Ditemukan 1 dokumen yang sesuai dengan query
Jennifer Christie
"[Kurkumin merupakan pigmen berwarna jingga kekuningan yang dapat mengalami dekomposisi struktur apabila terkena cahaya. Hal ini menyebabkan senyawa kurkumin menjadi tidak aktif. Salah satu upaya untuk mempertahankan kestabilan kurkumin ini adalah dengan penyalutan lapis tipis. Tujuan dari penelitian ini adalah membuat mikropartikel ekstrak kunyit dengan hidroksipropil metilselulosa (HPMC) menggunakan fluidized bed. Proses penyalutan dilakukan pada ekstrak kunyit 35 mesh (F2) dan 60 mesh (F3) dengan penyalut hidroksipropil metilselulosa (HPMC) 0,5%. Hasil SEM menunjukkan permukaan halus dan glossy pada formula F2 dan F3. Mikropartikel ekstrak kunyit diuji stabilitasnya di bawah pengaruh suhu; sinar matahari; sinar UV 254 nm; dan sinar lampu. Pada formula F2 diperoleh perubahan kadar berturut-turut sebesar 0,09%; 1,62%; 0,09%; dan 0,15%. Pada formula F3 diperoleh perubahan kadar berturut-turut sebesar 4,88%; 9,35%; 3,32%; dan 3,84%. Proses penyalutan ekstrak kunyit dengan hidroksipropil metilselulosa menggunakan fluidized bed belum memberikan hasil yang optimal secara fisik serta penyalutan ekstrak kunyit dengan hidroksipropil metilselulosa dapat meningkatkan kestabilan dari pengaruh suhu dan cahaya.
Curcumin is yellow-orange pigment. The structure of curcumin can be decomposed when exposed to light, which causes the compound of curcumin becomes inactive. To maintain the stability, curcumin has performed thin film coating. This research was intended to produce microparticles of turmeric extract coated hydroxypropyl methylcellulose by fluidized bed. The coating process is performed on curcumin extract 35 mesh (F2) and 60 mesh (F3) with 0,5% hydroxypropyl methylcellulose (HPMC) polymer. SEM results showed that formulation F2 and F3 have smooth surface and glossy. Microparticle of curcumin extract has been exposed at certain temperature condition, sunlight, UV 254 nm light, and light. F2 formulation is obtained change of assay consencutively by 0,09%; 1,62%; 0,09%; and 0,15%. F3 formulation is obtained change of assay consencutively by 4,88%; 9,35%; 3,32%; and 3,84%. Coating process of curcumin extract with hydroxyprophyl methylcellulose by fluidized bed, not provide optimal physically results yet. Coating of turmeric extract with hydroxypropyl methylcellulose could increases the stability of curcumin that affected by temperature and light exposure., Curcumin is yellow-orange pigment. The structure of curcumin can bedecomposed when exposed to light, which causes the compound of curcuminbecomes inactive. To maintain the stability, curcumin has performed thin filmcoating. This research was intended to produce microparticles of turmeric extractcoated hydroxypropyl methylcellulose by fluidized bed. The coating process isperformed on curcumin extract 35 mesh (F2) and 60 mesh (F3) with 0,5%hydroxypropyl methylcellulose (HPMC) polymer. SEM results showed thatformulation F2 and F3 have smooth surface and glossy. Microparticle of curcuminextract has been exposed at certain temperature condition, sunlight, UV 254 nmlight, and light. F2 formulation is obtained change of assay consencutively by0,09%; 1,62%; 0,09%; and 0,15%. F3 formulation is obtained change of assayconsencutively by 4,88%; 9,35%; 3,32%; and 3,84%. Coating process ofcurcumin extract with hydroxyprophyl methylcellulose by fluidized bed, notprovide optimal physically results yet. Coating of turmeric extract withhydroxypropyl methylcellulose could increases the stability of curcumin thataffected by temperature and light exposure.]"
Depok: Fakultas Farmasi Universitas Indonesia, 2014
S60524
UI - Skripsi Membership Universitas Indonesia Library