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"Osteonectin adalah glikoprotein matricellular yang terlibat dalam berbagai proses biologis seperti remodeling jaringan, perbaikan luka, angiogenesis serta diferensiasi seluler, adhesi, proliferasi sel endotel dan fibroblas serta migrasi. Tujuan: mengevaluasi ekspresi mRNA osteonectin sebagai indikator potensial penyembuhan setelah skeling dan penghalusan akar pada pasien periodontitis. Pemeriksaan kedalaman poket dan indeks perdarahan gingiva dilakukan sebelum dan empat minggu setelah skeling dan penghalusan akar. Sampel cairan krevikuler gingiva dikumpulkan dari lima pasien sehat (kontrol) dan 14 pasien periodontitis dengan kedalaman poket absolut 4-6 mm (subjek penelitian) pada sebelum, satu minggu, dua minggu dan empat minggu setelah skeling dan penghalusan akar. Ekspresi mRNA osteonectin dianalisis menggunakan quantitative real-time polymerase chain reaction (qPCR). Uji Friedman ekspresi mRNA osteonectin antara sebelum dan sesudah skeling dan penghalusan akar menunjukkan terdapat perbedaan ekspresi mRNA osteonectin antara sebelum dan satu minggu setelah skeling dan penghalusan akar (p<0,05); penurunan kedalaman poket dan indeks perdarahan gingiva terjadi secara bermakna (p<0,05) antara sebelum dan empat minggu setelah skeling dan penghalusan akar. Uji Spearman menunjukkan tidak ada hubungan antara ekspresi mRNA osteonectin dengan kedalaman poket (p>0,05, r=0,036) maupun indeks perdarahan gingiva (p>0,05, r=0,421). Ekspresi mRNA osteonectin sebelum dan setelah skeling dan penghalusan akar tidak berhubungan terhadap kedalaman poket maupun indek perdarahan gingiva.

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Osteonectin is a matricellular glycoprotein that is involved in various biological processes involves tissue remodeling, wound repair, angiogenesis, cellular differentiation, adhesion, endothelial cell proliferation and migration. Objective: to evaluate the expression of osteonection mRNA as potential indicator of periodontal healing response after scaling and root planing (SRP) in periodontitis patients. Gingival crevicular fluid (GCF) samples were collected from five periodontally healthy subjects and fourteen periodontitis patients with probing pocket depth (PPDs) of 4-6 mm at baseline and one, two, and four weeks respectively after SRP. The expression levels of osteonectin mRNA were measured using quantitative real-time polymerase chain reaction (qPCR). The Friedman test results of osteonectin mRNA expression between before and after SRP showed there were differences in osteonectin mRNA expression between before and one week after SRP (p< 0.05). A decrease in PPDs and Papillar bleeding index (PBI) occured significantly (p<0.05) between before and four weeks after SRP. The Spearman test showed no association between osteonectin mRNA expression and pocket depth (p>0.05; r=0.036), also with gingival index (p>0.05; r=0.421). The expression of osteonectin mRNA before and after SRP is no related to PPD and PBI."

"Latar belakang: Skeling dan penghalusan akar (SPA) dapat mengubah komposisi bakteri patogen. Tujuan: Mengetahui efek klinis dan mikrobiologis (P. gingivalis, T. forsythia) setelah SPA pada periodontitis kronis poket 4-6 mm. Metode: Empat puluh tiga subjek diperiksa kedalaman poket, indeks pendarahan gingiva, sampel plak subgingiva, serta dilakukan SPA pada kunjungan awal, bulan kedua, ketiga, keenam. Hasil: Kedalaman poket, pendarahan gingiva, populasi P. gingivalis, T. forsythia menurun (p<0,05). Penurunan kedalaman poket tidak berhubungan dengan penurunan populasi P.g (p>0,05). Kesimpulan: SPA meningkatkan kondisi klinis dan mikrobiologis poket 4-6 mm. Perbaikan kondisi klinis berhubungan dengan penurunan kedua bakteri kecuali kedalaman poket dengan populasi P.gingivalis.

