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Abstrak :
ABSTRAK
Penduduk bumi telah mencapai lebih dari 7 milyar jiwa dan pertumbuhannya terus meningkat. Kondisi ini menimbulkan tekanan pada penyediaan pangan terutama sumber protein. Peternakan konvensional banyak menyebabkan terjadinya degradasi dan pencemaran lingkungan. Masyarakat kawasan karst Gunung Sewu (KKGS) dikenal sejak lama memanfaatkan serangga sebagai sumber protein, namun tidak ada data penelitian tentang pemanfaatan serangga. Tujuan penelitian ini adalah mengumpulkan data jenis serangga yang dimanfaatkan sebagai sumber protein pada masyarakat KKGS, menganalisis faktor yang mempengaruhi konsumsi serangga pada masyarakat KKGS, dan mengkaji dampak pemanfaatan serangga sebagai sumber protein pada masyarakat di KKGS. Penelitian ini menggunakan pendekatan kuantitatif. Pengumpulan data dilakukan dengan observasi lapangan, penyebaran kuesioner, dan wawancara kemudian dilakukan telaah pustaka. Hasil penelitian menunjukkan masyarakat di kawasan Karst Gunung Sewu memanfaatkan 18 jenis serangga yang sebagian besar berasal dari ordo Coleoptera (kumbang), Orthoptera (belalang dan jangkrik), dan Lepidoptera (kupu-kupu dan ngengat) sebagai sumber protein, karena pada musim tertentu memiliki kelimpahan yang sangat tinggi. Faktor Internal (serangga mempunyai rasa yang enak dan lezat) dan faktor eksternal (lingkungan, ekonomi, dan sosial) mempengaruhi dan saling berkaitan dalam membentuk perilaku konsumsi serangga pada masyarakat di kawasan karst. Pemanfaatan serangga sebagai sumber protein pada masyarakat di kawasan karst Gunung Sewu mempunyai dampak yang positif terutama pada aspek lingkungan dan ekonomi yaitu dapat membantu menggantikan peran predator alami serangga yang hilang dan juga mampu meningkatkan perekonomian masyarakat setempat

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ABSTRACT
Earth's population has reached more than 7 billion people and its growth continues to increase. These conditions led to pressure on the provision of food, especially protein sources. Many conventional farms cause environmental degradation and pollution. The community of Gunung Sewu karst area (GSKA) known since long time been using edible insects as a protein source, but there is no research data on the use of insects. The purpose of this study is to collect data species of insect used as a protein source on GSKA community, to analyze factors influencing the consumption of edible insects on GSKA community, and examines the impact use of edible insects as a protein source on GSKA community. This study uses a quantitative approach. The data collection is done by field observations, questionnaires and interviews later conducted literature review. The results showed people in the Gunung Sewu Karst Area use of 18 species of insects are largely derived from the order Coleoptera (beetles), Orthoptera (grasshoppers and crickets), and Lepidoptera (butterflies and moths) as a protein source because in a particular season has an abundance of very high. Environmental factors and economic factors, has the highest influence on the consumption of insects in GSKA community. Internal factors (insect has a good flavor and delicious) and external factors (environmental, economic, and social) influence and interrelated in the consumption activities of insects. Utilization of insects as a protein source in the GSKA community has a positive effect especially on environmental and economic aspects, which can help replace the role of natural predators of insects were lost and also able to improve the local economy

