bentuk muatan coulomb. Perhitungan dan plot antara muatan dan dosis akan mendapatkan faktor kalibrasi yang digunakan untuk memperoleh dosis pengukuran pada pasien. TLD dan film EBT3 ditempelkan pada 5 titik di masker yang digunakan pasien dimana titik 1 daerah trakea, titik 2 daerah aksila, titik 3 daerah mammaria interna, titik 4 daerah nipple, dan titik 5 mammae inferior. Hasil perbedaan dosis menunjukkan penggunaan film gafchromic EBT3 pada verifikasi dosis titik kasus kanker payudara lebih baik daripada TLD rod pada teknik 3D-CRT dan teknik IMRT. Perbedaan dosis antara TPS dan film EBT3 dalam rentang 0,66 sampai dengan 5,67 teknik 3D-CRT dan -0,67 sampai dengan -7,57 teknik IMRT . Perbedaan dosis antara TPS dan TLD rod dalam rentang -2,63 sampai dengan 29,14 teknik 3D-CRT dan -16,41 sampai dengan -46,84 teknik IMRT . Uji statistika menunjukkan korelasi kuat 1,00 tetapi tidak signifikan sig < 0,05 serta terdapat perbedaan dosis titik rata-rata yang signifikan antara film EBT3 dan TLD rod pada kelompok pasien sebelum dan setelah dilakukan operasi. Tidak terdapat perbedaan dosis titik rata-rata antara kelompok sebelum dan setelah dilakukan operasi baik teknik 3D-CRT maupun IMRT dan tidak terdapat perbedaan dosis titik rata-rata antara teknik 3D-CRT dan IMRT.

---

ABSTRACT
The aim of thisresearch is to verify dose distribution in 3D CRT and IMRT by using TLD rod dosimeter and Gafchromic EBT3 films on breast cases that have been made in TPS based on clinical data at Siloam Hospital TB Simatupang.This research was conducted using Linac Trilogy with TPS using Eclipse module version 11 which produces photon beam with radiation of 6 and 10 MV.EBT3 films of size 4 4 cm2 were irradiated using 6MV photon beams in dose variation of 0 260 cGy. Radiation field of size 10 10 cm2 was used in this research. The irradiated EBT3 film was scanned using Epson V700 flatbed scanner to evaluate the pixel value. The calculation and plot between netOD and dose was used to get the calibration curve which will be used to obtain dose measurement for patients. TLD rod of size 3 mm was irradiated using 6 MV in dose variation of 200 cGy. TLD was read by using HarshawTLD reader in coulomb. The calculation and plot between netOD and dose will generate calibration factor used to get dose measurement for patients. TLD and EBT3 film were taped to 5 points in the mask used by patients where 1 point is the OAR trachea and 4 points is the PTV50. The results of dose difference at PTV50 with point orientation.TLD and EBT3 film were taped to 5 points in the mask used by patients wherethe first point is in the OAR trachea , the second point is in the axilla, the third point is in the mammaria interna, the fourth point is in the nipple, and the fifth point is in the mammae inferior. The result of differences in dose shows the use of gafchromic EBT3 film in dose verification on breast cancer is better than TLD rod in 3D CRT technique and IMRT technique. The dose difference between TPS and EBT3 film ranged from 0.66 to 5.67 3D CRT technique and 0.67 to 7.57 IMRT technique . The dose difference between TPS and TLD rod is in the range 2.63 to 29.14 3D CRT technique and 16.41 up to 46.84 IMRT technique . The statistical test showed a strong correlation 1.00 but insignificant sig

Abstrak :
ABSTRAK
Penelitian ini diajukan dalam rangka melanjutkan penelitian sebelumnya oleh Wibowo (2015) tentang evaluasi Gamma Index (GI) untuk material homogen dan inhomogen dengan teknik IMRT. Penelitian ini dilakukan dengan menggunakan film gafchromic EBT3 sebagai detektornya. Kemudian, registrasi antara image dosis planar TPS dengan image hasil pengukuran menggunakan film dilakukan. Perencanaan radioterapi telah disiapkan sebanyak 5 pasien menggunakan modalitas FBCT, TPS Philips Pinnacle3, energi foton 6 MV, teknik IMRT 50 segment, dan CGR 0.2 cm. Evaluasi GI dilakukan dengan DD 2%, DTA 2 mm dan DD 5% DTA 3%, SAD 100 cm, dan kedalaman pengukuran pada phantom yaitu 5 cm dan 10 cm. Hasil penelitian menunjukkan GI pada material homogen lebih tinggi daripada material inhomogen. Selisih rata-rata hasil pengukuran GI terhadap penelitian sebelumnya untuk material homogen berkisar 1.98% (kedalaman 5 cm) dan 2.05% (kedalaman 10 cm) dan untuk material inhomogen sebesar 2.98% (kedalaman ekuivalen 5 cm) dan 4.59% (kedalaman ekuivalen 10 cm).

