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Abstrak :
ABSTRAK
Metode sederhana untuk mensintesis turunan lawson 2-Hidroksi-1,4-naftoquinon dari sinamaldehida telah berhasil dilakukan menggunakan nanokatalis CuFe2O4. Nanokatalis CuFe2O4 diperoleh dengan metode kopresipitasi dan dikarakterisasi menggunakan XRD, TEM, dan PSA. Hasil TEM menunjukkan nanokatalis CuFe2O4 yang memiliki ukuran 15-36 nm. Nanokatalis CuFe2O4 mampu mengkatalis pembentukan senyawa turunan lawson 2-Hidroksi-1,4-naftoquinon dan dapat digunakan sampai 5 kali pengulangan reaksi dengan recovery yang baik. Senyawa turunan lawson yang diperoleh dikarakterisasi melalui Spektrofotometer UV-Vis, Spektroskopi IR, dan GCMS. Produk yang dihasilkan memiliki yield sebesar 48,62 hingga 81,52 dan memiliki aktivitas antioksidan dengan nilai IC50 sebesar 8 ppm, 50 ppm dan 77 ppm.

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ABSTRACT
A simple method for synthesis of derivates lawsone 2 hydroxy 1,4 nafttoquinone from cinnamaldehyde has been successfully synthesis used nanocatalyst CuFe2O4. Nanocatalyst CuFe2O4 were obtained from co precipitation methode and characterized by XRD, TEM and PSA. The result of TEM show that CuFe2O4 nanocatalyst that were 15 36 nm. Nanocatalyst CuFe2O4 was able catalyzed the formation of the lawsone derivatives 2 hydroxy 1,4 naftoquinone and can be used up to 5 times in the same reaction procedure with good recovery. The compounds obtained were characterized by Spectrofotometry UV Vis, Spectroscopy IR and GCMS. The product is obtained in fairly high yield from 48,62 to 81,52 and has antioxidant activity with IC50 value 8 ppm, 50 ppm and 77 ppm.

Abstrak :
Senyawa 2-hidroksi-1,4-naftokuinon atau lawson merupakan senyawa yang terkandung dalam tanaman Lawsonia inermis biasa juga disebut pacar kuku. Pacar kuku merupakan tanaman yang mudah dijumpai dan di dalamnya terkandung senyawa fenolik, khususnya naftokuinon yang memiliki aktivitas biologis seperti antibakteri, antikanker, antitumor, serta berpotensi menjadi antioksidan. Melalui pendekatan reaksi multikomponen sintesis senyawa turunan 2-hidroksi-1,4-naftokuinon dengan variasi aldehida aromatik (banzaldehida, sinamaldehida, 4-hidroksi benzaldehida), hidrazin, dan katalis iodin telah berhasil disintesis. Berdasarkan hasil (senyawa 1) hasil reaksi menggunakan benzaldehida belum berhasil disintesis dengan nama IUPAC 2-(hidrazinil(fenil)metil)-3- hidroksinaftalen-1,4-dion dengan rendemen sebesar 91%, untuk (senyawa 2) hasil reaksi menggunakan sinamaldehida juga belum terbentuk 2-(1-hidrazinil-3-fenilalil)-3- hidroksinaftalen-1,4-dion dengan rendemen sebesar 91,75%, untuk (senyawa 3) dengan rendemen sebesar 87,22% belum berhasil juga membentuk senyawa 2-(hidrazinil(4- hidroksifenil)metil)-3-hidroksinaftalen-1,4-dion dari hasil reaksi menggunakan 4- hidroksi benzaldehida. Analisis produk hasil sintesis dikonfirmasi dengan KLT, UV-Vis, FTIR, dan GC-MS. Uji aktivitas antioksidan didapatkan nilai IC50 dari senyawa 1 dan senyawa 2 masing-masing sebesar 204,94 dan 139,06 ppm
2-hydroxy-1,4-naphthoquinone or lawson are compounds where is contained in the Lawsonia inermis plant, also commonly called pacar kuku. Pacar kuku is a plant that is easily to found and it contained in phenolics, especially that naphthooquinone derivativies have biological activities such as antibacterial, anticancer, antitumor, and have the potential to become antioxidants. Through a multicomponent reaction synthesis approach 2-hydroxy-1,4-naphthooquinone derivativies compounds with aromatic aldehyde variations; banzaldehida; cinnamaldehyde; 4-hydroxy benzaldehyde, hydrazine, and iodine catalyst have been synthesized. Based on the results (compound 1) have not succeeded with the name IUPAC 2- (hydrazinyl (phenyl) methyl) -3- hydroxynaphthalene-1,4-dione with 91% yield, for the (compound 2) is still have not ducceeded with the name (E) -2- (1-hydrazinyl- 3-phenylallyl) -3-hydroxynaphthalene- 1,4-dione with 91,75% yield, and then (compound 3) with 87,22% yield have not succeeded in forming 2- (hydrazinyl (4-hydroxyphenyl) methyl) compounds - 3- hydroxynaphthalene-1,4-dione from the reaction using 4-hydroxy benzaldehyde. The analysis of the synthesis products was confirmed by TLC, UV-Vis, FTIR, and GC-MS. The antioxidant activity test found IC50 values of compounds 1 and 2 respectively 204,94 and 139,06 ppm.