Abstrak :
Latar Belakang. Prevalensi balita wasting di Provinsi Nusa Tenggara Barat mencapai 10%, hal ini dapat memengaruhi tumbuh kembang anak balita. Hasil penelitian sebelumnya menyimpulkan bahwa terdapat hubungan antara infeksi dan asupan nutrisi terhadap wasting. Penelitian ini ditujukan untuk mengetahui karakteristik balita, prevalensi wasting, dan asupan karbohidrat, protein, dan lemak serta hubungannya terhadap wasting pada balita di Desa Sembalun Bumbung, NTB. Metode. Studi potong lintang telah dilaksanakan dengan melibatkan 112 balita usia 6-59 bulan di Desa Sembalun Bumbung, Kecamatan Sembalun, Lombok Timur, NTB pada Agustus 2019. Data antropometri berupa tinggi badan dan berat badan diukur untuk menentukan status gizi. Wawancara menggunakan kuesioner dilakukan untuk mendapatkan data demografi, sedangkan untuk mendapatkan asupan makronutrien balita menggunakan multiple-pass 2x24 hour food recall terhadap ibu balita. Data antropometri diolah menggunakan WHO Anthro Survey Analyser, sedangkan kuesioner diolah dengan bantuan perangkat lunak Epidata versi 4.4. Data asupan makanan dari food recall diolah menggunakan Nutrisurvey 2004. Data dianalisis menggunakan uji Fisher’s Exact Test pada SPSS versi 20. Hasil. Prevalensi balita wasting di Desa Sembalun Bumbung adalah 7%. Uji bivariat menyatakan bahwa asupan karbohidrat, protein, dan lemak tidak memiliki hubungan yang signifikan terhadap wasting (p>0.05). Kesimpulan. Asupan karbohidrat, lemak, dan protein tidak memiliki hubungan terhadap wasting pada balita usia 6-59 bulan di Desa Sembalun Bumbung

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Background. Wasting prevalence in children under-five in Nusa Tenggara Barat Province is 10%, while wasting is an important factor affecting children’s growth and development. Current research shows that infection and nutrition intake affect wasting. This research is aimed to identify characteristics, prevalence of wasting, and association between carbohydrate, protein, and fat intake on wasting in children under-five at Sembalun Bumbung Village, NTB. Method. A cross sectional study was conducted in Desa Sembalun Bumbung, Kecamatan Sembalun, Lombok Timur, NTB in August 2019; 112 children of 6-59 months age were recruited. Anthropometry data including height and weight was obtained to analyze nutritional status. Children’s mothers were interviewed to collect sociodemographic data and macronutrient intake through multiple multiplepass 2x24 hour food recall using food portion pictures from Indonesian Ministry of Health. Anthropometry and questionnaire data were processed using WHO Anthro Survey Analyser and Epidata version 4.4. According to Indonesian Ministry of Health Food Composition Data, macronutrient intake from dietary recall was processed using Nutrisurvey 2004. Statistical data was analyzed with Fisher’s Exact Test using SPSS version 20. Result. Wasting prevalence of children under-five in Sembalun Bumbung Village was 7%. Bivariate analysis showed that carbohydrate, protein, and fat intake were not statistically significant on wasting prevalence (p>0.05). Conclusion. Carbohydrate, fat, and protein intake was not associated with wasting in children under-five in Sembalunbumbung Village

Abstrak :
Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal chemists who are developing small molecule drugs to target proteins and treat diseases. In addition, the book examines the full range of complex biological systems and their interrelationship with chemistry, from the interaction of biological response modifiers with proteins to the chemical biology of cell surface oligosaccharides. Distinguished by an overview of chemical biology that is reinforced and clarified by detailed examples and descriptions of techniques, Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications:* Introduces key technologies and methods of chemical biology designed to detect the interactions of small molecules and proteins* Facilitates the discovery of small molecules that bind to proteins and describes the molecules' application in the investigation of biological processes* Presents timely coverage of the development of fluorescent probes for small molecules, as well as the generation of small molecule ligands and inhibitors* Reviews important techniques such as chemical genomics, target profiling, immobilization technology, detection methods, chemical inhibition, and structure-based targeting* Offers a compelling synopsis of data that underscores the recent progress made in the area of targeting proteins by small molecules

Abstrak :
This book about protein-protein Interactions as drug targets, targeting the MDM2-p53 protein-protein interaction for new cancer therapeutics, the development of small-molecule IAP antagonists for the treatment of cancer, protein-protein interaction targets to inhibit HIV-1 infection, inhibitors of protein-protein interactions paramyxovirus fusion ? a focus on respiratory syncytial virus, rational design strategies for developing synthetic inhibitors of helical protein interfaces, and the discovery of navitoclax, a Bcl-2 family inhibitor.

Abstrak :
While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Aggregation of Therapeutic Proteins provides an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. This book also covers an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins. The knowledge in this book will help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area.