---

ABSTRACT
This study was the extended work which has been done by Wibowo (2015) about Gamma Index (GI) evaluation for homogeneous and inhomogeneous material with IMRT techniques. This study was done to evaluate the gamma index for registering between the planar of dose planning and the measurement from EBT film. Treatment plan was simulated for 5 patients using FBCT modality, Philips Pinnacle3 planning system, 6 MV photon energy, 50 segments IMRT technique, and calculation grid resolution (CGR) of 0.2 cm. GI evaluation was done with criteria of dose difference (DD) of 2%, dose to agreement (DTA) of 2 mm and DD of 5% DTA of 3 mm, SAD 100 cm, depth of 5 cm and 10 cm of the phantom. The result shows that GI for homogeneous material is greater than for inhomogeneous material with discrepancy to previous work is about 1,98% for homogeneous material (depth 5 cm) and 2.05% (depth 10 cm) while it was found of 2,98% for inhomogeneous material (equivalent depth 5 cm) and 4.59% (equivalent depth 10 cm).

Abstrak :
ABSTRAK
Film EBT3 merupakan model film radiochromic yang didisain khusus untuk keperluan radioterapi eksternal (external beam therapy, EBT) respon film terhadap radiasi pengion mengakibatkan perubahan pada spektrum serapan dan sifat optiknya membuat film radiochromic menjadi pilihan yang banyak digunakan dalam bidang oncologi. Respon film terhadap radiasi biasanya diukur dalam hal perubahan kerapatan optik (netOD) yang nilainya bergantung dari banyaknya berkas yang melewati film dan juga panjang gelombang cahaya dari alat pembaca (densitometer optik). Penelitian ini bertujuan menyelidiki pengaruh penggunaan densitometer optik yang berbeda, yakni scanner, densitometer dan spektrofotometer dalam mengukur respon dosimeter film terhadap radiasi pengion. Penyelidikan respon film dilakukan dengan mengirradiasi film menggunakan pesawat Linac Varian Trilogy dengan energi 6 MV. netOD yang terbaca pada film dilakukan dengan mengekstrak mean pixel value dari kanal merah ketika menggunakan scanner. Ketika menggunakan densitometer netOD dihasilkan dari perubahan nilai OD yang terbaca secara langsung. Sedangkan nilai netOD didapat dengan melihat perubahan spektrum serapan film sesudah dan sebelum irradiasi menggunakan spektrofotometer. Evaluasi penggunaan metode dosimetri dilakukan menggunakan fantom homogen untuk evaluasi dosis uji dan juga untuk evaluasi pada variasi lapangan penyinaran, dan fantom non-homogen (rando) untuk implementasi metode pada perlakuan klinis radioterapi. Untuk mendapatkan hasil pengukuran yang optimum juga dilakukan penyelidikan karakteristik spektrum serapan pada variasi level dosis dan variasi waktu pengukuran pasca irradiasi. Hasil pengukuran respon film menunjukkan tidak terjadi perubahan pita serapan film terhadap perubahan level dosis ataupun terhadap perubahan waktu pasca irradiasi, yakni berada pada pusat pada panjang gelombang 635 nm untuk pita serapan maksimum, dan pita serapan ke-dua berpusat pada 583 nm. Penyelidikan sensitivitas ketiga metode menghasilkan tren kurva sensitivitas yang mirip namum memiliki besar yang berbeda dimana sensitivitas tertinggi didapat ketika menggunakan spektrofotometer. Sementara ketidakpastian (1σ) netOD untuk ketiga metode menghasilkan nilai ketidakpastian yang cukup besar untuk dosis dibawah 100 cGy dan nilai ketidakpastian mulai membaik ketika level dosis meningkat. Pada aplikasi klinis ketiga metode dosimeteri dievaluasi dengan melihat besar diskrepansi yang dihasilkan pada adaerah target kepala, paru-paru dan prostat. Penggunaan scanner dan spektrofotometer menghasilkan rata-rata diskrepansi dibawah 2% untuk semua target pengukuran, sedangkan densitometer menghasilkan rata-rata diskrepansi sampai 3%.