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Background: Scaling and root planing (SRP) can change the composition of bacterial pathogens.

Objective: To know the clinical and microbiological effects (P.gingivalis and T. forsythia) of SRP at 4-6 mm pocket depth of chronic periodontitis.

Method: Forty-three subject were performed with SRP on the initial visit, two, three, six month. Pocket depth, gingival bleeding index (PBI) and subgingival plaque samples were examined.

Result: (There is a) decrease in pocket depth, gingival bleeding index, populations of P. gingivalis and T. forsythia (p <0.05). The decrease in pocket depth was not associated with a decrease in the population of P.g (p >0.05).

Conclusion: SRP can improve clinical and microbiological condition in the treatment of chronic periodontitis with 4-6 mm pocket depth. The improvement of clinical condition is associated with the decreasing of bacteria population, except pocket depth is not associated with the P. gingivalis population."

"Latar Belakang: Poket periodontal merupakan karakteristik periodontitis. Scaling dan root planing merupakan standar emas untuk perawatan periodontitis. Antimikroba lokal tambahan direkomendasikan pada pasien dengan kedalaman probing ≥5 mm. Tujuan: Untuk mengetahui efektivitas klorheksidin dibandingkan dengan antimikroba lokal lainnya pada periodontitis. Metode: Pencarian dilakukan dengan menggunakan panduan Preferred Reporting Items for Systematic Review and Meta Analysis (PRISMA). Meta-analisis dilakukan pada studi yang memenuhi kriteria inklusi setelah penilaian risiko bias. Hasil: Meta-analisis antara chip klorheksidin dan antimikroba lain menunjukkan perbedaan rata-rata kedalaman probing setelah satu bulan sebesar 0,58 mm (p<0,00001) sedangkan setelah tiga bulan perbedaan rata-rata kedalaman probing adalah 0,50 mm (p=0,001), indeks plak 0,01 (p=0,94) dan indeks gingiva -0,11 mm (p=0,02). Antara gel chlorhexidine dan antimikroba lainnya menunjukkan perbedaan rata-rata kedalaman probing 0,40 mm (p=0,30), indeks plak 0,20 mm (p=0,0008) dan indeks gingiva -0,04 mm (p=0,83) setelah satu bulan. Kesimpulan: Chip klorheksidin lebih efektif pada indeks gingiva dibandingkan antimikroba lainnya setelah tiga bulan. Antimikroba lainnya lebih efektif daripada chip klorheksidin pada kedalaman probing setelah satu dan tiga bulan, dan dari gel klorheksidin pada indeks plak setelah satu bulan.

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Background: Periodontal pockets are characteristic of periodontitis. Scaling and root planing is the gold standard for periodontitis treatment. Additional local antimicrobials are recommended in patients with a probing depth of ≥5 mm.

Objective: To determine the effectiveness of chlorhexidine compared to other local antimicrobials in periodontitis.

Method: Searches were conducted using the Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines. Meta-analysis was performed on studies that met inclusion criteria after risk of bias assessment.

Results: Meta-analysis between chlorhexidine chips and other antimicrobials showed a mean difference in probing depth after one month of 0.58 mm (p<0.00001) whereas after three months the mean difference in probing depth was 0.50 mm (p=0.001), index plaque 0.01 (p=0.94) and gingival index -0.11 mm (p=0.02). Between chlorhexidine gel and other antimicrobials showed a mean difference in probing depth of 0.40 mm (p=0.30), plaque index of 0.20 mm (p=0.0008) and gingival index of -0.04 mm (p=0.83) after one month.

Conclusion: Chlorhexidine chips were more effective on the gingival index than other antimicrobials after three months. The other antimicrobials were more effective than chlorhexidine chips on probing depth after one and three months, and than chlorhexidine gels on plaque index after one month."