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Abstrak :
Recurrent Aphthous Stomatitis (RAS) is characterized by painful recurring ulceration of oral mucosa and is the most common oral ulcerative disease. The specific etiology of the disease remains unknown. This situation makes the therapy of RAS difficult and uncertain. This article will discuss the effectiveness and the safety of amlexanox 5% in relieving the symptoms and accelerate healing in RAS lesions. Amlexanox 5% is a new drug used topically in treatment of RAS. The mechanism of action by which amlexanox accelerates healing of RAS is unknown. Clinical study of efficacy amlexanox 5% has been demonstrated significantly accelerate healing and reduce pain of RAS, compared to amlexanox 1%, vehicle and no treatment. 5% amlexanox oral paste has an advantageous pharmacological activity to accelerate healing and reduce the pain of RAS, thus it can be used as one of the modality in this therapy.

Abstrak :
Indonesian Journal of Dentistry 2006; Edisi Khusus KPPIKG XIV: 215-220 The purpose of this study was to disclose one of the etiopathogenesis of recurrent aphthous stomatitis (RAS) at molecular level by analyzing the expression of protein anomaly in oral mucosa. This was a cross-sectional explorative and analytic observational study. Samples, who met inclusion and exclusion criteria, were taken from total population. Samples of protein swab were obtained from oral mucosa, serum were taken from 15 patients with major RAS, 20 patients with minor RAS and 15 were control. The characterization of protein anomaly expressed on the surface of oral mucosa epithelium was carried out using SDS-PAGE 12% and Westemblot methods. The result of oral mucosa protein anomaly expression analysis in patients with major RAS using SDS-PAGE 12% revealed five protein bands with molecular weights of 87, 65, 30, 25, and 20 kDa. In minor RAS cases with protein anomaly expression there were four proteins with molecular weights of 87, 65, 25, and 20 kDa, and the protein in remission RAS had four proteins bands with molecular weight of 87, 65, 25 and 20 kDa. The band disappearances by using Westemblot test, of 30 kDa of major cases, 87 and 20 kDa of minor cases and 20 and 25 kDa of remission cases, indicated that those patients were not reacted with polyclonal antibodies of rabbit serum; therefore they had no role in the induction of RAS. ln conclusion, the antigenic protein expressed in oral mucosa of major, minor, and remission RAS was predominantly 65 kDa molecular weight.

Abstrak :
Recurrent aphthous stomatitis (RAS) is an inflammatory condition of oral mucosa and is very common that occur in 20% of population, in which 80% of all cases are minor type. Etiology remains unknown but there are factors that can precipitate the attack, known as predisposing factors, which are haematinic deficiency, food hypersensitivity, bacterial or viral infection, hormonal changes, psychological stress, drugs and local trauma. Management of minor RAS are symptomatic and also discovering all predisposing factors which may play role in order to give the appropriate treatments to all predisposing factors. The appropriate treatment for all predisposing factors is to prevent recurrency or reduce the severity of RAS.This paper presents 2 cases of minor RAS which have bacterial infection from poor oral hygiene; local trauma from radices, irritating tooth cusp and rough surface of calculus; haematinic deficiency; physical / psychological stress and food hypersensitivity, as predisposing factors. The management of those cases are scaling, grinding irritating cusp, giving advice of proper and healthy diet including vitamin supplementation, finding any stress factor and also overcome it. We concluded that finding and eliminating predisposing factors can reduce recurrency and severity of RAS.