---

ABSTRACT
EBT3 film is a radiochromic film model specially designed for external radiotherapy (EBT). The response of the film to ionizing radiation results in changes in the absorption spectrum and its optical properties making radiochromic films a widely used choice in oncology. The response of the film to radiation is usually measured in terms of the change in optical density (netOD) whose value depends on the number of beams passing through the film and also the wavelength of light from the reader (optical densitometer). This study aims to investigate the effect of using different optical densitometers, namely scanners, densitometers and spectrophotometers in measuring the response of film dosimeters to ionizing radiation. The investigation of the film response was carried out by irradiating the film using a Linac Varian Trilogy with an energy of 6 MV. The netOD read on the film was done by extracting the mean pixel value from the red channel when using a scanner. When using a densitometer the netOD results from changes in OD values that are read directly. While the netOD value was obtained by measuring changes in the absorption spectrum of the film after and before irradiation using a spectrophotometer. Evaluate the use of the dosimetric methods was carried out using homogeneous phantom for the evaluation of test doses and also for evaluation of variations in the radiation field, and non-homogeneous phantom (rando) for the implementation of the method in clinical radiotherapy treatment. To obtain the optimum measurement results, an investigation of the characteristics of the absorption spectrum was also carried out at variations in dose levels and variations in measurement time after irradiation. The results of the measurement of the response of the film showed that there was no change in the absorption band of the film due to changes in dose levels or to changes in time after; irradiation, which was at the center at a wavelength of 635 nm for the maximum absorption band, and the second absorption band was centered at 583 nm. The sensitivityinvestigation of the three methods resulted in a trend of similar sensitivity curves but different magnitudes with the highest sensitivity obtained when using a spectrophotometer. Meanwhile, the uncertainty (1σ) netOD for the three methods resulted in a fairly large uncertainty value for doses below 100 cGy and the uncertainty value began to decrease as the dose level increased. In clinical application, the three dosimetric methods were evaluated by measuring the resulting discrepancy in the target areas of the head, lungs and prostate. The use of a scanner and a spectrophotometer resulted in an average discrepancy of below 2% for all measurement targets, while the use of a densitometer resulted in an average discrepancy of up to 3%.

Abstrak :
[ABSTRAK
Film gafchromic EBT2 dan EBT3 cocok digunakan untuk jaminan kualitas (QA) pada treatment planning systems (TPS) dan linear accelerator (LINAC) serta verifikasi radioterapi teknik IMRT dan VMAT. Namun generasi selanjutnya dari film gafchromic EBT yaitu EBT2 dan EBT3 ketika dilakukan scanning (pemindaian) menggunakan scanner flatbed masih terdapat artefak geometris yang dahulunya juga ditemukan pada film EBT sehingga memerlukan penanggulangan dan koreksi yang sesuai. Pada penelitian ini menggunakan scanner flatbed Epson expression 10000XL, Epson perfection V700 dan Mikrotek 1000XL plus yang dapat menangkap warna dengan rinci dan presisi. Perangkat lunak yang digunakan dalam koreksi ini adalah FilmQA Pro 2015. Hasil yang diperoleh yaitu Koefisien A dan B diterapkan untuk variasi posisi lateral terhadap nilai tanggapan di lokasi yang bersamaan, sehingga pengkoreksian tanggapan artifak lateral dapat dilakukan. Pada dosis maksimum nilai koreksinya <0,5% dan pada kasus <0.2%. Pada pengukuran ulang untuk setiap film, standar deviasi yang diperoleh untuk setiap film sekitar 0.19%. Pengujian dosimetri channel tunggal (merah) sebelum dan sesudah koreksi pada kasus IMRT didapatkan hampir 91% dari piksel memenuhi 3% / 3mm kriteria gamma keseluruhan dengan ambang batas dosis > 10%. Untuk pengujian kasus VMAT, film di scan dengan posisi di pusat scanner dan posisi ektrim tepi scanner, maka pengukuran di channel warna merah 4% lebih tinggi dibandingkan channel warna hijau dan biru. Rata-rata konsistensi pengukuran dosis selama daerah terkena dosis > 100 cGy adalah sekitar 21,8 cGy dan di daerah yang paling dekat dengan tepi scan window sekitar 10 mm dengan perbedaan dosis 35 cGy. Setelah dilakukan koreksi, rata-rata konsistensi dosis pada tiga channel di sekitar daerah terpapar sekitar 5,1 cGy. Perbedaan dosis antar channel sekitar 9 cGy. Hasil ini menunjukkan koreksi respon artefak lateral memang perlu dilakukan. Respon yang diukur tergantung pada posisi film pada pemindai dan dosis yang diberikan. Pengukuran pada channel warna merah menunjukkan sensitivitas yang lebih besar pada dosis rendah, sedangkan respon pada channel hijau atau biru memberikan perpanjangan jangkauan dinamis dari film ke dosis tinggi. Metode triple-channel dosimetri telah terbukti memiliki keuntungan signifikan atas single channel dosimetry dengan akurasi dosimetri yang baik.

