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Abstrak :
Indonesian Journal of Dentistry 2006; Special Edition KPPIKG XIV: 379-382 Oral infection can have an adverse effect on other organs of the body. Oral infection especially periodontitis may effect the course and pathogenesis of a number of systemic diseases, such as diabetes mellitus, cardiovascular disease, pre-term low birth weight infant and respiatory disease. The purpose of this article is to evaluate the current status of oral infection especially periodontitis as a potential risk factor of systemic diseases. Three main pathways linking oral infection to secondary systemic effects have been proposed: metastatic infection, metastatic injury and metastatic inflammation. Periodontitis can cause bacteria to enter the blood stream and activate immune cells. These activated cells produce inflammatory cytokines that have a destructive effect thtoughout the entire body. Therefore, periodontitis as a mayor oral infection may eflect the host's susceptibility to systemic disease.