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Abstrak :
Tujuan: Mengetahui status asam folat dan perilaku tentang asupan asam folat pada akseptor KB, sehingga dapat dipertimbangkan perlu tidaknya suplementasi asam folat pada akseptor KB, khususnya akseptor pil. Tempat: RW 014 Kelurahan Pisangan Baru, Kecamatan Matraman, Jakarta Timur. Bahan dan Cara: Penelitian crows-sectional dan subjek penelilian adalah semua akseptor KB yang memenuhi kriteria penelitian. Data yang dikumpulkan meliputi data sosio demografi, pola makan, asupan giri (makro matrial dan asam folat), status kadar asam folat serum dan sel darah merah (SDM). Hasil: Tidak didapatkan kadar asam folat serum < 3 ag/ml. Status asam folat serum subjek tidak berhubungan dengan pemakaian pil, karakteristik demografi, asupan gizi dan status gizi. Persentase kadar asam folat SDM < 160 mg/ml. adalah 3,5%. Kadar asam folat SDM subjek pil tidak berbeda dengan subjek bukan pil, namun ada kecenderungan kadar asam folat SDM subjek pil lebih rendah dari subjek bukan pil. Secara bermakna kadar asam folat SDM subjck bcrhubungan dengan kebiasaan mengkonsumsi sayur hijau dan kelompok umur. Perbedaan dalam mengolah sayur menyebabkan perbedaan bermakna pada jumlah subjek yang mempunyai kadar asam folat SDM < 160 mg/ml. Rata-rata asupan zat-zat gizi subjck penelitian di bawah AKG yang dianjurkan. Subjek pil mempunyai rata-rasa asupan asam folat lebih rendah bermakna dari subjek bukan pil, namun tidak didapatkan korelasi antara asupan asam folat dengan kadar asam folat serum dan SDM subjek penelitian. Kcsimpulan: Status asam folat serum dan SDM subjek penelitian tidak berhubungan dengan pemakaian pil dan bukan pil, sehingga belum diperlukan suplementasi pada subjek penelitian khususnya subjek pil. ...... Objective: To determine the folic acid slates and the behavior of folic acid intake in contraceptive users. This is in order to decide whether folic acid supplemeration is necessary, especially for pill users. Location: RW 014 Kelurahan Pisangan Baru, Kecamatan Matraman, Jakarta Timur. Methods: cross-sectional study and subjects were all contraceptive users who fulfill study criteria. Data ' collected were socio-demographic, eating paucrn, nutritional intake (macro nutrient and folic acid), nutritional status, serum and RISC folic acid level. Results: Serum folic acid level of < 3 mg/ml, was not found, Scrum folic acid level was not associated with using pill or non pill, socio-demographic, eating pattern, nutritional intake and nutritional status. The percentage of RISC folic acid level of N 160 mg/ml, was 3.5%. RISC folic acid level was not associated with using pill or non-pill, but there was a tendency Chef ItBC folic acid level in pill users was lower than non-pill users, There was a significant correlation between R13C folic acid level wish the frequency of green vegetables consumption and age group, 'Ihe difference in the manner of cooking significantly associated with the number of subject with RBC folic acid level of 160 mg/ml. Nutritional intake was under RDl level in almost subjects. Pill users had in average significant lower folic acid intake compare to non-pill users, but there was no correlation between folic acid intake with scrum and RBC folic acid level. Conclusions: Serum and RHC folic acid stains is not associated with using pill or non-pill. From this study it is still not necessary for folic acid supplementation, especially for pill users.

Abstrak :
Keluhan perdarahan endometrium merupakan efek samping utama yang menjadi alasan akseptor KB susuk menghentikan cara KB yang dipergunakannya. Hal ini merupakan problem penting bagi Program Keluarga Berencana Nasional. Penyebab perdarahan endometrium ini mungkin karena adanya gangguan proses regenerasi jaringan endometrium, termasuk juga gangguan proses angiogenesis. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas angiogenik endometrium peserta KB susk dengan dan tanpa perdarahan. Diharapkan dari hasil penelitian ini dapat mengembangkan cara terapi non hormonal pada perdarahan endometrium. Subyek diambil dari akseptor KB susuk dan telah menggunakan KB susuk selama 3-9 bulan. Untuk pemeriksaan angiogenesis digunakan metoda Folkman. Eksplan endometrium ditanam dalam matriks gel kolagen 3 dimensi yang berisi sel endotel dari umbilikalis manusia dan ditanam selama 96 jam. Potensi aktivitas angiogenik diukur dengan derajat migrasi sel endotel menuju eksplan ( skor 0 - 4 ). Kadar plasma estrogen, progesteron dan SHBG dimonitor selama 2 minggu sebelum biopsi. Telah diperiksa aktivitas angiogenik dari 26 kontrol dan 46 akseptor. Hasilnya menunjukkan skor aktivitas angiogenik dari kontrol lebih tinggi peserta KB susuk. ( skor 1 hampir 0 dengan p C 0,001 ). Skor aktivitas angiogenik pada akseptor dengan perdarahan lebih rendah dari akseptor tanpa keluhan perdarahan, namun perbedaan ini tak bermakna. Kadar plasma estrogen, progesteron tidak mempunyai korelasi yang bermakna dengan aktivitas angiogenik endometrium.

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The Effect Of Vitamin E On Endometrial Angiogenic Response In Implant Contraceptive Users With Bleeding ProblemsThe bleeding problems can be one of the major reason for acceptors discontinuing the use of hormonal contraceptives. The cause of endometrial bleeding may be the disturbances of endometrial regeneration and also the disturbances of angiogenic process. The aim of this study is to look for the differences in endometrial angiogenic activity from women using Implant contraceptives with and without bleeding. The results of this study may provide the basis for developing non hormonal therapy for patients with endometrial bleeding. Subjects was selected from implant contraceptive acceptors and they have had an exposure 3-9 month to implant contraceptives. The Folkman method was applied in the angiogenesis assay. The endometrial explants were placed in a 3 dimensional collagen gel matrix containing suspended Human Umbilical Vein Endothelial Cells and culture for 96 hours. The potency of angiogenic activity was measure by the migration of the endothelial cells toward explants ( score 0 - 4 ). Blood serum levels of estrogen, progesteron and SHBG were monitored for 2 weeks prior to biopsy. The endometrial angiogenic activity from 26 controls and 46 acceptors were measured. The results showed that the endometrial angiogenic activity from controls were significantly higher from Implant contraceptive acceptors (score 1 vs approximately 0 with p t 0,001). The endometrial angiogenic activity in acceptors with endometrial bleeding were lower than the acceptors without bleeding, but the differences was not significant. The plasma levels of estrogen and progesteron have no correlation with the endometrial angiogenic activity.