---

ABSTRACT The film of gafchromic EBT2 and EBT3 are appropriate for quality assurance (QA) to the radiotherapy technics verification of IMRT and VMAT. In the next generations of EBT which are EBT2 and EBT3, are still attained the geometrical artifacts once scanning by flatbed scanner which is used to be found on EBT film in order to need an overcome ways and an appropriate correction. This research used a flatbed scanner EPSON expression 10000XL, EPSON perfection V700 and Microtech 1000XL plus and FilmQA Pro 2015 as a software for correcting it. The result shows that coefficient A and B were applied for lateral correction artifacts responses can be made. On the maximum dose, it has correction value as much as <0,5% and in case was <0.2%. The deviation standard was approximately 0,19% on re-measure for each film. Prior to the dosimetry measurement of single channel (red) and subsequent to the correction IMRT has got almost 91% of pixel which met with gamma criteria, 3% / 3mm, with dose threshold 10% TH. In the measurement of VMAT‟s case, film scanned on the center of scanner and the extreme position of the scanner edge. Thus, measurement in the red channel was 4% higher than green and blue channel. The average of dose measurement consistency during area exposed to doses > 100 cGy is approximately 21,8 cGy and the closest area with the edge of scan window is around 10 mm at difference doses 35 cGy. After correction, the average of doses consistency was 5,1 cGy on the three channel where exposed. The distinction of doses was approximately 9 cGy among channels. This result stated that the correction of artifacts lateral response is needed to carry on. The method of triple-channel dosimetry has the significant advantage on single-channel dosimetry with a good consistency. Through escalation dose and variation of lateral position, the distinct response would be increased on single-channel which is red channel. The measurement on red channel reveals the highest sensitivity on the slight dose. Whereas, a green or blue channel response provides a dynamic range extension of film to a high dose. Thus, the method of dosimetry triple-channel has the significant contribution of single-channel evidently with a good dosimetric accuracy., The film of gafchromic EBT2 and EBT3 are appropriate for quality assurance (QA) to the radiotherapy technics verification of IMRT and VMAT. In the next generations of EBT which are EBT2 and EBT3, are still attained the geometrical artifacts once scanning by flatbed scanner which is used to be found on EBT film in order to need an overcome ways and an appropriate correction. This research used a flatbed scanner EPSON expression 10000XL, EPSON perfection V700 and Microtech 1000XL plus and FilmQA Pro 2015 as a software for correcting it. The result shows that coefficient A and B were applied for lateral correction artifacts responses can be made. On the maximum dose, it has correction value as much as <0,5% and in case was <0.2%. The deviation standard was approximately 0,19% on re-measure for each film. Prior to the dosimetry measurement of single channel (red) and subsequent to the correction IMRT has got almost 91% of pixel which met with gamma criteria, 3% / 3mm, with dose threshold 10% TH. In the measurement of VMAT‟s case, film scanned on the center of scanner and the extreme position of the scanner edge. Thus, measurement in the red channel was 4% higher than green and blue channel. The average of dose measurement consistency during area exposed to doses > 100 cGy is approximately 21,8 cGy and the closest area with the edge of scan window is around 10 mm at difference doses 35 cGy. After correction, the average of doses consistency was 5,1 cGy on the three channel where exposed. The distinction of doses was approximately 9 cGy among channels. This result stated that the correction of artifacts lateral response is needed to carry on. The method of triple-channel dosimetry has the significant advantage on single-channel dosimetry with a good consistency. Through escalation dose and variation of lateral position, the distinct response would be increased on single-channel which is red channel. The measurement on red channel reveals the highest sensitivity on the slight dose. Whereas, a green or blue channel response provides a dynamic range extension of film to a high dose. Thus, the method of dosimetry triple-channel has the significant contribution of single-channel evidently with a good dosimetric accuracy.]